!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!ligand_name	estradiol
!ligand_id	CHEBI:23965
!cell_type	hematopoietic stem cells (HSCs)
!organism	mouse
!end_metadata
MYL10	0.147628
ITGAM	0.123563
THBS1	0.123252
GSTM5	-0.118936
APOE	-0.117407
CHAD	0.114712
GPR56	-0.109455
HIST1H4A	-0.103015
S100A9	-0.100026
FADS2	0.096383
ERN1	0.094000
S100A4	0.087710
S100A8	-0.087351
MPO	-0.086008
CD97	0.081235
CRIP1	-0.076939
MPL	-0.076481
HIST1H2BC	-0.076150
JDP2	0.076009
HIST2H2AB	-0.073708
EGR1	-0.071948
MYB	-0.071218
PIM1	0.070375
GPX1	0.065141
HIST1H2BN	-0.065050
KRT18	-0.064021
U2AF2	0.062241
HIST1H2AA	-0.061505
PF4	-0.061239
HIST1H4C	-0.059483
GBP6	0.058798
CD27	-0.058209
KIT	-0.057677
COX6B1	0.056596
SERPINF1	-0.055516
MYL12A	-0.055393
DUSP1	-0.054071
LY6E	-0.053789
TXNIP	-0.053486
ITGAE	0.052608
PDZK1IP1	-0.052443
CCND2	-0.049721
MYC	-0.049720
C11orf54	0.049412
RPS9	-0.049254
LAT	-0.048963
GATA2	-0.048746
SUMO3	0.048742
MUC13	-0.048649
CLIC1	-0.048512
GLRX3	0.048116
LGALS9B	-0.047614
ETV6	-0.047501
CD164	-0.047495
MIF	0.046981
CD81	-0.046787
GNG11	0.046499
CD34	-0.046272
PGK1	0.046258
IQGAP2	-0.046223
PCNA	0.046127
PFDN5	-0.045660
EIF4EBP2	-0.045545
CORO2A	0.045444
SOX4	-0.045304
VEZF1	-0.045201
KRTCAP2	0.045046
SERINC3	-0.044777
ZFP36	-0.044571
EEF2	-0.044525
VEGFA	0.044209
RBP1	-0.043878
GFI1B	-0.043440
SHISA5	-0.043172
C1orf168	0.043113
TMEM11	-0.042926
RNASEK	-0.042833
DDAH2	-0.042308
CPNE2	-0.042098
GPX3	0.041367
PTPN7	-0.041337
NFE2	-0.041317
LTB	-0.041010
LMO2	-0.040874
RPL9	-0.040868
EIF2A	-0.040377
CNN2	-0.040156
TUBA4A	-0.040014
DAPP1	-0.039732
NDRG1	-0.039395
NEDD9	0.039167
ZYX	-0.039130
F2R	-0.038842
FTL	-0.038817
MLEC	0.038733
FAM107B	-0.038517
GRN	-0.038496
JUN	-0.038436
FOXO3	-0.038355
CTSD	-0.038321
NAP1L1	0.038188
YPEL3	-0.038052
FUT8	0.037984
ARNTL	0.037475
RPL19	-0.037428
BNIP3L	-0.037329
GLTSCR2	-0.037249
RSU1	-0.037177
NKG7	-0.036912
SEPT9	-0.036634
SIRPA	-0.036596
SRSF2	0.036442
PLXNC1	-0.036254
NACA	-0.036193
CDK6	-0.036106
RAMP1	-0.035971
LAPTM4A	-0.035863
SLC16A12	0.035819
SLC22A3	-0.035725
CCNB2	0.035635
SLC25A5	0.035629
MSI2	-0.035599
C1orf54	-0.035393
AP2S1	0.035253
ANGPT1	-0.035205
OSTC	0.035187
BASP1	0.035092
DACH1	-0.035092
HSCB	-0.035088
GALNT6	-0.034948
MAP1LC3B	-0.034772
ELF1	-0.034606
REXO2	0.034592
TES	-0.034538
CMTM7	-0.034521
SELP	0.034512
GCNT2	-0.034342
HIST1H4B	-0.034316
MYCT1	-0.034251
COPG2	-0.034249
ERICH1	-0.034069
HIST1H2AK	-0.033979
HIST3H2A	-0.033940
NCOA4	-0.033754
SPCS3	0.033714
SPN	-0.033494
PLEK	-0.033302
IER2	-0.033278
ZFPM1	-0.033275
GM2A	-0.033132
ANXA6	0.033110
RPS28	-0.032967
GIMAP6	-0.032903
ADRB2	0.032601
LYZ	-0.032485
DCTN4	-0.032238
INSIG1	-0.032134
HLA-E	-0.032089
HIST1H3A	-0.031944
