!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!ligand_name	estrogen
!ligand_id	CHEBI:50114
!cell_type	beta null aorta
!organism	mouse
!end_metadata
GREM2	0.182956
ANO4	0.142530
MMD2	0.099735
CILP	0.097546
RAG1	-0.086789
GALNT15	0.084570
MYB	-0.079987
WIF1	-0.079603
HP	0.075213
MKI67	-0.073635
LRG1	0.071053
GPX3	0.070993
CASQ1	-0.070898
APLNR	-0.070652
TIPARP	0.070271
CISH	-0.069856
NNAT	0.069734
CAMK2B	0.069054
VLDLR	0.068810
FZD8	0.068432
SPP1	0.065428
HEPH	0.064751
ERRFI1	0.062906
DIO2	0.062122
MFSD2A	0.062014
THBS1	0.061946
TRIM10	0.060019
EMB	-0.058968
LAT	-0.057558
IGFBP6	0.057522
GHR	0.056559
GCLC	0.056445
TUBB1	-0.055957
SUSD2	-0.054847
SFRP2	-0.054846
TNMD	0.054814
SFRP4	0.053829
PLOD2	0.052757
MFAP4	-0.052586
DNTT	-0.051894
CLEC1B	-0.051661
LYVE1	0.051604
CYP2E1	-0.051596
SLC22A3	-0.051534
VWF	0.051296
CYP2B6	0.051288
RSAD2	0.050600
PON1	0.050507
CFD	0.049998
DLL1	0.049623
PAQR6	-0.048912
SLC10A6	0.048649
RETN	-0.046650
ARRDC2	0.046522
LGALS3BP	0.046408
COL1A1	-0.046263
STC1	0.045950
IGFBP2	-0.045455
PDGFRL	-0.045227
QPCT	-0.044677
ADH1C	0.044220
C1QTNF9B	-0.044028
SOST	-0.044011
BMP6	-0.043773
ANGPTL7	-0.043486
PAK3	0.043414
PTGER3	-0.043408
ZDHHC23	0.042521
IFIT1B	0.042336
MMP3	0.042312
ID4	-0.040603
FRZB	0.040583
FBXO31	0.040417
LCK	-0.040296
OMD	0.040217
NRIP1	0.040092
PTPRC	-0.040087
CORO1A	-0.039808
CA2	0.039701
CPN2	-0.039660
TPPP	-0.039649
USP18	0.039561
FMOD	-0.039533
HMGB2	-0.039406
MST4	-0.039130
VSTM4	-0.038798
ASPN	0.038474
RRM2	-0.038434
HSD11B1	0.038162
TGFBI	-0.037523
PLBD1	-0.037358
ISYNA1	0.037326
C10orf10	0.037229
BCL6	0.037151
CYGB	0.037066
ITGB8	0.037003
IRS2	0.036976
C3	0.036547
DPEP1	0.036520
DESI2	0.036260
FAM107A	0.036185
C1QTNF3	-0.036071
TUBB2B	-0.035943
CAP1	0.035887
PPP1R3B	-0.035859
TTC25	-0.035756
PLEK	-0.035727
EMCN	-0.035492
BMP2	0.035180
P2RY10	-0.035009
AR	0.035000
LPAR6	-0.034941
ITGA6	-0.034907
FABP5	-0.034899
CD274	-0.034746
TMEM117	-0.034678
GJA4	0.034572
STMN1	-0.034465
MYL7	0.034371
RGS5	-0.034338
INSIG1	-0.034330
RGS10	-0.034197
CA4	-0.034137
ID1	-0.034111
EMILIN2	0.034098
FBP2	-0.034048
RGS18	-0.033994
SLC4A1	0.033904
SREBF1	-0.033835
MYOCD	0.033792
APOD	0.033681
FAM46B	0.033652
ISG20	0.033627
CD163	0.033525
BCAN	0.033463
KCNK1	0.033352
WASF1	0.033301
SLC6A7	-0.033165
PYGL	-0.033068
CD3G	-0.033029
COL18A1	-0.033014
ITGA5	0.032861
FAM214A	0.032838
CTSE	0.032761
LCMT2	0.032749
KCNC4	-0.032642
TPPP3	-0.032586
CMBL	-0.032583
CRIM1	0.032509
HLA-DQA1	-0.032452
KCTD15	-0.032370
PRTN3	0.032181
MFAP5	-0.032124
TES	0.031832
IL2RG	-0.031810
IRF4	0.031610
LBP	0.031416
BCL11B	-0.031413
LEPREL1	0.031359
ID2	-0.031335
GRIA1	0.031153
DDIT4	0.031007
AGO2	0.030965
BTG2	0.030960
