!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	Irinotecan
!smiles	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
!drugbank_id	DB00762
!pubchem_cid	60838
!cell_type	jejunum
!organism	rat
!end_metadata
CCL20	0.129444
CXCL13	0.120142
DDIT4	0.107542
DBP	-0.090721
ADAMTS1	0.085927
PLK2	0.079827
CYP1A1	-0.078769
GEM	0.078698
MS4A1	0.078603
DUSP6	0.072222
TXNIP	0.070659
REG3G	0.070496
CXCR4	0.068926
P2RY10	0.067882
NFKBIA	0.066405
SGK1	0.065811
ATP8B1	-0.063669
ARL4A	0.061539
FKBP5	0.059603
FAIM3	0.059469
PDK4	0.059094
GADD45A	0.058729
ARRDC4	0.057771
EGR1	0.057072
FABP4	0.056968
CIPC	0.056497
CD83	0.055155
PMP22	-0.054342
AQP3	-0.054038
RGS1	0.053877
CCRN4L	0.053596
CYP4B1	-0.053573
ERRFI1	0.053246
GADD45G	0.053106
GADD45B	0.052802
FABP6	0.051334
SLC38A2	0.050501
TSC22D3	0.049919
FOXQ1	0.049600
ONECUT2	-0.049575
N4BP2L1	0.049280
REG3A	0.048397
AREG	0.047937
SLC16A10	-0.047794
CFD	0.046352
FOSB	-0.043789
DDIT3	0.043687
HERPUD1	0.043624
ABCC2	-0.043335
BIRC3	0.043144
RHOB	0.043084
CXCL2	0.043037
RGS2	0.042685
ENTPD5	-0.042674
PCK1	-0.042077
SAMD8	-0.041304
IER3	0.041282
CCNG1	0.041143
CA3	0.041112
WSB1	0.040968
FAM84A	0.040710
SLC5A1	-0.040499
TMEM120A	-0.040347
PTGS2	0.040252
POU2AF1	0.040017
FAM43A	0.039890
MME	-0.039849
ALPI	-0.039643
SLC16A3	-0.039474
SOWAHC	0.039094
BHLHE40	0.039058
ZNF354A	0.038513
BCL6	0.037740
TPPP	-0.037704
VCAM1	0.037502
PRSS35	-0.036924
TNFRSF21	-0.036776
ATF4	0.036583
GREM1	0.036531
IER2	0.036514
CCNL1	0.036281
IDI1	0.036117
THRSP	0.036088
CDO1	0.035919
TGIF1	0.035656
TNC	0.035240
DNAJB1	0.035223
PER1	0.034936
TCP11L2	0.034913
LCP1	0.034861
LTBP1	0.034788
NR0B2	0.034398
GDF15	0.034296
ARL4D	0.034188
FAM160B1	-0.034139
PHOSPHO1	-0.033920
LPL	0.033852
IFI16	0.033606
CAV2	0.033539
SLC2A5	-0.033042
ADIPOQ	0.032822
RASL11B	0.032799
SPIDR	0.032473
CLU	0.032386
CCL13	0.032066
NT5E	-0.032028
COL4A5	0.031895
CYP2U1	0.031487
CR2	0.031345
ACTA1	-0.031330
ABHD2	-0.031215
ACKR3	0.031114
CHAC1	0.031113
NET1	0.031081
PDZK1	-0.030960
VHL	0.030812
PCDH1	-0.030781
CEBPD	0.030695
HOPX	-0.030674
FN1	0.030631
CD79B	0.030562
COL3A1	0.030330
GPD2	-0.029952
CLEC14A	0.029867
LPIN2	-0.029747
GPRC5A	-0.029730
CORO1A	0.029707
EEPD1	-0.029633
IP6K2	0.029511
DGKH	-0.029415
SATB1	0.029394
IER5L	0.029391
CNDP2	-0.029378
KLF9	0.029069
CREB3L2	-0.028995
LPAR6	-0.028991
HEXIM1	0.028988
SLC5A12	-0.028949
DUSP2	0.028876
DUSP1	0.028845
CYR61	0.028842
ZFP36L2	0.028814
SLC25A10	-0.028807
LYVE1	0.028793
ACSL3	-0.028691
TMEM171	0.028570
F3	0.028538
SLC9A3	0.028367
IRF2BP2	0.028101
PPARGC1A	-0.028045
ANGPTL4	-0.027992
POSTN	0.027870
BBC3	0.027846
CCNG2	-0.027794
BCMO1	-0.027671
SPHK1	0.027631
NUAK2	-0.027492
PER2	-0.027482
