!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Bortezomib
!smiles	CC(C[C@@H](B(O)O)NC(=O)[C@@H](NC(=O)c1cnccn1)Cc1ccccc1)C
!drugbank_id	DB00188
!cell_type	NA
!organism	human
!end_metadata
HSPA7	0.189951
HSPA6	0.157724
DDIT4	0.109335
HSPA1B	0.093553
BAG3	0.091739
ZFAND2A	0.089547
HMOX1	0.088154
DNAJB1	0.078606
GDF15	0.076466
TUBA4A	0.075067
B4GALNT1	0.074845
DEDD2	0.074313
MLLT11	0.073548
HSPA4L	0.071559
ME1	0.069501
DNAJA4	0.069408
PMAIP1	0.064843
TEX19	0.064215
GADD45A	0.063479
C10orf35	0.061534
CHORDC1	0.060796
HSPH1	0.057189
DNAJC2	0.057127
SLC7A5	0.056024
CITED2	-0.055794
HSPA1A	0.055006
PPP1R15A	0.054930
SERPINH1	0.054735
PHTF1	0.053298
IER5	0.053002
STC2	0.052711
RAB39B	0.051972
NOTCH1	0.051295
AHSA1	0.050036
AP4B1	0.049990
HSPB8	0.049745
ASCL1	-0.049383
MTHFD2	0.049373
ACKR3	-0.048919
PELO	0.047712
LPIN1	0.046860
PSMD12	0.046619
CEBPB	0.046221
SQSTM1	0.045260
JUN	0.044241
SLC8B1	0.044208
DNAJA1	0.044190
CYB5R1	0.043974
ABHD4	0.043669
ERRFI1	0.043624
SPTSSB	-0.043042
SLC3A2	0.042683
PSMD14	0.042484
VPS37A	0.041961
CIART	0.041869
DNTTIP2	0.041345
ASNS	0.041024
TXNL1	0.040630
DNAJB6	0.040548
MRPL18	0.040475
ARID5B	-0.040174
UBQLN1	0.039806
YWHAG	0.039773
CAMK2G	0.039423
UCHL1	0.039306
CDKN1A	0.039231
DUSP1	0.039224
PSMC6	0.038985
PALLD	0.038923
ALS2	0.038899
HSPA8	0.038519
PSMC2	0.038153
PSRC1	-0.038010
EPB41L4A-AS1	0.037926
DDIT3	0.037882
HILPDA	-0.037569
GPX3	0.037556
IRX3	-0.037540
ELOVL5	0.037302
HSPE1	0.037015
DCTN4	0.036673
CCRN4L	0.036359
MPHOSPH10	0.036319
EPDR1	0.036050
FTL	0.036040
PANX2	0.034648
MSRB1	0.034048
OTULIN	0.033889
KIF21A	0.033782
RTCA	0.033669
GLA	0.033315
DKK1	-0.033242
OSER1	0.033189
HSP90AB1	0.033101
UBFD1	0.033066
BLVRB	0.033043
TBK1	0.032971
DYNC1H1	0.032876
PSMC1	0.032740
UBC	0.032573
MARCKS	-0.032503
PRR15L	-0.032484
IFRD1	0.032321
GARS	0.032307
HIST1H2AC	-0.032258
CGN	-0.032243
ZFAND5	0.032235
TARS	0.032220
TAX1BP3	-0.032191
ADRM1	0.032161
SLC7A1	0.032009
NKRF	0.031843
SDE2	0.031788
SLC38A6	0.031666
GATA3	-0.031477
TLE1	-0.031426
PSMD1	0.031217
FAM46C	-0.031062
ARRDC4	0.030971
BLMH	0.030804
ZNF770	0.030758
ABCB6	0.030496
HPS3	-0.030271
VEZT	0.029998
KPNA2	-0.029997
SLC2A10	-0.029913
PSME4	0.029902
FGD3	-0.029850
TMEM60	-0.029823
CCNF	-0.029774
AZIN1	0.029748
STIP1	0.029731
FBXO30	0.029713
SLC35C1	-0.029687
ZNF761	0.029619
HIST1H2BD	-0.029523
POP1	0.029290
AURKA	-0.029175
PFDN4	0.029040
LIMA1	-0.029024
ORC3	0.028941
SPATS2	0.028823
C11orf73	0.028793
CEBPG	0.028744
SRXN1	0.028717
TATDN1	0.028715
GCLM	0.028668
VGF	-0.028532
MYC	0.028440
SPATA2L	-0.028433
GADD45G	0.028377
CDC20	-0.028317
GMNN	-0.028268
CCDC117	0.028087
CBX6	-0.028022
MICB	0.027969
PSMA3	0.027845
P4HA2	0.027824
PRNP	0.027696
CCND1	-0.027613
