!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!drug_name	Metformin
!smiles	CN(C)C(=N)N=C(N)N
!drugbank_id	DB00331
!pubchem_cid	4091
!cell_type	liver
!organism	mouse
!end_metadata
FGL1	0.243498
LCN2	0.242349
FGB	0.206721
APCS	0.199770
INMT	-0.174434
APOA4	0.166377
ITIH4	0.156635
ITIH3	0.153446
FGA	0.147882
SAA1	0.137640
LRG1	0.133608
CYP2F1	-0.130843
IGFBP1	0.127512
PHYH	-0.124357
HP	0.115990
ANG	0.105832
RNASE4	0.100509
KRT8	0.097975
SERPINA10	0.097186
PLIN2	0.096327
KRT18	0.094474
SCD	-0.093576
HPD	-0.092332
CES1	-0.090407
CA3	-0.084228
CLU	0.084028
INSIG2	0.078197
SLC27A2	-0.077724
SERPINA7	0.077347
GNMT	-0.076537
HERPUD1	-0.076004
GSTP1	-0.073359
EPHX2	-0.073213
GSTA5	-0.071979
RETSAT	-0.071461
PIGR	-0.070785
FGG	0.070431
SLC27A5	-0.068288
AADAC	-0.066394
P4HB	0.065655
LY6D	0.065414
NNMT	0.064457
TAT	-0.063699
LDHA	0.062528
SPP1	0.061239
AHSG	0.060853
HSPA5	0.060728
FMO3	0.060528
PON1	-0.060343
HSD11B1	-0.059591
TMEM205	-0.059257
APOC2	0.057969
GAPDH	0.057857
UGT2B7	-0.057417
SERPINA6	-0.056786
CYP4A22	-0.055849
C8G	-0.054523
TTC36	-0.054176
NDUFA13	-0.053875
LPIN1	-0.053579
CRP	0.053141
EPHX1	-0.052610
HPX	0.052582
AZGP1	-0.052315
RPLP0	0.052314
ACAD11	-0.052271
MDH2	0.051980
CTSV	0.051885
S100A10	0.050757
EHHADH	0.050121
CYP1A2	-0.050057
SLC10A1	-0.049825
SERPINF1	-0.049074
ALAS1	-0.047922
HIST1H1C	0.046775
APOA2	-0.046298
AKR1C4	-0.046216
TMEM176B	0.044850
PRDX1	0.044834
GHR	-0.044576
ERRFI1	-0.044554
MBL2	-0.044507
PNPLA7	0.043386
AMBP	0.042537
RPS12	0.042399
OAT	-0.042100
NME2	0.041723
C8A	-0.041151
PPA1	0.040710
UPB1	-0.040489
ACTB	0.040367
SORD	-0.040004
SERPINA3	0.039979
CDO1	-0.039833
CYP2C8	-0.039416
ECH1	-0.039385
NUDT7	-0.039290
UPP2	-0.038533
SPRR1A	0.037856
FN1	0.037572
ATP6V0C	0.037534
HEBP1	-0.037255
REEP6	-0.037140
BNIP3	-0.036872
CCRN4L	-0.036689
AHCY	-0.036451
EIF4A2	-0.036312
ELOVL5	0.035516
NDRG2	-0.035508
MORF4L2	0.035381
GLS2	-0.035308
VKORC1	-0.035179
CYCS	0.035173
CP	0.035041
UGT2B17	-0.035023
GABARAPL1	-0.035000
APOH	-0.034738
CALR	0.034474
CYP4V2	-0.034317
EEF1B2	0.034227
PPP1R3G	-0.034165
RPL38	0.034033
MANF	0.034018
SSR3	0.034001
KNG1	0.033878
KLF15	-0.033774
SULT1E1	0.033761
LGALS9B	0.033751
RPL7A	0.033686
ACAA2	-0.033666
ACAT1	-0.033633
RPS7	0.033474
PLG	-0.033458
RPS5	0.033427
UGT2A3	-0.033369
IFITM3	0.033123
FXYD1	-0.033088
TUBB2A	0.032960
PROC	-0.032957
ETNPPL	-0.032787
ACADM	-0.032529
HIST1H2BI	0.032414
HAAO	-0.032362
PGRMC1	-0.032261
VTN	0.032259
CYP3A7	0.032080
GSTM5	-0.032059
KLKB1	-0.031836
APOF	0.031723
LIPC	-0.031685
CPS1	0.031270
HRSP12	-0.031262
SLCO1B3	-0.031155
UGT2B28	-0.030884
ATF5	0.030498
RGN	-0.030099
GLUD1	0.030092
RPL36AL	0.030041
PSMD8	0.029771
