!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	Interleukin-1 beta
!ligand_id	Drug Bank ID: BE0001051
!cell_type	epidermal keratinocytes
!organism	human
!end_metadata
S100A12	0.258701
LCN2	0.258203
DEFB4A	0.203571
S100A7	0.186866
SERPINB4	0.175035
S100A9	0.168733
SPRR2B	0.147153
SPRR4	0.139767
CNFN	0.118006
DAPL1	-0.114660
RHCG	0.107842
SPINK7	0.091295
CLIC3	0.091053
TUBB3	0.087348
ODC1	0.083941
S100A11	0.080548
FTH1P5	0.079995
KLK5	0.078919
IL36G	0.077586
S100P	0.077576
IVL	0.074352
TUBB4B	0.074067
SPRR1A	0.073021
FGFBP1	0.072415
ATP1B1	0.071769
TDP2	0.071681
GJB6	0.071575
GJB2	0.071532
CEBPB	0.070377
SLPI	0.070309
KRT9	-0.069339
ND2	0.068442
TUBA4A	0.068341
CD24	0.068098
KRT17	0.066057
AKR1C3	0.065963
ACTB	0.064801
TUBB6	0.064522
FTL	0.064148
HSPA8	0.059952
KLK12	0.059720
TUBA1A	-0.059718
SBSN	0.059588
A2ML1	0.059560
ACTG1	0.058985
WFDC5	0.058630
RPS14P3	-0.058590
KLK7	0.058029
AVPI1	0.057846
ALOX12B	0.057240
CDSN	0.057234
LCE3D	0.057230
YWHAG	0.056116
LY6G6C	0.055548
S100A6	0.055458
GLRX	0.055067
KRT16	0.054902
SPINK5	0.054869
TGM3	0.053528
CRCT1	0.053363
DHCR24	0.053270
DEGS1	-0.053220
SPRR3	0.052929
SPRR2G	0.052605
SERPINB3	0.052445
HPSE	0.052423
PPL	0.051899
S100A14	0.050820
SERPINB7	0.050382
GGCT	0.049943
KRT6A	0.049902
DYNLL1	0.049895
ELOVL1	0.049503
TGM1	0.049416
JUP	0.048856
PPIF	0.048655
CARD18	0.048557
TMSB10	0.048546
GPX3	0.048519
C10orf99	-0.047280
S100A16	0.047249
HSPA1A	0.046980
KLK6	0.046958
VSIG10L	0.046441
PRDX1	0.045699
RNASE7	0.045385
DCN	-0.045336
UPK1A	-0.045282
AKR1B1	0.045254
GARS	0.044936
HSPB1	0.044570
SULT2B1	0.044359
LGALSL	0.044116
CRABP2	0.043499
PCBP1	0.043278
TMEM45A	0.043266
FABP5	0.043109
YWHAZ	0.043034
CREG1	0.042912
LDHB	0.042113
TMEM123	0.041903
C20orf24	0.041067
GDPD3	0.040810
SNHG5	-0.040599
CCL20	0.040469
CSRP2	-0.040104
ABCA12	0.039969
FAU	0.039678
NME7	0.039088
HSP90AA1	0.039010
FLG2	0.038494
KLK10	0.038494
TUBB2A	0.038394
PNRC1	-0.038260
RNF11	0.038006
KRT2	0.037971
UGCG	0.037801
S100A2	0.037589
ASPRV1	0.037413
COX1	0.037338
RHOD	0.037235
CAP1	0.037107
MLF2	0.037083
EEF2	0.037072
RAB10	0.036513
DSC1	0.036505
PLS3	0.036501
HSPB8	0.036440
FAM214A	0.036423
LOR	0.036265
C15orf48	0.036224
SH3BGRL3	0.036053
RNASEK	0.036050
YWHAQ	0.035989
EIF4H	0.035953
SERPINB2	0.035913
PLBD1	0.035650
DUSP14	0.035250
DSP	0.034701
CES1	0.034451
TMEM164	-0.034387
CTSB	0.034299
C5orf46	-0.034102
P4HB	0.034067
MSMO1	0.034044
KRT14	0.034014
BZW1	0.033982
KRTDAP	0.033806
IARS	0.033641
ACTN4	0.033610
ARF4	0.033505
BTG1	-0.033199
SOD1	-0.033196
EPHX3	0.032900
KLK11	0.032817
ATP5B	0.032428
IFFO2	0.032283
MSMB	-0.032278
GPNMB	-0.032040
GGH	0.031918
MYL12B	0.031713