PARM1	-0.030928
ID3	-0.030859
HLA-DQB1	-0.030627
PANK3	0.030480
LRCH1	0.030476
CLEC10A	0.030100
PSPH	-0.030058
B3GNT9	-0.030016
SEPT4	-0.029824
ASPG	-0.029794
SBK1	-0.029690
MAP3K6	0.029627
GBP6	-0.029585
TUSC5	-0.029579
DNAJB1	0.029552
MMP17	-0.029427
GPAM	0.029348
GPSM2	-0.029333
AFF4	0.029282
MANBA	-0.029239
SATB1	-0.029147
RHOU	0.029066
SMIM5	-0.029035
MYL2	-0.029031
SCHIP1	0.029021
BNC2	0.028992
EZH2	-0.028931
CCRN4L	0.028834
WISP1	-0.028799
IDI1	-0.028731
IRS1	0.028487
SLC36A2	-0.028487
SPTA1	0.028482
ZFP3	-0.028452
IRF7	0.028435
DGAT2	-0.028334
LIMD2	-0.028023
CFH	0.028009
TMEM79	-0.028008
ENTPD4	-0.028005
HIST1H3C	0.027922
PDPN	0.027918
ENPEP	-0.027896
PM20D1	-0.027751
INMT	0.027619
KIAA1551	0.027590
ADM	0.027576
PM20D2	-0.027536
C16orf54	-0.027516
OGN	0.027495
FLRT2	0.027479
CD8B	-0.027412
KIAA1919	-0.027209
CD34	0.027123
DHRS3	-0.027079
C1QTNF2	-0.027062
TLE1	0.027058
PF4	-0.027040
IL33	0.026998
HSPA4	0.026991
SEMA3D	0.026961
RYBP	0.026916
SMOC1	0.026905
MEOX2	-0.026892
GMFG	-0.026884
TRABD2B	0.026759
GADD45A	0.026755
KLF15	0.026642
IGFBP3	-0.026641
HLA-DRB5	-0.026626
PRICKLE3	-0.026604
CHSY1	-0.026532
CLEC11A	-0.026474
FAM84A	-0.026472
ZMIZ1	0.026459
COL14A1	-0.026329
C11orf86	-0.026270
G6PD	0.026235
TSPAN13	-0.026213
TESK1	0.026166
FAM102B	0.026031
CEBPD	0.026011
GGA3	-0.025932
SNCG	0.025894
FAM124A	0.025815
RTP4	0.025771
LTBP2	-0.025627
PCOLCE2	-0.025525
SLC15A2	-0.025504
KLHL6	-0.025500
C1QA	0.025476
MICAL2	0.025398
TNFRSF12A	0.025350
FAM46C	0.025346
NFIL3	0.025261
FBF1	-0.025214
KANK4	-0.025068
SPNS2	0.025059
KCNH2	-0.025057
SSR3	0.025047
MYL1	-0.024937
SDC4	0.024932
PDLIM4	-0.024931
EZR	-0.024716
THY1	-0.024643
DAGLA	-0.024623
TRIOBP	0.024622
LANCL3	0.024586
TOP2A	-0.024544
RCAN1	0.024499
F3	-0.024490
TMEM161B	-0.024479
TNFAIP6	-0.024456
ISLR	-0.024448
SCN7A	0.024432
GALNT16	-0.024426
AQP1	-0.024398
ECHDC1	-0.024296
PALD1	-0.024286
ALDH16A1	0.024272
ATF3	0.024254
DNAJB14	0.024166
LIMD1	0.024154
BHLHB9	-0.024128
PPP1R36	-0.024100
ZBTB16	0.024088
NET1	0.024060
C1GALT1	0.024008
ITM2A	-0.024003
FYB	-0.023983
PMVK	-0.023933
ERAP1	-0.023909
MYLK2	-0.023897
ITGB2	-0.023866
NDRG1	0.023857
NR4A1	0.023843
ACOT11	-0.023832
RMND5B	0.023801
GIMAP4	-0.023787
UCHL1	-0.023709
FIBIN	0.023629
LGALS9B	0.023613
ECHDC2	-0.023570
CTGF	0.023470
TBC1D10C	-0.023465
ELOVL6	-0.023434
SEPT9	-0.023396
AACS	-0.023348
IGF1	-0.023285
FAM53B	-0.023169
KIAA1324L	-0.023165
CD8A	-0.023131
SWAP70	0.023124
CIDEA	-0.023110
SOCS2	0.023106
SERTAD4	-0.023049
MMP2	-0.023034
GIPC2	-0.023021
NPR1	0.023003
SLC25A42	0.022971
AFF3	0.022951
SLC7A5	0.022917
COMTD1	0.022884
KAZALD1	-0.022882
TMEM35	-0.022871
TSC22D3	0.022867
S100A8	-0.022867
HPGD	-0.022825
