!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	NICKEL CHLORIDE
!smiles	Cl[Ni]Cl
!pubchem_cid	24385
!cell_type	H4-II-E-C3 LIVER-derived cell line - 40 uM
!organism	rat
!end_metadata
FABP1	-0.069765
BAAT	-0.062331
ATF3	0.061078
MAFF	0.051071
LMNB2	0.049351
ITIH4	-0.048732
GDF15	-0.046890
BCS1L	0.046610
TM4SF20	-0.046428
DIXDC1	-0.044943
PLA2G1B	0.044233
ANGPTL3	-0.042855
RAPGEF4	-0.042838
BNIP3	0.042400
HAO1	-0.042236
ERO1L	0.041234
KCTD15	0.040355
ITIH2	-0.040202
HMOX1	0.039529
TCEAL1	-0.039122
HMGCS2	-0.039010
TRIB3	0.038975
P4HA1	0.038559
LGALS2	-0.038146
TAP2	-0.037951
ZC3H6	0.037657
SLC7A11	0.037628
SULT1C2	0.037295
PFKFB1	-0.037205
ACKR4	-0.037173
SWI5	-0.036858
OLFML3	-0.036549
VTN	-0.036361
CYP7B1	0.035984
PDZK1	-0.035936
CCNG1	-0.035850
NDRG1	0.035778
WNT4	0.035623
SERPIND1	-0.035593
ZMYND10	-0.035348
PIK3C2G	-0.035141
PPIG	0.034980
EMP1	0.034865
THSD4	0.034670
DDIT4	0.034636
CCDC181	0.034390
ALDOB	-0.034302
DDIT3	0.034088
FRS3	0.033999
TAF15	-0.033872
ALOXE3	-0.033676
FGFBP3	0.033303
DDC	-0.033137
LYST	0.032548
AMPD3	0.032168
SOCS2	0.032089
SPPL2A	-0.032056
CHGA	-0.031863
TPRKB	-0.031760
MIA3	-0.031586
RGS7	-0.031302
FAM118A	0.030926
CLCNKB	-0.030795
ARHGEF2	0.030695
C9	-0.030621
PCYOX1	-0.030596
CASP4	0.030593
IL18	-0.030474
SLC12A6	0.030331
PKM	-0.030145
PDK1	0.029997
ACSS2	0.029871
SLC7A7	-0.029641
PIP5KL1	-0.029397
ANKRD44	-0.029349
SULT4A1	-0.029308
UCK2	0.029263
PLP1	0.029161
C5	-0.029102
KLF5	0.029038
ABCC4	0.029029
ME1	0.028978
DCAF12	0.028960
ZNF335	-0.028880
P2RY2	0.028780
FGA	-0.028706
GLIPR1	-0.028649
ZNF143	-0.028619
NAMPT	0.028399
PCDHB6	0.028389
PAX4	-0.028363
NFE2	0.028285
NDUFAF3	0.028149
AADAC	0.028103
FMN1	-0.028065
LRP5	-0.028027
FAM72A	0.027995
PLK2	-0.027939
RHOH	0.027844
ID2	-0.027831
ID1	0.027811
MFSD10	-0.027810
MSH3	-0.027777
SYT16	0.027729
AIDA	0.027642
APH1A	-0.027628
FGF21	-0.027573
BBS12	0.027570
FAM180A	-0.027549
RAD52	0.027545
RIOK3	0.027544
SUFU	0.027391
NFKBIE	0.027376
SPSB4	-0.027325
AKR1B10	0.027304
OCRL	0.027297
MUC13	-0.027241
PPIP5K1	0.027147
LCN2	0.027079
CA6	0.027009
ABCA4	-0.026956
KCNH1	-0.026956
DAPL1	-0.026868
ANKS4B	-0.026815
NQO1	0.026773
MORN5	-0.026750
IGFBP1	0.026701
SLC2A1	0.026664
S100PBP	0.026641
COL3A1	-0.026564
XPNPEP2	-0.026531
YIPF2	-0.026504
MUS81	0.026476
HSPA2	-0.026463
ZNF777	0.026435
SEPSECS	0.026409
PTGR1	0.026392
TCF19	-0.026390
RBM48	-0.026389
TAS2R1	-0.026332
EGLN3	0.026323
TVP23A	-0.026242
STBD1	0.026184
DIO2	-0.026156
CAMKMT	-0.026145
CRYGC	0.026127
EMILIN2	-0.025976
C11orf82	-0.025917
CIDEC	-0.025883
MMP11	0.025829
COL7A1	-0.025758
DSTYK	0.025738
GGT7	-0.025646
MAL2	-0.025616
CRYL1	0.025557
ST6GALNAC3	-0.025550
LCK	-0.025547
CSF1R	0.025493
UGCG	-0.025486
HES2	-0.025448
