!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Creatine
!smiles	CN(CC(=O)O)C(=N)N
!drugbank_id	DB00148
!pubchem_cid	586
!cell_type	Brains of C57Bl/6J animals (fed a creatine supplemented diet for 6 months)
!organism	mouse
!end_metadata
TTR	0.186929
EEF1A1	-0.183087
RPL11	-0.155054
ATP6V0C	-0.131821
HPCA	0.131235
ACTB	0.127595
SPARCL1	-0.123193
FTH1	-0.120214
ATP5B	-0.104536
FAM81A	0.104271
BASP1	-0.103665
CST3	-0.099582
EIF4A2	-0.087119
MORF4L1	-0.085118
MBP	-0.084936
PLP1	-0.084148
APOE	-0.082810
PLD3	0.082691
GAPDH	-0.081278
RPL38	-0.074495
CTXN1	0.070435
ALDOC	-0.069417
RPS27A	-0.068255
VCP	0.068105
PSAP	-0.068094
CPLX2	0.066395
ATP1A1	0.066125
ATP6V1A	0.064839
MEF2C	0.064380
CALB2	-0.064253
HNRNPAB	0.063875
GOT1	-0.063779
RPS2	-0.063149
MDH2	0.062861
MLF2	0.062305
NDRG4	-0.062217
GPX4	-0.061845
HPCAL4	0.061713
YWHAB	0.061682
PCSK1N	0.061526
PPP2R1A	0.060877
RPS14	-0.060819
EEF1A2	-0.060802
NCKAP1	0.058354
HNRNPA2B1	-0.057393
ATP6AP2	0.057390
HSP90AB1	0.056892
CYC1	-0.055969
COX8A	-0.053295
SEPW1	-0.053174
PTGDS	-0.053064
COX6A1	-0.052160
RPS29	-0.052080
EGR1	0.051746
APPL2	-0.050321
ARL6IP5	0.050183
TMA7	0.049565
ITM2B	-0.049465
TPPP	0.048916
RPS5	-0.048873
CKB	-0.048742
RPL26	-0.047374
PCP4	0.047246
BZRAP1	-0.047137
NDRG2	-0.046055
EEF1B2	-0.045576
ATP2B1	0.045543
WSB1	-0.045417
STXBP1	0.045137
RPL19	0.045093
SEPP1	-0.044779
NDUFB5	-0.044402
AKAP11	0.044217
TRIM32	0.044165
SNAP25	-0.044006
ENO2	-0.043819
BSG	-0.043720
RPL7A	-0.043415
DDX17	-0.043385
COX4I1	-0.042750
STX1A	0.042353
ATP5H	-0.042286
NDUFS8	0.042104
PRICKLE2	0.041873
LAMP5	0.041865
SLC17A7	0.041820
OMG	0.041450
CLSTN1	0.041140
HSP90AA1	0.041006
AKIRIN2	0.040168
EID1	0.039751
ATP6V0E2	0.039566
RABAC1	-0.039415
AGO2	0.039110
C1QBP	0.039068
TMEM151A	0.038993
KHDRBS3	0.038538
LPPR4	0.037986
ATP5G3	-0.037932
CFL1	-0.037678
SYN1	0.037437
NNAT	-0.037407
KCNA1	0.036783
FAU	-0.036716
PURB	0.036650
RPS15	-0.036443
VTI1B	0.036433
C8orf46	0.036334
RPL37A	-0.036208
ALDH1A1	-0.036177
DYNC1LI1	0.036137
RPL12	-0.036039
PRKAR1B	0.035890
PVALB	-0.035796
WDR45B	0.035734
C14orf2	-0.035695
HNRNPH1	-0.035674
CAMK2A	0.035524
FUT9	0.035398
ATP6V1G2	0.035365
LAPTM4A	-0.035205
RPS7	-0.035121
TUBA1A	-0.035117
ENC1	0.035005
THY1	0.034968
HK1	0.034965
GAP43	0.034814
SLC3A2	0.034346
RGS7BP	0.034323
NDFIP1	-0.034238
NCDN	-0.034223
NME2	0.034114
PPP3CA	0.034028
OAZ1	-0.033980
RPL9	-0.033906
DDX5	-0.033890
UBL3	0.033814
CLTC	-0.033811
NBEA	0.033729
GAD1	-0.033719
EIF5A	-0.033535
FAT1	-0.033490
ARHGAP32	0.033382
SQSTM1	-0.033230
SLC25A3	-0.033059
NGEF	0.033058
TBCB	0.033039
DDX3X	0.032935
S100B	-0.032880
CHMP4B	-0.032839
ARHGEF4	0.032796
GABRB1	0.032781
ALDOA	0.032661
NXT2	-0.032649
