!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	Pioglitazone
!smiles	CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
!drugbank_id	DB01132
!pubchem_cid	4829
!cell_type	17 months
!organism	rat
!end_metadata
NDRG4	0.205435
COX1	0.152677
DPYSL2	0.130826
RPL13A	-0.119847
SERBP1	-0.108688
ITIH3	-0.106524
CD74	0.106019
C1QA	0.101078
FOXG1	-0.100998
VDAC3	-0.098821
YWHAG	-0.096260
RNF44	-0.094438
CTSS	-0.091855
ND3	0.090634
WASF1	-0.090157
BRSK1	-0.089836
C3	0.077548
NEDD8	-0.076245
RPS19	-0.075563
RPS27A	-0.074945
GSTO1	-0.073915
RPL5	-0.072840
RPL27	-0.071687
GRINA	-0.070684
BHLHE22	-0.067394
NME2	-0.066395
OCIAD1	-0.066039
SGK1	0.064997
CTTNBP2	-0.063869
NDRG2	-0.063848
ACTB	0.063759
SH3BGRL	0.063024
RPL19	-0.062146
UQCRB	-0.059907
TMEM130	-0.059815
RPS7	-0.056843
PRKCG	-0.056462
ND1	0.055669
PTGDS	0.055572
UCHL1	0.055263
BSG	-0.054794
PLP1	0.054784
DDN	-0.054428
MORF4L2	0.054340
COX2	0.054249
RPS4Y1	-0.053887
TUSC3	-0.053488
OAZ1	0.052872
S100B	-0.052567
CST3	0.052036
GRIA1	0.051818
TSPYL1	-0.051749
TPT1	0.051686
CDO1	-0.051657
GPM6A	-0.051091
CHCHD10	-0.051004
BCAS1	-0.050360
AP2M1	-0.049939
RCHY1	0.049838
COX7A2	-0.049821
RPL21	-0.049471
GFAP	-0.048929
NOP10	-0.048767
MTCH1	0.048635
RPS3	-0.048250
CMPK1	-0.048008
MOCS2	-0.047990
RPS12	-0.047603
SNX3	0.047530
DDX5	-0.047309
POLR2K	-0.047038
SOD1	-0.046685
ITM2B	0.046636
RPS8	-0.046347
COX4I1	-0.046082
RPS6	-0.046069
HSP90B1	-0.045807
YWHAH	0.045519
SLC22A17	-0.045331
PGBD5	-0.045308
HSPA5	-0.044740
GABRG2	-0.044585
OLFM1	-0.044580
TOMM70A	0.043912
RTN1	-0.043554
RPL23	-0.043371
RPL38	-0.043279
PTGES3	-0.043158
FTL	-0.042842
SLC25A3	-0.042590
USP14	0.042080
RPS13	0.042004
ZCCHC18	-0.041942
CSE1L	-0.041653
STMN1	0.040303
UBA1	0.040207
POMP	-0.039845
ACOT7	-0.039774
MOBP	-0.039735
UBE2V2	-0.039712
RPS28	0.039633
HMGCS1	-0.039622
S100A13	-0.039562
HPCA	-0.039331
EIF3G	0.039161
PCP4	-0.038671
C1QB	0.038379
TIMM8B	0.038233
RPL30	-0.038025
SLC30A3	-0.037965
ZWINT	0.037648
STMN4	0.037493
FABP7	-0.037275
KLHL7	-0.037053
SYT1	0.036999
GLO1	-0.036932
TTR	0.036930
OPCML	0.036804
CKB	0.036564
PTBP2	-0.036536
ATP5F1	-0.036474
NCKAP1	-0.036450
PYGB	-0.036127
LRRN2	-0.035487
NDUFB11	0.035473
FAM107A	-0.035426
MMD	0.035367
RPS9	-0.035353
GABRB1	0.035296
NAP1L5	0.035215
VGF	-0.035194
NCL	-0.034885
PRNP	0.034722
NPTX1	-0.034719
SST	0.034718
CRYM	0.034449
FLOT1	0.034222
MICU3	-0.034219
GDI1	-0.034104
ARL15	-0.033941
CPNE7	0.033913
RPS5	-0.033835
PHYHIP	-0.033833
PSMA7	-0.033749
PLCXD3	-0.033611
PDIA6	-0.033607
USMG5	-0.033603
SCN3B	-0.033489
RAB3A	0.033454
SCPEP1	-0.033226
GRIA2	0.033217
RHOB	0.033180
PTN	0.033178
PPP1CA	-0.033144
EGR1	-0.033062
MGST3	0.033020
GRIA3	-0.033006
MAT2B	-0.032976
