!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Heroin
!smiles	CC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C
!drugbank_id	DB01452
!pubchem_cid	5462328
!cell_type	striatum, day 6 treatment
!organism	mouse
!end_metadata
ND6	0.353845
PLIN4	0.194051
TTR	0.149254
CSHL1	0.129258
SPINK8	0.126277
PCP4	0.123666
PRKCD	0.104336
CDHR1	-0.101975
ND4L	0.099009
GLUL	0.095180
S100A5	-0.088201
HBB	0.084050
ACTB	-0.081861
FFAR3	0.076279
TBC1D8	0.073930
CIART	0.073640
COX7B	0.073474
NTN5	0.071319
PENK	0.067627
SLC12A5	0.065740
PMCH	-0.065538
CLDN5	-0.064146
DLK1	0.058394
NDUFB5	0.058057
SLC25A4	0.055171
IDO1	-0.055004
LRP1	0.051280
RPL18A	0.051118
RGS5	-0.049687
TBR1	-0.048909
SOX18	-0.047963
DDT	0.047847
NDUFB4	0.047354
ALAS2	0.047015
CARTPT	0.046911
RGS16	0.046824
H3F3C	0.046685
SPON1	0.046395
NDUFB9	0.044978
CHIC1	-0.044471
SLC17A7	-0.044166
PLA2G7	0.043405
PTPRT	-0.043016
CCK	0.042860
ATP1B1	-0.042525
YWHAE	0.042126
ND5	0.042090
GNB2L1	0.040876
ZNF687	0.040675
NDRG4	0.039890
PTGDS	0.039805
C16orf80	0.039510
TPT1	0.038709
GPR88	-0.037695
OTX2	0.037512
NFU1	0.037306
JAM3	-0.037291
USMG5	0.036057
TUBB2A	0.035877
CCDC3	0.035700
CHAT	-0.035432
C8B	0.034945
SCN1A	-0.034614
BFSP2	-0.034445
NR4A2	-0.034424
HIF3A	0.034035
H1F0	0.033996
WNK2	0.033844
KCNE2	0.033635
ACIN1	0.032962
PDYN	0.032947
CALML4	0.032919
INMT	0.032328
SERPING1	0.032145
PTPN1	0.032134
CSNK2A1	-0.032014
SELK	0.031834
FSTL5	-0.031697
CRHBP	0.031655
ADAMTS4	-0.031624
DDB1	0.031542
ZNF322	0.031374
PRR7	0.031287
BIRC3	0.031054
MCCC1	0.030661
REC8	0.030485
LHFPL5	0.030474
LAPTM4B	0.030459
RGS9	-0.030409
DZANK1	0.030372
CIRBP	0.030359
TMEM158	0.030228
SP4	-0.030164
NT5C	0.029799
LIN7C	0.029509
FLT1	-0.029446
RXRG	-0.029341
ZIC1	0.029319
TSPAN2	-0.029198
WDR89	0.029170
ERBB2IP	-0.029106
S100B	0.029022
GBX2	0.028931
SLC7A14	-0.028882
TJP1	-0.028880
SPARC	0.028763
ANO2	0.028676
TEK	-0.028647
CAV1	-0.028566
TET1	-0.028555
AGT	0.028318
ZBTB7A	-0.028303
SLC4A1	0.028172
DBP	0.028137
SLCO1C1	-0.028092
ADAL	0.028067
WFS1	0.027810
PDE10A	-0.027807
NDUFB10	0.027798
ALCAM	-0.027725
CRYBG3	-0.027580
RHBDL2	0.027267
PER1	0.027244
CYP1B1	0.027135
CALR	-0.027114
NR1D1	0.027082
SOSTDC1	-0.027037
CHMP5	-0.026940
HIST1H2AG	0.026844
NECAB3	0.026807
ZFP1	0.026794
CRABP1	0.026675
ITIH2	0.026528
SPOCK3	-0.026351
IMPA1	0.026349
SOX17	-0.026335
CHPF	0.026316
EMCN	-0.026290
RASGEF1A	0.026047
VPS4B	0.025965
CKMT2	0.025949
EEF1A1	0.025784
SLC26A4	0.025770
MRPL52	0.025596
ZBTB38	-0.025589
CABP7	-0.025555
CA4	-0.025451
SPP1	0.025427
PAM16	0.025335
MDH1	0.025319
LRRN2	0.025276
OXT	0.025158
IP6K2	0.025126
HTR1D	-0.025075
PTPRN	0.025003
LBP	0.024916
SLC30A3	0.024708
SMG9	0.024608
UNC5B	-0.024555
FIG4	0.024495
GRP	-0.024393
