!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Heroin
!smiles	CC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C
!drugbank_id	DB01452
!pubchem_cid	5462328
!cell_type	striatum, day 18 withdrawal
!organism	mouse
!end_metadata
TTR	0.371352
CSHL1	0.213417
PMCH	-0.196932
ND6	0.139052
S100A5	-0.136926
PLIN4	0.115099
PRL	0.105404
PRKCD	0.088068
STMN1	-0.086747
PCP4	0.083398
LTF	-0.077942
ND5	0.075098
NR4A2	-0.074640
CDHR1	-0.071494
ND4L	-0.070896
CHMP5	-0.070379
MAP2K1	-0.070098
KRT14	-0.069720
TBR1	-0.068734
KPNA3	-0.067836
NECAB1	-0.065970
LGALS3BP	0.063751
DDX3X	-0.062329
SPINK8	0.061869
MXI1	-0.059832
SLC17A7	-0.059783
PAIP2	-0.058557
PTPRA	-0.053861
PCMTD2	-0.053084
CTSS	-0.052371
SEPP1	-0.052022
MYL4	-0.051628
CHIC1	-0.051626
PLS3	-0.051108
NTN5	-0.050852
C8orf46	-0.050283
KLHL13	-0.049098
OMP	-0.048319
SPARCL1	-0.048062
KIAA1462	-0.047585
COX2	-0.047202
VPS26B	-0.046649
SEC11C	-0.045796
NRN1	-0.045451
FOS	-0.045289
C2orf40	0.045063
SNX1	-0.044875
CBLN1	-0.044630
CCK	-0.044285
NDRG4	-0.044031
CARTPT	0.043488
SLC6A3	-0.043340
TRIM59	-0.042516
TJP1	-0.042342
CACYBP	-0.041968
VAPA	-0.041539
OTUD6B	-0.041436
LCN2	0.041251
NOL7	-0.040883
HLA-DQA1	-0.040566
R3HDM2	-0.040261
TMEM158	0.039060
ATP6V1A	-0.038614
CABP7	-0.038235
PTPRT	-0.038173
FFAR3	0.037642
SPTY2D1	0.037050
LIN7C	-0.036200
HIGD1A	-0.035431
TUBA1A	-0.035101
LRRN2	-0.035080
IP6K2	0.034211
H1F0	-0.034184
TBC1D20	-0.033884
SPON1	0.033029
GRAMD4	-0.032644
IL22RA1	-0.032450
TUBB2A	0.032078
TBC1D19	-0.032039
GNB2L1	-0.031952
NLGN1	-0.031444
SYNDIG1L	0.031175
USMG5	-0.031081
RER1	-0.031053
IFITM3	0.030810
IPCEF1	-0.030789
EMC7	-0.030736
COX4I2	0.030651
PCDHB16	-0.030615
CCT5	-0.030566
SCN1A	-0.030564
CRYBG3	-0.030557
FOXA1	0.030543
GHITM	-0.030420
TH	0.030387
CHSY1	-0.030361
ST13	-0.030199
TMEM178A	-0.030139
ERBB2IP	-0.029945
RASL11B	-0.029799
PSCA	-0.029689
ISL1	0.029625
C2	0.029483
AEBP1	0.029227
CDC123	-0.029224
KCTD12	-0.029005
MICU3	-0.028938
SDHD	-0.028835
ZNF326	-0.028773
TRH	0.028714
CCNG2	-0.028647
PCNA	-0.028580
INHA	0.028450
SLC7A14	-0.028357
KL	0.028291
DLK1	0.028249
MEF2C	-0.028153
CTGF	-0.028124
TSHB	0.028057
SLPI	-0.027861
LMTK3	0.027844
CIART	0.027748
TRRAP	-0.027708
BHLHE22	-0.027457
RRAS2	-0.027440
PSMD14	-0.027348
SLC26A4	0.027305
UBE2N	-0.027184
FOXG1	-0.027169
ALCAM	-0.027154
PRMT8	-0.027081
SMIM13	-0.026824
TTC9	-0.026764
ABCD3	-0.026750
NKIRAS1	-0.026718
BCAS2	-0.026655
MEIS2	-0.026510
PMPCB	-0.026488
ECEL1	0.026459
NR1D2	-0.026310
LPAR1	-0.026252
ADAMTS4	-0.026251
ATP6	-0.026227
ZNF445	-0.026225
SLC39A10	-0.026205
NPC2	-0.026194
CSNK2A1	-0.026167
KPNB1	-0.026066
GCC2	-0.026065
RSU1	-0.025847
SMARCA5	-0.025834
ATP5A1	-0.025826
HCRT	-0.025676
PENK	0.025369
FSTL5	-0.025303
JAM3	-0.025277
C10orf10	-0.025170