TALDO1	0.031489
FDPS	0.031450
AKR1C2	0.031232
IER2	0.031141
ATP6V0C	0.031092
RPL29	-0.031007
PRSS3	0.030863
RPL24	-0.030747
SMIM14	-0.030733
PABPC3	0.030355
PSORS1C2	0.030268
MLLT11	0.030069
CALML5	0.030056
RRAGA	0.029846
HSPA5	0.029783
SFN	0.029781
IER5	0.029767
ALOX15B	0.029478
SCD	0.029328
BNIP3L	0.029247
GSTA4	-0.029030
HMOX1	0.028863
FAM213A	-0.028761
ERH	0.028577
TMEM45B	0.028543
KRT10	0.028531
GJA1	0.028369
EIF4A1	0.028307
SDCBP2	0.027976
CITED2	0.027954
SRP14	0.027807
ARPC2	0.027801
SHC1	0.027700
DYNLT1	-0.027590
RPL3	-0.027494
PRSS8	0.027107
AP2S1	0.027092
ATP12A	0.027005
CSTB	0.026979
HADHB	0.026952
TUBA1C	0.026864
CKAP4	0.026864
SLC7A5	0.026776
SDR9C7	0.026640
RPS9	-0.026503
ALDH2	-0.026391
RTN4	0.026223
HIF1A	0.026130
PRDX6	-0.026025
RPL7A	-0.025960
SERPINB13	0.025829
OASL	0.025698
LDHA	0.025687
CXCL14	-0.025570
PPP1R14C	-0.025471
RAB25	0.025416
TPT1	0.025416
ME1	0.025347
KRT6B	0.025214
SPRR2C	0.025187
RPL23	-0.025183
SAT1	0.025123
PGAM1	0.025092
RPL9	0.024848
MRPS24	-0.024846
KRT1	0.024815
CFL1	0.024771
GLTP	0.024743
TSPAN13	0.024682
TUBA1B	0.024639
SLURP1	-0.024629
C1orf116	0.024359
ROBO1	-0.024324
RPS21	-0.024318
ANKRD22	0.024301
ID2	-0.024282
RPL39	0.024260
SRXN1	0.024238
PSMA6	0.024232
AREG	0.024174
ATP6V0D1	0.023990
NARS	0.023977
TRIM16	0.023887
KRT80	0.023840
PTGES3	0.023696
METTL7A	-0.023688
MANF	0.023682
CYB5R2	0.023644
ARL5A	0.023585
AZGP1	0.023562
QPCT	0.023551
IER3	0.023442
RND3	0.023434
RPS13	0.023269
GLUL	0.023265
NLRP10	0.023221
CPA4	0.023176
ALOXE3	0.023166
ALDOA	0.023144
HPGD	0.023140
FXYD3	-0.023013
CDV3	0.022981
DANCR	-0.022882
RPL26	-0.022861
COL17A1	-0.022841
FOXQ1	-0.022790
CTSD	0.022761
TOB1	0.022711
LCE2B	0.022707
PKM	0.022702
S100A8	0.022700
MANSC1	0.022676
LYPLA1	0.022604
UBC	0.022596
HSP90AB1	0.022500
HAL	0.022455
DYNLT3	-0.022433
CRYAB	-0.022343
GSTM1	-0.022274
MMADHC	0.022230
IL22RA1	0.022213
GMNN	-0.022208
PAM	0.022116
ATP5J	0.022113
APP	0.022074
RPL13	-0.022059
GM2A	0.022041
KRT77	-0.021968
CHCHD7	-0.021895
NSG1	-0.021827
METRNL	0.021719
SEC61B	0.021532
CEBPA	0.021507
COX2	0.021494
HMGN3	-0.021492
LAD1	0.021444
ABLIM1	0.021350
ND6	0.021329
COX6C	0.021244
IL36RN	0.021196
HIGD1A	0.021188
RPL12	-0.021147
ELMOD1	0.021115
HSD17B10	-0.021028
H2BFS	0.021004
GBAP1	0.020941
LCE1B	0.020931
ATP5A1	0.020903
RPL34	-0.020774
DEFB1	0.020748
AKR1C1	0.020740
PI3	0.020738
RPS4Y1	-0.020712
MAP2	0.020510
PNP	0.020466
DNAJA1	0.020428
NACA	-0.020369
ISL1	-0.020329
PDZK1IP1	0.020299
PTGS2	0.020284
ARL6IP5	-0.020195
SLC25A6	-0.020189
GLO1	0.020174
RPL36	-0.020094
PPDPF	0.019994
ANXA4	-0.019954
BAG3	0.019918
ZFP36	0.019861
SH3BGRL	-0.019860
HSP90B1	0.019854