AKR1A1	0.032926
RBM39	-0.032922
PPP3CA	-0.032749
NDN	0.032684
PJA2	0.032574
GAPDH	0.032525
MATR3	0.032481
CELF5	-0.032424
TMEM176A	0.032410
DOCK4	-0.032306
CHMP5	-0.032278
CTXN1	0.032191
SUMO1	0.032135
TAGLN3	-0.031835
TSPAN2	0.031823
ALCAM	-0.031744
MAP2	-0.031718
NCDN	-0.031622
NDUFS3	0.031555
RBBP7	-0.031478
CHMP2A	-0.031449
OMG	-0.030917
YWHAE	-0.030756
ALDOA	-0.030751
SPTBN2	-0.030727
ATP6V0E2	0.030560
LPPR4	0.030198
CFL1	0.030197
ITFG1	-0.030173
RPSA	-0.030128
ILDR2	-0.030037
RPL11	0.029891
FAM120A	-0.029867
PGK1	-0.029851
LDHA	0.029722
SEC61A2	-0.029635
FCER1G	0.029565
HSPA4	0.029561
CLDN11	0.029545
GPX1	0.029386
MMD2	-0.029356
SLC38A10	-0.029318
CAMK2A	-0.029169
SUGT1	-0.029119
ARAF	-0.029084
GAS7	0.028939
HS3ST1	0.028924
PTP4A1	-0.028819
GDA	0.028695
PPP1R9B	-0.028243
NAPA	-0.028086
SIRT2	0.027979
HNRNPAB	-0.027894
RCN2	0.027882
PCDH8	-0.027783
PLCB1	-0.027777
PLAC8	0.027738
OXR1	0.027635
NAPB	-0.027632
CHGA	-0.027482
RPS25	-0.027464
CAMKK1	-0.027457
SEPT4	0.027454
EVI2A	0.027448
NPC2	0.027249
SNX10	0.027242
ITM2C	0.027231
UQCR11	-0.027184
ID2	-0.027173
IQUB	-0.026851
NDUFA12	-0.026774
EEF1G	0.026758
TCP11L2	-0.026758
DYNLL2	0.026730
RAB21	0.026727
ACO2	-0.026721
AIG1	-0.026703
EIF5A	-0.026617
SV2B	0.026598
SYT5	0.026454
RPL37	0.026225
TIMP2	0.026205
RPL31	-0.026192
YPEL4	-0.026190
GLYR1	-0.025998
TMEM14A	0.025922
RABEPK	0.025771
RPL4	-0.025731
TSC2	-0.025577
NADK2	-0.025544
BAI2	-0.025479
JPH3	-0.025468
SORBS2	-0.025432
EIF4A2	-0.025418
OPALIN	0.025393
UFC1	-0.025332
PEBP1	0.025307
PRPF19	-0.025277
ATP1B1	0.025252
CHGB	-0.025203
CAMK2B	-0.025194
FTH1	-0.025167
GSTM2	-0.025098
RNF182	0.025093
CDC37	-0.025042
NOV	0.024923
RPS14	0.024904
PDE2A	-0.024860
SLC6A1	-0.024846
SYP	0.024844
GAA	-0.024833
SNN	-0.024820
PRDX5	0.024804
ATP1B2	-0.024778
TRAPPC2	-0.024736
VDAC1	0.024623
RPL12	0.024603
EZR	-0.024502
DCTN3	-0.024420
SLC12A5	-0.024370
PCYOX1	0.024317
GSTP1	0.024315
COA5	-0.024288
B2M	0.024268
KCMF1	0.024253
NDFIP2	-0.024227
POLR2C	-0.024225
CLIP2	0.024212
NPY	0.024193
IDH2	-0.024115
SNAP25	0.024112
APOE	-0.024056
MRPS25	-0.024026
RAPGEF5	0.023941
BTG3	-0.023937
PRKCZ	-0.023921
RPL7A	-0.023841
PLCG1	-0.023838
REEP5	0.023778
TFG	-0.023764
TMA7	0.023728
CLTC	0.023715
HIBADH	-0.023689
PGPEP1	-0.023659
PDIA3	-0.023616
NDUFC2	-0.023568
TCP1	-0.023517
STRBP	0.023506
RAP1GAP2	-0.023495
CYP46A1	-0.023478
RPS26	-0.023473
AKAP11	0.023427
MAP1B	0.023354
CCT4	0.023322
ARHGDIG	0.023100
RB1	0.023072
ZNF330	-0.023049
PLLP	0.023039
MARC2	0.023038
PSMB6	0.023033
SCHIP1	0.023014
CLDN10	-0.023012
CASC4	-0.022975
MAP3K12	-0.022936
TUBB4A	0.022848
WDR1	0.022774
TNK2	0.022714
GPR37	0.022686
ESD	-0.022676
DYNLRB1	0.022518
ATP6V1B2	0.022435
TSPAN14	0.022395
