!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Lapatinib
!smiles	CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
!drugbank_id	DB01259
!pubchem_cid	208908
!cell_type	SKBR3 parental and resistant (SKBR3-R) cell lines
!organism	human
!end_metadata
SCGB1D2	0.203886
HSPB1	-0.157402
PAGE2	0.152923
RPL19	-0.145920
SCIN	0.143973
RPS13	-0.125839
PAGE2B	0.125390
H3F3A	-0.124869
RPL27A	0.120290
SNAR-A1	0.117718
PPT1	0.114523
RPS4X	-0.114029
XBP1	0.112636
COX8A	0.107434
BMP7	0.106564
RPL22	-0.106401
SUSD2	0.104971
S100A9	-0.103785
EEF1A2	-0.101871
TFRC	0.101065
KRT81	0.096954
RPLP2	0.094246
ADIRF	0.090829
CPS1	0.087633
PAGE5	0.087476
MYL6	-0.083062
S100A4	0.082969
ACTG1	-0.080939
RPS16	-0.079609
H3F3AP4	-0.077872
RPL13AP20	0.077732
S100A16	0.077509
SSU72	-0.077346
DDT	0.075345
NFKBIA	-0.072790
HIST1H4C	-0.071508
KRT19	0.071067
RPL37A	0.068195
EIF4A2	-0.068073
PRDX6	0.067438
RPS25	-0.065891
RPS28	0.065837
NDUFS8	0.065679
ATP5L	0.065206
HIST1H2BK	-0.064608
RPS17	0.064452
TRAM1	-0.064398
TMEM258	0.064240
SAT1	-0.063500
RPLP1	0.063273
TMSB10	-0.063130
NDUFA1	0.062784
TMEM59	-0.062413
PPA1	-0.061726
RPL41	0.061176
SEPT9	0.060854
PRDX4	0.060758
RPL8	-0.060187
TPT1	-0.059722
ACAT1	0.059024
PSMB10	-0.058244
EPRS	-0.058213
RPL35	0.058053
GLTSCR2	-0.058003
EZR	0.057992
PPIAL4B	-0.057895
EIF3E	-0.057756
COX6C	0.057716
CFL1	0.056400
CCNI	-0.056059
LPCAT1	0.055409
GPX4	-0.054430
TRMT112	0.053675
GNB2L1	-0.053368
JUND	-0.052594
NDUFA4	0.052516
LRRC26	0.052269
SCGB2A2	0.051570
MRPL37	-0.050370
YWHAQ	-0.050108
ATP6V1B1	-0.049931
CTNNA1	-0.049901
ACTB	-0.049454
RPL35A	-0.048742
COX5B	0.048633
UBA52	-0.048481
NDUFB5	-0.047803
SDHA	0.047610
RPL4	-0.047205
MRPL36	0.047022
CNDP2	-0.046962
TMX2	0.046758
MYH9	-0.046508
HSPE1	0.046362
NCCRP1	-0.046147
RPS5	-0.045913
RPL13A	0.045834
PRDX1	0.045459
EIF3L	-0.044920
PSMB1	0.044856
C8orf76	-0.044761
MRPL41	0.044360
MAL2	-0.044262
RPS12	0.043841
COX7C	0.043769
PRDX5	0.043513
TAP1	-0.043468
RPL3	0.043236
SEC61B	0.042911
INHBB	0.042654
CITED2	0.042591
ARPC5	0.042142
RPL6	-0.041759
ARL2	0.041551
ENO1	-0.041308
GARS	-0.040399
DHRS2	0.040163
TAX1BP1	-0.040079
CA12	0.040042
SOD1	0.040020
LDHB	0.039726
ATOX1	0.039714
CAPZA2	-0.039602
TMEM256	0.039525
CAPN1	0.039345
MAP1LC3A	0.039330
FBLN1	-0.039329
AP2S1	0.039121
C1orf64	0.038402
ATP6AP2	0.038253
CRACR2B	0.037902
TXN	0.037862
ZC2HC1A	-0.037684
LDHA	-0.037470
CD81	-0.037374
ATP5B	-0.037265
FAU	0.036900
RPL27	-0.036749
VTCN1	-0.036652
H2AFZ	-0.036638
FERMT2	-0.036615
LAMA5	-0.036546
DDIT4	-0.036526
CEBPB	-0.036189
TOMM7	0.036140
HBE1	0.035792
PURB	-0.035591
COX7A2	0.035309
PTTG1IP	0.035068
PGRMC2	-0.035000
RPL12	-0.034954
EFNA1	-0.034858
RANGAP1	0.034825
TARP	0.034776
TUBA1B	-0.034390
EEF1G	0.034318
