!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	NICKEL CHLORIDE
!smiles	Cl[Ni]Cl
!pubchem_cid	24385
!cell_type	H4-II-E-C3 LIVER-derived cell line - 400 uM
!organism	rat
!end_metadata
SLC17A3	0.055132
ALDH3A1	0.054065
SERPINA6	-0.052098
NDC80	-0.047973
CCNA2	-0.047859
COL3A1	-0.047467
HSPB6	-0.046762
KIF20B	-0.045609
TAP2	-0.045509
GDE1	0.043870
SWI5	-0.043414
LGALS4	-0.042714
AOX1	0.041951
FAM129A	-0.041626
TM4SF20	-0.041532
CITED1	0.041530
MEX3B	0.041408
PIR	0.041340
L2HGDH	0.040548
TMEM176A	-0.040518
KIF2C	-0.040505
ENTPD5	0.040326
TRAIP	-0.039355
HJURP	-0.038608
DLGAP5	-0.038503
LYST	0.037976
FANCD2	-0.037914
SLC7A11	0.037735
NUSAP1	-0.037304
AMPD3	0.037161
CHDH	0.037010
MAFF	0.036438
EML2	-0.036350
CDCA3	-0.036252
C3	0.036227
OCIAD1	-0.036169
ASF1B	-0.036014
IQGAP3	-0.035680
KIF22	-0.035630
SLC22A4	0.035103
ZBTB49	0.034906
DDIT3	-0.034861
ARHGAP11A	-0.034647
CA2	0.034632
PLK4	-0.034609
AURKB	-0.034465
NKRF	0.034239
CYSLTR1	-0.034078
TMEM176B	-0.033899
HMOX1	0.033798
PTTG1	-0.033683
KIF18B	-0.033605
CDKN3	-0.033552
UBE2C	-0.033271
BUB1	-0.033268
SKA3	-0.033027
ECT2	-0.032651
CENPQ	-0.032360
ZNF416	0.031826
HDDC3	-0.031702
ADRA1A	-0.031694
PDE3A	-0.031487
CASP4	-0.031487
MMP15	0.031443
ALDH1B1	-0.031218
EMP1	0.031210
HAO1	-0.031202
NPL	-0.030919
DDX58	0.030909
MKI67	-0.030840
CHAC1	-0.030668
GYS2	-0.030666
MTHFD2	-0.030640
ADRB3	-0.030634
USP29	-0.030619
LOXL2	0.030595
ZFAND2B	-0.030429
CXCL2	-0.030385
UNC13C	-0.030299
PRC1	-0.030276
TCF19	-0.030240
FBXO32	0.030144
FANCC	-0.030030
RECQL4	-0.029892
LAPTM4A	-0.029841
CENPW	-0.029771
CENPK	-0.029620
HMMR	-0.029513
TMEM130	-0.029474
CSF2RA	-0.029283
RIMS3	-0.029150
DDX11	-0.029111
OSGIN1	0.029076
CYP7A1	-0.029039
TXNRD1	0.029022
NCAPH	-0.029002
GSTA3	0.028985
UBE2T	-0.028919
PURG	0.028866
DUSP12	-0.028820
IL9R	-0.028816
PIAS3	-0.028775
SLC2A2	-0.028771
THNSL1	0.028584
BST1	-0.028482
DDX6	0.028426
ABCC8	0.028416
NUF2	-0.028393
CCL4	-0.028375
FMO5	-0.028342
MANSC1	-0.028285
ADM	0.028282
AXIN2	-0.028260
HEBP1	0.028223
TTK	-0.028130
FAM83D	-0.028125
MYCBPAP	0.028111
SLC48A1	0.028047
IL18BP	0.028019
CYR61	0.027978
CDK1	-0.027933
PDXP	0.027918
IGFLR1	0.027890
SLC13A4	0.027823
HIST1H2BD	-0.027780
MAT1A	-0.027764
FEZ1	0.027726
FGL1	0.027711
HPD	0.027696
SLC30A1	0.027665
KIF23	-0.027619
ASB18	0.027578
CKS2	-0.027570
SPTSSB	0.027546
AURKA	-0.027494
NR2C2	-0.027450
MCM5	-0.027279
COL10A1	-0.027225
LRP5	-0.027220
ACAD11	0.027207
DAB2	-0.027191
JAG1	0.027164
KIAA0430	-0.027092
MBD5	0.027040
CDCA2	-0.027027
APH1A	-0.026915
RRM2	-0.026900
CASC5	-0.026749
FBP1	-0.026747
MTHFD2L	0.026727
AMBN	0.026701
RACGAP1	-0.026664
MESP1	-0.026648
NAMPT	0.026642
NFATC1	0.026595
SLC50A1	-0.026555
RAMP1	-0.026552
CCNB1	-0.026539