LDHA	0.025438
RLF	0.025437
PTGES2	0.025435
USP29	-0.025405
PIK3R3	-0.025380
SPATA13	-0.025371
FABP2	-0.025355
ANO1	-0.025278
JMJD8	-0.025203
SULT1B1	-0.025191
NAPB	0.025170
APBB3	-0.025128
MEX3B	0.025120
ARHGAP4	-0.024988
BCL2L15	0.024934
NR5A2	-0.024916
CDKN2B	-0.024908
TXNRD1	0.024892
DYNC2H1	0.024824
NDC80	-0.024793
SLC38A7	-0.024768
MIF	0.024761
MYH8	0.024744
CYSLTR1	-0.024724
GCNT1	0.024701
GLRX	-0.024674
HPD	-0.024670
ELMOD2	0.024650
DMKN	-0.024628
DUSP8	0.024608
VPS4A	0.024591
ONECUT2	0.024589
DHX9	-0.024584
TRIM17	-0.024521
ANKRD9	-0.024518
ALPK2	-0.024422
UMOD	-0.024411
PPP1R42	0.024395
LPXN	-0.024381
TGFBR1	0.024353
DNAAF1	0.024349
ZNF354B	0.024347
DYRK3	-0.024328
NACC1	-0.024318
SAP25	-0.024279
SH2D4A	0.024279
DMPK	-0.024220
ARHGEF16	-0.024217
C12orf68	-0.024164
UBXN8	-0.024161
NFATC1	0.024158
KNG1	-0.024125
CELSR3	-0.024109
APOBEC1	-0.024100
GTSE1	-0.024073
SELENBP1	0.024031
SPP2	-0.024018
PPAP2B	-0.023997
SLC6A14	0.023991
DET1	0.023946
SLC2A2	-0.023944
NPAS2	0.023881
CIDEB	-0.023874
ERBB2	0.023811
ABCC6	-0.023805
GSR	0.023774
PRSS21	-0.023696
ZNF629	0.023675
LOXL2	0.023668
TGFBRAP1	0.023629
NEU2	-0.023544
LAP3	-0.023529
GNMT	-0.023526
TAS2R16	0.023475
ST3GAL3	-0.023451
S1PR1	-0.023450
FKBP9	-0.023440
MYLK	-0.023439
TAF1B	0.023423
TRIM45	-0.023379
CTTNBP2	0.023307
PIDD	-0.023296
WFDC1	-0.023291
TPI1	0.023221
AOX1	0.023214
SLC23A3	0.023196
BBS1	0.023124
TTC12	-0.023048
PLCD1	0.023017
POC1B	-0.022982
GEM	0.022931
FAM198B	0.022907
LAPTM4A	-0.022872
FMR1	-0.022859
MAP2K6	-0.022824
HIST1H2BA	0.022777
GPS2	-0.022775
AP5S1	0.022772
PLA2G2D	-0.022750
TGFBI	0.022741
ADIPOR2	-0.022736
NDRG2	0.022732
NR1I3	-0.022682
GCLC	0.022667
TYRO3	0.022667
MPZL1	0.022654
TYW3	-0.022631
STK36	-0.022629
INPP5E	0.022611
MEF2B	-0.022535
HEXIM1	-0.022490
TNFRSF1B	0.022404
HPGDS	-0.022401
CPT1B	-0.022395
TOB1	-0.022386
CRYAB	-0.022382
CDCA8	0.022338
CTRC	-0.022319
SEC16B	-0.022295
THOC6	-0.022278
HDDC3	0.022276
UHRF1BP1	0.022275
TNC	-0.022274
TEX10	0.022265
SORBS2	-0.022182
VEGFA	0.022169
ZBTB39	0.022150
CXADR	-0.022139
FAM102B	-0.022131
GDPD1	-0.022119
CITED1	0.022099
RIMS3	-0.022090
ZNF778	0.022087
GOLGB1	0.022015
ABCG4	-0.021960
DCBLD2	0.021935
SELM	0.021933
IFI44	-0.021899
ADCK2	0.021895
ALDOA	0.021882
MAGEH1	0.021880
DLX5	-0.021865
PRF1	0.021844
TESC	0.021809
PLA2G10	-0.021806
UGDH	0.021800
N4BP2L1	0.021790
LPAR6	-0.021781
ZFP36	-0.021773
TRA2A	-0.021755
PIGO	0.021746
LHFPL3	0.021740
PTGFRN	-0.021734
ARHGEF26	-0.021732
LACTB	-0.021732
CHST10	-0.021726
ASAH2	0.021725
PGPEP1	-0.021723
CYTH1	-0.021718
ACYP2	0.021718
CNTN3	-0.021716
NUBPL	-0.021713
TCAIM	-0.021713
PPP1R17	-0.021694
DNAJB13	-0.021637
DUSP12	0.021561
PEX14	0.021553
CST6	0.021511
ARL14EP	-0.021490
