!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Tretinoin
!smiles	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
!drugbank_id	DB00755
!pubchem_cid	444795
!cell_type	ME180 squamous cell carcinoma cell line - 1 hour 10μM
!organism	human
!end_metadata
CCL20	0.157689
FOSB	0.150554
EGR2	0.142821
CTGF	0.120884
DUSP1	0.118971
FOSL1	0.102965
DUSP5	0.097970
HBEGF	0.097677
CYP26B1	0.093174
F3	0.091871
IL1B	0.086219
EDN1	0.082616
CXCL8	0.080224
CYR61	0.079219
PTGS2	0.076292
RASD1	0.074946
BHLHE40	0.070949
CSRNP1	0.069983
SIK1	0.069159
EPHA2	0.068060
GADD45B	0.067719
IFFO1	0.066247
EDN2	0.066020
PTGER4	0.065578
TRIB1	0.065076
DUSP6	0.064556
ERRFI1	0.064256
ZFP36	0.062295
ELF3	0.059911
NR4A2	0.059654
CITED2	0.058706
IL36G	0.057937
LIPG	0.057238
RND3	0.056738
MAP3K8	0.056034
IER3	0.055746
IGFL1	0.054240
FOS	0.054065
TIPARP	0.051359
SLC20A1	0.049961
IL1A	0.049919
TNFAIP3	0.049747
NCOA7	0.049540
CD55	0.048983
MIR614	0.048778
ZC3H12A	0.048130
BCL3	0.047823
NR4A1	0.047208
EGR1	0.047084
JUN	0.046900
DEFB103A	0.046399
MAFF	0.046361
LCE3D	0.046316
GPRC5A	0.046006
THBS1	0.045640
ITPRIP	0.045014
DLX5	-0.044351
ANKRD37	0.044175
KPRP	0.044138
FCF1	-0.044035
JUNB	0.043363
CRCT1	0.043235
KLF6	0.043224
GADD45A	0.042784
ITPKC	0.042502
NUP43	-0.042492
CPA4	0.041936
PPP1R15A	0.041124
HES5	-0.040654
FAM84B	0.040112
SPINK6	0.040019
KRT75	0.039786
TRIM31	0.039637
IFFO2	0.039573
FERMT2	0.039453
GLIPR1	0.039088
ARL14	0.038950
SOWAHC	0.038875
SNCAIP	-0.038560
SOX2	-0.038370
TXNRD1	0.038264
STC2	0.038156
RNF39	0.038124
MIR21	0.037988
MIR205	-0.037628
SOX7	0.037609
ID2	-0.037419
LIF	0.036853
LDLR	0.036328
TMEM40	0.036202
HPGD	-0.036152
FAM212A	-0.035834
PSG9	0.035781
PLAUR	0.035717
ADAMTS1	0.035713
SLC20A2	0.035622
DLX3	-0.035564
CYP26A1	0.035514
OVOL1	0.035120
DUSP16	0.035075
SPINK13	0.034929
TAGLN	0.034785
TP53INP2	0.034702
PIM1	0.034562
KRT34	0.034419
KRTAP21-2	0.034309
IER2	0.034232
GCNT3	0.034120
ATF3	0.034006
EGR3	0.033554
MAFB	-0.033337
MAP3K9	0.033257
PHLDA1	0.032659
LOX	-0.032652
ADRB2	0.032586
BPNT1	-0.032522
IRS2	0.032015
ENC1	0.032000
TIMP3	0.031943
TRMT2B	-0.031728
PPARGC1A	-0.031643
PTPRH	0.031640
RELB	0.031210
TRAF4	0.031185
SAMD4A	0.031103
SKIDA1	-0.030948
BTG2	0.030865
SERPINB2	0.030811
PI3	0.030729
KRT80	0.030645
CASP9	0.030473
MYC	0.030334
HILPDA	-0.030231
FST	0.030037
TSPAN1	0.030001
ARPC3	-0.029858
ZFP36L1	0.029825
ETS2	0.029569
ISL1	-0.029500
C1orf116	0.029384
MAL	-0.029327
CEBPA	-0.029323
HOXA13	-0.029295
PLA2G4F	-0.029236
ZNF792	-0.029101
MIDN	0.029031
OSBP2	0.028912
RAB6B	-0.028854
TNFRSF12A	0.028843
CBX4	0.028801
ENTPD7	0.028606
C3orf52	0.028602
RCAN1	0.028430
SNORA12	-0.028368
TNFSF10	-0.028238
ANXA2R	-0.028173
SDC4	0.028088
MFAP5	0.027980
PTHLH	0.027889
