!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	Isoflurane
!smiles	C(C(F)(F)F)(OC(F)F)Cl
!drugbank_id	DB00753
!pubchem_cid	3763
!cell_type	Whole brain - 10 exposures
!organism	rat
!end_metadata
MBP	0.289044
TUBA1A	-0.234697
TTR	0.196384
SPOCK2	0.161079
ND2	0.159834
CYTB	-0.159297
RPS14	0.153839
NDRG2	0.148045
COX3	-0.136389
ND5	-0.131354
CKB	0.129589
SPARCL1	0.128049
PABPC4	-0.126489
CLU	-0.124626
ACTG1	-0.105953
RPL31	0.103212
PLP1	0.099711
DYNLL1	0.096375
ALDOC	0.095121
HSPA8	-0.090568
BASP1	-0.089674
RPS21	0.088747
NDRG4	-0.084993
UCHL1	-0.084055
COX8A	-0.080861
PTGDS	0.080493
CHN1	-0.077979
RPS17	0.077211
PPIA	-0.076054
YWHAG	-0.075563
CALB1	0.074728
RPL9	0.073383
RAB6A	0.073211
RPL39	0.069971
EEF1A2	-0.069571
YWHAZ	-0.069511
RPS8	0.069480
CCK	-0.069260
PVALB	0.068795
MPC1	-0.068389
RAB3A	-0.067335
NME2	-0.064975
GSTM2	-0.064332
RPS15A	0.063508
SYP	0.063219
NCDN	0.063186
ND4	0.062825
CTXN1	-0.061448
GAD1	0.061213
RPL19	-0.060684
CALB2	0.060354
PKM	0.059806
TECR	-0.058540
PGAM1	-0.058259
STX1A	-0.058230
PCP4	0.057634
BCAT1	0.056964
YWHAH	0.056376
CST3	0.055938
DYNLRB1	-0.055255
RPL17	0.054361
RPL10	0.053784
COLQ	-0.053653
COX2	0.053592
HSP90AB1	-0.052249
S100B	-0.052101
BTG1	0.050755
MFGE8	-0.050428
EGR1	-0.050299
CSNK2B	0.050297
GABARAPL2	0.050244
GLUL	0.049649
RPLP0	-0.049142
TUBB	-0.048892
PSAP	0.048781
SLC25A3	0.048029
CHN2	0.047947
APOD	0.047823
PPP3CA	0.047801
MGST3	-0.047791
NDUFB4	-0.047686
RPS23	0.047581
FTL	0.046882
APP	-0.046742
GAPDH	-0.046715
MRFAP1	-0.045261
FABP6	-0.045164
RPS10	0.044995
GABRA6	0.044947
ATP1A3	-0.044898
SLC12A5	-0.044654
YWHAB	-0.044300
DDX3X	0.043454
CLTC	0.043302
PMEPA1	-0.042623
ATP5F1	0.042573
RELN	0.041608
RPS27A	0.040729
SYN1	-0.040554
RPL5	0.040527
STMN1	0.040263
MDH2	0.039999
GDA	-0.039580
ITM2B	0.039486
NDUFC2	0.039479
GNAS	0.039314
MORF4L2	0.039217
MAL	0.039188
SOD1	-0.039180
VGF	-0.039140
MDH1	-0.039128
NSG1	0.039068
TUBA1B	-0.038701
KCNC1	0.038509
ENO1	-0.037818
MAP1LC3B	0.037503
NDUFB2	-0.036838
ST3GAL5	-0.036361
CYC1	0.036187
SDC4	-0.036107
NGFR	-0.035697
HSP90AA1	-0.035494
PRDX2	-0.035218
CX3CL1	-0.035171
UQCR11	-0.035105
TNFRSF1A	-0.035094
LDHB	0.035092
PTP4A1	-0.034933
SNAP25	-0.034805
RPL37	0.034771
ATP5J	0.034691
CHGB	0.033791
ENPP2	0.033789
PPP2R1A	-0.033476
QDPR	0.033327
RPL22	-0.033097
SDHA	0.032960
EIF5B	-0.032956
PRKAR1B	-0.032645
RPL30	0.031891
FEZ1	0.031798
SLC3A1	-0.031567
ATP6AP1	0.031540
FKBP1A	-0.031527
NEUROD1	0.031504
FLOT1	0.031316
ACTB	-0.030814
BNIP3L	0.030772
PCBP4	0.030632
CPE	0.030456
LIN7B	-0.030339
PITPNA	0.030015
PDIA6	-0.030004
RALGDS	-0.029811
NEFH	0.029604
NCKAP1	-0.029206
PPT2	-0.029189
TPI1	-0.028986
AP2M1	-0.028814
