!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!ligand_name	Interleukin-1 beta
!ligand_id	Drug Bank ID: BE0001051
!cell_type	embryonic fibroblasts from IRAK-4 kinase deficient mutants
!organism	mouse
!end_metadata
CCL13	0.192186
NFKBIA	0.181568
RPS12	-0.116144
PLCB3	0.105225
SPP1	0.101430
RHEB	0.099597
RPL38	-0.096364
EREG	0.095000
S100A6	-0.092683
CST3	-0.091558
CXCL2	0.090929
RPS8	-0.089746
RPL18A	-0.087436
RPL13	-0.085869
RPS23	-0.083388
EEF1A1	-0.082268
PTGS2	0.081204
CD81	-0.077858
BGN	-0.075448
HIVEP1	0.075113
IER3	0.075096
HADH	-0.074995
VASN	-0.073009
FAM84B	0.072844
RPS15	-0.072763
PHLDB2	0.072151
RPL35	-0.070711
RPS29	-0.070668
RPL4	-0.070570
EGR2	0.070120
EIF2S3	0.069255
RPS7	-0.069230
RPS19	-0.068868
EGR1	0.068322
TMUB2	-0.067266
RPS27A	-0.067011
CNN2	-0.066935
VGLL3	0.066492
P4HB	-0.065552
SGK1	0.065542
NFKBIZ	0.065342
NDUFA13	-0.064909
CPNE1	0.064788
IFRD1	0.064785
LGALS1	-0.064288
LRRC58	0.063791
KLF10	0.062537
MGP	-0.061689
PFN1	0.061315
UBC	-0.060141
ZNF778	0.060079
RPS26	-0.058840
RPL8	-0.056895
RPL18	-0.056825
ZFP36L1	0.056517
RPL6	-0.056211
MAT2A	0.056038
HCFC1R1	-0.055979
RPL26	-0.055461
PTP4A2	0.055085
MEX3B	0.054198
KLF6	0.053832
EEF1B2	-0.053818
RPL10A	-0.053784
RPLP2	-0.052788
ASAH1	0.052731
TNFAIP6	0.052681
RPS13	-0.052492
THBS1	-0.052356
S100A4	-0.052213
RPL28	-0.051415
CDH11	0.051337
FTL	-0.050414
RPL13A	-0.049916
ACTR3	0.049604
ACAT2	-0.048465
NFE2L1	0.048396
TUBA1A	-0.048344
RPL23	-0.048291
FUBP3	0.048253
HACE1	0.048241
FAS	0.047037
COX7A2	-0.047027
TMA7	-0.046885
RPL19	-0.046844
ACKR3	0.046809
CHSY1	0.046778
RPLP0	-0.046707
RPL10	-0.046470
TTC13	-0.046436
FAM98A	-0.045821
SEC23A	0.045257
ABCG2	0.044996
AMOTL2	0.044991
PRDX2	-0.044826
SERTAD4	0.044714
FNDC3B	0.044612
FAU	-0.044317
RPS11	-0.044297
LTBP2	-0.044249
TXNIP	0.043984
ABRACL	-0.043303
BRD9	-0.043094
ENO2	-0.042983
BCL10	0.042865
CKAP4	-0.042864
RPS24	-0.042851
KLHL9	0.042769
RPS17	-0.042471
SH3BGRL	0.042462
RAB33B	0.042336
PPP1CB	0.042123
CTPS1	0.042066
ZFC3H1	-0.041893
SOX11	0.041799
CTNND1	0.041262
GPC1	-0.040948
COL1A1	-0.040726
EDA2R	0.040688
GPX8	-0.040612
UQCRHL	-0.040504
AGGF1	-0.040331
AKAP12	-0.040096
WSB1	0.040034
FBN2	0.039503
RPS14	-0.039320
RBMS1	0.039280
RPL11	-0.039260
PSMB5	-0.039196
PGAM1	-0.038953
COL4A1	-0.038710
RPS28	-0.038567
ATF5	-0.038462
VASP	0.038379
NR2F6	-0.038147
RPL21	-0.038011
RPL27A	-0.037888
FOSL2	0.037865
BRK1	-0.037687
RPL37A	-0.037581
HNRNPH2	0.037510
RND3	0.037476
SPRY2	0.037396
MORF4L2	0.037310
RPS20	-0.037228
MBD6	-0.037167
HNRNPH1	0.037139
NDUFB11	-0.037129
LPHN2	-0.037070
TRAM1	0.036742
CEP170	0.036742
RPS21	-0.036709
ADAM9	0.036616
PGRMC2	-0.036589
ELL2	0.036424
GAPDH	-0.036314
TUBB2B	-0.036049
CRIM1	0.036026
