!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	Uterus - single injection of 400 ug/kg - 4 Hours after treatment
!organism	mouse
!end_metadata
CKB	0.198369
DIO2	0.145521
ENG	0.125695
RAN	0.123696
GAS6	0.123612
DCN	-0.121876
PLET1	0.115968
PLAC8	-0.107927
LSP1	-0.107415
GADD45G	0.105980
RPS19	-0.104893
PNP	0.104766
ERRFI1	0.099589
CSTB	0.093908
ANXA2	0.091488
ISYNA1	0.089328
COL6A3	0.088482
IER3	0.087198
SLC7A5	0.084436
LTBP4	-0.084294
HSPA5	0.082931
APP	-0.080699
TUBB6	0.079919
ACAA2	-0.074571
SPARCL1	-0.074175
SRSF2	0.073568
CTSD	-0.071275
ATF4	0.070946
ID2	-0.067954
HSPH1	0.067544
DYNLL1	0.066764
SERP1	0.065891
CNN1	0.065776
RPL7	-0.065689
PLP2	-0.064882
ATP1A1	0.064091
RPS15A	-0.063653
YPEL3	-0.063432
NCL	0.062085
PADI1	0.061951
RPS5	-0.061923
EEF2	-0.061650
BCAT1	0.061643
HIF1A	0.059844
APCDD1	-0.058960
PLK2	0.058652
MAT2A	0.058521
MYH11	-0.058160
RPS26	-0.057939
ITM2B	-0.057530
SLC3A2	0.056992
RABAC1	-0.056405
SOCS1	0.056384
MYH9	0.056255
LRRC59	0.056209
KCTD12	-0.056106
LAPTM4A	-0.055629
CEBPB	0.055502
CTDSP2	-0.055029
EIF3G	0.055011
HSD17B11	0.054956
IGFBP3	-0.054923
GNB2L1	-0.054712
ATP6V0C	0.054689
PTP4A1	0.054013
ISLR	-0.053918
TWIST2	0.053753
NREP	-0.053646
CTPS1	0.053550
HSP90AA1	0.053324
ATF5	0.053148
CFL1	0.052734
RAMP3	0.051862
SURF4	0.051825
TSR1	0.051527
SERPING1	-0.051522
SRM	0.051376
HSPA8	0.051358
RHOB	0.051101
LDHA	0.050964
NHP2	0.050528
WDR92	-0.050377
GSPT1	0.050360
MAF1	-0.049697
ARF1	0.049616
IFITM3	-0.049416
HSPA9	0.049235
SVIL	-0.048881
SLC35B1	0.048738
HSP90B1	0.048476
MAD2L1	0.048258
EIF3D	0.047860
MXD4	-0.047070
RPL10A	-0.047031
RNF167	-0.046328
IGFBP6	-0.046075
LUM	-0.046019
AZIN1	0.045924
TIMM23	0.045851
FMO1	-0.045790
RIN2	-0.045571
BGN	-0.045412
RPL3	-0.045409
UQCRQ	0.045135
CTSB	0.044871
TOP1	0.044752
MYLK	-0.044715
ELF3	0.043972
SOX18	0.043895
PENK	-0.043849
EIF3C	0.043653
MRFAP1	0.043504
GSTM5	-0.043374
SFRP2	-0.043183
S100A6	-0.043030
U2AF2	0.042716
COL1A2	-0.042395
ANGPTL2	0.042328
WFDC2	-0.042281
RARRES2	-0.042063
COL5A2	-0.041916
FKBP4	0.041764
COL3A1	-0.041642
ETF1	0.041573
RPLP0	-0.041458
NFIX	-0.041388
HDLBP	0.041344
EID1	-0.041155
RPS10	-0.041145
FKBP1A	0.040984
RPS7	-0.040966
PCBP1	0.040917
ARHGDIA	0.040646
ACTR3	0.040546
SEC61A1	0.040545
RPL13	-0.040293
YWHAZ	0.040235
HNRNPH1	0.040035
EIF3J	0.039974
IARS	0.039879
TEF	-0.039744
CCT7	0.039522
MYL12A	-0.039396
THY1	-0.038970
MARVELD1	-0.038703
ANXA6	0.038608
MGP	-0.038604
CPE	-0.038427
GORASP2	0.038305
GAPDH	0.038008
RPL21	-0.037687
GNG12	0.037611
WDR1	0.037533
SERPINH1	0.037423
COL1A1	-0.037112
PGRMC1	-0.036911
MMP14	-0.036786
TPT1	-0.036656
ADD1	-0.036534
GJA1	0.036499
AKT1	0.036392