SIM1	-0.026534
ARHGEF10	-0.026502
ATF5	-0.026481
CCDC104	-0.026442
C12orf68	-0.026386
SALL1	0.026383
SPINK4	-0.026349
MSTO1	-0.026298
PTGR1	0.026140
RAD51	-0.026137
SERPINE1	0.026083
TIMELESS	-0.026023
KIFC1	-0.025951
CENPF	-0.025939
BSND	0.025835
ISG20	0.025767
E2F8	-0.025751
SPC25	-0.025648
TOP2A	-0.025629
RFC3	-0.025595
CRACR2B	0.025550
SUV420H1	0.025491
RAD51AP1	-0.025448
NAT8B	0.025437
PTPRO	0.025375
FOXM1	-0.025345
HSD3B1	-0.025325
ACKR4	-0.025270
GPATCH2L	-0.025139
PKM	-0.025132
ISLR	-0.025121
HIRIP3	-0.025093
CACNA1S	0.025052
GDF15	-0.025017
NEU3	-0.024972
SS18L1	-0.024958
TMED5	0.024893
DCTD	0.024884
GNAT1	-0.024875
TBX19	-0.024854
AMOTL2	0.024850
SHPK	0.024850
GNGT1	0.024829
RAMP3	0.024745
SLC7A7	-0.024728
PIP4K2B	0.024713
PDZD2	-0.024701
LSMEM2	0.024648
MFNG	0.024605
ASPHD2	0.024560
KIF18A	-0.024515
TULP2	-0.024501
METRN	-0.024463
DPEP2	-0.024406
PLAT	0.024387
IFIT3	-0.024386
AKR1B10	0.024378
SPAG5	-0.024338
ALDH1A1	0.024322
PLK1	-0.024313
AR	-0.024309
GRHL1	0.024300
CDYL2	0.024296
MAGEE1	-0.024289
SKIDA1	0.024278
IGF2BP1	-0.024267
UHRF1	-0.024210
ZNF689	-0.024173
PARPBP	-0.024154
GPR83	0.024096
FOXQ1	0.024090
XKR5	-0.023970
CHTF8	-0.023918
HMCN1	-0.023893
SGK2	-0.023882
RGS7	-0.023867
TRIB3	-0.023833
ST18	0.023765
MIS18A	-0.023714
PRSS45	0.023695
HOXB2	-0.023674
WIPF1	-0.023672
ZNF131	0.023654
CREB3L2	-0.023650
FANCL	-0.023647
KCTD15	0.023645
MUM1L1	0.023638
TK1	-0.023636
SGMS2	0.023606
GADD45B	0.023593
CCNH	-0.023538
MYO9A	0.023494
ACSM1	-0.023494
P2RY1	-0.023489
SGK1	-0.023444
SNRK	0.023441
GNMT	-0.023422
ST6GALNAC3	-0.023414
FBXO2	0.023379
TACC3	-0.023361
NR0B2	-0.023351
SELENBP1	0.023321
PCSK1N	0.023305
PDZD3	-0.023291
HMGB2	-0.023266
KNSTRN	-0.023252
PSD3	0.023157
NQO1	0.023156
OPLAH	0.023137
LEP	-0.023133
TROAP	-0.023071
UHMK1	0.023063
USP31	0.023034
APOA1	0.023022
SLC22A15	-0.023021
POLE2	-0.022994
H2AFX	-0.022954
ZFP37	-0.022949
PCK2	-0.022914
ZNF580	-0.022893
WDHD1	-0.022889
INO80B	-0.022885
GPC1	-0.022829
CLCN1	0.022782
EXTL3	0.022763
AMIGO3	-0.022753
EVA1B	-0.022708
CH25H	-0.022703
SEMA6A	-0.022664
CLCNKB	-0.022612
TUBGCP2	-0.022547
GOT1L1	-0.022531
PPM1N	-0.022510
SNX17	-0.022478
TGFA	0.022434
MCOLN1	-0.022401
KIF20A	-0.022391
MCM8	-0.022376
PDE3B	0.022363
DIO1	0.022305
MAP4K1	-0.022294
NACC1	-0.022284
MSX1	-0.022250
ST8SIA5	-0.022217
FMO1	-0.022211
BIRC5	-0.022164
CLEC9A	-0.022147
ABCD2	-0.022136
SOX7	-0.022114
TAF9B	-0.022092
ZDHHC2	-0.022074
FAM167A	-0.022064
C1GALT1	0.022044
PANX3	0.022022
GNGT2	0.022004
KIF15	-0.021998
BEX4	-0.021956
RFX3	0.021944
GABRA1	-0.021937
VILL	0.021871
BACH1	0.021867
LXN	-0.021799
EFEMP1	0.021761
CDHR5	-0.021738
KCNJ14	0.021705
GPSM2	-0.021681
PLK3	-0.021664
PRSS21	-0.021614
CTNND2	-0.021604
MEF2D	-0.021601
