!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	MLN4924
!smiles	C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
!pubchem_cid	73014187
!cell_type	A375 melanoma cell line - 8 Hours
!organism	human
!end_metadata
SLC26A2	-0.180479
TXNRD1	0.175703
HMOX1	0.149744
SRXN1	0.130209
NQO1	0.116121
FTL	0.108260
GCLM	0.103475
ERRFI1	-0.103111
HSPA1A	0.100987
SPRY2	-0.095081
SLC7A5	0.090590
SLC7A11	0.090130
GADD45A	0.088060
TUBA1A	-0.085485
SNAPC1	0.085097
WNT5A	0.082775
ID1	-0.082763
DDX21	0.081371
FTH1	0.080367
RPS14P3	-0.079978
NNMT	0.074766
PSAT1	0.073955
PFN1	-0.073837
NARS	0.073576
TSPAN13	-0.073293
PPIF	0.072959
UBB	-0.071865
SLMO2	-0.071586
UAP1	0.069423
FST	-0.069128
PTTG1IP	0.068910
CTGF	0.068684
GGCT	0.067627
SNHG1	0.067250
S100A4	-0.066655
NAA50	0.066024
GMNN	0.065205
S100A2	-0.065107
TRMT112	-0.065064
LDHA	0.064510
C20orf24	0.063761
ABHD17C	-0.063650
MTHFD2	0.062783
LINC00657	-0.062526
CAV1	0.062157
NACAP1	-0.061782
TRIM16	0.060752
CCND1	0.060751
CTSL	0.060124
GNE	-0.059838
PDLIM1	0.059810
XPOT	0.059687
GLA	0.059185
FLRT3	-0.059098
TGFA	-0.058739
GARS	0.058727
TIMP1	-0.058373
RRM2	0.058133
IARS	0.056933
AMOTL2	0.056770
PMAIP1	0.056314
SLC20A1	-0.055973
PRDX1	0.055968
PHLDA1	-0.054708
H1F0	-0.054518
ND6	0.054324
MANSC1	-0.054102
LINC01419	-0.053754
RPL27	-0.053321
DNTTIP2	0.050548
DYNLT3	-0.050087
CRY1	0.049126
YWHAZ	-0.049021
MARCKSL1	-0.048236
PLK2	0.048184
RRAGA	-0.047941
ZWINT	0.047847
SERPINA3	-0.047443
BNIP3	0.046782
POLE3	0.046495
SLBP	0.046427
ATF4	0.045729
MRPL3	0.045683
RPL41	0.045574
STK17A	0.045432
DTL	0.045321
FOS	-0.044704
ARL6IP5	-0.044659
DKK1	-0.044649
SELK	-0.044356
TNPO1	0.043366
SMAGP	0.043355
CYR61	0.043340
DKC1	0.042829
PLIN2	-0.042603
DPM1	-0.042453
TFRC	0.042276
MANF	-0.042116
DNAJB1	0.041843
HOXC6	-0.041188
WWTR1	-0.040211
SACS	0.039584
SNHG17	0.039368
SYTL5	-0.039366
MAGEA4	-0.039356
AGPAT9	-0.038943
ANXA1	-0.038766
CD63	-0.038373
HOXB2	0.038291
LGALS1	-0.037975
SNRPB2	-0.037647
FAM84B	-0.037641
FAT1	0.037638
SRP14	-0.036907
S100A11	-0.036874
KRT18	0.036710
IER5	0.036685
SMURF2	0.036561
RCN1	0.036446
RSL24D1	0.036364
MIA	-0.036351
NEAT1	-0.036342
DYNLL1	-0.036312
MAPK6	0.036249
EID1	-0.036194
GABARAP	-0.035921
RAD51AP1	0.035913
EMP3	-0.035873
ITM2B	-0.035679
SEPW1	-0.035632
ACTB	0.035544
INHBA	-0.035439
S100A16	-0.035347
RPA3	-0.035155
PGAM1	0.035049
RPS13	-0.034984
EIF3I	-0.034873
ANKRD1	0.034806
GBE1	0.034787
RPL7L1	0.034742
DDOST	-0.034624
YWHAG	0.034536
TMEM14A	-0.033902
MAT2A	0.033881
GLO1	0.033836
CETN3	-0.033765
EGR1	0.033753
METTL23	-0.033556
TMEM123	0.033476
COX8A	-0.033383
KTN1	0.033353
NPIPA1	0.033325
CHCHD4	0.033279
AKR1B1	0.033165
PRKAR1A	-0.033071
CLIC1	-0.032923
PXYLP1	-0.032676