PSMA6	0.036344
SUN2	-0.036285
SLC25A39	0.036280
GPX3	0.036219
REV3L	-0.036207
RPL10	-0.036056
PRRX2	0.036025
RPL28	-0.036015
SCARB1	-0.035934
SLC39A7	0.035826
WDR77	0.035569
PSMA3	0.035544
COL6A2	0.035534
H1F0	-0.035450
TMEM176B	-0.035213
LY6E	-0.034953
ELAVL1	0.034868
PRMT1	0.034714
GTPBP4	0.034612
CD164	0.034521
PSMD1	0.034501
TUBA1C	0.034455
GABARAPL1	-0.034294
RECK	-0.034203
LBP	-0.034171
CNBP	0.034046
NUMA1	-0.033997
NHP2L1	0.033748
ZBTB20	-0.033632
CCT4	0.033491
RASD1	0.033482
SPARC	-0.033444
TUBB3	0.033332
SEC13	0.033182
TGFBI	-0.033095
TSC22D1	-0.033089
IER2	0.033029
GAS1	-0.032798
HOPX	0.032729
THBS1	0.032669
CALB1	-0.032615
GTF2I	-0.032606
PSAT1	0.032549
ACTA1	-0.032383
FZD2	-0.032178
TINAGL1	0.031994
BRI3	-0.031913
TSPAN9	-0.031877
MTHFD2	0.031866
GNG5	0.031840
LAMC2	0.031601
EIF4A3	0.031525
DDX21	0.031508
SSR3	0.031495
UBE2N	0.031392
SLC6A13	0.031387
ARF4	0.031028
RHOU	0.031009
RPL5	-0.030959
HDAC5	-0.030896
RPL6	-0.030849
LGALS1	0.030591
TXNIP	-0.030475
BZW2	0.030405
LPP	-0.030394
PSD	-0.030164
SOCS2	0.030093
TLE3	0.030077
LITAF	0.030053
SESN1	-0.029999
DBP	-0.029993
MIDN	0.029967
RBBP7	0.029929
RMND5A	-0.029902
ARHGEF25	-0.029544
C20orf24	0.029455
ECH1	-0.029278
MAPKAPK2	0.029256
GPS1	0.029162
COL15A1	-0.029049
CBX6	-0.028905
ASNS	0.028860
RRS1	0.028763
SOX17	-0.028680
STK40	0.028607
POSTN	-0.028604
PCP4	-0.028544
AARS	0.028364
CPT1A	-0.028344
COX7A2L	-0.028317
CLPTM1	0.028259
PSMD7	0.028222
MCAM	-0.028109
C12orf57	-0.027935
PNRC2	-0.027902
SQLE	0.027779
STAT3	0.027737
SERINC3	-0.027704
CCT3	0.027702
IGF1R	-0.027671
MEF2D	-0.027650
DOCK9	-0.027594
EIF2S1	0.027559
CLTC	0.027524
WLS	-0.027482
SRSF6	0.027296
APOE	-0.027294
IGSF8	-0.027217
EMP1	0.027158
WDR6	-0.027143
GLRX3	0.026979
ALAD	0.026859
FBL	0.026847
PTPN1	0.026820
GARS	0.026746
SH3BGRL	-0.026717
RALBP1	-0.026592
SAR1A	0.026456
RRAGA	0.026258
ANPEP	-0.026223
CDK2AP1	0.026191
GNAI2	0.026058
LDB2	-0.026038
PLTP	-0.026025
KRT7	0.026000
RPL19	-0.025872
RPS24	-0.025831
SELT	0.025760
IDI1	0.025723
HADH	-0.025556
F3	0.025523
NDP	-0.025516
INHBB	0.025414
ACTG2	0.025333
B2M	-0.025319
PDXK	0.025304
FXYD1	-0.025251
LTA4H	-0.025248
RAMP1	-0.025239
JUND	0.025232
SMTN	-0.025165
RPS3	-0.025134
PTOV1	-0.025123
RBPMS	0.025032
SMOC1	0.024865
MYADM	-0.024739
PPA1	0.024622
PSMB6	0.024592
ARPC2	0.024522
FAM101B	-0.024497
DDAH2	-0.024475
AQP1	-0.024438
PNO1	0.024431
MARC2	-0.024390
CTSF	-0.024172
SGK1	0.024085
CST3	-0.024029
RHOC	0.023968
ADRM1	0.023939
CLDN7	0.023890
SLC6A6	-0.023884
NPNT	-0.023836
ACTB	0.023815
PTGES	0.023815
ZFAND6	-0.023813
SFT2D1	0.023801
ENPP2	-0.023780
IGF1	0.023765
BOK	-0.023747
H2AFV	-0.023693
TXNL4A	0.023652
