!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	orotic acid
!smiles	C1=C(NC(=O)NC1=O)C(=O)O
!pubchem_cid	967
!cell_type	Livers ( from outbred Wistars - fed a diet with 1% orotic acid) - 14 Day
!organism	rat
!end_metadata
ND5	0.321848
APOE	0.247167
ABCD3	0.226876
VTN	-0.212745
RPS29	-0.167758
APOA2	-0.166874
RPL23	-0.160288
COMT	0.154337
APOA1	-0.128968
RPS16	-0.122784
HSP90B1	0.119421
FGB	-0.118351
FTH1	-0.117740
COX3	0.116820
MGST1	0.110373
PCK1	-0.109600
PDIA4	0.099782
BHMT	0.099655
CDO1	-0.098971
ACAA2	-0.095773
CFB	-0.093816
PABPC4	0.088175
RBP1	-0.086980
TPT1	-0.086684
RNASE4	0.085192
ATP5G1	0.084436
SLC27A2	-0.084237
PAH	-0.080888
GNMT	0.079925
BAAT	-0.079421
INSIG1	-0.078672
AFM	-0.078476
SEPP1	-0.078101
ITIH3	-0.076510
RPS12	-0.075734
CYP2E1	0.073933
PLIN2	-0.073024
APOH	-0.071291
ALDH2	-0.070466
RPS13	-0.070403
PROS1	-0.069702
SERPING1	-0.069027
RPL31	-0.068149
CALR	0.067891
SPP2	-0.067781
ATP5B	-0.067465
UPB1	0.067283
RPL12	-0.065899
KHK	-0.064637
SERPIND1	-0.064567
ARG1	-0.064387
HSPA5	0.064169
ADH1C	0.063808
LDHA	-0.063713
EEF2	0.062771
RPS27A	-0.062293
GSTM1	0.061382
F2	-0.061178
GLUD1	-0.060850
TMEM205	-0.060507
HPX	-0.060351
B2M	-0.059966
APOM	-0.058930
ALDOB	-0.058836
RPL18A	-0.057376
CYB5A	-0.056756
METTL7B	-0.056736
PON1	-0.055930
HYOU1	0.055043
RPL18	-0.054574
PDIA6	0.053120
EEF1A1	0.053020
PGRMC1	-0.052441
RPL19	-0.052267
HSD11B1	-0.051893
CSAD	-0.051387
SLC10A1	-0.051199
AMBP	-0.051111
TARS	-0.050709
FBP1	0.050121
RPS21	-0.050004
ST6GAL1	-0.049591
HRSP12	-0.049211
DBI	-0.048541
RPL9	-0.047818
ERRFI1	-0.047184
TUBA1C	-0.047060
ATP6	0.045678
MGST3	0.045378
HPD	0.044360
MIF	-0.043881
GJB1	0.043524
PTTG1IP	-0.043475
C3	0.043438
GHR	-0.043333
ND1	0.043066
RPS4Y1	-0.042721
PROC	-0.042408
ACTG1	-0.042364
G6PC	-0.042259
C8B	-0.042089
ACLY	-0.040998
G0S2	-0.040533
SERPINA3	0.040374
RPSA	-0.040118
CPS1	-0.040061
RPL15	-0.040034
RPL4	-0.039983
FASN	0.039861
BSG	-0.039253
BDH1	-0.039185
RPL28	-0.039158
SULT2A1	-0.038997
KYNU	-0.038936
HSP90AB1	-0.038584
TST	0.038276
TDO2	-0.037683
HAGH	-0.036942
UGT1A1	0.036240
RPS24	0.036009
GM2A	0.035504
HSD17B13	-0.035283
RPS11	-0.034680
APOC4	-0.034593
RPL26	-0.034538
ND4	0.034397
GSTM5	-0.034201
HP	0.033953
SCD	-0.033948
RPS23	-0.033548
ACTB	0.033433
APCS	-0.033251
RPL24	-0.033134
ND2	0.032675
PPIB	0.032179
C9	-0.032107
CTSC	-0.031985
HDLBP	0.031882
TTPA	-0.031614
RPS27L	0.031174
RPL11	-0.030977
RPL13A	-0.030856
RPL8	-0.030384
PSMB4	0.030363
CAT	-0.029993
RPL5	-0.029962
PDIA3	0.029537
GAMT	0.029473
RPS6	-0.029442
LIPC	-0.029403
PGK1	-0.029282
FDPS	0.028876
UBC	0.028765
ITM2B	0.028712
ARF1	0.028662
CST3	-0.028618
IGFALS	-0.028317
RPS9	-0.028223
RPS26	-0.028007
