!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Tretinoin
!smiles	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
!drugbank_id	DB00755
!pubchem_cid	444795
!cell_type	cranial neural crest - 48 Hours
!organism	mouse
!end_metadata
HOXA5	0.265175
PLAT	0.170055
MDK	0.154745
FAM107B	0.152973
EMP1	0.127873
RBP1	0.127871
TUBB	-0.116703
H19	0.110167
ANXA2	-0.108554
SLC38A4	0.107112
CTGF	-0.105468
RPS23	-0.105314
HSPA9	0.100926
COL5A2	-0.098628
SAT1	-0.094698
CHD4	-0.091194
NCL	0.091191
TSC22D1	0.090414
MYADM	-0.089868
COL7A1	0.089315
LDHA	-0.088899
ACTC1	-0.088334
GAS1	0.086549
AHNAK	-0.086448
PLIN2	0.084930
TUBA1C	-0.084057
ATP1B3	-0.082377
EIF3G	0.081794
BGN	-0.080755
RPL8	-0.078785
ERRFI1	0.078186
NPM1	0.074996
CXCL12	0.073874
HSP90B1	0.071885
CSN3	0.071615
DUSP6	0.071086
CSRP2	-0.070389
PRMT1	0.068584
KRT8	0.066633
FABP5	0.066559
TUBA1B	-0.065421
FOXG1	0.065143
HOXA1	0.065131
UBE2R2	-0.065032
ACTA1	-0.064561
IGF2R	-0.064013
TRA2B	0.061276
TMOD3	-0.060933
LAMP1	-0.058536
EIF4A2	0.057969
STMN4	0.057131
SLC7A5	0.055420
PABPC1	0.055167
ARG1	0.054900
FAM101B	-0.054400
F11R	0.054311
RNF145	0.054208
DDAH2	-0.053893
TIMP3	-0.053264
SELT	0.053061
BCAT1	0.052998
HNRNPM	-0.052820
BIN1	0.052770
TUBA1A	-0.052662
CBFB	-0.051697
VAMP8	0.051170
S100A10	-0.050615
RPS3	-0.050286
REV3L	0.050113
CST3	-0.049841
JTB	0.049577
PLK2	0.049150
RPS2	-0.049122
PNRC2	0.048924
SKAP2	0.048507
CTPS1	0.048469
PSAT1	0.048026
RPLP0	0.047824
GPX3	0.047714
PDRG1	0.047700
EEF1A1	0.047478
NDUFV1	0.047286
HSPD1	0.047191
ARL2BP	-0.046037
CD63	-0.045771
ILK	0.045233
VCAN	-0.045166
FABP7	-0.045034
STMN1	-0.044596
THBS1	-0.044324
LTA4H	0.043414
DHRS3	0.043374
SHROOM3	0.043172
RPS15A	-0.043031
GDI1	0.043024
MEF2D	-0.042880
TNFAIP8	0.042709
WDR1	-0.042391
MYH7	-0.042143
GADD45A	0.042083
RPL5	0.042025
IGF2BP1	-0.041927
RDX	0.041760
GSK3A	0.041612
CD164	0.041596
COL1A2	-0.041532
GNB2L1	-0.041462
FOXC2	0.040695
PMP22	0.040393
PPP3R1	0.040247
ARHGDIA	0.040199
CRABP2	0.040102
ZWINT	-0.040023
HN1	-0.039855
MMP14	-0.039645
APP	-0.039479
SPSB1	0.039313
BDNF	-0.039307
ATP5A1	0.039246
HSPA5	0.038983
GTPBP4	0.038953
HOXB5	0.038899
RPL28	-0.038795
FSCN1	0.038570
CSNK1A1	0.038275
ATF4	0.038242
ENO3	0.038061
TUBB3	-0.037880
PARK7	0.037851
ACTR3	0.037788
MAGED2	-0.037566
ABRACL	-0.037447
MYH9	-0.037345
LGALS1	-0.037183
RHOC	0.037083
SEPT7	0.036859
MFGE8	0.036395
RPL6	0.036383
GNAI3	-0.036331
COL4A1	-0.036313
GCSH	0.036272
PPID	0.036258
CCT7	0.035910
FYTTD1	0.035745
ARF4	0.035700
OTUD7B	0.035618
GLRX3	0.035436
ETV2	0.035155
CDC20	-0.035056
MYL12A	0.034519
C20orf24	0.034381
GARS	0.034295
TXNRD1	0.034223
MFSD1	-0.034183
LIMA1	0.034163
CAPNS1	0.034154
AKR1A1	-0.034150