RPN1	0.031848
ATP5J2	0.031788
GP5	-0.031577
UBE2I	-0.031504
ERBB2IP	-0.031432
YWHAE	0.031389
SRRT	0.031375
NHP2	0.031301
ATP5G3	0.031295
MAGED1	-0.031294
TAP2	0.031253
HNRNPDL	0.031213
RPS5	-0.031204
RNF144A	-0.031199
ERG	-0.031163
WBP2	-0.031097
ART4	-0.031063
ARID1B	-0.030906
HNRNPD	0.030904
EXTL3	0.030737
KLK8	-0.030444
SLC48A1	-0.030406
RPL18A	-0.030379
TFDP1	0.030308
TCN2	-0.030266
CBX5	0.030218
NINJ1	-0.030178
ELOVL1	-0.030128
RASA4	0.030127
KLHL24	-0.029990
KCTD1	-0.029904
RPL22	-0.029868
IFITM3	-0.029822
HLA-DQA1	-0.029734
PRTN3	-0.029717
EYA2	-0.029535
NME1	0.029404
PNRC1	-0.029390
HIST1H2AD	-0.029378
CYSLTR2	0.029347
TK1	0.029180
STAT1	-0.029177
LAX1	0.029034
TRPC6	0.028987
CEBPA	0.028914
PAIP2	-0.028859
HIST4H4	-0.028702
DPF2	-0.028673
HSPD1	0.028664
GNB2L1	-0.028579
RAB37	-0.028412
VAT1	-0.028365
RPL24	-0.028338
CREBBP	-0.028261
RNASE6	-0.028142
DUSP6	0.028122
GLUL	-0.027964
RPL21	-0.027961
ZNRF1	0.027947
CLNK	0.027924
RELA	-0.027739
DCTPP1	0.027732
TTPA	0.027661
PTP4A3	0.027634
GP9	0.027634
LAMP2	-0.027615
PYGM	0.027598
RBM38	-0.027531
RBPMS	-0.027307
SDCBP	-0.027167
PIGT	-0.027115
ZNF706	-0.027072
RPS29	0.027067
EIF3K	-0.027006
PLCB2	-0.026968
ACYP1	-0.026796
FAM65B	-0.026782
ATP6V1E1	-0.026765
RABAC1	-0.026748
ERH	0.026702
TCEAL8	-0.026627
PDCD4	-0.026626
EIF3E	-0.026616
TAL1	-0.026583
ZFP36L2	-0.026557
CAMP	-0.026528
MDC1	-0.026522
UCHL5	0.026449
SLC13A2	0.026436
C19orf53	0.026322
HIST1H4I	-0.026314
PYCARD	0.026299
RBBP7	0.026276
EIF4G2	-0.026272
FCER1G	-0.026188
RAB10	-0.026160
HIST1H4F	-0.026152
PDLIM1	-0.026134
SLC35C1	-0.026051
COPS3	0.026042
SREBF2	-0.026026
GBAS	-0.026009
CDKN1B	-0.025882
TMBIM6	-0.025807
TMEM109	0.025735
TEX2	0.025715
SMIM24	-0.025685
SUGP2	0.025574
FLI1	-0.025539
MDGA1	-0.025505
PBX1	-0.025445
H2AFZ	0.025354
NCAPD2	0.025320
SLC44A2	-0.025298
PHB	0.025202
RPL5	-0.025176
RSL24D1	0.025127
PRDX4	0.025030
RPS12	0.025013
TMEM127	-0.024913
DNAJC9	0.024866
KDM5B	-0.024849
UHRF1	0.024774
CREG1	-0.024732
NCEH1	-0.024699
TNFRSF13C	-0.024680
SMPDL3A	-0.024628
CLK1	-0.024616
SUMO1	-0.024542
GAPDH	0.024536
FADS3	0.024460
ACTG1	-0.024448
KCTD13	-0.024380
SSR1	0.024311
CMAS	-0.024302
RGS10	-0.024286
RPL37	-0.024236
HIST1H2BB	-0.024232
TBXAS1	0.024136
KMT2E	-0.024076
HADH	-0.023986
TFR2	-0.023977
GTF2I	-0.023977
BTF3	-0.023856
TUBA8	-0.023849
MINOS1	0.023839
PPP2R2B	0.023792
RPL10A	-0.023782
NEDD8	0.023705
RUNX3	-0.023696
CSNK1D	-0.023689
LGALS1	-0.023681
XPO1	0.023664
IDE	0.023636
KHK	-0.023545
IFNAR2	-0.023531
UAP1L1	-0.023445
CAT	-0.023426
FBRS	-0.023406
TACSTD2	-0.023386
ALAS1	-0.023343
EIF4A3	0.023293
HNRNPU	0.023273
TNIP3	0.023041
GSG2	0.022866
CITED2	-0.022837
AFF4	0.022782
VIM	-0.022775
RTN3	0.022733
HNRNPA2B1	0.022730