IGFBP4	0.032632
PUS7	0.032590
EIF4A3	0.032479
PKD1P1	0.032425
SMNDC1	0.032326
TXN	0.032238
NDUFB9	0.032238
ATRAID	-0.032200
S100A6	-0.032083
BCCIP	0.032046
LBR	0.032036
EIF1	0.031948
NOP10	-0.031856
NEIL3	0.031738
PSMB4	-0.031727
BTG1	-0.031678
GNL3	0.031329
ATP6V0B	-0.031221
ZNF367	0.031000
BZW2	0.030913
IGF2BP3	0.030866
MOK	-0.030847
SH3BGRL3	-0.030835
FBXO30	0.030635
ADM	0.030566
ERBB3	-0.030536
TOMM20	0.030508
TRIB3	0.030497
ATP5E	-0.030442
SPCS1	-0.030309
DCTPP1	0.030244
CRIM1	0.030244
WBP11	0.029952
PRDX6	0.029881
CTNNAL1	0.029746
ITGB8	-0.029583
LASP1	0.029491
TMEM14B	-0.029448
GINS1	0.029407
CCT7	0.029373
TMSB10	0.029160
MTERF3	0.029118
CCDC86	0.028838
GSR	0.028817
IL17RD	0.028787
PCNA	0.028783
TMEM2	-0.028616
SRPX	-0.028599
EI24	0.028533
NDUFA1	-0.028532
STAU1	0.028494
CTPS1	0.028315
ASNS	0.028227
CCT6A	0.028226
ACTG1	0.028153
SRP9	-0.028143
CKS1B	0.028123
TMEM243	0.028033
EEF1B2	0.028015
PSMA1	0.028000
CTSC	-0.027950
HMGN2	-0.027883
PTBP1	0.027738
HLA-DRA	-0.027717
RNF145	-0.027698
RPL7	-0.027601
ETF1	0.027592
MEIS2	-0.027510
HSP90B1	-0.027468
BCAR3	-0.027326
EXO1	0.027240
ALDOA	0.027186
RAB10	0.027167
PTDSS1	0.027046
PEA15	0.027040
COX1	-0.027030
LINC01029	0.027007
TIMP3	-0.026981
EIF2S2	0.026969
PSMD14	0.026961
GPRC5A	-0.026922
MYL6	-0.026895
PARK7	-0.026880
DANCR	-0.026821
CCDC59	0.026741
MSN	0.026657
MLLT11	-0.026654
UQCRQ	-0.026651
TMEM230	-0.026635
RPL26	-0.026552
CTSB	0.026451
DIMT1	0.026432
AMIGO2	-0.026427
MRPS15	0.026361
SLC3A2	0.026320
SOD1	0.026292
SOX10	-0.026189
POP7	0.026080
NPTN	0.026065
NAE1	0.026005
NME1	0.025920
ERH	-0.025864
BTBD3	-0.025789
SH2B3	-0.025772
FBL	0.025762
WDR43	0.025757
PSMG2	0.025754
ALAS1	0.025719
RASSF8	-0.025694
HSPA9	0.025638
EPHA2	0.025548
MINPP1	-0.025472
HSPB1	-0.025342
FERMT1	0.025309
LAMC1	0.025242
DEGS1	0.025213
EIF3L	-0.025194
RBM3	-0.025066
LAPTM4A	-0.025048
ZFAS1	0.025045
TMX4	-0.025031
LARP1	0.024949
RRP1B	0.024838
ORMDL2	-0.024758
MARS	0.024667
DDX46	-0.024583
FEN1	0.024547
LOXL4	-0.024470
TMBIM4	-0.024313
NCL	0.024308
PSMD12	0.024291
PPARG	-0.024272
SKA2	-0.024217
KARS	0.024201
ASAP1	0.024166
KPNB1	0.024112
TATDN1	-0.024106
CMSS1	0.024101
ATP1B3	0.024092
RPS9	-0.024050
TIMM10	0.024005
RPS12	0.023961
UHRF1	0.023926
SLITRK6	-0.023918
TOMM5	0.023917
PTTG1	-0.023871
ANP32B	0.023858
ARCN1	0.023828
ANKRD50	-0.023825
RPS15	0.023811
HK2	0.023810
DNAJA2	0.023809
ID3	-0.023707
AHR	-0.023687
MORF4L2	-0.023664
SLC5A3	-0.023660
TRIM28	0.023619
CS	0.023608
EEF2	0.023584
INPP5F	-0.023577
MRPL49	0.023571
CHMP2A	-0.023513
SRP19	0.023460
PSMD10	-0.023310
SNHG7	0.023304
GNG5	-0.023295
YARS	0.023258
SGK1	-0.023229
PHB2	0.023159
SETD1B	0.023136
KIF20A	-0.023115
PITPNB	0.023102