DAP	-0.023590
TMED2	0.023589
PSMC2	0.023562
PADI2	0.023537
MBTPS1	-0.023477
MFAP2	-0.023468
FLNB	0.023387
SSBP2	-0.023370
CRELD2	0.023347
EGR1	0.023260
CLK1	-0.023131
AIMP2	0.023002
LDLR	0.022962
NDUFA7	-0.022946
NEDD4L	0.022916
SLC39A4	-0.022731
CNPY2	-0.022720
FKBP9	-0.022705
DPT	-0.022664
NSA2	-0.022462
SRRT	0.022421
HSPE1	0.022413
DAZAP2	-0.022328
PSME3	0.022300
NAB2	0.022258
PPM1G	0.022238
EIF6	0.022226
DNAJA1	0.022170
PAPSS1	-0.022128
HCFC1R1	-0.022119
EZR	0.022115
BNIP3L	-0.022032
CPNE3	-0.022000
STAT5A	0.021992
PDCD4	-0.021975
CNN3	-0.021922
VMP1	0.021913
PSMD6	0.021889
CCL13	0.021854
RANBP1	0.021833
EEF1A1	-0.021791
ABCE1	0.021747
PPP4C	0.021675
HK1	-0.021576
DSTN	-0.021560
TUBB2A	0.021545
SOCS3	0.021539
C19orf43	0.021499
PRKCDBP	-0.021479
ANXA5	-0.021459
TARS	0.021431
MANF	0.021378
GPC3	-0.021357
GPI	-0.021331
VAPA	0.021312
NOP2	0.021254
FAM8A1	-0.021250
FAM171A1	-0.021246
HIST1H1C	-0.021245
VKORC1	-0.021231
LAPTM4B	-0.021217
NOP56	0.021185
POLR2L	0.021137
EMG1	0.021136
CEBPD	0.021107
PQLC3	0.021080
ITM2C	-0.021031
RPL13A	-0.020980
PSMB3	0.020932
PALM	-0.020925
SLC12A4	0.020925
SGCE	-0.020889
MAP1LC3B	-0.020837
FOS	0.020753
CACHD1	-0.020738
PSMB2	0.020721
TMEM123	-0.020708
PLAT	-0.020708
HNRNPD	0.020668
SPTBN1	-0.020619
ANXA11	-0.020599
SF3B3	0.020503
PSMD4	0.020430
NFIB	-0.020409
SPOCK2	-0.020394
DUSP1	0.020314
PGR	0.020314
SDPR	-0.020201
MORF4L2	0.020172
GAL	0.020152
GLIPR2	0.020098
FBLN2	0.020079
SPPL3	-0.020040
PTCH1	-0.020002
NR1D2	-0.020002
OSTC	0.019996
MYH14	0.019968
TNXB	-0.019921
FOXO3	-0.019919
THRA	-0.019874
TOMM7	-0.019866
RPS27A	-0.019823
PKD2	-0.019818
BZW1	0.019790
RARS	0.019705
TCN2	-0.019695
CCNG2	-0.019673
SMARCA2	-0.019650
CIRH1A	0.019617
S100A10	-0.019588
PPP1R14B	0.019566
DMPK	-0.019537
RERE	-0.019502
EPHX1	-0.019462
GADD45A	0.019461
TNFSF12	-0.019420
KIAA0020	0.019399
TRADD	-0.019374
CD47	-0.019371
PCYOX1	-0.019367
PDGFRA	-0.019346
CSNK1A1	0.019334
DVL1	0.019308
SRSF9	0.019302
GDF10	-0.019274
CDH5	-0.019234
LMNA	0.019218
NRP1	0.019198
AGPAT5	0.019174
TACSTD2	0.019138
JMJD6	0.019128
ACTN1	0.019085
PTGES3	0.018996
USP10	0.018879
G3BP1	0.018868
IGF2R	-0.018818
FRMD6	0.018778
GRINA	-0.018777
TPST1	-0.018753
CNIH1	0.018718
VPS28	-0.018602
DNAJC10	-0.018602
MOGS	0.018581
ERGIC3	-0.018571
SEC61B	0.018542
ANXA3	0.018542
NUCB1	-0.018520
GSTZ1	-0.018497
GBP7	-0.018477
NARS	0.018352
AOC3	-0.018344
SNRPB	0.018334
GRB7	-0.018285
HSPA4	0.018282
RAMP2	-0.018245
KRT83	0.018163
APLP2	-0.018117
SRPR	0.018082
MSX1	-0.018044
GDI1	0.017938
EMD	0.017938
NOP58	0.017924
ITIH5	-0.017845
SMDT1	0.017743
LARP1	0.017707
SERPINF1	-0.017657
HOXA11	-0.017599
WNT4	0.017578