KIFC3	0.024388
CHRD	0.024378
DDX6	-0.024352
CHORDC1	-0.024273
CPNE7	0.024267
BACH1	-0.024230
SGK1	0.024173
ZNF326	-0.024170
CLSPN	-0.024076
TMEM178A	-0.024055
ARHGAP33	0.024051
ARHGEF39	0.023995
PIN4	0.023905
KCND2	-0.023856
SERPINA9	-0.023855
GRAMD4	0.023827
PCDH20	-0.023788
CCNG2	-0.023750
OSBPL11	0.023576
SLC6A12	0.023565
FRS3	0.023536
ANKRD13D	0.023384
HKDC1	0.023352
VASN	0.023297
NUDT3	0.023278
PEBP1	0.023264
UBE2J1	0.023218
TBC1D20	-0.023173
LPCAT1	0.023149
MLC1	0.023143
AEBP1	0.023115
SOWAHA	0.023044
SPARCL1	0.023021
EGR4	0.023010
PHYHIP	0.022947
PAIP2	-0.022896
MGP	0.022890
RPRM	-0.022840
NECAB1	-0.022832
TNNC1	0.022733
CAMP	0.022701
MEGF9	-0.022687
FOS	-0.022665
IDH3A	0.022622
CRYBA2	0.022601
JUNB	0.022585
NRN1L	0.022541
ACVR1C	-0.022533
CHST2	-0.022525
P2RY12	-0.022507
LYSMD2	0.022411
SAMD5	-0.022372
SMIM13	-0.022331
OMP	-0.022248
KCNAB3	0.022227
CXCL12	-0.022208
TGFB2	0.022186
VPS41	-0.022180
ST8SIA3	-0.022169
C1GALT1C1	-0.022086
ARHGEF19	-0.022032
LRRTM1	0.021920
ZNF445	-0.021877
C2orf82	0.021789
ZNF180	-0.021690
LPHN1	0.021688
TRIM59	-0.021680
CLIC6	0.021667
ECEL1	0.021639
TNNT1	-0.021638
IL22RA1	-0.021636
PCNA	0.021451
GLTSCR2	0.021429
PLEKHA3	0.021405
CDADC1	0.021320
HAUS1	0.021260
CCDC109B	0.021235
APPBP2	-0.021234
DCN	0.021228
TMEM110-MUSTN1	0.021216
MEF2C	-0.021191
WBSCR16	0.021122
KLHL13	0.021081
TSR3	0.021060
TSPAN3	0.020963
ZNF780A	0.020958
GCC2	-0.020926
DDIT4	0.020898
CCDC6	0.020882
FAM134A	0.020863
GPX3	0.020855
PITPNM1	0.020849
SCARF2	0.020818
SMPDL3B	0.020783
WDR73	0.020773
ZFP91	-0.020768
BCAS1	-0.020700
HIST1H2BD	0.020679
EEF1B2	0.020635
STK40	0.020627
ZBTB22	0.020621
CTGF	-0.020599
MYL9	-0.020561
MEIS2	-0.020544
CEBPB	0.020539
GBP4	-0.020511
PTPRB	-0.020488
NEUROD2	0.020440
OTX1	-0.020431
MTSS1L	-0.020396
HS3ST1	-0.020382
SOWAHB	-0.020313
SLC17A8	-0.020309
KIAA1462	-0.020068
GPR17	-0.020039
RESP18	0.020026
SLC40A1	-0.019965
CCT5	0.019943
PSCA	0.019929
UGT8	-0.019833
TXNRD1	0.019812
NCKAP1	-0.019794
TEF	0.019767
RAB34	0.019746
CYP4F8	0.019744
HACE1	-0.019685
RBP1	0.019629
NPDC1	0.019529
NDUFAF3	0.019525
SCYL1	0.019493
RNF112	0.019422
TBL3	0.019402
TSHB	0.019379
SIDT1	0.019336
CBLN1	0.019326
MAP1A	-0.019274
IFRD1	0.019260
FRZB	-0.019224
NXPH2	-0.019204
KLK6	-0.019195
S100A10	0.019113
SPC24	0.019107
SEC14L2	0.019107
NEU2	-0.019069
KIAA1549L	-0.019066
ENG	-0.019062
CTSS	-0.019056
PPP1R14B	0.019017
SCRG1	0.019005
LRFN2	0.018993
EVI2A	-0.018977
TMIE	0.018937
DLX2	0.018896
TFAP2D	-0.018894
HSPE1	-0.018873
TMEFF1	-0.018869
ATP6	0.018854
EIF3C	0.018781
PIM3	0.018775
FBXW7	-0.018764
WFDC2	0.018751
SLC6A3	0.018739
GPR153	0.018729
GNG4	-0.018723
CHIA	0.018715
CLIP3	0.018705
DCTN1	-0.018700
KERA	0.018699
ANKRD46	0.018662