S100P	0.034205
RSL24D1	-0.034200
TKT	-0.034119
RPL23	0.033786
CLIC1	-0.033655
NPC2	0.033654
NCOA4	-0.033639
PDCD6	0.033542
MSH3	-0.033473
RBM22	-0.033466
PGM5	0.033374
PPP1CC	-0.032566
VPS35	-0.032358
ACTN1	-0.031925
SRP14	0.031721
MUCL1	0.031515
RPL17	-0.031417
RPS9	-0.031202
NDUFB10	0.031163
UBB	-0.030902
COMT	0.030722
RPL18	-0.030549
MTSS1	-0.030458
ZNF217	-0.030452
CDC42EP4	-0.030297
PGRMC1	-0.030269
COX17	0.030212
JMJD8	0.030148
TACSTD2	-0.029864
HYAL1	0.029624
ELF3	-0.029530
NOL7	-0.028852
HDDC2	0.028762
SLC25A5	-0.028721
CPNE3	-0.028692
PROM2	0.028660
HIST2H2AA3	-0.028571
HIST1H1C	-0.028371
SAE1	0.028297
S100A8	-0.028277
CFD	-0.028249
TYMP	-0.028197
STARD10	0.027891
ATP6AP1	0.027841
CYP1B1	-0.027774
EIF4G2	-0.027701
MRPS24	-0.027617
EIF3H	-0.027574
FBXO32	-0.027562
RHPN2	-0.027491
STOM	0.027397
RDH10	-0.027379
DERL1	-0.027301
PSME1	-0.027216
LILRB3	0.027211
RAB9A	0.027116
ACSL1	0.026986
NOA1	-0.026873
CLINT1	-0.026873
IGFBP5	-0.026779
ROCK2	0.026723
RNF114	0.026676
S100A6	0.026638
CYC1	-0.026619
SARAF	-0.026603
EIF3M	-0.026537
VIPR1	-0.026488
SDF2L1	0.026397
RPS29	0.026323
COX4I1	0.026309
TMEM179B	0.026270
RPL23AP64	0.026161
TRPM4	-0.026036
KIAA0101	0.026034
PDCD7	0.026033
NOP10	0.025983
IMPDH2	-0.025945
PMPCB	-0.025935
MKRN1	-0.025859
ARPC1A	-0.025781
VAMP8	0.025520
PSMA5	-0.025445
TXNDC17	0.025281
B4GALT5	-0.025270
SPINT2	0.025239
IL18	0.025203
SHROOM3	-0.025108
SQSTM1	-0.025093
TST	0.024730
RHOA	0.024659
CITED4	-0.024610
MIF	0.024546
CYP4B1	0.024525
EBNA1BP2	-0.024502
DDIT4L	0.024474
BOP1	-0.024443
SNX3	-0.024436
RPS15	0.024420
ACLY	-0.024107
RPL15	-0.024094
SCYL1	0.024089
ITPK1-AS1	0.024044
FBXL20	-0.023958
TMEM14B	0.023951
NDUFV1	0.023939
KRT8	0.023883
BTF3	-0.023820
NDUFA8	0.023681
RPL30	-0.023628
P4HB	0.023571
GPR56	-0.023541
AMY1C	-0.023517
EIF4A3	-0.023483
TMED3	0.023384
DENND2D	-0.023368
ANKRD33	0.023365
OSBP	0.023278
RAB25	-0.023130
IER3	-0.023126
WASL	-0.023101
PTBP1	-0.022852
YBX3	-0.022842
SLC7A5	0.022714
CD151	0.022655
CCDC6	-0.022612
RPL5	-0.022585
UHMK1	-0.022574
C15orf52	0.022567
FAF2	-0.022513
TMED10P1	0.022500
FTL	-0.022453
RPS27	-0.022427
NFKB1	-0.022414
DYNLL1	-0.022172
RPSA	0.022112
CMC2	0.022107
EIF3D	-0.022103
RPL7	0.022014
PSMA6	-0.021993
GTSF1	0.021962
CCT8	-0.021838
CNN3	-0.021773
MGST3	0.021729
ITPR3	-0.021673
RPS11	0.021622
SMIM14	0.021587
SLC16A3	0.021559
APOA1BP	0.021484
STT3A	0.021430
KRTCAP2	0.021388
PLOD1	0.021385
CLEC2D	-0.021329
UQCRHL	0.021307
SERBP1	-0.021278
PHPT1	0.021255
CLCN7	0.021207
UQCRQ	0.021199
TIMP2	0.021151
ROMO1	0.021146
H19	0.021066
MPC1	0.021065
TSPAN9	0.020954
UQCRFS1	0.020922
ZNF704	-0.020818
CD163L1	0.020766
EFHD1	0.020699
GPNMB	0.020629
POLR1D	-0.020538
ATP6V1F	-0.020468
VPS51	-0.020432
NDUFS3	-0.020400
