!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Heroin
!smiles	CC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C
!drugbank_id	DB01452
!pubchem_cid	5462328
!cell_type	striatum, day 12 treatment
!organism	mouse
!end_metadata
CSHL1	0.317098
PLIN4	0.269643
TTR	0.243112
PRL	0.186648
OXT	-0.125764
FOS	-0.124200
PMCH	-0.115313
SPINK8	0.114150
S100A5	-0.112791
HCRT	-0.111901
S100A8	0.111863
CIART	0.110207
EGR2	-0.108672
S100A9	0.105020
SLC13A4	-0.102224
ARC	-0.097633
ND6	-0.094751
SGK1	0.092530
C2orf40	0.086668
LCN2	0.086203
SLC6A13	-0.080378
PCSK9	0.068069
STMN1	-0.066779
RASL11B	0.066443
KL	0.063036
R3HDM2	-0.060771
RXRG	-0.060548
ND4L	-0.060532
KIAA1462	-0.060141
HLA-DQA1	-0.057254
ANO2	0.054873
OMP	-0.052848
AEBP1	-0.052635
NR4A2	-0.052422
WFDC2	0.052204
NDRG4	-0.050640
CRHBP	0.050636
HBB	0.050129
CAMP	0.049282
MXI1	-0.049221
PTGDS	-0.048937
SLC6A12	-0.048560
ST13	-0.048118
THBD	-0.047315
HIF3A	0.046492
CRYAB	-0.045949
SPARCL1	-0.045487
CIRBP	0.045370
VPS26B	-0.045163
HLA-DRB5	-0.044056
SERPING1	-0.043677
CALB2	-0.043483
DBP	0.043297
SOSTDC1	0.043099
GLUL	-0.042780
KCNE2	0.041992
FAM180A	-0.041598
ARNTL	-0.041136
PRKCD	0.040594
CHMP5	-0.040499
PDYN	0.040472
STK32C	0.039783
HEBP1	0.039179
PAIP2	-0.038935
IL22RA1	0.038879
AMN	0.038348
PRR7	0.038141
NR1D1	0.038090
PCMTD2	-0.038074
CORT	0.037840
VAPA	-0.037664
SMPDL3B	0.037644
CCL21	0.037436
IGF2	-0.037341
ACER2	0.037197
SLC4A1	0.036969
ALAS2	0.036867
DRD4	0.036706
ARHGEF39	0.036492
HRH3	0.035960
GPR17	-0.035936
TRIM59	-0.035842
CLDN2	0.035825
IDO1	-0.035300
CRYBG3	-0.035102
CD74	-0.034695
NTN5	-0.034503
HLA-DQB1	-0.034206
MAS1	0.034110
INMT	0.033978
ARHGAP33	-0.033318
HSPE1	-0.033266
DOK3	-0.033004
EFNB2	-0.032632
CCL17	0.032569
NEUROD2	0.032435
AGPAT3	-0.032231
VHL	-0.032221
EGR4	-0.031493
FOLR1	0.031441
C2orf74	0.031214
CARTPT	0.030684
WNT2	-0.030595
AQP1	0.030394
ARPC2	-0.030335
PGRMC1	-0.030326
TRRAP	-0.030318
WFS1	0.030292
XDH	0.030278
C2orf82	0.030269
TOMM70A	-0.029855
SLC22A6	-0.029796
ERBB2IP	-0.029787
CLIC6	0.029442
S100B	-0.029358
DCN	-0.028961
RASGEF1A	-0.028743
CDKN1A	0.028684
CYFIP2	-0.028520
TOP2B	0.028340
TH	0.028340
GJB2	-0.028116
TPPP	-0.027947
MMP23B	-0.027856
CLSPN	-0.027726
MFSD2A	0.027532
SDHD	-0.027451
PCP4	-0.027006
OGN	-0.027000
CHMP4B	0.026972
RPL18A	-0.026911
FAM171A1	-0.026885
LRRTM1	0.026754
TMEM178A	-0.026744
DUSP1	-0.026193
TBC1D21	0.026148
BGN	-0.026078
ADAM9	-0.025981
MAP2K1	-0.025958
TFRC	0.025880
TUBA1A	-0.025608
NPTX1	0.025165
HSPA8	-0.024468
SLC6A3	0.024380
NFKBIA	0.024254
SLAIN1	-0.024243
SNAPC1	-0.024181
OTUD6B	-0.024073
ID2	0.023959
GRAMD4	-0.023794
TRA2A	-0.023705
LCT	0.023668
C8orf46	-0.023480
SLC35D3	-0.023459
KLHL40	0.023421
ACADSB	-0.023277
RASAL1	0.023265
SNX3	-0.023246