TFDP1	0.035621
HIPK3	0.035530
RRN3	0.035488
SEC24A	0.035403
CTBP1	-0.035262
COL4A2	-0.035165
SEPW1	-0.035110
CAPN2	-0.035087
RSL24D1	0.035000
CEP170B	-0.034980
IGF2BP2	-0.034953
PDGFA	-0.034883
ATP5G3	-0.034230
CRYAB	-0.034228
MFGE8	-0.034168
RPL22	-0.033979
ERRFI1	0.033866
SMIM15	0.033719
UPF1	-0.033587
USMG5	-0.033517
SFXN3	-0.033436
HARS	-0.033268
RPS25	-0.033186
ACTB	0.033069
GJA1	0.033006
RPS5	-0.032952
THBS2	0.032818
DEK	-0.032763
CCRN4L	0.032748
DSE	0.032680
FRMD4A	0.032548
PSMD6	-0.032499
HMGN1	-0.032254
ZBTB1	0.032223
AP2M1	-0.032142
SERPINE1	0.032084
DUSP22	0.031998
EMC3	-0.031992
PRNP	0.031918
FAM168B	0.031892
CHCHD2	-0.031838
ASPN	0.031476
ATXN1	0.031291
ATP5O	-0.031276
RNF111	0.031192
HEXA	-0.031029
RAPGEF2	0.030798
RPS10	-0.030797
FKBP9	-0.030623
SPTSSA	0.030598
DHCR7	-0.030543
MRFAP1	-0.030541
CDK2AP1	-0.030494
FGF7	0.030393
PEBP1	-0.030278
NUDT3	-0.030179
ARF4	0.030127
NME2	-0.030018
UST	0.029955
TGFB1I1	-0.029922
FST	0.029693
HSPA8	-0.029632
MYADM	0.029507
PGRMC1	-0.029480
RPL14	-0.029392
SEPT11	0.029349
HIF1A	0.029346
PMP22	-0.029260
ZNF280C	0.029250
HOXC4	0.029160
TNMD	-0.029141
IDH3G	-0.028952
ATP5H	-0.028879
GADD45A	0.028847
ATP6AP2	-0.028832
ARL8A	0.028744
EEF1G	-0.028673
RAB8B	0.028614
SERPINE2	0.028587
C14orf166	-0.028519
IGFBP7	-0.028421
TUBB	0.028341
COX6A1	-0.028288
UBR5	-0.028161
ADRM1	-0.028124
PSAT1	-0.028063
YIPF4	0.027957
SKIL	0.027954
NCKAP1	-0.027932
B2M	-0.027924
SEPT7	0.027822
EFEMP1	-0.027790
OSBPL8	0.027761
RIN2	-0.027542
LYRM4	-0.027492
GDI2	-0.027470
CAPZA1	-0.027386
OTUD1	0.027139
HIGD1A	-0.027102
NSA2	-0.027079
COX6B1	-0.027039
PFDN5	-0.027016
PGD	-0.026872
FBXO11	-0.026803
FLNA	-0.026756
CLIC4	0.026752
VIM	-0.026683
HDGF	-0.026660
MSN	0.026645
PRDX1	-0.026542
HTRA1	-0.026484
LRP1	-0.026387
PLEC	-0.026381
APLP2	0.026258
YWHAB	-0.026102
SDC4	0.026079
RAB6A	0.026039
RNF150	0.026034
TMED9	0.025916
WBP5	0.025909
MCM4	0.025874
AGA	0.025565
PDK4	0.025547
CCT2	-0.025526
RASA2	0.025520
TFE3	-0.025441
EIF3E	-0.025405
REXO2	-0.025197
RPL27	-0.025192
SMAD1	0.025100
TMEM123	0.025076
BASP1	-0.024909
DDX17	0.024886
C5orf24	0.024869
MAGED2	0.024867
CSTF2T	0.024836
CCDC59	-0.024809
ST5	0.024750
PTGES3	0.024626
RPL3	-0.024617
SENP3	-0.024612
EXOC4	-0.024577
C14orf2	-0.024540
RPL36AL	-0.024539
IFITM2	-0.024531
ACSL4	0.024497
ZDHHC5	0.024479
PTPLA	-0.024453
SECISBP2L	0.024421
RC3H1	0.024418
ZNF275	0.024341
MAN1C1	-0.024309
ARL6IP6	0.024276
GAS1	0.024244
CAV1	0.024153
RAB10	0.024151
F2R	0.024118
HSPA4	-0.024116
IDI1	-0.024079
LSM14B	0.023906
GABARAP	-0.023884
TPBG	0.023856
PSMC4	-0.023808
ARGLU1	-0.023777
MORC3	0.023750
RAP2C	0.023705
LRCH2	0.023659
PJA2	0.023557
COL1A2	-0.023506
POMP	-0.023505
SPARC	-0.023496
MDFIC	-0.023472