HMMR	-0.027489
SEC24D	0.027451
BRF2	0.027444
ZNF227	0.027418
KBTBD8	0.027404
TRAPPC2P1	0.027395
FKBP4	0.027381
MAP1LC3B	0.027271
DAP3	0.027245
AZI2	0.027212
RDH11	0.027086
E2F3	0.026971
PUS3	0.026705
C1orf52	0.026686
RND1	0.026620
CAMLG	0.026593
NQO2	0.026455
NAP1L2	0.026374
ST13	0.026363
UBE2O	0.026277
HSPA13	0.026273
SUGT1	0.026264
NOTCH3	-0.026197
CTXN1	-0.026149
DNAJB9	0.026129
GCLC	0.026083
PARVB	0.026051
HIST1H3F	-0.025964
ZBTB42	-0.025869
ABHD3	0.025724
GABARAPL1	0.025723
LRP8	0.025668
HENMT1	-0.025501
PROM2	-0.025492
FAM72D	-0.025489
TGFB3	-0.025445
GOLGB1	0.025343
TBL1X	0.025342
APTX	0.025328
SNX3	0.025321
MXD3	-0.025236
GPBP1	0.025181
ULBP1	0.025166
LARP4	0.025155
SOX4	-0.025130
TNFRSF10A	0.025114
IMP3	-0.025081
PPP1R3C	-0.025036
AEN	0.025034
ZNF362	-0.025019
PSMA5	0.024970
RAD23B	0.024845
S100A16	-0.024827
TP53INP1	0.024786
PSMD11	0.024761
PSMC4	0.024728
HIST2H2BE	-0.024700
CLDN3	-0.024652
TAF15	0.024641
MXD1	0.024608
BTG1	-0.024569
RABGGTB	0.024563
CAP2	0.024558
MSANTD3	0.024512
HES6	-0.024476
HIBCH	0.024357
BASP1	-0.024345
TUBE1	0.024327
COPS2	0.024281
ZNF222	0.024242
ELOVL6	-0.024202
ZNF229	0.024185
GKAP1	0.024142
MARS	0.024109
JKAMP	0.024077
CCDC83	-0.024071
GOLGA3	0.024017
RB1CC1	0.024010
TNFRSF11B	-0.024009
TTF2	-0.023991
BOD1	0.023977
ZNF277	0.023955
HSPA9	0.023952
INHBB	-0.023867
LOC113230	-0.023859
SLMAP	0.023813
PAWR	0.023796
PHGDH	0.023747
MAK16	0.023686
SCPEP1	0.023654
CCDC59	0.023650
RUSC1	-0.023622
PSMA2	0.023615
KDM2A	0.023597
NAA25	0.023594
PSMD3	0.023576
TMEM14A	-0.023524
RAB21	0.023519
NPLOC4	0.023505
RHBDF1	-0.023502
TNS3	-0.023491
GPR89B	0.023477
EIF1	0.023458
SMAD6	-0.023448
SLC27A3	-0.023434
KIF22	-0.023426
ARHGAP1	-0.023412
PHLDA3	0.023412
GOLGA6L9	0.023390
PSMB5	0.023382
TUBB2A	0.023334
HMGB2	-0.023331
SPR	0.023324
UBB	0.023197
LIN54	0.023194
SNORA19	0.023177
NR2F6	-0.023142
KYNU	-0.023112
DHRS4-AS1	-0.023074
TACSTD2	-0.023066
LMAN2L	0.023039
MSH6	-0.023025
UBXN4	0.022953
HES4	-0.022929
MIS18BP1	-0.022902
ZNF337	0.022896
KCTD20	0.022844
PLAA	0.022840
SOD1	0.022833
MARCKSL1	-0.022744
SNHG15	0.022698
KIF20A	-0.022695
MAPRE3	0.022686
FEN1	-0.022659
ZSWIM6	0.022654
MCM6	-0.022625
TBC1D15	0.022622
PDXP	-0.022596
MRPS6	0.022417
RNU1-1	0.022366
ACBD3	0.022334
MLKL	0.022330
TTC1	0.022323
PSMB3	0.022281
MAPK6	0.022263
IGFBP5	-0.022258
SPIN4	-0.022255
ANAPC13	-0.022223
YWHAH	-0.022211
CLDND1	0.022206
GINS2	-0.022167
LDLR	0.022152
CSRP2	0.022131
TXNDC9	0.022126
CA12	0.022112
PP7080	-0.022080
PLK1	-0.022065
ZCCHC7	0.022055
HK2	-0.022029
C20orf24	0.021986
GNPDA2	0.021964
LXN	-0.021927
LONP1	0.021915
RPUSD4	0.021888
CCT6A	0.021863
MAP6D1	-0.021843
LAP3	0.021832
STK40	0.021828
TNFRSF10B	0.021820
RIOK3	0.021786
FBXO5	-0.021766
