!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	orotic acid
!smiles	C1=C(NC(=O)NC1=O)C(=O)O
!pubchem_cid	967
!cell_type	Livers ( from outbred Wistars - fed a diet with 1% orotic acid) - 3 Day
!organism	rat
!end_metadata
ND5	0.336692
HSP90B1	0.203142
VTN	-0.165048
GSTM5	-0.143996
RPS29	-0.136590
TTR	-0.124637
TMEM205	-0.124540
APOE	0.124066
RPL23	-0.117481
FAU	-0.117212
RPS16	-0.116165
ATP6	0.114789
HSD11B1	-0.114604
FGB	-0.110275
CYP2E1	0.108157
FTL	-0.107715
FTH1	-0.106436
DDT	-0.104731
KHK	-0.100654
SOD1	-0.098891
METTL7B	-0.098219
PON1	-0.094599
ITIH3	-0.092747
COX2	-0.091148
PDIA4	0.089467
CFB	-0.088570
AMBP	-0.087599
MIF	-0.086222
RBP1	-0.082778
PCK1	-0.081776
COX8A	-0.080909
SCD	-0.079874
RPS12	-0.079743
RPS21	-0.079059
CDO1	-0.078927
ARG1	-0.078834
SPP2	-0.077227
PLIN2	-0.077043
ECHS1	-0.076921
THRSP	-0.076128
RPS13	-0.075919
INSIG1	-0.075599
ALDOB	-0.075283
ALDH1L1	-0.075214
HPX	-0.073960
TSC22D1	-0.072635
RPS27A	-0.072576
APOA2	-0.071520
TTC36	-0.070910
RPS26	-0.070369
COX4I1	-0.069117
EPHX1	-0.068942
GSTM1	-0.068325
GPX1	-0.067731
LDHA	-0.067613
GLUD1	-0.067486
RBP4	-0.067360
ALDH2	-0.066177
HMGCS2	-0.066134
B2M	-0.065779
AFM	-0.065643
CALR	0.065351
RPL19	-0.064799
SDC4	-0.064136
ABCD3	0.063368
ATP5B	-0.063241
BSG	-0.062081
RPL28	-0.061554
RPL31	-0.061403
APOM	-0.060703
SLC27A2	-0.060659
FAH	-0.059717
ND2	0.058860
HP	-0.058391
CSAD	-0.057909
MARC2	-0.056842
CYB5A	-0.056677
EEF1A1	0.056599
RPS23	-0.055736
DBI	-0.055637
OAZ1	-0.054524
F2	-0.054452
RPSA	-0.054340
ALDH6A1	0.053277
HSPA5	0.053059
RPL18	-0.052993
UPB1	-0.052753
PDIA6	0.052549
RPLP2	-0.052511
ATP5O	-0.052295
RPL18A	-0.051968
HAAO	-0.051904
GSTA5	-0.051886
APOH	-0.051696
RPS9	-0.051117
PPIA	-0.051052
TECR	-0.050550
AHSG	-0.049436
PCBD1	-0.049119
ADH1C	-0.048415
RPL22	-0.047751
RPL8	-0.047621
ACLY	-0.047478
G6PC	-0.046664
GAMT	-0.046595
ASS1	-0.046344
BAAT	-0.045900
ST6GAL1	-0.045368
RPL12	-0.045108
SORD	-0.044148
GHR	-0.043595
HPN	-0.043419
SERPING1	-0.043157
SLC10A1	-0.042668
GPX4	-0.042322
TST	-0.041830
SLC37A4	-0.041673
G0S2	-0.041516
RPS11	-0.041013
CTH	-0.040885
HYOU1	0.040213
CD81	-0.040203
APOC4	-0.039956
CLU	-0.039875
UGT2B28	-0.039382
CPQ	-0.039338
PEMT	-0.039181
CAT	-0.038872
RPL35	-0.038831
COX5A	-0.038829
HDLBP	0.038783
PXMP2	-0.038597
POMP	-0.038436
PGRMC1	-0.038179
TPT1	-0.037693
HMGCS1	-0.037615
ALB	0.037347
RPL9	-0.037330
EEF2	0.037236
RPLP0	-0.036392
RPS10	-0.036392
RPL11	-0.036388
APOA1	-0.036382
MGST3	-0.036362
ALAD	-0.036121
MST1	-0.035635
CYP1A2	-0.035611
SPINT2	-0.035442
RPL27	-0.035304
ND1	0.035238
HRSP12	-0.034686
TPI1	-0.034647
SEC61B	-0.034568
SQSTM1	-0.034567
RPS14	-0.034557
ACTG1	-0.034393
UQCR11	-0.034343
PCYT2	-0.033880
