!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	ischemic cerebral cortex
!organism	rat
!end_metadata
ND5	-0.410428
ATP6	0.252777
PKM	-0.208042
ND2	-0.202837
RPS14	-0.169822
MBP	-0.166203
CPE	0.154469
CKB	-0.133985
STXBP1	-0.130337
TSPAN3	0.129322
COX2	0.126384
CCK	-0.125127
COX8A	-0.117855
COX4I1	-0.109360
CYTB	0.107250
ALDOA	-0.106107
TUBA1A	0.104706
TUBA1B	-0.104366
PRKAR1B	-0.103185
EEF1A2	-0.096109
ATP6V0C	-0.088596
CTXN1	-0.088181
NR4A1	0.087374
ATP1B1	-0.087028
TAGLN3	-0.082183
TTR	-0.080147
OLFM1	-0.076444
TPI1	-0.075699
PPIA	-0.075059
ND1	-0.074591
HSPA8	0.074563
HSP90AB1	0.074550
COX3	-0.074028
EGR1	0.071158
PABPC4	-0.070482
MDH1	-0.068789
HSPB1	0.068482
PENK	0.066427
PSAP	-0.063860
ALDOC	-0.063002
FAU	-0.062721
GAPDH	-0.062257
FTH1	0.059541
FOS	0.059485
SEPW1	-0.058333
RPL22	-0.057593
LDHA	-0.057341
NDRG2	0.056824
RAB3A	-0.055165
APP	-0.055118
CAP2	-0.054706
STX1A	-0.053505
COX6A1	-0.053183
TUBB	-0.052988
BCAT1	-0.052780
SNRPN	-0.052640
ENO1	-0.052607
UQCR11	-0.052418
GNAS	-0.052347
SNRNP70	0.051718
CHN1	-0.051634
ARC	0.051277
PRNP	0.050409
JUNB	0.050116
SPOCK2	0.050007
NELL2	-0.049786
RPL23	0.049592
YWHAH	-0.049478
ATP1A3	-0.049083
UBC	-0.048517
DYNLL1	-0.048344
RPS10	-0.047576
AKR1A1	-0.047059
EIF4A2	-0.046969
MAP1A	-0.046747
ENO2	-0.046650
BSG	-0.044090
FAIM2	-0.044000
PTP4A1	0.042602
MGST3	-0.042523
VAMP2	-0.042397
COX7A2	0.041930
RPS29	0.041840
SYN1	-0.041585
LDHB	-0.041387
VSNL1	-0.039928
IQSEC1	-0.039817
PTGDS	0.039622
NDUFA3	0.038938
SLC25A3	-0.038784
APOE	0.038784
HSP90AA1	0.038379
ATP5O	0.038232
GPX4	-0.038121
RPL19	0.037534
RPL8	0.037366
TPT1	0.037154
TOMM20	0.036282
ADCY2	-0.036227
RPLP0	-0.036188
UCHL1	-0.035999
PPP1CA	-0.035742
BASP1	0.035595
RPL27A	0.035529
SLC25A5	-0.035430
NEFL	-0.034935
MFGE8	-0.034821
TAC1	0.034728
SV2B	-0.034206
PSMB5	-0.034034
RPS16	-0.033791
TUBA4A	-0.033148
RPS6	0.032472
NNAT	0.032331
ND4	-0.032259
RPS26	-0.031903
BIN1	-0.031725
STMN1	-0.031499
OXT	0.031396
RPS3	-0.031329
SPARCL1	-0.031201
CDC37	-0.030576
COPZ1	-0.030517
MAP1LC3A	-0.030238
TOM1L2	-0.030072
SPTBN2	-0.030001
SLC25A4	-0.029958
RPL26	0.029872
GAA	0.029825
NDUFA8	-0.029549
TMEM47	0.029364
RPL31	-0.028909
SLC12A5	0.028767
RPS11	0.028745
RPS9	-0.028564
CPLX1	-0.028475
INF2	-0.028169
CSNK2B	-0.028148
SDCBP	0.028088
ATP5G2	0.028082
PLAT	0.028063
DDX3X	0.028051
YWHAZ	-0.028040
GSK3A	0.027679
ENPP2	-0.027646
SYP	-0.027525
SCN1B	-0.026975
RPL9	-0.026921
RPS21	-0.026688
GNB1	-0.026595
TMEM59	-0.026317
CAPNS1	-0.026287
RPS15A	-0.025830
TMBIM6	-0.025750
ITIH3	0.025725
MOBP	0.025699
LPHN1	-0.025682
FLOT1	0.025121
GSTM5	0.025049
CFL1	-0.024975
EGR4	0.024963
STX1B	-0.024962