ENPP2	0.027439
JUN	0.027430
APLP1	-0.027327
CEMIP	-0.027188
DMPK	0.027176
KLF6	0.027175
FA2H	-0.027166
CDT1	0.027081
MXD1	-0.027067
FAM118A	0.026985
HSPB1	0.026959
SLC43A2	-0.026948
PDP1	0.026927
HSD17B13	0.026898
RTP4	0.026787
TREH	-0.026785
ADCK5	0.026758
TSPYL1	0.026463
CHSY1	0.026296
CCDC62	0.026127
CDCA8	-0.026102
CEBPB	0.026033
RGCC	0.025995
TMEM123	0.025983
ACE	-0.025978
CD53	0.025969
OGFRL1	0.025935
ABCB1	-0.025921
CYP27A1	0.025897
GBP2	0.025895
JAG1	-0.025860
BAMBI	0.025818
SGK2	-0.025803
PPARG	-0.025784
ZFP36	0.025754
MSMO1	0.025704
RPS6KA5	-0.025674
NFE2L2	-0.025578
NNAT	0.025532
CREM	0.025523
GSTA5	0.025521
APOBEC1	0.025492
TIFAB	-0.025439
VIM	0.025430
IL1R2	0.025403
CLDN7	-0.025389
ZNF395	0.025350
MAP3K8	0.025349
SLC20A1	-0.025333
SLC46A3	0.025329
SFXN3	0.025293
AGPAT1	-0.025237
ATF3	-0.025187
SH3BP5	0.025074
EVI2A	0.024983
IRS2	0.024724
TIGD3	0.024635
RAPGEF2	-0.024618
COLEC12	0.024599
ETS2	0.024585
POR	-0.024466
GHRL	-0.024459
SLC26A3	0.024438
DGAT2	-0.024420
RAPGEF5	-0.024343
PTPRO	-0.024343
ARNTL	0.024304
NAPSA	0.024261
TXNRD1	-0.024221
KLF10	0.024191
ALDH1A1	-0.024142
ALAS1	0.024131
FLCN	0.024104
SAT1	0.024083
SLC40A1	-0.024049
INSIG1	0.024030
FXYD5	0.023910
MAPK6	0.023862
PPP1R1B	-0.023823
DNMBP	-0.023790
TUBB2A	0.023775
LOXL1	0.023765
TASP1	-0.023725
FLNA	0.023706
HSPB6	0.023669
NR4A1	0.023644
IL7R	0.023639
S1PR1	0.023608
PRKG2	-0.023606
TRIM25	-0.023585
RAMP3	0.023518
CISH	0.023468
ZNF367	0.023437
DEGS1	0.023386
TMEM194B	0.023238
RAB30	-0.022977
STARD13	-0.022921
ALDH1B1	-0.022868
TNFRSF1A	-0.022833
PTPRC	0.022821
MAD2L1BP	0.022712
SLC4A7	-0.022706
BTG1	0.022704
ACSF2	-0.022650
PARP8	-0.022632
MPP5	-0.022631
KLF2	0.022594
PIM3	0.022589
CLDN8	0.022501
ANKRD49	0.022467
GNA11	-0.022426
ROCK2	-0.022423
GDNF	-0.022416
SRSF6	0.022385
TMEM45B	-0.022369
MKNK2	0.022364
LTB	0.022354
SVEP1	0.022325
B3GALT5	0.022318
MRGBP	0.022312
CYYR1	0.022276
EDN1	0.022232
GLRX	0.022208
TIPARP	0.022193
MAP3K19	0.022175
CLIC5	-0.022100
RBM15	0.022057
LPGAT1	-0.022056
S100B	0.022017
IL2RG	0.021993
DUSP14	0.021956
CD69	0.021950
ALDH3A2	-0.021939
LIPA	-0.021902
B3GALNT1	0.021885
ABCD3	0.021878
SAMHD1	-0.021798
RGS4	0.021796
FZD1	0.021767
COL5A2	0.021760
FDXACB1	0.021748
ALDH1A3	0.021715
SERTAD1	0.021709
FCHSD2	-0.021653
DYNLT3	0.021646
RIPK4	-0.021643
MSN	0.021597
CAV1	0.021593
RAC2	0.021514
SLC15A1	-0.021508
STK17B	-0.021498
LNX1	-0.021460
KLK3	-0.021453
ROPN1L	-0.021442
TRDMT1	-0.021321
GPNMB	0.021317
CBL	-0.021309
GPD1	-0.021294
MOXD1	0.021250
MSL2	-0.021241
HES1	0.021241
EIF4A2	0.021202
C15orf60	-0.021170
LPAR4	0.021159
LALBA	0.021135
DEPDC7	0.021128
KCNK10	-0.021096
GP2	-0.021087
LAMA2	-0.021084
ELMOD1	0.021083
TTPAL	0.021034
