!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	estradiol
!ligand_id	CHEBI:23965
!cell_type	MCF-7 breast cancer cells
!organism	human
!end_metadata
EGR3	0.114811
SLC26A2	0.109201
GREB1	0.073816
TARP	-0.064637
PKIB	0.063022
TSKU	0.058972
H19	0.058779
BAMBI	-0.058598
GRB14	-0.057680
PRSS23	0.056640
CSTA	-0.054800
SIAH2	0.050324
IGFBP4	0.048384
LRP11	-0.047791
GPR160	-0.047300
SGCG	-0.047194
SLC7A5	0.046630
FABP5	0.046306
PTP4A1	0.046233
RBM24	0.045189
FAM110C	-0.044623
FAM214A	-0.044039
RFTN1	-0.043044
SLC2A10	-0.042673
BNIP3L	-0.042560
CA12	0.042500
IRF2BPL	-0.041698
SIDT1	-0.041233
GALNT12	-0.040747
SLC3A2	0.040609
PPAP2C	-0.040515
ADM	-0.040495
BIK	-0.040426
NRIP1	0.039846
EFNA1	-0.039457
MB	-0.039304
TPD52L1	0.039059
SLC6A14	0.038761
C9orf152	-0.038123
SYTL2	-0.038039
CGN	-0.038007
PLK2	-0.037735
IFT20	-0.037503
CEACAM6	-0.037068
CREB3L4	-0.037046
FAM129A	-0.036922
APPL2	-0.036606
RND3	-0.036545
YPEL5	-0.036412
PLEKHF2	-0.036056
SQRDL	-0.035901
ORAI3	-0.035693
RAB26	-0.035546
WDSUB1	-0.035383
HSPB8	0.035257
PPL	-0.035217
CELSR2	0.035126
HILPDA	-0.035102
SLC19A2	0.034707
VPS9D1-AS1	0.034636
KMO	-0.034509
SLC7A11	0.034368
ARHGAP12	-0.034355
OR7E14P	-0.034002
PCTP	-0.033940
SLC12A2	-0.033891
MOAP1	-0.033813
SAT1	-0.033797
FREM2	0.033523
FBP1	-0.033492
PPM1K	0.033356
HEY2	0.033239
MYO6	-0.033162
UTP20	0.033009
ABHD12	-0.032795
WWC3	-0.032740
MIR21	-0.032713
TMEM150C	-0.032379
LYPD3	-0.032028
ATP2A3	-0.031794
PRSS8	-0.031681
LXN	-0.031614
NPNT	-0.031522
SLC35A1	-0.031366
ZG16B	-0.031263
PDZK1	0.031241
ABAT	0.030936
SRM	0.030812
CCDC86	0.030663
ZFP36L2	-0.030655
NEU1	-0.030619
SUMF1	-0.030498
LIMA1	-0.030440
CMSS1	0.030350
HIST2H2BE	-0.030345
CCNG2	-0.030323
NIPSNAP3A	-0.029977
SH3BGRL	-0.029794
PNRC1	-0.029760
UPK2	-0.029710
ERMP1	-0.029702
FOXA1	-0.029687
NUDT4	-0.029344
CCDC53	-0.029303
AIM1	-0.029248
NTN4	-0.029151
SLC25A32	0.029123
SPATA17	-0.029065
PNPT1	0.029065
DEGS1	-0.028973
TGFBI	-0.028856
DOK7	0.028763
HIST1H2AC	-0.028724
ACSL3	-0.028633
VEGFB	-0.028551
OAT	-0.028456
RERG	0.028311
IER3	0.028222
AREG	0.028204
RAB11A	-0.028057
CXCL12	0.027997
NAGK	-0.027981
DHX33	0.027971
FRAT2	-0.027820
ST6GALNAC2	-0.027760
AGR2	-0.027723
SLC9A3R1	0.027657
WSB2	-0.027631
NMI	-0.027562
TMEM116	-0.027556
KLHDC2	-0.027452
GATA3	-0.027404
TTK	-0.027274
HOXA5	-0.027236
PSMB9	-0.027171
MCCC1	-0.027170
FAM216A	0.027136
MYC	0.027095
NEAT1	-0.026982
KIAA1324	-0.026974
VMP1	-0.026774
S1PR3	-0.026741
OSR2	-0.026694
BCAS3	-0.026686
RGL2	-0.026677
SELENBP1	-0.026620
DAB2	-0.026601
C10orf32	-0.026493
CHST15	-0.026372
E2F6	0.026325
IGF1R	0.026313
PIK3C2B	-0.026236
DHRS1	-0.026210
ST3GAL1	-0.026082
EPS8	-0.026051
PPAP2A	-0.025965
HSPA2	-0.025878
FUNDC1	-0.025771
GCHFR	-0.025745
TXNIP	-0.025711
CORO1B	-0.025705
ECHDC3	-0.025675
DHCR24	-0.025587