S100A10	-0.023076
MAFF	0.023065
HAPLN1	-0.023004
MYL12B	-0.022954
TM9SF2	-0.022953
ITGA6	-0.022884
PHGDH	0.022782
ZFAND2A	0.022761
STARD7	0.022757
SF3A3	0.022754
EIF2A	0.022736
DLEU1	0.022707
USP1	0.022688
TCF7L2	-0.022660
PRKAG1	-0.022658
CTH	0.022599
EIF3J	0.022581
GSTP1	0.022538
DHX15	0.022533
KIAA0020	0.022494
SLC38A2	0.022410
E2F6	0.022384
CIRH1A	0.022317
MSH6	0.022265
BCAT1	0.022260
ANKRD27	0.022209
UBLCP1	-0.022095
PAIP2	-0.022094
TIMMDC1	-0.022039
C16orf52	-0.022002
GRPEL2	0.021925
DDX5	-0.021925
CDC6	0.021844
TM4SF1	0.021759
GEMIN5	0.021749
IRF2BPL	-0.021679
POP5	-0.021666
PSMB6	-0.021660
VDAC3	0.021644
TCERG1	0.021638
RAB13	-0.021619
BIRC2	0.021618
NOLC1	0.021594
SERINC1	-0.021570
SNX10	-0.021535
RPS29	0.021534
C1orf43	-0.021531
SLC38A1	0.021518
ATP6	0.021460
RCAN1	-0.021451
C12orf75	-0.021447
STUB1	-0.021440
HSBP1	-0.021387
HNRNPAB	0.021366
SUCO	-0.021345
COX3	0.021286
ISCU	0.021272
MXI1	0.021268
CDV3	0.021266
NRIP1	-0.021208
ZCCHC24	-0.021200
TUBB2A	0.021199
NOP56	0.021158
NDUFA5	-0.021132
NDRG1	0.021129
HSPA5	-0.021120
ESM1	0.021055
GPX1	-0.021027
S100A13	-0.021020
LPCAT1	0.021010
RACGAP1	0.020943
ARPC2	-0.020916
CSDE1	0.020904
CAPN2	0.020904
PDP1	-0.020838
ACSL3	-0.020833
HMMR	-0.020761
RPL8	0.020761
BUB1B	0.020754
MT1HL1	-0.020727
DARS	0.020654
TIPARP	-0.020631
HIF1A	0.020627
SACM1L	0.020564
C12orf29	0.020563
MIR21	0.020508
SCAND1	-0.020494
RAN	0.020348
PRKRIR	0.020311
CD96	-0.020310
COX16	-0.020273
LOC399491	0.020267
TMX2	0.020232
SLC25A46	-0.020212
AP3S1	0.020154
PSMD11	0.020136
SET	0.020098
HPCAL1	-0.020093
AFG3L2	0.020087
RRS1	0.020085
FAM83D	-0.020062
NDUFB5	-0.020058
TFAP2B	-0.019946
ENO1	0.019929
TSG101	-0.019918
TAF1D	0.019863
PNPT1	0.019836
GPI	0.019813
ZBTB38	-0.019804
UTP18	0.019801
POLR3K	0.019798
FABP5	0.019759
SNRPE	0.019758
RPS11	0.019750
VDAC2	0.019748
RCC2	0.019661
ENC1	-0.019661
RPS2	0.019657
KLF4	-0.019627
PRDX5	-0.019550
PLP1	-0.019538
MDM2	0.019513
UNG	0.019443
ME1	0.019384
CAPNS1	-0.019358
CDKN1B	-0.019344
TIPIN	0.019342
EIF4H	0.019256
IFRD2	0.019113
PA2G4	0.019113
DUSP14	0.019110
NUSAP1	0.019068
PSMA6	0.019054
POPDC3	0.019008
TES	0.019002
PNMA1	-0.019001
ISG20	-0.018944
RBBP8	0.018897
PTPLAD1	0.018880
EPS8	0.018788
LRP8	0.018773
PNRC2	-0.018740
COX5B	-0.018732
MRPS24	0.018701
TCEAL4	-0.018701
ADD3	-0.018689
TOP1	0.018656
COA6	0.018630
GULP1	-0.018608
EPDR1	0.018593
TYMS	0.018591
SNHG12	0.018573
WDR83OS	-0.018559
UBE2G1	0.018530
ART3	-0.018492
DNAJB4	0.018408
ILF2	0.018392
TARS	0.018378
CRELD2	-0.018372
NSUN2	0.018265
DNAJC2	0.018170
RPL23A	0.018147
NDUFA12	0.018141
AASDHPPT	-0.018131
KRTAP2-3	0.018120
PABPC4	0.018106
MRPL51	-0.018097
SPARC	-0.018094
MT2A	0.018080
ATXN10	-0.018061
CFAP20	0.017994