RSPRY1	-0.025102
RGS5	-0.025082
DUSP1	-0.024912
NDUFB5	-0.024883
PDE1A	-0.024868
PIN4	-0.024810
DIO2	-0.024694
C15orf61	-0.024658
RGS16	0.024642
B4GALT4	-0.024588
CRIPT	-0.024578
ALDH6A1	-0.024410
FBXL16	0.024373
TMEM106B	-0.024338
YWHAE	-0.024290
IDO1	0.024177
ALDH3A1	-0.024174
CHPF	0.024165
DDX6	-0.024109
FRZB	-0.024080
TBC1D22B	0.024037
MPPED1	0.023967
SLC6A13	0.023947
GPR68	0.023921
EGR2	-0.023765
IDH2	-0.023729
GLUL	-0.023722
TTC33	-0.023584
S100A10	-0.023569
ATP1B2	0.023560
HLA-DRB5	0.023530
KRTDAP	-0.023453
GPX3	0.023450
TNNT1	0.023406
WFS1	0.023357
RBP4	-0.023240
SFR1	-0.023236
DUSP7	0.023198
MAGOHB	-0.023112
CYCS	-0.023063
DNAJB9	-0.023023
PDE10A	-0.023014
SPATA2L	0.022910
CLIC6	0.022860
TET1	-0.022817
AVP	0.022810
NUDCD2	-0.022749
NDUFA5	-0.022662
C1GALT1C1	-0.022593
SLC6A12	0.022584
ARFGEF2	-0.022569
FIG4	-0.022565
EHD1	0.022539
NEU2	-0.022462
ISCA1	-0.022447
ZFHX3	0.022388
GBX2	0.022266
MEDAG	-0.022257
UNC5B	-0.022247
TNR	-0.022134
SELK	-0.022113
ACTR6	-0.022107
OPALIN	-0.022056
ZKSCAN3	-0.021995
NPTX1	-0.021893
SKP1	-0.021775
PGRMC1	-0.021746
TRIM54	-0.021631
VIP	-0.021612
FAM102B	-0.021583
RASGEF1A	-0.021455
CYP46A1	0.021411
ATP6V0A1	0.021400
ACVR1C	-0.021400
FOLR1	0.021363
FAM216B	0.021313
PCSK9	0.021292
GOPC	-0.021287
DGAT2	0.021184
SLC30A3	-0.021163
CORT	-0.021161
OLFM3	-0.021062
HKDC1	-0.020960
DMXL2	-0.020923
CGA	-0.020914
PCDHB8	-0.020848
TPPP	-0.020804
ND1	-0.020791
HRSP12	-0.020676
TSR3	0.020469
HSPE1	-0.020466
EIF4E	-0.020445
ZSWIM4	0.020400
NPAS4	0.020350
TXNDC12	-0.020312
KRT17	-0.020231
TMEM14A	-0.020166
WISP1	-0.020103
RASAL2	-0.020096
BDP1	-0.020008
CNFN	-0.019965
IQSEC3	0.019948
PDAP1	-0.019880
DEK	-0.019874
C17orf96	-0.019838
HSPA5	0.019833
FRMD4B	-0.019782
HADHB	-0.019737
TMEM125	-0.019735
SYT13	-0.019732
BIRC3	0.019711
DAZAP2	-0.019681
PRKCG	0.019651
PTPN5	0.019632
MAP1A	-0.019606
PSD3	-0.019520
VBP1	-0.019492
SOX18	0.019420
APPBP2	-0.019413
JOSD2	0.019396
KATNAL1	-0.019351
SAMD5	-0.019248
EIF4B	-0.019243
WIPF3	0.019220
EID1	-0.019173
NAP1L5	-0.019163
PPM1K	-0.019131
DDN	0.019104
PIP5K1B	0.019067
PTGES3	-0.019065
UBE2I	-0.019061
CCT7	-0.019034
EGR4	0.019002
RET	0.018944
TRIM37	-0.018934
RAMP3	0.018897
CYFIP2	-0.018839
ZFAND6	-0.018794
EMP1	-0.018782
SRP72	-0.018759
HSP90AA1	-0.018730
APOB	-0.018695
AKAP8	-0.018691
ME1	-0.018685
PARVG	0.018684
OPRK1	-0.018675
APC2	0.018663
TXN	-0.018617
IST1	-0.018606
HSF2	-0.018605
H3F3C	-0.018572
IFIT3	0.018542
SLC23A2	-0.018528
PLAC8	-0.018496
KLF2	0.018496
SDE2	-0.018480
TRHR	-0.018446
PCYT1A	-0.018387
NAMPT	-0.018373
KCNE2	0.018323
BACH1	-0.018308
NDFIP2	-0.018275
MCCC1	-0.018221
AGT	0.018219
KIAA1549L	-0.018199
IL25	-0.018184
NDUFB4	-0.018177
THEM6	0.018152
PRR5L	-0.018094
SLC16A6	-0.018086
WNT10A	-0.018067