SMIM3	-0.025566
MRTO4	0.025517
FAM84B	-0.025490
CISH	0.025452
SERINC5	-0.025360
DTX3L	-0.025345
TRAPPC1	-0.025343
TMEM30A	-0.025243
CLIC3	-0.025186
MLPH	-0.025141
TUFT1	-0.025133
SOX2	-0.025064
TSTD1	-0.024981
KHNYN	-0.024972
CYP2J2	-0.024942
PRMT3	0.024894
PRR34-AS1	-0.024839
ELF5	-0.024832
PRR15	-0.024779
PPM1E	0.024693
RPL22L1	0.024655
ALDH4A1	-0.024650
MIPEP	-0.024618
DDX21	0.024513
CCNDBP1	-0.024394
KRTAP4-6	0.024386
MEIS2	-0.024215
SMIM19	-0.024120
MGME1	-0.024109
MED21	-0.024029
VPS54	-0.023984
MANSC1	-0.023956
HEBP1	-0.023940
CPE	-0.023851
METTL23	-0.023847
CTPS1	0.023764
LRIF1	-0.023732
FZD6	-0.023692
NECAB1	-0.023648
EFR3A	-0.023634
CTSD	0.023626
SNHG15	0.023625
ANXA9	-0.023621
WDR54	-0.023619
PC	-0.023612
IQGAP1	-0.023600
MDK	-0.023568
PIK3R3	-0.023500
C11orf52	-0.023485
EFNB2	-0.023428
PFAS	0.023419
TIPARP	0.023414
STARD3NL	-0.023402
CBFA2T3	0.023396
GADD45A	0.023379
RPIA	0.023352
BRINP2	0.023240
CAB39	-0.023232
ITGAV	-0.023139
FAM83B	-0.023117
PIK3R1	-0.023116
BYSL	0.023059
LOC100505774	0.023054
CCDC6	-0.023031
SGK1	0.023010
QPRT	-0.022975
SCP2	-0.022945
NXT2	-0.022899
MPPED2	0.022895
TMEM54	-0.022771
TMEM251	-0.022764
PRRT3	-0.022565
RAB27B	-0.022493
LYN	-0.022491
RFX5	-0.022476
CSRP1	-0.022465
TPK1	-0.022305
TSC22D3	-0.022292
PYCARD	-0.022277
NKX6-1	-0.022266
CTSH	-0.022249
TMEM135	-0.022229
SUOX	-0.022224
CAP2	0.022168
TRAPPC6B	-0.022160
AGL	-0.022154
ATP6V0E2	-0.022122
KYNU	-0.022058
IER5	-0.021945
RPP40	0.021929
PPP3R1	0.021924
RNF11	-0.021912
CORO2A	-0.021723
LOC100506100	-0.021693
FJX1	0.021587
SDC4	-0.021576
NOLC1	0.021576
LOC642361	-0.021518
BRINP3	-0.021505
DRAM1	-0.021485
CLU	-0.021468
ERBB3	-0.021426
CRBN	-0.021376
LINC00867	0.021306
SLC29A1	0.021288
VAMP8	-0.021284
C17orf58	-0.021237
PDCD11	0.021235
IPO4	0.021234
DERA	-0.021167
MAGED2	-0.021146
S100P	-0.021129
PUS1	0.021118
TCEAL1	-0.021071
ABCE1	0.021057
ZNF823	-0.021041
RPF2	0.021027
FNBP1L	-0.021022
PRR15L	-0.020998
SLC7A2	0.020986
MRPS23	0.020954
GPRC6A	0.020897
NAT10	0.020827
RHBDF1	-0.020742
TMEM125	-0.020738
C4orf32	-0.020737
INHBB	-0.020723
BASP1	-0.020664
TMTC2	-0.020649
KIF18A	-0.020606
MRFAP1L1	-0.020602
UBR7	-0.020554
EPB41L5	-0.020552
MITD1	-0.020551
ASB12	0.020550
GRHL1	-0.020545
SDCBP	-0.020531
KIF21B	0.020522
GRHL3	-0.020518
H2BFS	-0.020497
SGOL2	-0.020497
CHAC1	0.020472
VTCN1	-0.020434
SH2D2A	0.020422
NFIA-AS1	0.020396
NAT1	-0.020381
TOP2B	-0.020282
BATF	-0.020245
S100A13	-0.020209
GNS	-0.020200
SLC22A5	-0.020187
ARHGEF18	-0.020147
LOC100289361	-0.020133
CARKD	-0.020124
C19orf81	-0.020107
SNHG1	0.020107
PPP3CA	-0.020103
CCND1	0.020092
CRIP2	-0.020067
LRP10	-0.020061
VGF	0.020051
TXNDC16	-0.020043
PPAN	0.020041
KIAA1147	-0.020035
VPS37B	-0.020019
NEK2	-0.019996
BOP1	0.019994
SH2D4A	-0.019993
CD3EAP	0.019987
SDC1	-0.019972