PSAP	-0.027852
ADK	-0.027647
RPS5	-0.027606
RGN	-0.027391
HMGCS2	-0.027359
APOA4	-0.027086
APOB	-0.026984
MST1	-0.026900
KLKB1	-0.026684
RPS15A	-0.026577
TECR	-0.026488
UGT2B17	-0.026187
SERPINA10	-0.026142
ALDH6A1	-0.026125
RPS7	-0.026111
ATP5C1	-0.025912
MDH1	0.025911
SULT1B1	-0.025789
RPS15	-0.025728
CTSS	-0.025648
DDC	-0.025478
SSR3	0.025472
PRDX1	-0.025014
P4HB	0.024808
SQLE	-0.024704
MTCH2	-0.024469
TTC36	-0.024466
TSC22D1	0.024357
GAPDH	0.024348
SLC3A2	0.024237
MORF4L2	-0.024085
PSMD11	0.024082
AK4	-0.024078
SDC4	-0.024071
GNAS	0.024012
SPINT2	-0.023980
RPL22	-0.023949
HSD17B6	0.023864
AGT	-0.023845
OAZ1	-0.023776
AMACR	0.023720
DPYS	-0.023679
HAAO	-0.023648
FABP1	0.023607
RPL17	-0.023602
NDUFA8	-0.023487
SREBF1	0.023388
CPQ	-0.023347
SRD5A1	0.023327
CES1	-0.023312
OTC	-0.023251
ALAD	-0.023242
FTL	-0.023228
NDUFA6	0.022800
GPT	0.022759
NR0B2	-0.022711
FN1	-0.022613
NUP88	-0.022357
UGDH	0.022200
SEC61B	-0.022032
DIO1	-0.022017
HNRNPK	-0.021622
IGF1	-0.021613
GNE	-0.021466
NDUFB2	0.021421
COX6A1	0.021346
AKR1A1	0.021209
CTSB	-0.021176
KRT8	0.021055
MAOB	-0.020862
ASS1	0.020841
EPHX1	-0.020638
CD63	-0.020549
CYP7A1	0.020488
TMBIM6	0.020478
EIF5	-0.020476
SLC41A2	-0.020470
CTH	-0.020225
LAMP2	-0.020175
NDUFV2	0.020086
RPS8	-0.020055
DDX3X	-0.020038
FAU	-0.019805
UBR5	-0.019295
TMED10	0.019048
CP	-0.018986
RPL35	-0.018839
MPC1	-0.018649
RPL30	-0.018400
PAPSS2	-0.018272
CYP1A2	-0.018254
SLC6A13	-0.018248
MAN2B1	-0.018231
GOT1	0.018219
CPT2	-0.018125
MDH2	-0.018053
TALDO1	-0.017918
PPP1CA	-0.017907
PDYN	0.017865
RPS17	-0.017737
ETNK2	-0.017611
ATP5H	0.017462
PCBD1	0.017413
ENPP3	-0.017379
TRAP1	0.017326
AUH	-0.017292
COX7B	0.017031
COX1	-0.017018
UGT2B28	-0.017017
ALDH1A1	0.016993
ACADM	-0.016952
C11orf73	-0.016949
AGTR1	-0.016942
GSTA5	-0.016938
RPLP2	-0.016931
ATP5G2	0.016819
HPN	-0.016790
SCLY	-0.016765
RPS10	-0.016684
NDUFAB1	0.016652
F9	-0.016643
FAAH	-0.016397
ACADL	-0.016363
ARPC4	0.016244
XDH	-0.016180
ALB	0.015955
PEBP1	0.015917
ANAPC5	-0.015852
PXMP2	-0.015730
RPL37	0.015697
AADAT	-0.015695
SERP1	0.015539
RPS3	-0.015377
ITIH4	-0.015191
EEF1G	-0.015147
DDT	-0.015146
NDUFA3	0.015081
SLC25A5	0.015079
DDRGK1	-0.015015
IDH2	0.014878
DAO	-0.014824
PDAP1	-0.014816
TXN2	0.014797
NDUFB8	-0.014797
AGXT2	-0.014763
TMEM47	-0.014741
HSD3B7	-0.014704
MARC2	-0.014660
GSTK1	0.014549
TMED2	-0.014499
C1QB	-0.014404
RPL27	-0.014333
IDH1	-0.014182
AZGP1	-0.014127
AMY2B	-0.014119
SLC2A2	-0.014096
ETFA	-0.013911
SDS	0.013673
PHB2	0.013573
MAOA	-0.013478
HIBADH	-0.013423
COX7A2	-0.013406
IGFBP1	-0.013341
FGG	-0.013338
ACSL1	0.013282
OAT	0.013253
ZFP36L1	0.013245
PPIA	-0.013180
NDUFB3	-0.013171
CTDSP1	-0.013165
CYC1	0.013158
SLC26A1	-0.013126