CPT1A	-0.023464
COL4A5	0.023446
VPS26A	-0.023437
NDUFA5	-0.023384
FOXC2	0.023380
EPHA4	0.023361
ATF1	0.023353
ANAPC4	-0.023302
SHFM1	-0.023286
CD44	0.023268
ESYT2	0.023237
GNB2L1	-0.023231
POLR3GL	-0.023231
HIATL1	0.023229
PLS3	-0.023149
SEC61B	-0.023130
SPPL3	-0.023110
CFL1	-0.023101
TRAM1L1	-0.023086
CNTD1	-0.023071
GNAI3	0.023048
ZSCAN25	-0.023033
ALKBH5	0.023006
HMGCS1	0.022873
CHSY3	0.022840
ADCK3	-0.022785
ADAM19	0.022759
COQ10B	0.022686
FOXN2	0.022644
CNIH1	0.022509
ZBTB18	0.022492
RNF44	0.022485
ASNS	-0.022469
TMOD1	-0.022420
ROBO1	0.022336
DR1	0.022318
FMOD	-0.022300
CDK8	0.022237
JUN	0.022020
MYL6	-0.022006
PAM16	-0.021972
KDM2B	-0.021935
EEF2	-0.021929
PSMB7	-0.021918
FHL1	-0.021858
YWHAE	-0.021749
GNG10	-0.021745
TMEM261	-0.021739
H19	-0.021731
SERP1	0.021567
KCTD9	0.021468
NEXN	-0.021438
GADD45B	0.021379
MZT1	0.021308
ELP2	-0.021293
SASH1	0.021289
DDR1	0.021239
SGMS2	0.021234
SRP19	-0.021209
ZCRB1	-0.021204
LDLRAD3	0.021180
GLO1	-0.021131
MKNK2	-0.021114
PSMA7	-0.021080
SS18L2	-0.021075
FAM107B	0.021011
SH3BGRL3	-0.020967
UBA2	0.020931
TM9SF2	0.020926
COL12A1	0.020902
OTUD7B	-0.020802
MRPL52	-0.020758
SPCS1	0.020711
ACTG2	-0.020662
EHBP1	-0.020651
NFKBIE	0.020643
BMP2K	0.020625
HDDC2	-0.020619
MAN2A2	-0.020615
IRF2BP2	0.020594
NEDD8	0.020579
RDX	0.020514
HSD17B12	-0.020499
PDCD4	-0.020430
LAMTOR5	0.020424
ACTR2	0.020362
NDUFB10	-0.020330
SLC12A2	0.020300
VAMP3	-0.020295
NAA20	0.020291
ZBTB41	0.020273
PPHLN1	-0.020243
BMP4	-0.020233
SERTAD2	0.020232
MEX3C	0.020159
YWHAZ	0.020157
CAPZA2	0.020129
SPTBN1	-0.020125
FTH1	0.020096
RNFT1	0.020081
HCCS	0.020051
TXNDC15	0.020047
MCL1	0.020028
ALDOA	-0.019956
PTPLAD1	-0.019894
ZNF878	0.019873
ARRDC3	0.019873
PLEKHF1	0.019841
PDCL	0.019796
LIMD1	-0.019794
ARL3	-0.019777
FBXL14	0.019772
HBEGF	0.019766
STRN3	0.019671
CDC123	-0.019609
KRTCAP2	-0.019546
YTHDF3	0.019506
CTDSP1	-0.019434
CAPNS1	-0.019412
DSEL	-0.019395
SEC61G	-0.019388
FIBIN	0.019375
YTHDF2	0.019322
SLC35E3	-0.019203
CYR61	0.019165
CDCA4	0.019123
MCTS1	-0.019090
EP300	0.019071
TAGLN	-0.019048
PRKAR1A	0.019046
PALLD	-0.018973
ATP5A1	-0.018939
TMED7	0.018937
SEC16A	-0.018933
ADAM10	0.018925
PARM1	-0.018856
CPEB4	0.018703
MSANTD4	-0.018686
MAX	0.018660
NUCKS1	0.018632
SERPINF1	-0.018608
QDPR	-0.018563
VCAM1	0.018548
TEAD1	0.018540
NDFIP1	0.018476
LAMP2	0.018469
TRIT1	-0.018454
CXCL3	0.018425
CCDC107	-0.018372
IER3IP1	0.018342
TOB1	0.018328
TCEAL8	0.018282
RILPL1	-0.018230
TCP1	-0.018172
UAP1	0.018157
SDHD	-0.018156
AKAP2	0.018132
FAM102B	0.018103
PRICKLE1	-0.018082
DCTN5	-0.018080
VAT1	-0.018065
PKIG	-0.018063
RIPK2	0.018025
COG3	-0.018015
RAB5A	0.018005
DCAF13	0.017974
MTCH1	-0.017906
ADAM23	0.017878
EXOC5	0.017876
ADM	-0.017869