CNTNAP1	-0.024933
RPL28	-0.024859
FTL	0.024846
GLS	-0.024834
NPY	-0.024688
ATP5H	-0.024309
AP2M1	-0.024245
RPL10	-0.024042
REEP2	-0.024020
NDUFB3	0.023912
NDUFB2	-0.023802
RHOB	0.023478
ATP2A2	-0.023338
CCNL1	0.023296
DNAJB1	0.023126
DYNLRB1	-0.022911
ARF5	-0.022836
NME2	0.022825
APOD	-0.022667
SLC3A2	0.022566
CTSS	0.022135
COX1	0.022024
RPL5	0.022011
BCAN	0.021918
MDH2	-0.021742
MAPKAPK2	0.021411
CYC1	-0.021408
ARRDC1	0.021406
CAMK2N1	-0.021406
YWHAB	0.021261
DUSP6	0.021244
TSPAN17	-0.021079
CD81	0.020958
KLC1	-0.020925
NTSR2	0.020777
PTPN5	0.020702
APLP2	-0.020571
NDUFA4	0.020512
YWHAG	0.020499
RPS13	-0.020414
ATP6V0A1	-0.020387
INA	-0.020343
MARC2	0.020303
ATP2B2	-0.020266
HSPA5	0.020247
NDRG3	0.020162
ZFP36L1	0.020139
SYNJ1	-0.020066
ACTB	-0.020039
PRKCB	-0.019907
HSPD1	0.019866
SCG5	0.019706
UBE2J2	0.019675
HMOX1	0.019671
ALKBH7	-0.019668
GABBR2	-0.019517
PLEKHM2	-0.019427
KCNH1	-0.019367
ID2	0.019353
PIP5K1C	-0.019143
MATK	-0.019093
NDUFS7	0.018961
PTOV1	0.018935
B4GALT6	0.018926
RHEB	0.018905
DUSP1	0.018603
GAS7	-0.018526
STMN4	-0.018497
SLC27A1	0.018482
PDIA6	0.018382
DNM1	-0.018344
SYT11	-0.018311
DGKZ	-0.018199
GPD1	0.018187
INSIG1	0.017906
LZTS1	-0.017864
NFKBIA	0.017817
PAK1	-0.017809
APBB3	0.017712
PITPNA	0.017704
MRFAP1	-0.017624
GAD1	0.017589
GRIK5	0.017567
NDRG4	-0.017558
UNC50	-0.017558
SLC6A8	0.017523
SLC6A1	0.017487
RPL14	0.017407
HIBADH	-0.017380
RASGRF1	-0.017221
PLEKHA1	0.017159
DDN	-0.017081
CCDC124	0.017058
SST	-0.017012
ZFP36	0.016931
SYT17	-0.016876
RPN2	-0.016872
PSAT1	0.016827
SOD1	0.016775
GIT1	-0.016743
ACTG1	0.016711
PSMC5	0.016692
NDUFB9	-0.016646
COX7B	-0.016396
PEX14	0.016323
ATP5D	-0.016303
ZMYM3	0.016224
RPL27	0.016131
RPL30	0.016111
PLP1	-0.015931
GJA4	0.015853
NEK7	-0.015829
CD63	0.015793
APEX1	0.015688
RPL21	0.015665
MAPK8IP2	-0.015654
PI4KA	-0.015632
RPS24	-0.015627
OAZ1	-0.015539
SUB1	-0.015522
CTSD	-0.015289
RPS25	-0.015280
STARD3	-0.015244
PFKP	0.015238
BTG1	0.015230
SVOP	-0.015189
NEDD8	0.015176
SNN	-0.015057
NPTX2	0.015029
CADPS	-0.015021
ATP6V1B2	-0.014990
TMED10	0.014963
YLPM1	0.014931
RALGDS	-0.014893
RPL13A	0.014823
TPST2	0.014733
RAB10	0.014717
VIM	0.014710
ENSA	-0.014700
NDUFB8	-0.014692
CLTC	0.014675
LGALS3BP	-0.014665
FKBP2	-0.014662
ELAVL4	-0.014613
TRDMT1	0.014603
HIVEP2	-0.014561
PSMC3	-0.014547
CDK16	-0.014542
BTG2	0.014513
PGAM1	-0.014494
PPP1R1A	-0.014490
ITPKA	-0.014413
HPCA	-0.014404
MAT2A	0.014286
GABRD	-0.014266
HADHA	0.014255
SH3GL2	-0.014243
METTL7B	0.014210
MYCBP2	0.014199
PLIN2	0.014192
CLIP2	-0.014140
CITED2	0.014128
TH	0.014083
HSPH1	0.014020
PRDX6	0.013991
CTSV	0.013946
HNRNPK	-0.013931
CST3	-0.013910
CD200	0.013897