CYP8B1	-0.029508
DUSP1	-0.029474
PYGL	-0.029348
MARC1	-0.029097
CFHR1	-0.029096
APOA5	0.028755
G6PC	-0.028701
MARC2	-0.028612
FAH	-0.028589
ALB	-0.028494
HSD17B6	-0.028484
CROT	0.028261
PPARA	-0.028088
MCFD2	0.028018
ITIH2	0.027937
CFH	0.027832
TTPA	-0.027574
NDUFA1	0.027534
DBP	-0.027524
SERP1	0.027251
LYZ	-0.027233
C5	0.027204
RPS11	0.026920
TMBIM6	-0.026848
AFM	-0.026766
ANXA5	0.026693
CSTB	0.026433
PHLDA1	-0.026157
SLC37A4	-0.026124
ALDH3A2	-0.026104
COX7A2	0.026008
NDUFA4	-0.025866
C3	0.025818
FAU	-0.025762
PIPOX	-0.025667
PAQR9	0.025572
FH	0.025464
CFI	0.025445
CYP4A11	0.025317
METTL7B	0.025196
ACSM1	-0.025169
MAOB	-0.025159
SDHB	-0.025146
LCAT	-0.025142
CSAD	-0.025088
CISD1	-0.025008
FDX1	-0.024932
CMBL	-0.024876
LECT2	0.024774
ASNS	0.024767
PIM3	-0.024564
CEBPA	-0.024534
RPS10	0.024454
ACTG1	-0.024453
ABCC3	-0.024378
SGK1	0.024351
PXMP2	-0.024301
SQSTM1	0.024243
RGS16	-0.024231
CTH	-0.024153
ECI1	-0.024147
ACSL1	-0.024087
BLVRB	-0.024067
OTC	-0.024037
RAN	0.023999
GSTA3	-0.023891
THRSP	-0.023666
RPL27A	0.023541
DBI	0.023531
SLC2A2	-0.023395
HPN	-0.023310
RPS20	0.023202
UGT3A1	-0.022933
ISCU	-0.022910
ABHD14B	-0.022833
RPS24	0.022721
ELOVL2	0.022677
PEX11A	-0.022610
SARDH	-0.022519
PBLD	-0.022509
EIF5A	0.022508
SUCLG1	-0.022463
IFITM2	0.022406
GLO1	-0.022345
PPAP2B	-0.022334
CEBPB	-0.022305
HSP90B1	0.022297
GOT1	0.022155
ADH4	-0.022149
PSMA4	-0.022007
FTL	0.021868
SEC14L2	-0.021751
RPL4	0.021589
SEC61G	0.021560
GRN	0.021533
GPLD1	-0.021497
HAGH	-0.021487
RBP4	-0.021476
ETFA	-0.021416
TXNDC12	0.021383
TGM2	0.021333
PGK1	0.021331
CYP4F12	-0.021280
SAT1	0.020955
CTSS	-0.020952
COX4I1	-0.020948
AMY2A	-0.020840
CHCHD10	0.020745
PNP	0.020697
ALDH1L1	-0.020632
METTL9	0.020458
SDC1	0.020236
GPCPD1	-0.020062
AGXT	-0.020013
HMGCS1	0.019967
SAA2-SAA4	-0.019952
APOE	-0.019847
DPYS	-0.019818
SLC38A3	-0.019674
RAB1A	0.019579
ARRDC3	0.019557
ALDH9A1	-0.019525
HADH	-0.019414
ITM2B	-0.019298
ANGPTL3	-0.019296
TM4SF4	0.019187
LRRC59	0.019163
ABCD3	-0.019034
AOX1	-0.018907
CYP27A1	-0.018888
GSTZ1	-0.018845
ACSL4	0.018797
EEF1A1	0.018739
FABP5	0.018690
TMEM176A	0.018625
B2M	0.018599
RPL13	0.018593
DAP	0.018547
TMPRSS6	-0.018473
TPI1	0.018440
MOXD1	0.018299
CLDN2	0.018298
NARS	0.018287
GPT2	0.018190
RPN1	0.018165
ATP5A1	-0.018136
CCBL2	-0.018115
MAT1A	0.018061
SLC35B1	0.018037
PPP2R1A	0.017948
HSP90AA1	0.017914
BHLHE40	-0.017892
PTPLAD1	0.017818
FTH1	0.017765
TMEM37	0.017750
RPS27A	0.017692
PPIB	0.017661
KHK	-0.017651
COX5A	0.017616
ABCC2	-0.017547
VMP1	0.017498
SLC16A1	0.017409
EIF4EBP1	0.017374
FTCD	-0.017353
PSMD6	0.017306
GLUL	-0.017295
FABP2	0.017288
RPL13A	0.017254
C6	-0.017197
GPNMB	-0.017190
CLPTM1L	0.017154