GABRB2	0.032500
OLFM1	0.032485
SGTB	0.032398
SNF8	-0.031993
SESN3	0.031972
SLC12A5	0.031868
HSPH1	0.031709
ABI2	0.031599
CAMKV	0.031586
NSMF	-0.031565
PSMA4	0.031531
CHCHD2	-0.031227
YWHAQ	-0.031123
EIF3C	0.030980
NEGR1	0.030890
NDUFV3	0.030751
NLK	0.030746
UQCRHL	-0.030693
NRN1	0.030626
CNP	0.030522
NDUFA3	-0.030491
OLIG1	0.030322
PLTP	0.030305
ATP6V0D1	0.030299
CCT2	0.030212
CADPS	-0.030209
SUCLG1	-0.030201
RAP1GAP	-0.030192
PGM2L1	0.029966
IGIP	-0.029909
KIF5A	-0.029824
ZBTB18	-0.029810
ZWINT	-0.029809
ARHGDIA	0.029762
OCIAD1	0.029695
FEZ1	-0.029693
GNG3	0.029334
DAAM1	0.029252
C6orf136	0.029181
MAP1LC3A	0.029131
ACTG1	0.029110
UQCRC2	0.029077
GLRB	-0.029038
BAI2	0.028693
CD81	-0.028615
MMD	0.028526
VDAC1	0.028501
PFKM	0.028452
RNF149	-0.028402
NAE1	-0.028352
HCN1	0.028323
FKBP2	0.028320
NDUFA10	0.028319
PSMB4	0.028313
LARGE	0.028177
SLC39A10	0.028160
HNRNPU	0.028095
TPT1	-0.028039
JUND	0.027928
SST	0.027879
CTNND2	0.027823
PJA2	0.027791
ABHD3	-0.027749
TMEM246	0.027685
MLLT11	0.027592
ELMOD1	-0.027542
RAB3A	-0.027510
HAX1	0.027470
AKR1A1	0.027470
SNAP47	0.027432
RPL13A	-0.027361
CPE	-0.027334
BTBD10	0.027282
MTPN	0.027261
CELF5	-0.027260
GNG10	0.027052
KIAA1211L	0.027023
WASF1	0.027001
OGT	-0.026839
NCALD	0.026835
LPHN1	0.026819
RASL10B	0.026727
LMO4	0.026659
FBXO34	0.026614
SRSF9	-0.026490
RPS19	0.026448
TMEM14A	-0.026431
NAPB	0.026408
WBP5	0.026231
DZANK1	0.026229
KIF5C	0.026139
ACOT7	0.026138
ARPC3	0.026127
PSMC3	0.026127
PABPN1	-0.026074
FAM127A	-0.026044
ITIH3	-0.025921
RBFOX1	0.025853
COX17	0.025851
CHGB	0.025840
MAPK8IP1	0.025778
DMXL2	-0.025511
CSNK2B	0.025503
KCNB1	0.025491
SPIN1	0.025465
DBP	0.025465
MAPT	0.025380
PHYHIP	0.025367
SELK	-0.025338
RGS7	0.025253
DNAJB14	0.025252
RPL18A	0.025228
SLITRK1	0.025139
MATR3	-0.025056
SLC1A2	0.025031
PFN2	0.025024
RPS12	-0.024997
FCF1	-0.024996
NOV	0.024950
SCN2A	0.024914
SNX17	-0.024896
MAP7D2	0.024801
PRDX5	-0.024799
NDUFB11	0.024664
IQSEC1	0.024663
PUM1	0.024610
RNF11	0.024604
PPP3R1	0.024596
SUMO1	-0.024485
PCBP3	-0.024465
MAT2B	-0.024383
RPL28	0.024357
AIFM3	-0.024287
PDIA3	0.024118
SWI5	0.024111
FBXL16	0.024104
SYT1	0.024079
ANK3	0.023974
GABRA1	0.023861
RAB1A	-0.023759
HCN2	0.023674
ATP2B2	0.023651
UCHL1	-0.023646
TSPAN7	-0.023607
STAU2	0.023467
NDUFA8	0.023437
MAP7D1	0.023399
MPPED1	0.023383
PACSIN1	0.023368
RELN	-0.023348
NSFL1C	0.023289
ATP9A	0.023254
ASTN1	0.023244
FBXO41	0.023178
PGBD5	0.023167
DNAJC7	0.023089
APLP1	0.023072
RPL10	-0.023070
HDAC5	0.023021
DKK3	0.022957
PFN1	-0.022924
LDLRAD3	-0.022906
DUSP1	0.022895
GLYR1	0.022766
SKP1	0.022750
GSK3A	-0.022731
AMFR	-0.022675
MAP1B	0.022670
NTRK2	0.022609
TRIM2	0.022521
YWHAG	-0.022489
NTM	0.022424
PTK2B	0.022411