COX1	-0.028793
OXR1	-0.028790
APOE	-0.028673
LPHN1	-0.028534
PPP2CA	-0.028423
PICALM	0.028186
GABARAP	0.028163
ZFP36L1	-0.028046
NELL2	-0.028042
CAPNS1	0.028018
RPL26	0.027978
ATP5B	0.027970
MAP1LC3A	-0.027850
ATP6	0.027616
SNN	0.027395
SH3GL2	-0.027394
NRN1	-0.027352
RPL12	-0.027313
TRAPPC3	-0.026935
PFN1	0.026573
CAMK2N1	-0.026545
CTBP1	-0.026527
PTPRS	-0.026427
HNRNPK	0.026302
COX6A1	-0.026063
C11orf73	0.025886
DNM1	0.025865
APBB1	-0.025579
SCHIP1	0.025498
SRSF11	0.025473
SLC25A5	0.025368
MYL12A	-0.025276
SEPP1	0.025230
RESP18	0.025224
PDYN	-0.025215
SLC4A4	0.025152
ND1	0.024997
PSME2	-0.024913
RPL4	0.024574
KLC1	-0.024357
PADI3	-0.024275
PSME1	-0.024220
HNRNPU	-0.024135
RTN1	0.024041
PRKCG	-0.023949
HIBADH	0.023915
MAPK8IP2	0.023878
CD63	0.023563
THY1	0.023432
FHL2	-0.023421
CAMK2B	-0.023403
TMEM55B	-0.023270
RPS25	0.023252
STX1B	0.023194
USE1	0.023097
CSPG5	-0.023075
GNB2L1	0.023055
CRP	-0.022892
RGS4	-0.022753
RPL11	-0.022718
SCG5	0.022683
ATP1A2	0.022567
ATP6V1D	0.022531
GSTK1	-0.022499
CYCS	0.022494
PPP2R5A	-0.022474
RPL8	-0.022414
LEP	-0.022264
VIM	-0.022187
DBP	0.022140
GUCY1B3	0.022138
PEX14	-0.022129
MEF2D	-0.022123
SEC62	0.022116
SERINC3	0.022100
PSMB2	-0.022058
RPL10A	0.022054
PEX6	-0.022038
HSPE1	0.022006
INA	0.021804
YWHAQ	0.021600
HSPB1	-0.021555
ENO2	-0.021408
GPX4	0.021389
UBALD1	0.021350
UBQLN1	0.021258
EHMT2	-0.021122
B4GALT6	-0.021013
PRKAG1	-0.020779
CDC37	-0.020764
HYAL2	-0.020753
SERBP1	0.020694
RPS26	-0.020551
RASGRF1	-0.020535
CNTNAP1	0.020399
SREBF1	-0.020374
GPT	-0.020320
TUBB4B	0.020312
CSDE1	0.020309
AQP4	0.020248
CFL1	-0.020194
ALDH1A1	0.020161
RHOB	-0.020152
NDUFA8	-0.020114
MECR	-0.020104
CPLX2	0.020103
SYNJ1	0.020046
DGKZ	0.020010
SCG3	-0.019943
PSMB3	-0.019552
DNAJB1	-0.019537
ATP5G1	-0.019516
NEDD8	-0.019501
DBI	0.019485
FXYD1	0.019478
KLF13	-0.019418
HIAT1	0.019401
SYT11	-0.019374
NAPA	-0.019307
MIF	-0.019304
DDT	0.019278
NUDT4	-0.019258
PPT1	0.019166
GOT1	0.019052
DTD1	0.019040
NSFL1C	0.019022
PLLP	0.019004
LPAR1	0.018926
MATR3	0.018701
CCND2	-0.018636
DDR1	-0.018532
PIP5K1C	0.018516
HNRNPAB	0.018510
AATK	0.018465
IDH3G	0.018443
RPL27A	-0.018416
CORO1A	0.018367
IL1R2	-0.018242
PRKAR1A	0.018200
CRYBB3	-0.018194
ITGB1	0.018152
RBCK1	-0.018150
TMEM59	0.018122
ARF4	0.018103
SCARB1	-0.018078
RAB5B	0.018051
POMP	-0.017901
RASL11B	-0.017871
GRM5	-0.017862
CADPS2	0.017792
NDUFB9	-0.017755
RPS9	0.017675
CLTA	0.017655
NFYC	0.017647
PSME4	0.017622
SCAMP1	0.017593
NDUFB8	-0.017561
PTGIR	-0.017524
SUB1	0.017458
RARA	-0.017400
VDAC1	-0.017343
GNB1	-0.017291
NDUFB6	0.017290
TAGLN3	-0.017278
TRAPPC1	0.017227
NPEPPS	0.017227
ALAS2	-0.017143
GRIP2	-0.017139
CNKSR3	0.017139