AVPI1	0.027711
DUSP8	0.027609
FBN2	0.027488
MCL1	0.027429
TMEM2	0.027215
TSC22D2	0.027155
MYLIP	-0.027010
ELOVL1	0.026900
SPOCD1	0.026854
STON1	-0.026784
PRR15L	-0.026734
FAM110C	0.026541
DCUN1D3	0.026405
HAS3	0.026380
LOC100128288	-0.026286
SCHIP1	0.026248
TUFT1	0.026210
KRT85	-0.026139
KCNH4	-0.025844
SERTAD4-AS1	0.025786
MAP3K14	0.025778
LMOD3	-0.025775
DUSP2	0.025726
GINS4	-0.025714
TOB1	0.025678
ISL2	-0.025437
KRT6C	0.025265
RAB30	0.025253
NTF3	0.025188
DENND3	0.025112
SGMS2	0.025054
MYLK	0.025045
IRF1	0.024995
KRT9	-0.024988
GPR3	0.024980
S1PR5	-0.024951
KRTAP3-1	0.024902
RAB26	-0.024859
HMOX1	0.024831
ZNF184	-0.024663
CHMP1B	0.024639
C17orf59	-0.024576
PRIM2	0.024575
C10orf99	-0.024503
TBC1D2	0.024444
CYSRT1	0.024369
CLCF1	0.024216
LMCD1	0.024152
PSG5	0.024134
B4GALT1	0.024022
KRT23	0.024018
PHF23	-0.023978
TICAM1	0.023894
SPRR2G	0.023889
CCNF	-0.023885
CD59	0.023790
ZC3H10	-0.023787
PWWP2A	-0.023755
AP2B1	0.023730
KRT16	0.023708
GDF15	0.023667
LOC646626	0.023584
GBP1	0.023512
FAM46A	0.023443
EPN3	-0.023433
MT1F	-0.023371
RNA28S5	0.023350
MAT2A	0.023172
MYADM	0.023135
CLASRP	0.023106
PRDM8	0.023030
IRF2BP2	0.023003
TPM1	0.023001
IL1R2	0.022996
KBTBD2	0.022967
DEFB1	-0.022964
GPCPD1	0.022831
CCDC137	-0.022789
RHOBTB2	0.022776
PISD	0.022729
TGFA	0.022714
ULBP1	0.022695
FA2H	-0.022678
ALG1L	-0.022621
MXD4	-0.022610
CLDN4	0.022554
CAPN14	-0.022552
GPC3	-0.022486
EGR4	0.022421
SOX9	0.022356
FHL1	0.022272
IL1F10	0.022265
PSG4	0.022240
VCPIP1	-0.022239
ZNF664	-0.022193
HOXD1	0.022191
PLA2G4C	0.022110
GJB4	0.022069
RP9P	0.021963
SEPP1	-0.021951
KLHL29	0.021941
AKR1B15	-0.021863
KRTDAP	0.021857
NFKBIA	0.021855
SCNN1G	0.021777
EMP1	0.021736
GABARAPL1	0.021717
HIC2	-0.021663
BCL6	-0.021616
USP36	0.021567
SERTAD1	0.021414
SPDYE2B	-0.021384
PSRC1	-0.021371
KRT6B	0.021315
ZNF616	-0.021290
SPRED2	0.021289
ZNF211	-0.021261
CCL8	0.021252
SLFN5	0.021229
ZNF697	-0.021180
CD70	0.021146
NT5C3A	0.021101
ETV4	0.021091
NT5E	0.021064
SFTPD	-0.021017
NR2F1	-0.020959
CYP4F12	-0.020957
LMO1	-0.020923
LRRC75B	0.020898
RUSC2	0.020864
ZNF564	-0.020825
EPHA4	0.020800
XIAP	-0.020775
MAP4K1	-0.020763
PHLDA2	0.020709
PDCD4	-0.020697
ZYX	0.020668
VMP1	0.020614
ZDHHC8P1	-0.020604
SOCS3	0.020485
TIGD5	-0.020451
TTLL1	0.020436
SIRT4	-0.020428
GPR98	-0.020393
RAC3	-0.020358
KDM6B	0.020310
ZNF775	-0.020289
DRAM1	0.020259
LDLRAD4-AS1	0.020196
ZKSCAN4	-0.020180
SAMD11	-0.020178
HMMR	-0.020170
ALDH1A3	0.020152
MIS18BP1	-0.020130
ELMO3	-0.020081
FEM1B	0.020062
LAMC2	0.020050
ULBP2	0.020030
RHOB	0.020026
UGCG	0.020012
GUCY1A2	0.019978
INPP4B	0.019906
SAV1	0.019848
CLCA2	-0.019801
AKR1B10	-0.019786
ZNF680	-0.019773
CCNL1	0.019755
TMEM123	-0.019755
PARS2	-0.019747
CLK1	0.019706
CLDN23	0.019690