PTGS2	-0.022343
RNF112	-0.022325
CD9	0.022242
PFN1	0.022218
KCNAB1	0.022198
PIN1	-0.022175
CHN1	-0.022165
CYCS	0.022151
C11orf73	-0.022148
KCTD4	-0.022111
NSF	0.022073
RBM3	-0.022056
RELL2	-0.022040
RGS10	-0.021964
FGF13	-0.021955
NAA38	-0.021904
CUL4A	-0.021899
CNIH2	0.021837
PTPRZ1	-0.021829
TBC1D9	0.021826
MAGED1	0.021767
CHST1	0.021724
PDAP1	-0.021715
SLC6A15	0.021703
KAT7	0.021673
UBE2O	0.021656
ENO2	-0.021598
WFS1	-0.021595
HADHB	0.021583
CALCOCO1	-0.021562
CRIM1	0.021453
PLEKHB1	0.021447
SRSF1	-0.021438
ABHD17A	-0.021397
SYNJ1	0.021364
SEMA6D	0.021274
WDR13	-0.021272
NEK7	-0.021269
CAMTA2	-0.021232
CNOT7	-0.021194
PPP1CB	-0.021179
CETN2	-0.021080
AP1AR	0.021052
SAT1	-0.021050
GABARAPL1	-0.021023
AMZ2	0.021008
DNAJC6	-0.021007
NRN1	-0.020949
HGS	-0.020921
HSD17B12	-0.020883
HYPK	-0.020876
BTG1	-0.020860
SLC17A6	0.020840
IPO7	-0.020840
USP9X	0.020737
PSMA6	-0.020736
ZEB1	-0.020729
APP	0.020694
PCBP2	-0.020688
PAFAH1B1	0.020657
SIRT5	-0.020624
EIF3C	0.020620
CACYBP	-0.020619
DYNLL1	0.020594
GOT2	0.020557
TRAPPC3	-0.020491
SWAP70	-0.020488
RPS11	0.020475
NDUFS7	0.020440
SERINC1	-0.020397
CPEB4	0.020389
LRRC4C	0.020336
ATP5H	-0.020313
CISD1	-0.020298
ATP5D	0.020278
ALKBH3	-0.020274
ZDHHC9	0.020264
PAPD5	-0.020256
RPL7	-0.020240
PAK1	0.020236
MEF2C	-0.020228
DNAJA1	-0.020211
GSTM3	-0.020179
RNASEK	0.020157
RPS29	0.020134
FOCAD	0.020114
RPL27A	-0.020058
P4HTM	0.020032
ALKBH7	0.020031
HNRNPH3	-0.019984
DDT	0.019945
CNR1	0.019890
FAM3C	-0.019862
STXBP6	-0.019786
TAF10	0.019752
PIP5K1C	-0.019738
SNRPN	-0.019730
PRMT8	-0.019727
CADPS2	0.019709
CNKSR2	0.019680
MEX3B	-0.019639
PCGF6	-0.019512
CCDC136	0.019505
RTFDC1	-0.019496
KLHL9	-0.019476
RPL9	-0.019357
TAF9B	-0.019312
TMEM9B	0.019306
SERPINE2	-0.019300
NDUFA4	0.019298
PKIG	-0.019297
BAP1	-0.019286
MAP2K1	-0.019248
RBM42	0.019229
SPCS2	0.019215
BEND6	0.019189
EMC4	0.019184
RAB5A	0.019178
ANKRD27	-0.019172
PCGF1	-0.019171
RPL36AL	-0.019128
RDH14	0.019121
CDC42EP2	0.019120
HNRNPU	-0.019091
CD81	-0.019060
RPS23	0.018997
TMX1	-0.018991
DUSP3	0.018956
MINK1	0.018944
NOL4	-0.018940
RAB18	-0.018936
QKI	0.018920
MAZ	0.018908
PAM16	-0.018904
MVB12B	-0.018903
ACSBG1	-0.018862
IRF2BP2	0.018765
PITPNM2	-0.018753
ARPC5	-0.018753
TLE1	-0.018741
CLTA	-0.018738
RASGRF1	-0.018710
ATRNL1	0.018700
ETFB	-0.018684
CCDC53	-0.018660
RANBP6	-0.018630
DDIT4	0.018625
SERPINI1	0.018611
MDM4	0.018595
YWHAB	0.018576
ATP1A1	0.018565
PPP1R21	0.018556
NRXN1	0.018547
SPOCK1	0.018536
TBCA	-0.018434
ACTR6	-0.018423
XBP1	-0.018353
GLRX3	-0.018338
LPL	0.018325
ACADSB	0.018302
ARL3	-0.018295
STK40	0.018294
SUMO2	0.018286
GMDS	0.018228
ATXN10	0.018224
SSBP2	0.018219
PRPF38A	0.018216
DARS	-0.018203
STUB1	0.018202
CACNA2D1	-0.018192