ARPC1A	0.019851
AADAC	-0.019817
FLG	0.019799
GDA	0.019773
GRHL1	0.019767
RPL22	-0.019750
CTSC	0.019693
RPL36A	-0.019680
CSTA	0.019659
NIPAL4	0.019644
CD55	0.019511
LRP10	0.019497
MRPS21	-0.019492
CYP4F22	0.019485
HMGN2	-0.019394
CTSA	0.019300
MYCBP2	-0.019201
TMEM40	0.019155
LGALS3	-0.019147
CAT	-0.019146
PPP1CB	0.019145
ATP6V1B2	0.019137
UPP1	0.019127
SERF2	-0.019103
ELOVL4	0.019042
DUSP6	0.019038
ORMDL2	0.018755
WBP5	0.018754
SPINK6	0.018751
ARHGEF18	0.018721
CAPNS2	-0.018668
APRT	-0.018630
BLVRB	0.018627
NUPR1	-0.018543
NLRX1	0.018525
IFI30	-0.018513
NCKAP1	0.018508
RPL15	-0.018476
TMEM99	-0.018443
PYCARD	0.018263
UBB	0.018187
TUBB	0.018072
CALM1	0.018023
OXSR1	0.018010
RAB5A	0.017957
KRT23	0.017880
ANKRD13A	0.017826
TMED2	0.017761
GAPDH	0.017756
WNT5A	0.017719
BASP1	0.017713
CD81	0.017626
ANXA1	0.017583
CTNNBIP1	-0.017568
CHCHD2	0.017546
SOX7	0.017544
PLP2	-0.017486
MDH2	0.017461
CHIC2	0.017437
RARS	-0.017431
GSTM2	-0.017393
RPLP2	-0.017273
NAMPT	0.017256
CGA	-0.017157
RAB1A	0.017097
CA2	-0.017079
SPNS2	0.017075
CTH	0.017070
STK39	-0.017057
TARS	0.017011
SQLE	0.016993
TXNIP	-0.016983
SMPD3	0.016962
TMEM86A	0.016947
ATP6V1G1	0.016878
AMOTL2	0.016821
CALCOCO1	0.016818
ASAH1	-0.016789
RXRA	0.016781
TM9SF2	0.016773
VCP	0.016772
CALR	0.016741
RAP1B	-0.016647
NME1	-0.016638
MAP2K3	0.016624
BNIPL	-0.016588
PERP	0.016504
ATP6	0.016459
KCTD11	0.016436
MYD88	0.016436
JUNB	0.016419
SNRPG	-0.016380
COX6B1	-0.016327
TM7SF2	0.016308
GCH1	0.016293
FRMD6	-0.016286
RPL13A	-0.016221
SERPINB5	0.016195
NDUFB9	-0.016194
PPIA	0.016192
TCP1	0.016130
SNRPD2	-0.016106
ITM2B	0.015973
TPRG1L	0.015905
RPL6	0.015890
UBQLN2	0.015878
PSAPL1	-0.015875
NDUFC2	0.015828
MGST2	-0.015756
MMP1	-0.015742
EDF1	0.015738
ZFAND6	0.015710
IL20RB	-0.015692
ATRAID	-0.015654
ATP6V1C2	0.015651
NQO1	0.015647
ANXA3	0.015631
ATG2A	0.015599
ZMPSTE24	0.015586
CASP14	0.015534
CS	0.015521
FGFR3	-0.015505
UFC1	-0.015501
EVPL	0.015453
HDGF	0.015442
HSD11B1	-0.015418
ADIPOR1	0.015415
EEF1B2	-0.015414
ID3	-0.015405
ADIPOR2	0.015397
LY6D	-0.015360
ARG1	0.015345
RPN2	0.015332
EBPL	-0.015268
DDX21	0.015263
HEBP2	-0.015235
MYO6	0.015234
FKBP5	-0.015217
KIF5B	0.015195
GLTSCR2	-0.015149
RPL8	-0.015110
PON2	-0.015101
ZFAS1	-0.015050
ELOVL7	0.015043
UBE2D3	0.015039
EIF4G2	0.015037
MGLL	-0.014990
G6PD	0.014972
APOL3	-0.014937
MBOAT2	0.014897
CRNN	-0.014886
MCUR1	0.014869
NEDD8	-0.014842
PSMB6	0.014835
TSG101	0.014830
PSG7	0.014800
SUCLA2	0.014781
MFSD1	0.014760
PPM1K	-0.014757
STARD7	-0.014744
SRGAP2C	-0.014730
NT5C3A	0.014705
ACTR3	0.014696
PPA1	-0.014678
PTMA	-0.014674
RPL10A	-0.014664
FLRT3	-0.014658
COX7A2L	-0.014635
EMB	0.014623