ITGA2B	-0.022707
DAZAP2	-0.022690
NDUFB10	-0.022680
NOC2L	0.022595
C7orf50	0.022595
NOP10	0.022559
CAPZA1	-0.022540
TRIP13	0.022529
FOXJ2	-0.022483
ARHGAP6	0.022470
PDK2	-0.022343
BACE2	0.022263
POLR2L	0.022259
IFI44	-0.022239
CD44	-0.022236
RAC1	-0.022225
TCF4	-0.022204
NDUFA6	-0.022183
GRIA3	0.022177
ENPP5	-0.022161
DUT	0.022159
RPL7A	-0.022140
COL1A2	0.022087
SEMA4A	0.022051
CORO1A	0.021992
RPL11	-0.021866
DKKL1	-0.021830
EEF1D	0.021811
IMP3	-0.021749
POLDIP3	-0.021711
IER3	-0.021693
CSNK1E	-0.021683
LCN2	-0.021668
SEC61B	0.021651
GUCY1A3	0.021650
BCL9	-0.021633
CA2	0.021625
BHLHE40	0.021619
TMEM180	-0.021597
MDH2	-0.021583
IRF2BP2	-0.021545
ABR	-0.021542
RPL15	-0.021533
UCP2	-0.021504
ERGIC3	-0.021486
SLFN5	-0.021434
ITM2B	-0.021350
SSR4	0.021312
FMNL2	0.021299
CYB5A	0.021295
RNF44	-0.021277
GRINA	-0.021258
COX6B2	-0.021247
BGN	-0.021194
LRRC58	-0.021164
ETV3	-0.021163
KMT2A	-0.021151
TAF1D	0.021147
UBE2S	-0.021130
NDUFB6	0.021083
TRIM47	-0.021058
NSA2	-0.021021
RTP4	-0.021014
CKS1B	0.020983
GPI	-0.020956
CTSG	-0.020937
PSME2	0.020921
PRKACB	-0.020917
FKBP2	0.020902
RCN3	-0.020889
CLSPN	0.020713
ERF	-0.020688
EEF1G	0.020667
SELPLG	-0.020644
PAICS	0.020573
AKAP13	-0.020556
ANXA5	-0.020541
FNBP1	-0.020493
SEPW1	0.020462
C17orf85	0.020461
TALDO1	-0.020393
NDUFA4	0.020376
FLII	-0.020370
FAM53C	-0.020305
TCF12	-0.020279
MC5R	-0.020274
TRIB2	0.020272
E2F1	0.020263
HIST1H2BJ	-0.020249
STT3A	0.020242
EMP3	-0.020226
ORC6	0.020200
CRTC3	-0.020198
ABHD2	-0.020181
ST3GAL1	-0.020173
PRDX2	-0.020168
TIMP2	-0.020137
NET1	0.020131
LSM14A	-0.020118
RPL30	-0.020084
RAB8B	-0.020058
EMB	0.020018
HIGD2A	-0.020016
MRPL34	-0.019915
CD47	-0.019878
PSMD1	0.019876
CORO1C	-0.019874
SNAP23	0.019873
GLIS2	-0.019799
CHD4	-0.019799
SPNS2	-0.019762
CTDSP2	-0.019712
DENND4A	0.019675
ALDOC	-0.019655
TP53INP1	-0.019547
CDK4	0.019546
VDAC1	0.019529
NFIL3	0.019511
SESN3	-0.019492
SRSF6	0.019455
DAP	-0.019388
CCR5	0.019319
STMN1	0.019317
PLAC8	-0.019293
TUBA1B	0.019255
TMEM234	-0.019197
GALT	-0.019189
LIG1	0.019181
GID4	-0.019168
HIST1H4J	-0.019167
MARCKSL1	-0.019162
MAPK1	-0.019125
UQCRHL	-0.019117
RAB1B	0.019099
NDRG3	-0.019091
MTHFD1L	0.019086
MXD4	-0.019083
PPM1G	0.019075
RNF114	-0.019042
MOV10	-0.019035
INPP5D	-0.019032
ALG8	0.018995
FAM43A	-0.018961
HSPE1	0.018940
PTPRS	-0.018922
RMND5B	0.018907
PRKCE	-0.018897
PSMA7	0.018888
TXN	0.018886
DDT	-0.018867
CAPN1	-0.018854
SCNM1	-0.018851
CETN3	0.018790
CCT3	0.018790
PIK3R1	0.018749
SPCS2	0.018747
FAM168A	-0.018715
CHTF8	-0.018680
RPL38	-0.018668
SYNGR2	-0.018656
HIRIP3	0.018648
MAPK3	-0.018645
CDC6	0.018592
PSMB5	0.018564
HID1	-0.018535
ACTR3	0.018517
MCM6	0.018487
ARL6IP1	-0.018476
NDUFA12	0.018464
LDB2	0.018462
AFAP1L1	-0.018434