F13B	-0.017118
LPL	-0.017096
ALDH1A1	0.016983
GAMT	-0.016921
PGM3	0.016859
SEC61B	0.016841
CLPX	0.016786
CDH1	0.016764
ARL6IP1	-0.016708
PPAPDC1B	0.016581
PEX7	-0.016508
CREG1	-0.016477
TTC39C	-0.016376
CYB5A	-0.016355
ITIH1	-0.016354
SEC23A	0.016301
GCHFR	-0.016296
NIT2	-0.016287
ECHS1	-0.016221
UQCR11	-0.016160
RAB30	-0.016111
SLC41A2	0.016069
ADH1C	-0.016045
RPL12	0.015946
SCP2	0.015927
AMACR	-0.015875
NIPSNAP3A	0.015859
ARF4	0.015843
ACOX1	-0.015826
RPLP2	0.015818
HIBADH	-0.015807
CHPT1	-0.015801
DCXR	-0.015766
LEPR	0.015732
AK2	-0.015709
CA2	-0.015692
ATP6V0E1	0.015656
TMA7	0.015639
GCH1	-0.015628
TYROBP	-0.015593
ABAT	-0.015566
KRTCAP2	0.015549
TOMM20	0.015547
ARF1	0.015528
CCS	-0.015504
RPL35	0.015416
SERPINC1	-0.015413
HSPA8	0.015399
CCT2	0.015399
RPL10	0.015323
SEC24D	0.015320
PTTG1	-0.015279
MMP12	-0.015273
FBP1	0.015265
MPC1	0.015225
BTG1	0.015206
CHCHD2	0.015167
DHRS4	-0.015122
STBD1	-0.015118
RPL8	-0.015075
GJB1	-0.015069
NR1I3	-0.015069
NDUFB9	-0.015053
CMPK1	0.015049
G0S2	-0.015017
HAO1	-0.015009
FADS2	0.014979
CDIPT	0.014963
CAT	-0.014958
ARL1	0.014943
ALDH7A1	-0.014840
CHMP4B	0.014830
EIF3F	0.014784
NLRP12	0.014693
ETFB	-0.014690
LBP	0.014666
RPL21	0.014650
GSTK1	-0.014644
CD74	-0.014605
NDUFA8	0.014559
DGAT2	-0.014546
FKBP1A	0.014465
SLC47A1	-0.014431
CYP4F8	-0.014404
METTL7A	-0.014360
CYP39A1	0.014293
GLDC	0.014251
RPS29	0.014249
NDUFA6	-0.014220
HSD3B1	-0.014219
ODC1	0.014173
COL18A1	-0.014133
NDUFV3	-0.014074
CTSZ	0.014015
UQCRC1	-0.013944
SLC17A2	-0.013919
LY6E	0.013908
XBP1	0.013884
RPS15A	0.013796
SERINC3	0.013779
BRI3	-0.013733
NME1	0.013714
PGAM1	0.013682
EDF1	0.013673
SSR2	0.013650
TIMM23	0.013617
HAL	-0.013609
SRP9	0.013599
MMP7	0.013582
GARS	0.013556
NFKBIA	-0.013480
HSD17B10	-0.013463
CHDH	-0.013461
FAM134B	0.013425
VSIG4	0.013369
UBC	0.013363
KDELR2	0.013355
CYP7B1	-0.013312
TSPAN31	0.013225
CD14	0.013163
C9	0.013151
BSG	0.013137
UFC1	0.013106
SLC7A2	-0.013094
IGSF5	0.013091
PSAP	-0.013088
HSD17B2	-0.013088
AVPI1	0.013062
RPL18	0.013055
SELENBP1	-0.013053
NDUFS6	0.013004
MLXIPL	-0.012992
ARG1	0.012984
MAT2A	0.012974
CD1D	0.012905
SEMA4G	-0.012888
SEC61A1	0.012881
ECI2	0.012753
COPE	0.012700
NUPR1	0.012697
PPP1R3B	-0.012687
RPS28	0.012666
IDH1	-0.012661
GJB2	0.012660
C11orf54	-0.012608
HINT2	-0.012587
ATRAID	-0.012574
TPT1	0.012540
CLEC7A	-0.012529
GSTM1	0.012526
AKR1C3	0.012494
NDUFA2	0.012490
GYS2	-0.012488
AKR7A2	-0.012452
SEP15	0.012433
HSPA9	0.012410
ASPG	-0.012324
CYP7A1	-0.012246
COQ10B	-0.012237
DHDH	-0.012231
PPIA	0.012180
NIPSNAP1	-0.012150
ALDH8A1	-0.012142
CST3	-0.012133
ID2	0.012116
TSC22D1	-0.012113
AGMO	0.012105
ELOVL1	0.012095
VIMP	0.012069
TFPI2	0.012053