NUCB1	-0.020375
MAT2A	-0.020336
AURKAIP1	-0.020225
GTPBP4	0.020203
EIF4B	-0.020193
TK1	0.020157
RPS2	-0.020133
TSPAN13	0.020055
UBC	0.020027
CAP1	-0.020014
SELENBP1	0.019998
RPL13AP6	-0.019922
TALDO1	0.019793
PTPRF	-0.019790
MRPS17	-0.019758
REXO2	0.019740
JUP	-0.019729
B2M	0.019723
ATP5H	-0.019719
EEF2	-0.019707
SCGB2A1	0.019700
TFAP2C	-0.019677
RPL10A	0.019644
ZMPSTE24	-0.019601
PALLD	-0.019592
TMEM238	0.019543
OAZ1	-0.019504
ATP5F1	-0.019458
CCR6	0.019385
ADM	-0.019385
C7orf50	0.019289
RPS21	-0.019275
OVOL2	-0.019273
CD2BP2	-0.019262
PSMC2	-0.019258
ERH	0.019220
PRDX3	0.019196
ZHX2	0.019169
ANXA2P1	0.019155
HNRNPAB	-0.019047
KLF2	0.019035
SPCS2	0.018991
SGCE	-0.018984
NOL11	-0.018908
C14orf166	0.018899
CCDC109B	-0.018830
GTF2H5	0.018775
TFAM	-0.018736
CDC20	-0.018728
ILF2	-0.018700
CPE	-0.018667
ZBED1	-0.018635
C9orf152	0.018557
APEX1	-0.018505
ATP5D	0.018488
RPL21	0.018468
ETFA	0.018326
RRAGA	0.018253
RPS20	-0.018163
VPS37C	0.018148
LILRB1	0.018142
TNS3	-0.018059
RAB10	-0.018007
HDAC1	-0.017958
SRSF6	0.017902
MSRB2	0.017900
ULK1	-0.017753
ZYG11B	-0.017750
DYNLRB1	0.017694
PGD	0.017573
RSPRY1	-0.017546
NME1	0.017542
RPS10	-0.017528
PGM1	-0.017516
CSF1R	-0.017455
ATP6V0E2	0.017398
CTSD	0.017391
ATP6V0E1	-0.017374
BAIAP2L1	-0.017372
MRPL18	0.017358
IMPA2	-0.017357
KPNB1	-0.017357
EIF1	-0.017325
GNB1	-0.017299
DAZAP2	-0.017257
RPL36	-0.017253
ATP5I	0.017219
CTDSPL	0.017207
CDC37	-0.017187
PABPC1	-0.017151
PGAP3	-0.017144
YIF1A	0.017122
COPS5	-0.017119
PCNP	-0.017096
TRIM2	-0.017095
PTPRK	-0.017094
TUG1	-0.017032
DARS	-0.016992
MORF4L2	0.016949
KYNU	0.016872
RN7SL1	-0.016844
BRD2	-0.016842
PXDN	0.016812
LGALS3BP	-0.016726
POLE3	0.016723
BRI3	0.016719
COBL	-0.016699
RPL39L	0.016674
RPL23A	-0.016660
RPL38	0.016635
UQCC2	0.016626
CRELD2	0.016565
HSPA8	-0.016560
CDAN1	0.016464
NIFK	-0.016432
MYL12B	0.016429
MFSD10	-0.016413
HK2	0.016404
ANXA2	0.016383
ISG20	0.016344
MTHFD2	0.016297
DDX21	-0.016270
PCBP2	-0.016237
YWHAZ	-0.016223
ANP32B	-0.016205
SNRPA1	-0.016190
IARS2	-0.016126
CRIP2	0.016117
EIF4A1	0.016080
HEXB	0.016074
MRPS12	0.016060
TBCA	0.016019
TSKU	0.016010
CEBPD	-0.015970
CX3CL1	-0.015967
PRPS1	0.015966
SS18L2	-0.015954
SERPINE1	-0.015947
SNRPD2	-0.015910
PTPLB	-0.015901
CIB1	0.015893
WDR13	0.015846
SLC9A3R1	0.015805
UQCRH	-0.015805
PUF60	-0.015772
MAL	-0.015766
MYO5C	0.015764
NDUFB2	0.015762
HIST2H2AC	-0.015702
MANF	0.015681
SIX4	-0.015668
PNPO	0.015648
HMGN1	-0.015498
LSM4	0.015471
SUMO3	-0.015462
RHOB	0.015449
EIF4H	-0.015438
NSA2	-0.015400
CARHSP1	-0.015393
LMNA	0.015390
MED1	-0.015337
BAIAP2L2	0.015310
NDUFAF3	0.015273
EVL	0.015267
GPX2	-0.015267
GLTP	-0.015239
DEXI	0.015230
PSMB4	-0.015227
APEH	0.015209
ADCY3	-0.015199
UFC1	-0.015193
RPL9	-0.015190
RPS23	0.015172