GNG11	-0.023237
NUPR1	-0.023061
SLC2A6	0.022793
ITPK1	0.022789
REM2	0.022699
TJP1	-0.022604
LPAR1	-0.022518
BHLHE40	0.022480
RGS9	-0.022368
TBC1D19	-0.022337
PRELP	-0.022285
ARRDC4	0.022270
EMP1	-0.022191
ITIH2	-0.021933
GPR88	-0.021849
C8orf82	0.021617
NT5E	0.021477
P4HA1	-0.021456
SELK	-0.021454
SYNDIG1L	-0.021424
MAP1LC3B	-0.021417
GPR83	0.021375
PCDH20	-0.021251
IDH3A	-0.021212
CALML4	0.021076
ARHGEF26	-0.021028
RGMA	-0.020935
CHORDC1	-0.020879
PRRT4	0.020875
FPR2	0.020799
PRSS12	0.020731
SLC47A1	-0.020719
PENK	0.020718
BHLHE22	-0.020678
RRAS2	-0.020567
FIG4	0.020539
CCNG2	-0.020530
C10orf10	0.020518
C1QL2	-0.020479
XRRA1	0.020422
CAMKK1	0.020379
DCLK1	0.020373
PER1	0.020350
FFAR3	-0.020323
DLK1	0.020299
GPR21	0.020295
GPR6	-0.020263
ST8SIA2	-0.020262
ST8SIA3	-0.020218
CACNG4	-0.019968
C15orf61	-0.019835
LBP	0.019739
PDCD5	-0.019737
RANBP3L	-0.019717
PKP2	0.019713
RRP8	0.019651
CPNE5	0.019606
RAB26	0.019593
EGR1	-0.019589
PLA2G7	-0.019574
SLC16A8	0.019516
NKX2-1	-0.019419
TRHR	-0.019361
DUSP11	-0.019359
PMPCB	-0.019305
CD93	-0.019279
PRPSAP2	-0.019071
FXYD5	-0.019054
RAB34	0.019034
ASIC4	0.019007
SPHK1	-0.018941
IGSF1	-0.018930
RBM14	-0.018927
PTPRA	-0.018836
ISL1	-0.018813
MYL4	-0.018792
NRARP	0.018749
STRIP2	0.018683
OTOF	-0.018677
LTF	0.018673
CRYZL1	-0.018663
ABLIM2	-0.018661
GJB1	-0.018655
PTPN1	-0.018636
DDIT4L	-0.018584
FBP2	0.018547
ID4	-0.018542
RASSF8	-0.018538
ATP5A1	-0.018531
NDUFA5	-0.018447
SPTSSA	-0.018415
OMD	-0.018407
NSUN7	-0.018347
TMEM40	0.018323
GBX2	-0.018297
STAC2	0.018294
GRIK5	0.018256
LLGL2	0.018238
AGR2	0.018232
DND1	-0.018221
PLTP	-0.018189
LIN7C	-0.018145
CHGA	0.018104
ETV5	-0.018069
PCOLCE	-0.018029
FOSB	-0.018025
FKBP5	0.017993
CACNG3	-0.017909
IRAK3	0.017872
GCLC	-0.017854
HIGD1B	0.017850
LHFPL2	-0.017825
RGS16	0.017819
HSPB1	-0.017722
NANOS2	0.017715
WDR54	0.017661
MICU3	0.017658
PSMD14	-0.017651
FAM107A	0.017631
NDUFB9	-0.017628
LAMB3	0.017608
NPAS4	-0.017581
IL11	0.017543
LHFPL5	-0.017542
RER1	-0.017394
IGFBP2	-0.017318
IRGM	-0.017296
ARRDC2	0.017279
ALOXE3	0.017272
SLC18A3	0.017258
SLC8A2	0.017194
KIF22	0.017165
DZANK1	-0.017144
CDHR1	-0.017094
HTR1D	-0.017083
GPM6A	-0.017054
TXNDC12	-0.017017
COL8A1	0.017016
ME1	-0.016992
RYR1	-0.016968
PAM16	-0.016947
TNFRSF25	-0.016893
ITGA10	-0.016890
SLC2A1	0.016877
FYCO1	-0.016850
NDUFAF5	-0.016821
FOXC1	-0.016791
CAMK1G	0.016789
S100A10	-0.016706
KRT14	-0.016645
MEIS2	-0.016619
NEU2	-0.016617
RARB	-0.016557
PECR	0.016535
PICALM	-0.016528
CCNO	0.016524
ZNF442	-0.016471
HTT	-0.016445
C3orf18	0.016386
NAP1L5	-0.016346
PGAM2	0.016329
GATAD2B	0.016310
HSP90B1	-0.016288
KCTD12	-0.016260
PCDHB8	0.016254
CAPRIN1	-0.016223
DOC2A	0.016172
MKL1	0.016119
METTL23	0.016113
ARHGEF19	-0.016111