GDI1	-0.013880
MATR3	-0.013876
TIMP1	0.013874
RPL36AL	-0.013861
CUTA	-0.013857
GRB10	0.013801
AKT1	-0.013787
RESP18	0.013742
NDUFB4	-0.013676
RPL10A	-0.013639
MYRF	0.013636
RPS12	0.013625
PSMA6	0.013589
CDC42EP3	0.013557
NDUFC2	0.013548
NDUFV3	-0.013502
NUCB1	-0.013502
NCKAP1	-0.013445
GABARAP	-0.013442
CAMKK1	-0.013418
TAF10	-0.013385
ALPL	0.013358
PAICS	0.013357
RPL24	0.013346
OLA1	-0.013345
RTN1	0.013283
RPL7A	-0.013273
CADPS2	-0.013253
KLF6	0.013246
FEZ1	-0.013236
ACY1	0.013232
HRAS	-0.013211
EIF4H	0.013133
UBXN1	0.013132
HNRNPF	0.013124
NGFR	-0.013107
MAPT	-0.013085
LITAF	0.013032
MAP3K12	0.012998
PSME4	0.012973
ARFGAP2	-0.012962
DLST	-0.012948
PRDX2	0.012942
GUCY1B3	0.012915
FRMD5	-0.012908
NGFRAP1	0.012904
EEF1G	0.012830
ATN1	-0.012810
SYT5	-0.012771
ATP9B	-0.012740
DDIT3	0.012708
EVL	0.012660
PSMB1	-0.012617
GABARAPL2	0.012483
MAL	-0.012481
MAP1LC3B	0.012478
RPL18A	-0.012445
FKBP1A	0.012443
RPL3	0.012404
RPS23	-0.012398
SLC32A1	0.012367
APH1A	-0.012359
SDHA	0.012297
VPS52	0.012183
ABCC6	0.012152
TMEM55B	0.012114
COX5A	0.012066
INO80E	-0.012044
SNCB	-0.012027
NACA	0.011958
TMEM205	-0.011921
GAP43	-0.011839
NEFH	-0.011819
CDIPT	0.011807
SEC62	0.011766
WIZ	0.011765
DUSP5	0.011646
CARTPT	0.011608
FASN	-0.011588
SLC7A5	0.011576
RPLP2	0.011571
BAG6	-0.011549
SERPINE2	0.011520
PSMD11	-0.011519
FABP3	-0.011516
UQCC2	-0.011484
PTPRN	0.011450
LGALS1	-0.011444
FURIN	-0.011441
FBXO2	0.011418
THY1	-0.011362
PPP2CA	0.011280
PRKCG	-0.011258
LYZ	-0.011226
RPS27A	0.011217
UQCRFS1	-0.011205
CNP	0.011142
PLEKHO1	0.011130
GRID1	-0.011043
HDLBP	-0.011041
PARK7	-0.011019
PEX1	-0.010993
GSTM2	0.010962
DNMT1	0.010942
SGK1	0.010940
MAOA	0.010934
B2M	0.010916
COPS7A	-0.010900
NRN1	-0.010868
ATP5A1	0.010850
PSMD2	-0.010843
FAM195B	-0.010838
PVALB	-0.010823
GIPR	-0.010804
SNAP91	-0.010788
RPL35	0.010773
GTF3C1	-0.010764
PSMB2	0.010757
GJB1	-0.010745
CPSF4	0.010732
CCNG1	-0.010724
SERBP1	-0.010699
EAF1	-0.010689
NDUFV2	0.010673
ARPP21	0.010672
VTN	-0.010639
SLC4A3	-0.010636
SPP1	0.010631
TNK2	-0.010606
ATP6V1D	0.010589
NDUFB10	0.010563
HNRNPA2B1	0.010508
PCOLCE	-0.010505
TULP1	0.010477
PSME2	-0.010466
SRPK2	0.010461
PFN1	-0.010445
ITFG3	0.010437
RPL11	-0.010426
PCBP4	0.010388
RBCK1	0.010379
RXRB	-0.010370
MIF	-0.010366
GOT1	-0.010341
NSFL1C	-0.010329
TIMM17A	0.010291
CCL4	0.010279
CDK5	-0.010275
CDO1	0.010187
NXF1	0.010186
SRSF2	0.010123
SDC4	-0.010119
PITX3	0.010112
RPL6	-0.010068
ARL4A	0.010067
RABGGTB	0.010050
PTTG1IP	0.010039
CDC34	-0.010038
CAMKV	-0.010027
PLLP	-0.009968
ATF3	0.009960
PPP2R1A	0.009953
GALNT5	0.009937
XPNPEP1	0.009869
CNN3	0.009860
ADRBK1	-0.009847
FAAH	-0.009829
SCG2	0.009818
CBFB	0.009812