BAMBI	0.021484
AHNAK	0.021441
HSD17B13	-0.021439
CYSLTR2	-0.021439
ZBTB9	-0.021427
ZHX2	-0.021422
TGM2	-0.021372
PIGR	-0.021317
SHC4	0.021313
SLAMF9	-0.021304
PDE5A	0.021252
NDNL2	-0.021236
JMJD6	0.021220
HSDL1	-0.021209
TTC30B	-0.021163
DUSP15	0.021125
PGAM2	-0.021083
FAM184A	0.021078
CLSTN3	-0.021066
STYXL1	0.021058
RGN	-0.021056
NAP1L2	0.021016
COQ3	0.021011
SCHIP1	0.020978
CRP	-0.020946
CACNB4	-0.020928
GBP2	0.020912
MFAP2	-0.020910
GGACT	-0.020907
C8B	-0.020899
RPS6KA5	-0.020896
VTCN1	0.020894
GDE1	0.020883
PGM2	0.020872
SLC10A3	-0.020870
WDR5B	-0.020869
KRT23	-0.020866
CLN6	-0.020857
EPS8L2	-0.020827
CXCR2	-0.020801
RAB40B	0.020789
CLN3	-0.020745
CHTF8	-0.020738
AKIRIN2	0.020729
IL2RB	-0.020719
ESYT3	-0.020671
KDM3A	0.020665
BPIFA2	-0.020603
KCNH3	-0.020601
CLCC1	0.020590
CCNA1	-0.020540
CPPED1	-0.020495
PAX9	0.020493
NKX2-3	0.020454
MEGF11	0.020452
GPR19	-0.020416
RUFY1	-0.020415
H1F0	0.020409
PPY	-0.020403
LOXL1	0.020401
TACC2	0.020382
MPZ	0.020379
MYOM2	-0.020369
RAB5C	-0.020352
RAB25	-0.020302
DOK3	-0.020294
CABYR	-0.020285
HYKK	0.020285
ITIH1	-0.020279
SLC38A9	0.020273
PLAG1	-0.020264
CPZ	-0.020261
SNCAIP	0.020243
POPDC3	0.020242
SRD5A2	0.020237
MMP7	0.020213
PDZD2	-0.020211
PIR	0.020187
ENKD1	0.020187
PLCB4	0.020159
GLRX3	-0.020143
DUSP26	0.020142
UNC13C	-0.020132
PAX1	0.020128
TMEM59L	-0.020105
TMEM52	0.020083
HSF2BP	0.020073
NUFIP2	-0.020055
MMP17	-0.020033
DFNB59	0.020031
OXTR	0.020028
TNFAIP8	-0.020026
TTLL7	-0.020015
MAP3K8	0.019998
MAP1A	-0.019967
GLUL	-0.019931
GDF9	-0.019917
FAM46B	-0.019882
BFSP2	0.019876
EIF2B3	0.019874
AARSD1	0.019862
PRKRIR	0.019856
LONP1	0.019825
GP2	0.019813
EML2	-0.019800
MTMR7	-0.019794
RABL3	-0.019777
CYBRD1	-0.019765
GALR1	-0.019759
ACRV1	-0.019744
CREM	-0.019708
BAK1	-0.019655
PIGH	-0.019611
SPICE1	0.019596
CLDN2	-0.019566
MEIS2	-0.019549
EFEMP1	0.019545
CNTNAP1	0.019537
LPHN2	0.019533
GHR	-0.019523
LIN28A	0.019523
TGFB3	-0.019512
ZNF846	-0.019509
PRSS45	0.019506
PEX10	-0.019497
ZNF518A	-0.019495
CACNG3	0.019492
MAP3K1	0.019491
PRDM11	-0.019490
ACBD5	-0.019473
CORO1A	-0.019461
DDX10	0.019447
BSND	0.019446
WBSCR28	-0.019437
ABCA1	-0.019431
FOXQ1	0.019408
SCNN1A	-0.019397
CRTC3	-0.019385
MORN1	-0.019376
GNPDA2	-0.019350
MBD5	0.019348
LRRC10	0.019347
NFE2L2	-0.019346
BPIFB2	-0.019337
FBXO15	-0.019336
SLC38A5	-0.019315
CCL4	-0.019287
TFCP2L1	-0.019262
EFHD1	-0.019242
HTATSF1	-0.019242
APLN	0.019237
CFP	-0.019212
PTK2B	-0.019208
ELMO3	-0.019135
KLF13	0.019134
CXCR3	-0.019131
PPP1R3C	0.019129
BBS9	-0.019115
FOXJ1	0.019108
VIP	-0.019096
FABP7	0.019086
SH3BGRL	-0.019067
TCERG1L	0.019059
TMEM196	0.019057
LEO1	-0.019051
FAM76B	0.019037
DCLRE1A	0.019025
CALML4	-0.018996
PDLIM1	0.018988
FAM129A	-0.018982
ZCCHC9	-0.018979