RHOU	0.016085
PTGES3	-0.016051
EMP2	-0.016035
PLEKHA3	-0.015993
OR1N2	-0.015978
INSL6	0.015974
LRRTM3	-0.015942
SERPINH1	-0.015927
STEAP1	0.015922
COX2	-0.015922
INSC	-0.015897
C17orf70	-0.015883
XRCC3	0.015866
DRD2	-0.015849
PLEKHF1	0.015799
SLC20A1	-0.015748
IGFBP5	-0.015736
FMOD	-0.015727
IST1	-0.015714
RPE65	-0.015705
FOXG1	-0.015656
FAN1	0.015605
SFR1	-0.015589
CLDN5	-0.015556
BMS1	-0.015555
MLH1	0.015545
CH25H	0.015538
TTC9B	0.015536
ABHD17C	-0.015460
OCIAD2	0.015456
FTL	-0.015437
PRKAB1	0.015402
PHOX2A	-0.015356
PLEKHD1	0.015354
CSRNP1	0.015333
PIP5KL1	0.015330
PGLYRP1	0.015318
BCAS2	-0.015314
CCDC88C	0.015297
OLAH	0.015270
NAP1L3	-0.015264
ATP6	-0.015245
CFP	-0.015208
YWHAE	0.015200
KLF2	-0.015107
AIM1L	0.015100
PF4	-0.015096
AVP	-0.015096
SPRN	0.015082
VIT	-0.015076
ARG2	0.015063
NRP1	-0.015030
SLC25A22	0.014994
EVL	-0.014984
USP28	-0.014981
AK4	-0.014934
KPNB1	-0.014932
FKBP2	-0.014914
PCNA	0.014879
CCKBR	-0.014829
LYRM9	0.014816
SLC25A47	0.014750
DKKL1	0.014742
TPT1	-0.014728
KRT12	0.014710
PDLIM7	-0.014686
LRG1	0.014661
SLC23A2	-0.014630
HMHA1	-0.014604
RIC8B	-0.014597
HUWE1	-0.014585
FGFBP1	-0.014582
PHEX	-0.014544
PARP8	-0.014538
HAPLN4	0.014536
AVPI1	0.014500
TPPP3	0.014494
LINGO1	0.014485
ZFP36L1	-0.014479
LTC4S	0.014461
TMEM64	-0.014457
IFITM3	-0.014445
SAT2	0.014443
ZNF780A	-0.014435
ANKRD2	0.014421
OPN1LW	-0.014409
RGS10	-0.014370
PNMT	0.014368
OLFM3	-0.014367
CDKL4	0.014358
IRX6	-0.014341
PDIA4	-0.014275
CCT5	-0.014261
NXF3	0.014244
YTHDF3	-0.014219
CCAR1	-0.014141
SPTY2D1	0.014121
GP5	0.014112
HPRT1	-0.014111
TMEM158	0.014100
DHCR7	0.014099
TPRN	0.014079
DDIT4	0.014071
SPAST	-0.014066
ENO1	-0.014044
FAM216B	-0.014044
SLC52A3	-0.014043
FBLN7	0.014031
NRN1	-0.014014
SOGA3	-0.013976
GADD45A	-0.013956
BDP1	-0.013949
ALCAM	-0.013904
CDK2AP2	-0.013877
ABT1	0.013837
FH	-0.013821
NETO2	-0.013811
YIPF5	0.013800
SERPIND1	-0.013796
SLC31A1	0.013789
CYP1B1	-0.013738
THRA	0.013731
STX1A	-0.013705
PPP1R1B	0.013702
HIST1H2BJ	-0.013694
SLC39A10	-0.013691
CTSK	-0.013686
VAPB	0.013683
CGA	0.013679
ADCY4	-0.013678
RETNLB	0.013667
CLDN1	0.013649
PDP1	-0.013648
TEK	-0.013637
PDCL3	0.013636
GAB1	-0.013636
KRT73	0.013633
PIN4	-0.013609
ST8SIA4	-0.013605
CA4	-0.013604
CCDC129	0.013598
MRO	-0.013595
OSBPL8	-0.013562
NKX6-2	-0.013543
ECI2	-0.013540
KCNIP3	0.013536
SUGCT	-0.013525
SDF2L1	-0.013519
EDNRB	-0.013499
MXD3	0.013497
USP3	0.013462
CALR	-0.013447
SEPT8	-0.013431
AGO4	-0.013425
JOSD2	-0.013419
DDT	-0.013418
TRIM54	0.013416
PRICKLE1	-0.013409
TXNRD1	-0.013395
MAP3K6	0.013393
GDI2	-0.013376
HSP90AA1	-0.013363
ASZ1	0.013327
FAM117A	0.013327
CA13	-0.013327
PIK3IP1	0.013324
LEAP2	-0.013289
PDE10A	-0.013280
DBNL	0.013237
PCOLCE2	0.013225
BCAP31	-0.013203
NFKBIB	0.013198