COX7A2	-0.033863
PROC	-0.033699
PDIA3	0.033553
UGDH	0.033422
CA3	-0.033362
RPS8	-0.033262
C9	-0.033066
GSTK1	-0.032051
NDUFB9	-0.031968
RPL5	-0.031864
ENO1	-0.031763
RNASE4	0.031678
PGK1	-0.031327
PROS1	-0.030781
CTDSP1	-0.030633
CPS1	0.030454
ATP5G2	-0.030264
RPL10A	-0.030081
SULT1B1	-0.029291
SERPINA10	-0.028819
NDUFC1	-0.028698
DDC	-0.028637
APCS	-0.028419
RPS15	-0.028343
ATP5G1	0.028287
CST3	-0.028159
RPL15	-0.027977
COX3	0.027973
COX6A1	-0.027972
GABARAP	-0.027920
ACADL	-0.027728
HSD3B7	-0.027630
GDA	-0.027619
AHCY	-0.027536
NDUFA8	-0.027532
QDPR	-0.027304
NDUFB8	-0.027272
TARS	-0.027206
TAT	-0.027106
ACTB	-0.027102
AK4	-0.026892
SEPP1	-0.026594
RPL10	-0.026458
PAH	-0.026357
PEBP1	-0.026296
AGT	-0.026273
ATP6V0C	-0.026122
COX1	0.025886
CES1	0.025853
RPS17	-0.025692
FDPS	0.025610
SLC22A18	-0.025531
MPST	-0.025416
PSAP	-0.024958
AUH	-0.024909
RPL4	-0.024901
RPS4Y1	-0.024521
RPS7	-0.024461
FBP1	-0.024197
CTSB	-0.024186
APOA4	-0.024147
NDUFV3	-0.024109
PTTG1IP	-0.024023
FABP1	-0.023930
SERP1	0.023908
ADK	-0.023907
MAN2B1	-0.023879
BDH1	-0.023828
RPL17	-0.023694
PIGR	-0.023651
HSPE1	-0.023439
GAPDH	-0.023372
HPD	0.023353
C3	0.023222
NDUFA4	-0.023190
NDUFB4	-0.023096
NME2	-0.022923
RPL27A	-0.022864
DPYS	-0.022818
FN1	0.022765
MPC1	-0.022590
RPS6	-0.022148
HSD17B13	-0.022126
PSME1	-0.022117
ERRFI1	-0.021989
SLC3A2	0.021971
GNB2L1	-0.021617
SLC22A1	-0.021501
NR0B2	-0.021418
OAT	0.021345
RPL26	-0.021321
RPS3	-0.021241
SSR3	0.021196
ATP5C1	-0.021113
AKR1A1	-0.021077
PFN1	-0.020866
HAGH	-0.020838
C8B	-0.020830
RPL13A	-0.020703
FAAH	-0.020621
RPL24	-0.020491
MDH2	-0.020419
PSMB5	-0.020407
IGFALS	-0.020338
ID2	-0.020312
ACY1	-0.020289
NDUFA3	-0.020270
CTSC	-0.020232
RPL30	-0.020176
LIPC	-0.020082
SQLE	-0.020078
RPS24	0.020076
RPS5	-0.019820
HIBADH	-0.019800
SLC35B1	0.019674
ATP5H	-0.019505
CYTB	0.019238
SLCO2A1	-0.019171
RPL7A	-0.019127
DIO1	-0.019108
NDUFS7	-0.019078
AGXT2	-0.019010
HSP90AB1	-0.018969
PABPC4	0.018928
NDUFB3	-0.018791
ACADM	-0.018599
GNE	-0.018563
DAK	-0.018514
TALDO1	-0.018444
F9	0.018438
CYP7A1	-0.018397
ND4	0.018306
FCGRT	-0.018275
ACSL4	0.018264
ARF5	-0.018222
UBC	0.018197
HSPA8	0.018190
DAD1	-0.018114
NDUFV2	-0.018014
UGT2B17	-0.017832
NDUFB2	-0.017749
AMACR	0.017537
PTPLAD1	-0.017507
SIGMAR1	-0.017500
CAPNS1	-0.017486
PSMB8	-0.017473
RPS25	-0.017447
BTG1	-0.017366
PLG	-0.017159
MAOB	-0.017101
PTPRF	-0.016999
RPL36AL	-0.016976
FLOT1	0.016927
MTCH2	-0.016758
NEDD8	-0.016698
RPP21	-0.016665
ITIH4	-0.016649
SEC61A1	0.016613
RPL37	-0.016582
ALDH7A1	-0.016459
YWHAE	0.016348
ARF1	0.016038
FGA	-0.016005
ECI1	0.015993
MAP2K2	-0.015912
GSTO1	-0.015809
MSMO1	-0.015749
HSD17B6	-0.015724
ETNK2	-0.015645
FABP6	0.015484
C1QB	-0.015408