VPS4B	-0.019965
MYCBP2	-0.019920
KITLG	-0.019919
PTRHD1	-0.019906
BTG1	-0.019867
TMEM106C	-0.019840
HIST1H2BK	-0.019832
CIRH1A	0.019789
TAP1	-0.019783
PRKAR2B	-0.019745
HEATR5A	-0.019731
PRR5	0.019726
TMPRSS3	0.019720
ATP1B1	-0.019695
CLN3	-0.019693
PARP12	-0.019681
PISD	0.019672
GMPR2	-0.019657
NARS2	0.019622
EPN3	-0.019606
LOC100132352	-0.019600
FKBP4	0.019595
LYPD6B	-0.019544
LOC101928597	0.019535
TRIP4	-0.019529
COQ5	-0.019509
ANXA4	-0.019507
FAM46B	-0.019476
RUVBL1	0.019468
LINC00963	-0.019467
MICU2	-0.019440
GOLT1A	-0.019385
KIAA0196	-0.019384
FAM50A	-0.019369
PSRC1	-0.019368
SPHKAP	0.019357
NDRG1	-0.019352
CDKN1B	-0.019339
TMEM14A	-0.019310
GRK7	0.019288
LITAF	-0.019279
SLC46A3	-0.019276
HIST1H1C	-0.019259
SPG20OS	0.019248
ATAD3C	-0.019242
PLEKHH2	-0.019218
GSTZ1	-0.019207
DPYSL2	-0.019190
SPATA20	-0.019186
LOC113230	-0.019181
FANCL	-0.019164
HIST1H2BH	-0.019152
C10orf25	0.019145
ETFA	-0.019132
GYS1	-0.019129
ALDH9A1	-0.019087
TM2D3	-0.019081
TEN1	-0.019073
ASAH1	-0.019061
BRIX1	0.019061
GFOD1	0.019055
CRNKL1	-0.019021
KLHL12	-0.018989
YIPF1	-0.018980
KIAA1598	-0.018974
RABAC1	-0.018959
KIAA1522	-0.018952
SMIM14	-0.018951
FHL1	0.018934
C17orf62	-0.018932
KRTAP7-1	0.018920
CCNE2	-0.018912
MGST2	-0.018898
WDR77	0.018882
HIST1H2BE	-0.018878
MYADM	-0.018865
SGSM3	-0.018854
LYAR	0.018850
CD36	-0.018826
RPS27L	-0.018807
PEX11B	-0.018796
EAPP	-0.018792
TLE1	-0.018788
MEGF9	-0.018743
PUS7	0.018701
LOC100131262	0.018686
RNF44	0.018683
ANKRD50	-0.018681
FAM177A1	0.018666
BMPR1B	-0.018640
ROGDI	-0.018637
EFEMP1	-0.018634
CENPK	-0.018611
ATP8B2	-0.018600
POLD4	-0.018593
TM7SF2	-0.018572
SIDT2	-0.018567
CANT1	-0.018566
AKTIP	-0.018551
SLC25A15	0.018548
CYP1A1	0.018532
WDR3	0.018505
FAM174A	-0.018501
MARCKS	-0.018494
SEH1L	0.018491
NPTN	-0.018488
YTHDF3-AS1	-0.018482
GRN	-0.018477
RAB15	-0.018456
RAB25	-0.018442
MANBA	-0.018441
ARFIP1	-0.018439
MAK16	0.018426
TMEM230	-0.018423
LOC154761	-0.018410
TMBIM4	-0.018389
GLTP	-0.018373
PPP1R3D	-0.018359
FFAR2	-0.018355
GCNT1	-0.018352
ASUN	-0.018344
STAP2	-0.018341
YRDC	0.018289
C4orf3	-0.018279
MED13L	0.018264
YTHDF3	-0.018225
CCDC84	-0.018178
TMEM184B	-0.018174
BIRC2	-0.018149
PVRL2	-0.018142
COL4A3BP	-0.018103
SLBP	-0.018096
CSRNP1	-0.018087
DDR1	-0.018081
IQCE	-0.018073
TRAPPC6A	-0.018032
SPPL2A	-0.018018
SNHG19	-0.018016
ASL	-0.018007
SPIN4	-0.018000
WIPI1	-0.017994
CPNE2	-0.017968
IFI6	-0.017943
EBNA1BP2	0.017942
MRPS28	-0.017930
FHL2	0.017925
RPA3OS	-0.017866
PMVK	-0.017865
LONRF2	0.017852
RBL2	-0.017838
PTPN13	-0.017832
OR1A1	0.017822
NOB1	0.017816
MAP1LC3B	-0.017809
ODF1	0.017796
KLHDC9	-0.017796
KEAP1	-0.017788
CABLES2	-0.017740
LOC100130264	0.017729
DCXR	-0.017713
MT2A	-0.017707
ZBTB41	-0.017692
MT1F	-0.017692
CUL4B	-0.017689
SH3BGRL3	-0.017685
RHOC	-0.017683
DEPTOR	0.017682