FGF5	-0.021598
CENPN	-0.021594
SOCS2	0.021573
TMEM139	-0.021565
TRIP13	-0.021542
CHAD	0.021503
ALKBH7	-0.021468
GLUL	-0.021382
MMP19	-0.021380
H2AFZ	-0.021337
MAD2L1	-0.021315
CTSE	0.021315
SAPCD2	-0.021314
OGT	0.021310
PSAT1	-0.021308
PRDM4	0.021293
GDPD3	-0.021272
DISP2	0.021259
CHST10	-0.021254
MIA3	-0.021248
LARP6	-0.021218
GRM3	0.021205
ATRNL1	-0.021202
FUT11	-0.021195
ME1	0.021181
FBLIM1	-0.021171
SLC22A23	0.021142
PARM1	-0.021112
GALP	-0.021090
LUM	-0.021086
GPR45	-0.021069
PGLYRP1	-0.021049
FGD1	-0.020989
FBN2	-0.020984
CARTPT	0.020967
NT5DC2	-0.020967
SUFU	0.020965
ALDH1A2	-0.020963
STAT5B	-0.020953
SCLY	-0.020951
SIRT4	0.020943
SOGA1	-0.020933
BRCA2	-0.020921
MUC2	-0.020914
SLCO1B3	0.020894
ZNF654	0.020884
BCS1L	-0.020875
GCLM	0.020868
CD247	-0.020844
LCK	-0.020842
LGALS2	-0.020822
CDH2	-0.020822
NARS2	0.020817
ERBB2	0.020788
ASNS	-0.020787
ARHGAP22	0.020786
PPP1CB	0.020755
ARMCX5	0.020747
TRIM2	0.020718
GABRG3	-0.020713
F2RL1	-0.020701
STOM	-0.020635
BUB1B	-0.020609
SLC35D3	-0.020605
RFC5	-0.020602
ITIH4	0.020590
NR4A2	0.020573
SALL4	-0.020554
CTGF	0.020533
COLEC12	-0.020523
P2RY2	0.020517
COQ2	0.020508
HYPK	-0.020489
ACVR2B	0.020470
PHLDA2	-0.020453
JAK3	-0.020445
FAM211A	-0.020432
EHHADH	0.020393
DSCC1	-0.020377
HYKK	0.020369
PDC	0.020350
MBNL3	-0.020337
SH3TC1	-0.020336
NMNAT1	-0.020308
PLA2G2D	-0.020303
CNTFR	-0.020284
RNF10	-0.020269
IRF2	-0.020267
SLC22A3	-0.020265
NAP1L3	0.020263
ABCC4	0.020249
CHTF18	-0.020246
HAP1	0.020235
PXMP2	-0.020230
PIK3AP1	-0.020230
CDT1	-0.020215
BBS2	0.020200
FXYD5	0.020192
CUTC	0.020181
SLC1A5	-0.020169
PLEK	0.020168
CLCN5	0.020160
RNF24	0.020160
PADI3	0.020150
LIPC	0.020144
VWC2	0.020134
SSBP2	-0.020134
DCTPP1	-0.020124
MCM10	-0.020121
VWF	-0.020118
IGFBP4	-0.020106
TRIM35	-0.020105
S100B	0.020061
KCNA5	-0.020056
CHRNA9	0.020045
FGGY	0.020043
TMED3	-0.020034
AAMDC	-0.020003
MED9	-0.019993
ZBTB11	0.019987
WNT8B	0.019985
HERC6	-0.019976
TMEM173	-0.019955
IGFBP2	-0.019954
DBN1	0.019953
KCNK1	0.019931
URB2	0.019929
SLC12A2	-0.019926
FAM111A	-0.019924
CRYGC	0.019896
TBC1D31	-0.019873
FCRLA	-0.019862
CERCAM	-0.019857
SDC1	0.019847
CCDC39	0.019845
SLC1A1	-0.019839
SCEL	-0.019829
PIGV	-0.019821
TAF8	0.019819
FAM219B	-0.019798
RUFY1	-0.019797
GTF2H4	-0.019791
ERCC6	0.019790
SERTM1	-0.019775
ATP11A	0.019760
ARHGEF2	-0.019751
WDR19	-0.019720
ASPM	-0.019675
ASTN1	-0.019639
FBXO30	0.019629
RNF31	0.019618
JMJD8	-0.019607
LRP6	0.019568
PDZK1	0.019567
ADIPOQ	-0.019557
G6PC	-0.019553
MAS1	-0.019550
RPS6KA3	-0.019542
CSPG5	-0.019540
TPPP3	-0.019538
STRBP	-0.019532
RIPPLY3	0.019532
TRIM29	-0.019531
MAX	-0.019491
TPPP	0.019487
STIM2	-0.019483
HTRA1	-0.019482
RAB3C	-0.019448
CSAD	0.019437
NKD2	-0.019434
SUMO3	-0.019422
SPP2	0.019404