AES	-0.015390
CD63	-0.015384
APOB	0.015353
PDK2	-0.015352
IGF1	-0.015345
GCKR	-0.015338
SLC2A2	-0.015257
ACAA2	-0.015224
PSMB4	-0.015031
LAMP1	-0.015027
KYNU	-0.014953
AQP8	-0.014693
MDH1	0.014638
LAMP2	-0.014633
IFITM3	-0.014583
EIF5	-0.014576
PPP2R5A	-0.014562
NPHP1	-0.014550
F10	-0.014522
GNG5	-0.014474
FUCA1	-0.014429
ASGR2	-0.014416
FGG	0.014298
GOT1	0.014258
ACAT1	-0.014210
SLC25A3	-0.014191
CYC1	-0.014129
FIS1	-0.014120
ONECUT1	0.014095
DUSP6	0.013918
P2RY2	-0.013916
CDC37	-0.013795
PRDX1	-0.013764
ABCC6	-0.013756
ALDH3A2	0.013572
DLST	-0.013571
MGST2	-0.013549
GRINA	-0.013472
ATP5A1	-0.013421
PSMB1	-0.013365
ACSL5	-0.013282
GRHPR	-0.013154
NUP88	-0.013015
SLC22A7	-0.012933
MBL2	0.012874
UGT1A4	0.012818
LAMTOR1	-0.012676
DAO	-0.012657
PAPSS2	-0.012597
SLC25A5	0.012572
GSTM2	-0.012451
RGN	-0.012394
ORAI1	-0.012356
P4HB	0.012338
PYGL	-0.012273
CTBS	-0.012239
GPAM	0.012195
GJB1	0.012126
NDUFC2	-0.012115
MAP3K1	-0.012071
AADAT	-0.012037
ENPP3	-0.012004
ZFP36L1	-0.011998
XDH	-0.011945
SCLY	-0.011749
CTSS	-0.011739
UQCRC2	0.011693
PARK7	-0.011553
ATP2A2	0.011502
RABAC1	-0.011381
CTSH	-0.011212
PRDX2	-0.011209
ACADSB	0.011187
ATRN	-0.011159
SARDH	0.011033
TKT	-0.010997
CHURC1	-0.010963
EIF3B	-0.010927
GCHFR	-0.010922
COPS7A	0.010881
BHMT	0.010788
ABHD14B	-0.010677
INHBE	-0.010657
DHFR	-0.010568
EDF1	-0.010563
SLC6A13	-0.010514
PPIB	0.010486
KLKB1	-0.010415
RPS15A	-0.010410
SDC2	-0.010402
AZGP1	-0.010393
DHCR7	-0.010389
HSPD1	-0.010363
SLC26A1	-0.010353
TOMM6	-0.010339
MAP1LC3B	-0.010280
SDS	0.010250
YWHAB	-0.010244
C11orf73	-0.010244
ATP6V1F	-0.010224
DDR1	0.010193
AKR1D1	-0.010182
ATP5D	-0.010177
CD14	0.010124
NDUFA9	-0.010123
CNPY2	-0.010122
HSD17B10	-0.010079
EIF4E2	0.009994
KRT18	-0.009910
ARAF	-0.009864
LEP	0.009794
CPT1A	0.009789
SEL1L	0.009769
MAOA	-0.009736
ABAT	-0.009707
PDLIM1	-0.009648
SUOX	-0.009607
ATP5F1	-0.009600
COPZ1	-0.009595
TIMM23	-0.009567
TUBA1C	-0.009525
APLP2	-0.009513
EEF1G	-0.009499
APRT	-0.009492
NUCB1	0.009483
PSMA6	-0.009419
CXXC5	-0.009340
PPDPF	-0.009333
UBXN1	-0.009322
NUDC	-0.009310
KNG1	-0.009301
FKBP11	0.009275
PDAP1	-0.009268
LCAT	-0.009257
HNRNPK	-0.009227
GLUL	0.009223
YIF1A	-0.009191
CLDN3	-0.009178
COMT	-0.009153
RPL39	-0.009100
IREB2	0.008982
EGFR	0.008969
PPP1R10	0.008936
HNF4A	0.008909
PPIF	-0.008852
PSMB9	-0.008844
RPL21	-0.008811
PGM2	-0.008766
GPD1	0.008743
ACSL1	0.008643
ETFA	-0.008602
GCK	-0.008595
NR1H4	-0.008567
GDI2	0.008519
RPS27L	-0.008490
TAF10	-0.008447
SULT1E1	-0.008441
VCP	0.008435
ASL	0.008399
FKBP2	-0.008372
HIGD2A	-0.008362
CLEC4F	-0.008339
UGT1A1	0.008266
LMAN1	0.008248
CD74	-0.008237
DDRGK1	-0.008225
VAT1	-0.008219
RPL6	-0.008217
TDO2	-0.008213
HADHB	0.008200
NR2F6	-0.008175