VGLL1	0.019665
SCD	-0.019619
JOSD1	0.019594
BAMBI	0.019568
CTSB	-0.019531
GRAMD3	0.019528
RAET1L	0.019500
CPA2	0.019496
GFOD1	0.019492
TCHHL1	-0.019484
GLI3	0.019479
ITGB8	0.019478
VTRNA2-1	-0.019474
PABPC4L	-0.019462
HES2	-0.019336
MFSD11	-0.019311
CSMD2	0.019292
DOCK5	0.019255
SNORA79	-0.019242
TINAGL1	0.019241
ERO1L	0.019215
MESDC1	0.019185
C22orf29	-0.019183
MSX2	-0.019136
FSTL1	0.019112
AKR1C3	-0.019100
KLK5	0.019085
PHF13	-0.019082
ZNF684	-0.019058
EFNA4	-0.018988
PLAT	0.018882
PAQR8	-0.018876
SLCO5A1	0.018847
FOSL2	0.018829
TMX3	-0.018786
SPRR2D	0.018781
C10orf67	0.018765
S1PR3	0.018706
NREP	-0.018705
ZNF385A	-0.018691
TMEM88	0.018681
CMYA5	-0.018668
RAMP2-AS1	-0.018656
NFKB2	0.018632
RBM20	-0.018612
SULF1	0.018604
C11orf24	0.018590
CENPF	-0.018536
SRF	0.018527
SLC1A3	-0.018524
SDPR	0.018495
ZBTB14	-0.018468
HOXB5	-0.018453
TRIM16	0.018409
MPP6	0.018389
SVEP1	0.018381
NYNRIN	-0.018380
DTD2	-0.018351
ANP32AP1	0.018350
LHX2	-0.018313
SCARNA9	-0.018224
DCP1A	0.018169
TBL1XR1	-0.018116
MTFR1L	-0.018107
NOS1AP	0.018092
ABCA1	-0.018089
CLDN1	0.018084
PACRG-AS1	0.018068
KCNJ2	-0.018061
ALDH1A1	-0.018034
BMP2	0.018030
BRF2	-0.018030
NKX3-2	-0.018010
FLNC	0.017983
SOX21	-0.017951
ZNF416	-0.017926
NAPB	-0.017918
ANXA3	0.017907
PLA2G10	-0.017892
ECHDC2	-0.017872
DOK7	0.017852
SLC39A2	-0.017838
YPEL2	-0.017820
FUT1	0.017746
F11R	0.017736
RIMKLB	0.017734
SUZ12	-0.017699
SPOCK2	0.017668
ITPK1-AS1	-0.017653
SALL2	-0.017641
FAR1	-0.017601
LY6D	-0.017584
MIR25	0.017570
KIAA0040	0.017542
ZSWIM5	0.017538
ETV5	0.017535
METTL7A	-0.017522
UTP18	0.017514
LETM2	0.017488
SSC4D	0.017486
ZNF264	-0.017462
UBA7	-0.017448
TUBB2A	0.017444
KIAA1551	-0.017444
LCE3E	0.017434
DSG1	0.017420
C15orf39	0.017419
IL7R	0.017408
PLK2	0.017398
RHPN2	0.017388
TSPAN7	-0.017372
COL16A1	0.017370
KRTAP3-2	0.017358
SLMAP	0.017304
CSRP1	0.017303
BRD8	-0.017298
LRRFIP1	-0.017284
DUSP19	-0.017279
BIK	0.017263
CLCA4	-0.017258
MIR1224	-0.017247
PRR7	0.017241
RGCC	0.017202
LIMCH1	0.017184
ZNF217	0.017163
KEL	-0.017124
MYCN	-0.017107
B4GALNT1	-0.017106
PCMTD1	-0.017087
SLC1A4	-0.017072
HOOK2	0.017056
AMOT	-0.017041
ZNF668	-0.017030
MIR1323	0.017011
C12orf5	0.017009
TRIM65	-0.017008
GJA1	-0.016985
LYRM7	-0.016973
CGA	0.016938
ZNF615	-0.016931
RNF170	-0.016920
ZIC2	-0.016899
STX11	0.016875
TRIM16L	0.016873
RGL1	0.016873
LHFPL1	0.016847
SLC25A25	0.016835
NRIP1	0.016808
ZNF212	-0.016804
EHD3	-0.016796
GM2A	-0.016787
SIAH2	0.016753
TGIF1	0.016703
MNT	0.016647
NABP1	0.016620
SAR1A	0.016613
SERPINF2	-0.016597
ASL	-0.016593
RSBN1	-0.016546
TRIM51	-0.016528
XRCC2	-0.016520
CUL5	-0.016519
SDE2	0.016511
ARRDC3	-0.016478
TMEM37	-0.016462
ZNF25	-0.016434
F2RL1	0.016426
NRG4	-0.016414
FOXC1	0.016391
CEMIP	0.016370