C11orf97	0.018641
IFNGR2	0.018629
POLR1C	0.018602
TMEM203	0.018595
UBE2N	0.018595
CLTA	0.018581
LAG3	-0.018499
LGALS3BP	0.018478
KATNAL1	-0.018398
HSP90AA1	0.018358
DDX19A	0.018268
PID1	-0.018260
ACTR8	0.018256
ETNPPL	0.018255
DDX3X	0.018185
SEPT1	0.018176
ATP5G2	0.018135
PDCD5	0.018124
NDUFB2	0.018119
LCN2	0.018054
SFMBT2	-0.018034
GAP43	0.018008
CTSD	0.017993
ABLIM2	-0.017992
PDE1A	-0.017990
MTPN	-0.017973
ARNTL	-0.017964
AMN	0.017931
CHMP4B	0.017931
SLC38A5	-0.017912
LAMTOR1	0.017904
TMEM125	-0.017884
DCT	0.017879
RIIAD1	0.017872
MXI1	-0.017869
TSPAN13	0.017868
C8orf46	-0.017823
FOXG1	-0.017815
PRKAA2	-0.017812
ZADH2	-0.017799
FAM171A1	0.017782
FBLN1	0.017774
CD93	-0.017773
UNC13C	-0.017746
COX2	-0.017723
EMP2	-0.017708
SLC24A3	0.017691
THBD	-0.017689
TMEM82	0.017672
WNT2	-0.017670
MAP1B	-0.017669
TSPYL4	0.017667
NPY	0.017626
SLC25A16	-0.017615
RAB3A	0.017569
EHD1	0.017560
DGAT1	0.017553
ATP2A1	0.017501
CACNA2D1	-0.017495
SLC2A1	-0.017476
C2orf74	0.017400
SARNP	0.017395
SLC25A22	-0.017342
DUSP11	-0.017268
FTL	0.017261
SPPL3	0.017245
CCL17	0.017243
PAM	0.017240
FAM107A	0.017229
DDAH2	0.017199
LMO2	-0.017182
PQLC2	0.017174
CCL21	0.017174
RBP4	0.017168
ADCY9	0.017146
UACA	-0.017142
NKAIN1	-0.017125
GADD45A	-0.017060
SYT1	-0.017045
ARPC2	0.017040
SLC25A10	0.017014
PLCXD3	-0.017008
ANKRD53	0.016966
TMEM106B	-0.016937
KPNB1	0.016904
KCTD1	-0.016894
ARL4D	0.016881
CPNE2	0.016872
CSNK2B	-0.016862
PLTP	-0.016852
HRH3	0.016849
NXT2	-0.016837
TRAF7	0.016811
CTRB2	0.016777
WASF1	-0.016744
HSDL1	0.016726
ALOXE3	0.016631
HOMER2	-0.016600
NPAS2	-0.016568
B3GALT5	0.016553
CDC42SE2	0.016535
DTX1	0.016522
TANC1	0.016494
HSPA12B	-0.016479
ARMCX5	0.016466
ZFAND1	0.016435
GAL3ST1	-0.016432
KIAA1279	0.016431
NTS	0.016421
SIX3	0.016405
ASPRV1	0.016397
ANGEL1	0.016373
GOLM1	0.016373
ELTD1	-0.016367
RTN4R	0.016363
RPL7A	0.016314
ST6GALNAC5	-0.016246
PDZRN3	-0.016242
CACNG3	-0.016237
ANKRD11	-0.016226
XRCC5	0.016221
IGFBP2	0.016192
AKR1C3	0.016099
LCT	-0.016084
STMN1	0.016083
MYH14	0.016077
FOLR1	-0.016060
FAM179A	0.016056
CYCS	0.016039
ENC1	-0.016030
TRH	0.016028
CALML3	-0.016028
MAF	0.016017
RBFOX2	-0.016010
CMBL	0.016001
BOK	0.015982
PVALB	0.015966
C11orf68	0.015965
CDS2	-0.015957
RHBDL1	0.015952
ACHE	0.015944
CPLX2	-0.015944
VEGFC	-0.015942
C9orf142	0.015920
CBX6	0.015920
HS3ST2	-0.015900
CREG2	-0.015886
OR1D2	0.015875
SLC11A1	0.015873
SIPA1L2	-0.015873
WNT8B	-0.015849
VIPAS39	0.015828
SMG5	0.015828
EGR2	-0.015749
RASL10B	0.015717
GATM	-0.015697
RSPRY1	0.015693
NPM3	0.015661
SPRED3	0.015650
FXR2	0.015629
SSTR2	-0.015629
CAP2	0.015595
TAX1BP1	-0.015586
CAPRIN1	-0.015547
B9D2	0.015543
CACNG7	0.015540
EIF3K	0.015534
NUDT8	0.015527
EVPL	0.015526
AIF1L	-0.015522