ITM2A	-0.034074
CNN2	-0.034003
PGAM1	0.033998
OSTC	0.033855
ELOVL5	0.033712
TARS	0.033636
PRDX1	-0.033477
ID2	0.033296
KLF6	-0.033238
JUND	0.033150
MARCH5	0.033099
KRT20	0.033084
COPA	-0.032981
SYNPO	0.032875
SOX2	-0.032856
NDN	-0.032772
EIF2S1	0.032758
EZH2	-0.032542
RIN2	0.032474
BTG2	-0.032347
TIMM23	0.032336
PPA1	0.032227
AAMP	0.032214
RNASEK	0.032030
PSMB3	0.031764
TRNT1	0.031750
CAPZA2	0.031690
RRS1	0.031670
SNAI2	-0.031625
TPT1	0.031575
NDUFA5	0.031492
FAM98A	0.031370
FBL	0.031159
PSMC2	0.031060
CSTB	-0.031057
PBX1	0.031003
EDN1	0.030953
ATP6V1B2	-0.030906
LMNA	-0.030852
KRT18	0.030775
INHBA	-0.030638
SRSF9	-0.030370
RPL13A	-0.030335
RPS26	0.030304
EXOSC7	0.030294
B2M	-0.030280
SERINC3	-0.030253
NHP2	0.030212
CPE	0.030206
ACTB	-0.030188
NARS	0.030040
PEG3	0.030016
SLC25A4	0.029630
TNPO3	-0.029518
PTX3	-0.029440
ASNS	0.029235
RPL18	0.029216
CA2	0.029190
SMAD4	0.029158
SERPINH1	0.029117
PDHB	0.029094
LMO4	0.029035
CYB5R4	0.028892
S100A6	-0.028888
CLU	0.028873
COL4A2	-0.028663
SRSF2	-0.028551
GAP43	-0.028458
YBX1	0.028404
ST3GAL5	0.028365
HDGF	-0.028363
NR2F1	-0.028306
TAGLN	-0.028125
TMED7	0.028093
IGF1R	-0.028049
IGFBP3	0.028020
WDR92	0.027891
ITGAV	-0.027859
FKBP4	0.027761
DRG1	0.027616
RPS28	-0.027408
FOXD1	-0.027301
RGS16	-0.027271
AKIRIN2	0.027245
TGIF1	-0.027243
RBM17	0.027235
PTP4A1	0.027190
TSPAN9	0.027175
BSG	0.027174
LOC728392	-0.027132
SERP1	0.027088
RBM8A	0.027066
SLC12A2	0.027023
KRT7	0.026985
RPL3	-0.026699
CA3	0.026670
GHITM	0.026571
BAX	0.026463
IGF2	-0.026417
NDUFS2	0.026392
PPP2R4	0.026378
NDUFB5	-0.026229
NREP	-0.026213
WDR81	-0.026128
ACTG2	-0.026060
RRAGC	-0.026002
UQCRQ	0.026001
ODC1	0.025891
RNF181	0.025825
CNN3	-0.025802
SNRPD2	0.025783
PPP4C	-0.025767
PRSS23	0.025714
SOCS2	-0.025590
SMARCC1	-0.025460
CORO1C	-0.025428
ALDOA	0.025128
EDEM3	0.025011
EIF1AX	0.024998
APOA1BP	0.024991
CCT8	0.024963
CCDC6	0.024877
PRRX2	-0.024775
SARAF	-0.024683
DDX39B	0.024679
DYNLL1	-0.024653
CCNG2	-0.024631
NSA2	0.024410
UGDH	0.024326
IMPDH2	-0.024292
RPS17	0.024253
TMEM43	-0.024211
AZIN1	0.024180
PSMA4	0.024125
GORASP2	0.024104
HMOX1	-0.024065
ACTA2	-0.023997
HMGN1	0.023986
FKBP1A	0.023968
RPL10A	0.023835
RBFOX2	-0.023807
CUL4A	0.023696
RPS27A	0.023685
SSRP1	0.023645
CFL1	-0.023644
ANXA1	-0.023621
CITED2	-0.023592
MCAM	-0.023483
PRNP	-0.023447
PRPSAP1	0.023432
PLP2	-0.023349
TUBB2A	-0.023309
CDKN2B	0.023306
PTOV1	-0.023270
OTUD4	0.023245
ARPC2	-0.023164
MGEA5	-0.023151
CYC1	0.022975
DDX17	-0.022974
CYFIP1	-0.022972
PSMB5	0.022912
WBP5	0.022728
BRK1	-0.022691
FZD2	0.022678
KRT19	0.022676
H2AFV	-0.022654
FBLN1	0.022639
OSBPL5	0.022576
RSL1D1	0.022568
KCTD12	-0.022568
EEF2	0.022556
KRTCAP2	0.022529