TRAPPC8	0.021713
CDC7	-0.021708
CAMK2N1	-0.021707
HSPD1	0.021699
DLGAP5	-0.021692
CLK1	0.021674
CBLL1	0.021655
FRAT2	-0.021618
PTGES3	0.021593
LSM2	-0.021552
SLC2A1	0.021545
COMMD3	-0.021507
KIAA1143	0.021500
OSBPL10	0.021490
ATAD2	-0.021468
GTF3C3	0.021467
ASPM	-0.021445
CCNA2	-0.021442
FADD	0.021436
LOC100130452	-0.021421
SCARNA18	0.021405
EAF1	0.021338
CYP1B1	-0.021274
TM7SF2	-0.021270
DNAJB2	0.021236
LOC727896	0.021157
RNASEL	0.021138
SLC5A6	-0.021107
CBR3	0.021098
POC5	0.021098
PIK3C2B	-0.021039
ZC3H4	-0.021029
HSPA4	0.020975
RASSF7	-0.020903
SNORD11	0.020898
CLDN7	-0.020896
SLC11A2	-0.020890
SLC44A2	-0.020879
PSMD6	0.020790
PSMC5	0.020776
MTMR11	0.020768
PSMB2	0.020757
KRT8	-0.020707
PIR	0.020706
IDE	0.020705
ZNF233	0.020689
GRPEL2	0.020602
MSX1	0.020602
MAFB	-0.020595
CDK1	-0.020584
LRFN4	-0.020553
FLOT2	-0.020498
C6orf211	-0.020490
RNASET2	-0.020472
TST	-0.020451
REEP5	-0.020422
CLIC3	-0.020414
KIAA1211L	-0.020402
NMI	0.020399
UPF3B	0.020386
TTK	-0.020368
TXNRD1	0.020367
SOWAHC	-0.020350
ERF	-0.020320
THBS1	0.020319
ELF3	-0.020305
FAM127A	-0.020290
NFE2L2	0.020235
XPOT	0.020230
EIF4A2	0.020205
BNIP3	0.020170
MAD2L1	-0.020164
TMEM41B	0.020153
AGPAT9	0.020081
SALL4	-0.020078
BIK	-0.020070
PQLC3	-0.020067
SUN2	-0.020027
C6orf62	0.020018
BUB1	-0.019994
CDK7	0.019909
BBC3	0.019903
DAZAP2	-0.019890
SLC1A5	0.019886
FOS	0.019827
FXR1	0.019822
PSMC3	0.019781
SNHG9	-0.019780
HES1	-0.019756
CCDC84	0.019725
SLC2A4RG	-0.019614
ANAPC10	0.019572
CDC42EP4	-0.019570
C7orf50	-0.019552
MBOAT7	0.019540
CCNG1	0.019533
CCNC	0.019498
SH2B3	0.019469
SPDEF	-0.019461
DNAJC9	-0.019443
PNPLA8	0.019442
CRIP2	-0.019440
CHTOP	-0.019389
CETN3	-0.019372
TOP2A	-0.019371
TMEM167B	0.019353
LINC00936	-0.019353
TNFRSF1A	0.019319
SNHG1	0.019299
REXO2	0.019296
PSMD4	0.019289
TRIM8	-0.019267
ZNF467	-0.019251
INO80	0.019235
PSMA4	0.019226
MFSD3	-0.019226
USH1G	0.019207
METRN	-0.019156
ARF3	-0.019138
TNFRSF12A	-0.019134
TNFSF9	0.019119
ASCL2	-0.019119
INTS10	0.019101
DAD1	-0.019087
FTH1	0.019080
CEACAM6	-0.019079
RAB27B	-0.019056
TCP1	0.019020
LOC146880	-0.019016
YARS	0.019011
JOSD1	0.019009
TAF1D	0.019009
UBR3	0.018976
CDK2	-0.018930
MUC1	-0.018921
YPEL3	-0.018911
SPATS2L	0.018899
STOX2	0.018878
CSRP1	-0.018852
PSMB4	0.018850
TRPM7	0.018846
PRC1	-0.018837
SHROOM3	-0.018801
ACTR6	0.018799
ZCCHC17	0.018790
IRX5	-0.018783
RGS2	0.018782
SHISA2	-0.018778
TMED5	0.018758
ZNF791	0.018720
ADNP2	0.018714
EFNB2	-0.018690
RSL24D1	0.018662
USMG5	-0.018629
DECR1	-0.018615
LMNB2	-0.018606
CNKSR3	0.018594
IRF2BPL	-0.018589
VGLL4	-0.018535
COPRS	-0.018534
MSX2	-0.018464
GPN1	0.018461
SKIDA1	-0.018455
ACOT13	0.018449
TSEN15	0.018434
SLC25A1	-0.018415
CD2BP2	0.018400
NAA16	0.018394
HACL1	0.018349