FXN	-0.022812
CCL11	0.022809
ACTC1	-0.022777
SRPK1	0.022686
GDA	0.022678
ADAMTSL2	0.022677
ANKRD9	0.022661
WSCD2	-0.022508
CCDC3	0.022468
FAM26E	0.022425
HEMK1	-0.022404
PRKAB1	-0.022359
ZC2HC1A	0.022341
C2orf40	-0.022328
HSPH1	0.022317
BLVRA	0.022300
TMEM86A	-0.022296
DCK	-0.022278
ADRB1	-0.022272
AKAP12	-0.022170
PDIA5	-0.022123
PPARGC1A	0.022056
BCL2	0.022011
SOX18	0.021949
C14orf37	0.021921
TMEM132A	-0.021880
SCARB1	-0.021864
KIF7	-0.021862
GAL3ST2	0.021822
LRP6	0.021799
CXXC5	-0.021757
ASB5	-0.021754
NDNF	0.021715
ATP2A3	0.021696
AMPD3	-0.021679
TSSC4	-0.021668
ATL2	0.021656
GEMIN4	0.021643
IRF1	-0.021639
MOG	-0.021633
AGFG2	-0.021596
FKBP10	-0.021542
PAMR1	-0.021537
EVA1A	0.021528
COL1A2	-0.021503
IFRD1	0.021468
TNC	-0.021428
SGK1	0.021405
CTR9	0.021333
LOXL1	-0.021261
TSPAN18	-0.021260
C1orf95	-0.021169
PLSCR4	0.021121
OPTC	-0.021066
ARRDC3	0.021023
NFKBIA	0.021011
KDELR3	-0.020943
ACSS2	-0.020937
COL3A1	-0.020912
TMEM182	-0.020910
DNAJB4	0.020891
CD300LG	-0.020871
NXPE4	-0.020869
PRRG3	-0.020784
CCNJ	-0.020777
MTFP1	-0.020743
JUNB	0.020695
SLC46A1	-0.020690
NPR2	0.020686
MAPKAPK3	-0.020679
FAM220A	0.020653
GPNMB	0.020643
PPP1R15A	0.020607
FGL2	-0.020604
ALDH1L2	-0.020585
PXDN	-0.020546
FXYD6	0.020533
HTRA4	0.020519
CRISPLD1	-0.020456
ADORA1	-0.020438
KIAA0101	-0.020435
FSTL1	-0.020433
GPX8	-0.020397
MYO1D	0.020349
C1QB	0.020307
KCNS3	0.020307
FBLN7	0.020300
MEF2C	0.020300
PPAP2B	0.020276
PDE7A	0.020264
P4HTM	-0.020259
ARHGDIB	-0.020251
PRR3	0.020204
TNK2	-0.020192
SCARB2	0.020187
POSTN	-0.020174
PODXL2	-0.020155
RGS4	-0.020108
PHRF1	0.020087
SLC8B1	0.020065
AGPAT2	-0.020048
FERMT3	-0.020046
FAM81A	0.020038
PPIC	-0.020035
MATN2	-0.020023
MTERF4	-0.019984
KRT18	-0.019938
C15orf41	0.019870
MME	-0.019867
CYP1B1	0.019851
NDEL1	0.019846
CCR9	-0.019844
CA5B	0.019837
CREB3L1	-0.019834
FXYD3	-0.019807
LEPR	0.019793
TMEM45B	0.019790
SLC27A2	-0.019783
ZNF496	0.019745
ZBTB21	0.019727
TMEM45A	0.019725
CACNB3	-0.019724
METTL7A	0.019712
PPA1	-0.019710
UBE2O	0.019700
LMO2	0.019692
GNG11	-0.019684
PDGFRA	0.019646
ZBED6	0.019611
PLCE1	-0.019533
C16orf74	-0.019475
KIAA0247	0.019474
ALDH1A2	0.019470
NAT8L	-0.019462
FSCN1	-0.019459
TMEM2	0.019420
LRCH2	-0.019376
SEMA3G	0.019362
SEC24B	0.019355
NIPAL2	0.019355
PYCR2	-0.019343
SLC25A16	-0.019288
RTN2	0.019252
NOXO1	0.019228
AMACR	-0.019209
TTC30B	-0.019203
GSK3B	0.019195
STAT5A	0.019171
BTBD2	-0.019159
FLNB	0.019152
NEGR1	-0.019150
ETS1	-0.019134
MRVI1	0.019133
GPRC5B	-0.019131
CHKA	0.019119
TMED1	0.019108
INPP1	-0.019105
HLX	-0.019095
MORN2	-0.019092
MMP11	-0.019086
MPC1	-0.019026
KIAA0430	0.019021
PDK1	-0.019017
DAAM1	0.019014
NAP1L5	-0.018961
LEPREL2	-0.018830
ST8SIA4	-0.018811
XDH	0.018797