CLEC4F	-0.013068
HSPA8	-0.013063
YWHAB	-0.012993
SARDH	0.012936
SERPINA6	-0.012830
NR1H4	-0.012776
COPS7A	0.012762
HACL1	-0.012729
ENO1	-0.012684
DUSP1	0.012681
DHCR7	0.012605
INHBE	-0.012604
FKBP2	0.012565
MMP14	0.012464
SEC61A1	0.012415
RPN2	-0.012398
ACOX2	0.012350
COX8A	0.012271
LITAF	-0.012212
NDUFB9	0.012203
COX5A	-0.012189
RPL10A	-0.012155
SLC25A3	-0.012131
AHSG	0.012103
EIF3B	-0.012097
RPN1	0.012084
FABP6	-0.012079
HSP90AA1	-0.012010
ATP1B1	0.011945
UQCR11	0.011932
CA3	-0.011916
RPP21	-0.011894
GDA	-0.011882
SDCBP	-0.011860
IDI1	0.011854
TMEM59	-0.011792
RFK	0.011785
DLST	-0.011742
FUCA1	-0.011741
NDUFS7	0.011633
PPDPF	0.011615
ALDH3A2	0.011581
ECI1	0.011566
PLG	-0.011551
NPM1	-0.011406
GLUL	0.011345
CD14	0.011294
FAH	-0.011260
ZFAND6	-0.011216
HNRNPA2B1	-0.011177
AQP9	0.011069
PTGR1	-0.011056
ATP2A2	0.011037
EHHADH	0.011036
FGA	-0.010991
FMO1	0.010966
PPP1R10	0.010949
MBL2	-0.010939
EBP	0.010911
FDFT1	0.010887
PTPLAD1	-0.010870
ATP5A1	-0.010846
LCAT	0.010799
NDUFB11	0.010736
AKR1D1	0.010647
TUBA1B	-0.010559
DDAH1	-0.010544
EIF4A2	-0.010515
DDR1	0.010497
CLTA	0.010432
GCKR	-0.010421
KNG1	0.010321
CXXC5	-0.010273
MAP3K1	-0.010267
ASGR1	0.010176
ARF4	-0.010142
ATRN	-0.010112
CEBPA	0.010100
H2AFZ	-0.010086
NPHP1	-0.010078
PSMD2	0.010042
HSD17B12	-0.010036
DHFR	-0.010020
COPZ1	-0.010015
PIGR	-0.009997
PRODH2	0.009973
ACSL4	0.009950
CDC37	-0.009939
SLCO2A1	-0.009892
SUCLG1	-0.009870
PEMT	-0.009691
NR1H3	-0.009634
FAM160B1	-0.009631
RPL27A	-0.009606
CTBS	-0.009574
AVPR1A	-0.009528
GYS2	-0.009471
SIGMAR1	-0.009436
SLC35B1	0.009380
LSS	0.009341
RDH16	0.009338
GNAI2	0.009264
CPD	-0.009136
TAT	-0.009090
HNF4A	0.009012
NDUFC2	-0.008998
CABIN1	-0.008910
SLC22A1	-0.008903
RPS25	-0.008797
FABP7	-0.008760
AP2S1	0.008755
GNG5	-0.008742
GCK	0.008727
RPLP0	0.008720
CA5A	0.008697
SPR	0.008636
AES	-0.008603
CTSD	0.008569
CPSF4	0.008518
FCGRT	-0.008514
DYNLRB1	0.008508
APMAP	0.008494
CTSH	-0.008423
PTPRF	-0.008423
CLUH	-0.008421
CDK5RAP3	0.008419
ALDH1L1	-0.008395
LEP	0.008385
BAX	0.008344
NME2	-0.008343
DCAF11	0.008291
GABARAP	-0.008283
SLC16A1	-0.008279
GRHPR	0.008257
YWHAH	-0.008234
TKT	-0.008220
CLTB	-0.008199
PGAM1	0.008179
RABGGTB	-0.008170
BCKDHB	-0.008169
CEBPB	-0.008164
UNC50	-0.008157
GPD1	0.008087
AIFM1	-0.008073
GDI2	-0.008066
GTF2A2	-0.008041
GNB2L1	-0.008013
LAMTOR1	-0.008002
GNB1	0.008001
PTP4A2	0.007951
RPL21	-0.007946
NDUFV3	-0.007898
GABARAPL2	-0.007840
PPIF	-0.007820
COPB2	-0.007812
HSD17B10	-0.007796
ADIPOR2	-0.007772
CIDEA	0.007767
NCKAP1	-0.007762
PSMC1	-0.007729
APLP2	-0.007728
DAD1	0.007704
INS	-0.007684
MAP1LC3A	0.007660
SQSTM1	-0.007659
NDUFC1	0.007653
CNPY2	-0.007635
BTG2	-0.007611
RBCK1	0.007601