C15orf59	0.018062
SMU1	-0.018046
GPR88	-0.018040
SP4	-0.018018
CARM1	0.017998
TM7SF3	-0.017958
FH	-0.017888
N4BP3	0.017823
DDI2	-0.017795
SPTSSA	-0.017760
KIAA0513	-0.017725
ZBTB38	-0.017718
DYDC1	-0.017666
KCTD4	-0.017660
KDELR1	0.017620
ADORA2A	0.017567
TMEM251	-0.017552
SLIRP	-0.017549
C14orf80	-0.017543
KTI12	-0.017542
IGF2	0.017528
SLC25A44	0.017486
SIX3	0.017473
CPNE9	-0.017442
KCNK2	-0.017420
ZNF280B	0.017392
TBX1	0.017385
CCRN4L	-0.017337
CNIH3	-0.017329
CAV1	-0.017326
LPGAT1	-0.017313
TUBB4A	0.017296
SNAP29	-0.017264
GPD2	-0.017243
CRYZL1	-0.017224
THOP1	0.017212
FREM3	0.017181
ACADSB	-0.017121
FDX1L	0.017087
AKR1E2	-0.016993
KCND2	-0.016969
RWDD4	-0.016957
VHL	-0.016953
SSTR2	-0.016923
CACNA2D1	-0.016909
PSMD12	-0.016904
RPTN	-0.016898
GKAP1	-0.016897
TIGD2	-0.016895
TSPYL5	-0.016850
SLC25A4	0.016846
LYPD6B	-0.016837
ATN1	0.016836
VGF	0.016829
IRGM	0.016818
KLF6	-0.016815
HRH3	0.016778
PRKAA2	-0.016759
HSD11B1	-0.016749
TM4SF20	-0.016742
GPR153	0.016735
S100A9	-0.016734
PLEKHA3	-0.016719
GRAP	-0.016716
PLAGL2	0.016661
MAP1LC3B	-0.016630
HCN2	0.016612
CAMK1G	0.016604
HES5	0.016590
FBXW7	-0.016583
IFFO1	-0.016559
UBE2QL1	-0.016437
PYCR2	0.016393
TAC3	0.016383
GNAI2	0.016364
RCOR1	-0.016352
HNRNPLL	-0.016347
AP2A1	0.016328
TMEM170B	-0.016239
FZD2	-0.016225
SLC17A8	-0.016224
USP18	0.016218
FKBP8	0.016212
DCT	0.016205
GGACT	-0.016203
EVL	-0.016199
MYF6	0.016196
MSX1	0.016131
RRAGD	-0.016125
PRPS2	-0.016121
YTHDC2	-0.016087
TSHZ2	-0.016077
SOS2	-0.016020
IGFBP2	0.015977
PHF20	-0.015934
PWP1	-0.015932
DRD2	0.015915
HERC3	-0.015894
SKIL	-0.015871
BTG2	0.015870
ZBTB7A	-0.015833
WNT8B	-0.015830
TTYH3	0.015818
GCK	0.015748
ID2	-0.015712
KIAA1279	-0.015712
NDP	-0.015703
IGDCC3	0.015647
CHST12	0.015629
MPEG1	-0.015601
OTOF	0.015599
HIST1H2BD	-0.015567
FAM101B	-0.015565
SP7	-0.015539
CDO1	-0.015531
SLC32A1	0.015508
CRBN	-0.015507
PRR7	0.015498
COX7A2	-0.015494
CBX6	0.015457
COG1	0.015436
HIST1H2AM	0.015424
NTRK1	0.015407
JUNB	0.015406
KLHL2	-0.015387
ARHGAP32	-0.015382
CREG2	-0.015376
BCAP31	-0.015371
GRM4	0.015349
ID3	-0.015344
LIMK1	0.015338
PGAM1	-0.015319
ANKRD11	-0.015291
RGS8	0.015279
INA	-0.015273
DGAT1	0.015269
XDH	0.015260
SLC25A25	0.015251
TUBA8	-0.015242
SYT2	0.015241
SERPING1	0.015232
TM9SF3	-0.015214
EPN1	0.015188
HUWE1	-0.015165
WNK4	0.015154
EFNB2	-0.015088
CDADC1	0.015074
POLR2G	-0.015063
GNL2	-0.015053
OR1N2	0.015036
POLE4	-0.015036
FBXL3	-0.015032
SLC38A5	0.015005
ZIC1	-0.014980
HDAC2	-0.014979
KIAA0368	-0.014956
RBM24	-0.014952
NCDN	0.014940
KRT23	-0.014898
ANKRD13B	0.014890
SETX	-0.014889
TNNT3	-0.014871
DYNLT3	-0.014863
STK40	0.014826
SPRR1A	-0.014815
PVALB	0.014810
SLC12A5	0.014805
TWISTNB	-0.014781
UNC5A	0.014772
FAM73A	-0.014770
F2	-0.014767
TEX2	-0.014761