SCG3	0.022397
NUAK1	0.022367
NDUFS1	0.022355
PENK	-0.022319
PPIA	-0.022315
LSM7	-0.022273
KLHL7	-0.022256
MAP1A	0.022221
SLC25A4	-0.022220
NDUFS3	0.022215
TMCC2	0.022185
ISCU	0.022179
COX5A	-0.022113
PCNP	0.022108
RPS8	0.022103
DUS3L	-0.022090
SRM	-0.022044
IMPAD1	0.022035
WDR6	-0.021965
LAMTOR3	0.021953
EIF3E	0.021948
PEA15	-0.021947
SLC9A6	0.021919
MAG	-0.021904
NDUFC1	0.021882
AMD1	0.021874
CFDP1	0.021815
FOXG1	0.021805
WBP2	0.021715
GLUL	-0.021710
GSTP1	0.021615
HSPA8	-0.021596
MAGEE1	0.021591
PTEN	0.021585
TCP1	0.021573
GJA1	-0.021511
TUBA4A	0.021510
VDAC2	0.021506
RPL10A	-0.021493
HNRNPK	-0.021476
WDR7	0.021436
PRDX1	-0.021414
ITGB8	-0.021387
VAMP2	-0.021380
NDUFA1	-0.021326
VPS28	0.021318
CAP2	0.021254
RPS23	0.021229
SSNA1	-0.021068
RIMS1	0.021023
PRKCB	0.021018
FEM1B	0.021013
KIAA1147	-0.020937
HARS	0.020935
TTC9B	0.020934
RNF34	-0.020926
LENG8	-0.020911
NACA	-0.020896
NELL2	0.020816
GAA	0.020781
PNMAL2	0.020762
SNN	0.020731
NRIP3	-0.020669
SH3GL3	-0.020641
RPN1	0.020564
RGL2	-0.020547
RBBP7	0.020525
ATP5J2	-0.020439
DLGAP3	0.020419
CYFIP2	0.020346
SCG2	-0.020253
CAMK2N2	-0.020236
ANKH	0.020202
LINGO1	0.020114
CACYBP	0.020113
FAM171B	-0.020108
WDR82	-0.020080
RPL13	0.020060
NCKIPSD	0.020035
CLK1	-0.020024
CDHR1	-0.020023
SEPT3	0.019970
C14orf166	0.019934
TCF4	0.019902
GRM3	0.019890
FAM168B	0.019883
HLF	0.019867
SCN1A	0.019844
DYNC1LI2	-0.019818
ACSL5	0.019808
PTPLAD1	0.019797
DSTN	-0.019783
STMN2	0.019774
SRSF1	-0.019679
SCN4B	0.019665
GJB6	-0.019631
NDUFS7	0.019626
PHAX	0.019613
DNM1	0.019589
RPS13	0.019547
NFIX	0.019534
RPS24	-0.019504
RANBP1	0.019504
MARCH6	0.019497
ALCAM	0.019485
ATP6AP1	-0.019446
CPNE6	0.019363
SYNJ1	0.019342
SYNPR	-0.019284
MYEOV2	-0.019279
RAD17	-0.019250
PQBP1	0.019226
SIRT7	-0.019205
RPL23	0.019194
NDUFA9	0.019182
PPT2	-0.019181
MRFAP1	-0.019085
CHN1	0.019071
DIRAS2	0.019063
BCAN	-0.019053
SH3BGRL3	0.019008
GSK3B	0.018969
GDA	0.018919
CETN3	0.018879
PRRC2B	0.018830
PSMC5	0.018827
NHP2L1	-0.018813
ZNF326	-0.018716
BAALC	0.018714
PPP2R4	0.018708
NKIRAS1	0.018701
UBE2D2	-0.018699
LSAMP	0.018679
TRRAP	0.018598
PEX14	0.018565
LHX2	0.018543
ARC	0.018511
NECAB2	-0.018467
ADD1	0.018453
RNF167	-0.018439
PSMB7	-0.018405
CRMP1	0.018401
PPP2R2B	0.018391
NOP10	-0.018322
SRP19	0.018308
CNTN1	0.018307
FAM102B	0.018256
RPL4	0.018252
TFF1	-0.018214
GNAI1	0.018179
G3BP2	0.018160
GNB2	0.018154
LRRC4C	0.018149
SLC8A1	0.018134
SENP3	-0.018133
EEF2	-0.018132
DNAJA1	-0.018109
TMEM9	-0.018109
NGFRAP1	-0.018107
CBX6	0.018058
STMN1	0.018010
SLC30A4	0.017958
RPL22	-0.017940
RAB5C	0.017896
PCP2	-0.017879
CACNG3	0.017867
MAPK10	0.017851
BCAP29	0.017768
TAB3	0.017696
DLG4	0.017691
PRKACB	0.017690
NAP1L5	-0.017685
KIAA1279	0.017683