DLL1	-0.021026
RASD1	0.020988
MFAP4	0.020983
TBC1D24	0.020966
ASPN	0.020938
TSPAN7	-0.020894
IL22RA2	0.020879
YPEL5	0.020853
TRIM35	0.020838
EFCAB14	-0.020762
ANXA5	0.020708
CES1	0.020707
SLC22A5	-0.020705
SLC28A2	-0.020668
TACC1	0.020651
DSG2	-0.020647
SEC31A	-0.020640
SUN2	0.020630
PUSL1	-0.020614
TMEM252	0.020595
SLC4A10	-0.020580
GRAMD1B	-0.020572
PEX11G	-0.020514
FMO4	-0.020512
SORBS2	0.020490
UTP3	0.020456
EXO5	0.020412
PTBP2	0.020412
MYC	-0.020370
LUM	0.020235
CRYAB	0.020234
CIDEB	-0.020212
PROSER1	0.020188
NHLRC2	-0.020166
ECHDC1	0.020161
TMCC3	0.020156
CUEDC1	-0.020141
CXCL16	0.020137
UBD	0.020116
EZR	-0.020113
SCEL	-0.020110
ELK4	0.020085
PLAU	0.020060
KLHL24	0.019988
POU2F1	-0.019972
LAMB3	-0.019964
COL4A1	0.019945
SEPT10	0.019917
SLC6A8	-0.019907
CDC14A	-0.019907
AQP7	-0.019904
PIGC	0.019821
TOMM40	-0.019816
DAB2	0.019798
WDR19	-0.019766
PPP1R15A	0.019756
GATA5	-0.019723
PELI1	-0.019667
GGA2	0.019630
WDR6	0.019620
DBR1	0.019605
TBC1D10A	-0.019601
LPAR3	-0.019593
SLC2A1	0.019552
TRAPPC2	0.019532
SELL	0.019516
ZSWIM6	-0.019505
CCDC134	0.019502
PGGT1B	-0.019471
LAT	0.019466
EPHX1	-0.019460
RMI1	0.019457
SNCG	0.019443
LAPTM5	0.019440
CRY1	-0.019393
YPEL3	0.019369
PAXBP1	0.019350
DIXDC1	0.019340
INPP1	0.019315
PDZD3	0.019294
GSN	0.019277
ANK3	-0.019251
CBLL1	0.019243
SIT1	0.019236
CD48	0.019209
RPS6KA1	-0.019189
DRAM1	0.019104
ELTD1	0.019044
CPT2	-0.018973
CNOT7	0.018964
PRKAA2	-0.018960
CDKN1A	0.018932
SCFD1	-0.018927
HELB	0.018911
HIC1	-0.018891
SUSD2	-0.018884
PEX3	-0.018880
AKAP8	0.018875
DUOX2	-0.018864
FLNB	-0.018845
CCDC68	0.018830
LPHN2	-0.018795
P4HA1	0.018788
UBC	0.018777
GTF3C3	0.018773
IGSF9	-0.018768
ANKRD44	0.018752
PLCG1	0.018742
MARCH3	-0.018722
GBP6	0.018719
GCNT3	-0.018710
HIBCH	0.018700
PRNP	0.018688
IGSF3	-0.018679
ATG12	0.018679
NGRN	0.018676
CC2D1B	0.018649
EPN1	-0.018633
TPBG	0.018632
PSTPIP1	0.018631
PNN	0.018542
NFATC1	0.018530
SLC9A3R1	-0.018521
SPARCL1	0.018508
CCK	-0.018504
FOXA2	0.018485
LIMD2	0.018470
CFL2	0.018470
ZC3H7A	0.018454
VNN1	0.018407
PTN	0.018401
PGAM5	0.018398
IVNS1ABP	0.018394
RABGGTB	0.018387
AMD1	0.018366
FGA	0.018338
MTHFD2L	-0.018336
RARS	0.018333
PRPF39	0.018328
PTPRCAP	0.018327
UNC5CL	-0.018281
FCGBP	-0.018274
TFB2M	0.018267
PIAS3	0.018264
UGGT2	0.018259
KIAA1217	0.018230
PDZRN3	0.018227
ZNF519	0.018219
VDR	-0.018207
LRRC58	0.018201
LY6E	0.018196
WASF2	-0.018191
TFCP2L1	0.018177
INPP5B	0.018175
PCDH20	0.018159
CDA	-0.018157
GLRA3	0.018148
MYPN	-0.018117
TM6SF1	0.018078
GUCY2C	-0.018070
PTPLAD1	-0.018070
HMGCS1	0.018066
NUDT11	0.018060
MED7	0.018043
MMP10	0.018029
ANKRD10	0.018028
CCND2	-0.018014
FADS1	0.018010
SH2D2A	0.017996
MEOX1	0.017993
TPPP3	-0.017988