SLC35B1	-0.017139
SYT5	-0.017130
SST	-0.017113
GPX1	-0.017000
HADHA	-0.016924
GABRD	0.016923
COX4I2	-0.016913
POMC	0.016901
SPTAN1	-0.016893
AUH	0.016883
ITPR1	0.016882
OLFM1	-0.016874
GIPR	-0.016838
SDCBP	0.016837
GATM	0.016746
MATK	-0.016724
GIT1	-0.016721
C1D	0.016679
GABRB1	-0.016595
PPP2CB	0.016466
ATP2A3	0.016435
SCN1B	0.016427
KLF6	-0.016401
URGCP	-0.016325
EEF2	-0.016204
RPS13	-0.016146
PIGR	-0.016131
TIMP2	-0.016124
MAOB	0.016099
EIF4H	-0.016088
FDXR	-0.016064
OPCML	-0.016047
ATP5O	-0.016007
TMEM69	0.015935
GRK4	-0.015919
NDUFB5	-0.015895
PSMC1	-0.015845
SEPHS2	0.015732
WDFY3	0.015657
GRM3	-0.015651
GFAP	0.015645
SLC14A2	-0.015611
TOMM6	-0.015549
YWHAE	-0.015507
TESC	0.015506
PTOV1	-0.015494
NCAPH2	-0.015445
RABAC1	0.015375
PKIA	0.015370
HNRNPA2B1	0.015345
VAMP2	0.015301
GRIN2B	-0.015289
TMBIM6	0.015268
SLC13A2	-0.015264
GRINA	-0.015220
SPP1	0.015118
HRAS	-0.015118
UGT1A1	-0.015107
GAA	-0.015087
KHK	0.015053
COX5A	-0.015029
DPM2	-0.014997
L1CAM	-0.014966
COX7B	0.014963
TUBA4A	-0.014935
HES5	-0.014922
APLP2	0.014915
PMCH	0.014911
YBX1	0.014878
MTCH2	0.014833
RPS29	0.014804
RPL3	0.014801
PGK1	0.014760
COL1A2	0.014757
CSF2RB	-0.014698
PFKP	-0.014681
HCRT	0.014659
DDRGK1	0.014623
F2R	0.014609
FASN	-0.014574
LENEP	-0.014572
NTM	0.014570
NTSR2	0.014559
BLVRA	-0.014558
ATP2A2	0.014547
RPL28	0.014532
YLPM1	0.014531
CNR1	0.014433
MTMR7	-0.014428
CNIH2	-0.014420
NR1D2	0.014402
MFSD6	0.014382
UBR5	-0.014363
EDF1	0.014293
GRIN1	-0.014269
KCNK1	-0.014262
CSAD	0.014218
MED25	0.014193
RAB11B	-0.014184
THOP1	-0.014153
IGF2R	0.014106
SS18	0.014087
GRIN2C	-0.014082
CADPS	0.014058
ARPC1B	-0.013938
CCNDBP1	0.013932
FAU	0.013921
KAT5	0.013882
PAPSS1	0.013866
PPP1CB	-0.013823
SPTBN2	-0.013822
ALDOA	0.013809
ATP6V0A1	-0.013803
RABGGTB	0.013730
LIMK1	-0.013713
GPS1	0.013710
BAX	-0.013576
GSTM3	-0.013572
CSRP2	0.013568
FIS1	0.013502
SV2A	0.013499
NDRG3	-0.013490
PSMD11	0.013480
FKBP2	-0.013475
PITX3	-0.013464
TAF6	-0.013416
MAG	0.013354
BECN1	0.013328
DYNC1I1	0.013290
PTPRJ	-0.013272
EEF1G	0.013257
HSP90B1	-0.013236
GRID2	0.013172
RPS7	-0.013168
OAZ1	-0.013109
PRDX3	0.013052
ENPP1	-0.013042
FBXO22	0.013006
RNF4	0.012967
CBFB	-0.012920
KCNB1	-0.012893
AMH	-0.012870
TFRC	-0.012868
SMIM5	-0.012839
RCHY1	0.012776
ITFG3	-0.012736
RASA2	-0.012703
TBCE	0.012701
CCNG1	0.012686
B3GAT1	-0.012685
CTSS	0.012684
SVOP	-0.012649
PIK3IP1	0.012647
PNMT	-0.012632
BCAN	-0.012600
CCKBR	-0.012537
MVD	-0.012509
CTSD	0.012496
DNASE1	0.012484
LAMP1	-0.012470
PDK2	0.012433
ODC1	-0.012430
PDHA1	0.012425
CLEC11A	0.012400
PTN	-0.012385
GRK6	-0.012368
DPYSL4	0.012312
TXNRD1	0.012280
RPL35	0.012244
TRAP1	0.012238
SFXN3	0.012234
DHCR7	-0.012204