UQCRC1	0.022492
PRSS12	-0.022402
ACTN4	0.022380
LIMS1	-0.022192
CLK1	-0.022181
PSMB2	-0.022069
ADM	0.022044
AMOTL2	0.021935
DR1	0.021867
SLC20A1	-0.021825
GAPDH	0.021812
TMX2	0.021795
EIF5	0.021750
MAPK6	0.021726
KDELR1	-0.021725
MRPL16	0.021680
TOMM70A	0.021639
CDCA7	0.021627
NOP56	0.021563
PLSCR1	0.021496
PRDX6	0.021356
GNL3	0.021334
GJA1	0.021311
FTH1	-0.021288
DUSP9	0.021288
RBMS1	0.021267
PHF5A	0.021150
TNNT1	-0.021132
RASL11B	0.021092
IFRD1	0.021029
SFXN1	0.020991
SGCE	-0.020986
SBDS	-0.020967
USP34	-0.020876
TIMP1	-0.020851
PSMD13	0.020813
TXN	-0.020797
RHOB	0.020723
CHORDC1	0.020687
ATP6V1G1	0.020620
GABARAP	-0.020616
PCYOX1	0.020493
DUSP1	-0.020408
EXT1	-0.020379
SPATA13	-0.020357
PDK3	-0.020334
GABARAPL1	0.020293
SERPINB2	-0.020274
PCBP1	0.020168
MAP2K5	0.020157
DNTTIP2	0.020044
CCRN4L	0.020037
KCTD10	0.019992
GPX4	0.019889
TSPO	0.019859
RARS	0.019786
EMP3	-0.019663
PPTC7	0.019652
YBX3	0.019629
CPT1A	-0.019617
MCL1	0.019603
NDUFS6	0.019555
ARFGAP2	0.019538
KDM3A	-0.019522
ISOC1	0.019512
PTGR1	0.019511
MEOX1	0.019409
RNF4	-0.019402
CTDSP2	-0.019321
WFS1	0.019229
CAPZB	-0.019229
KIAA1191	0.019227
CTNNA1	-0.019215
TPBG	-0.019207
UQCRC2	0.019177
MIDN	-0.019125
SRI	-0.019103
CARS	0.019088
RARS2	0.019085
EIF3M	-0.019081
CCT3	0.019019
ATP6V0C	0.019012
PPAP2B	0.018981
MRFAP1	0.018839
DSTN	-0.018757
MED22	-0.018751
UQCRB	0.018714
TLN1	0.018674
LARS	0.018637
RPL37A	0.018617
SRM	0.018600
TRIB3	0.018478
PRKAR1A	0.018467
DLG1	0.018423
GOLPH3	0.018402
WDR61	0.018383
CYP26A1	0.018358
BASP1	0.018349
YTHDF1	0.018344
NUP107	0.018309
GOLM1	0.018306
MYO1B	-0.018282
FZD3	-0.018281
PAWR	0.018267
MESDC2	0.018223
TNPO2	-0.018220
TPI1	-0.018145
SNAP47	0.018117
MTHFD2	0.018048
RPP25L	0.018017
ZNF35	0.018016
NT5DC2	0.017995
SPPL3	0.017994
RBBP4	-0.017984
CNIH1	0.017965
TXNDC9	-0.017868
P4HA1	-0.017818
MANF	0.017739
PPP1R14B	0.017737
NOP58	0.017724
PSMB6	-0.017704
WARS	0.017688
LITAF	-0.017683
PERP	0.017660
NPC2	-0.017650
PVRL2	0.017571
PABPN1	-0.017567
SERPINE1	-0.017561
SPP1	-0.017555
STK40	-0.017550
ARL6IP1	0.017543
PDIA5	-0.017481
DSP	0.017465
STUB1	0.017414
DNAJC2	0.017366
ANXA3	0.017348
PSMD7	0.017335
EYA2	0.017284
OSTF1	-0.017253
COX7A2L	-0.017232
ACO2	0.017225
UBC	0.017192
THUMPD3	0.017172
ZC3H11A	-0.017148
PTGIS	-0.017072
GNG5	-0.017062
MLLT3	-0.017055
AARS	0.017051
PSPH	0.017050
GSN	-0.017004
RBBP7	-0.016985
EIF3L	0.016951
BHLHE40	0.016894
GPC3	-0.016875
FAM136A	0.016838
GFER	0.016824
JARID2	0.016814
RPS7	-0.016814
PRPF38A	0.016808
TCF12	-0.016792
NNAT	-0.016733
SPTSSA	0.016723
LATS2	-0.016632
ANAPC5	-0.016581
PTPRF	-0.016446
HSP90AB1	0.016441
PAIP2B	0.016425
SERPINB6	-0.016425
WDR45	0.016392
MAEA	0.016384
NUDT1	0.016378