!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Heroin
!smiles	CC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C
!drugbank_id	DB01452
!pubchem_cid	5462328
!cell_type	striatum, day 24 withdrawal
!organism	mouse
!end_metadata
CSHL1	-0.432028
TTR	-0.297175
PRL	-0.295017
PMCH	0.226412
S100A5	-0.189033
NTN5	-0.129343
SLC17A7	-0.091965
NRN1	-0.088422
MYL4	-0.088415
FOS	0.083264
C8orf46	-0.082831
SOX18	-0.077812
ND6	0.075417
EGR2	0.073788
CDHR1	-0.072407
OMP	-0.071928
HBB	-0.069447
OXT	0.067501
CCK	-0.066639
FIG4	0.062967
HCRT	0.059211
CARTPT	0.058255
R3HDM2	-0.055915
C1QL2	0.054601
SLC12A5	0.054024
CCT5	0.053769
SPINK8	0.052975
GAL	0.050536
TMEM178A	-0.047574
CA4	-0.047365
ARC	0.046455
ECEL1	0.046002
C2orf40	-0.045918
PLIN4	-0.044571
CLDN5	-0.043083
NPTX1	-0.043066
TSR3	0.042572
ERBB2IP	-0.042534
NEUROD2	-0.041422
ALAS2	-0.041376
AVP	-0.040525
IPCEF1	-0.040162
STAC2	-0.039542
TCAP	-0.038631
STMN1	-0.038158
SUGT1	0.038099
GLUL	0.037919
GALNT9	-0.037767
TSPYL4	0.037753
TNNT1	-0.037437
STX1A	-0.037435
ACER2	-0.037294
JUNB	0.037226
CCL21	-0.036869
RASL11B	-0.036375
ELTD1	-0.036183
PCMTD2	-0.036164
TBR1	-0.036160
CPNE9	-0.035309
VPS4B	0.034852
ZIC1	0.034737
SLC25A4	0.034231
PTPRB	-0.034200
USMG5	0.034114
TH	-0.033857
DLK1	0.033831
FOXQ1	-0.033161
CNIH3	-0.033027
SPON1	0.032540
TSHZ3	-0.032453
KPNB1	-0.032381
NDUFB4	0.031920
EGR4	0.031908
FEZF2	-0.031715
MEDAG	-0.031570
NPPA	-0.031560
TEX40	-0.030780
IGSF1	0.030589
PTGES3	-0.029609
AGT	0.029499
XDH	-0.029272
H3F3C	0.029234
NRIP3	-0.029075
SOX17	-0.029045
SLC5A7	0.029008
ISL1	0.028795
TMIE	0.028678
BHLHE22	-0.028340
SCGN	-0.028298
SLC30A3	-0.028116
SLC30A4	0.028106
PDYN	0.028037
DGKK	0.027888
CTGF	-0.027880
TNNC1	-0.027867
PCP4	0.027625
NECAB3	-0.027545
MICU3	0.027462
CDC123	0.027443
SPARC	0.027416
MMRN2	-0.027128
NGB	0.027083
AQP1	-0.027045
FLT1	-0.026860
GATA2	-0.026830
C16orf80	0.026810
SOX2	0.026745
PHYHIPL	0.026595
GCLC	0.026496
VPS26B	-0.026473
ARHGAP33	0.026267
EAPP	0.026214
ESAM	-0.026188
GPX3	0.026149
TRIM59	-0.026092
ITIH3	0.025782
WFDC2	-0.025605
CRHBP	-0.025521
SLC6A3	-0.025474
COX2	-0.025125
H1F0	-0.024964
SERPINA9	0.024895
SELK	-0.024858
KCNE2	0.024855
VAPA	-0.024713
MXI1	0.024642
EDN1	-0.024562
MLIP	-0.024535
SOWAHB	-0.024397
IDI1	0.024227
OLFML2B	-0.024210
ST18	-0.024108
KIAA1462	-0.024057
NDUFB5	0.023949
CCDC3	-0.023757
TSPAN3	0.023733
VWF	-0.023700
CHRD	-0.023625
MYL9	-0.023596
ATP6	-0.023571
ZCCHC12	0.023514
VHL	-0.023201
HES5	0.023134
NR4A2	-0.023059
LIN7C	0.022867
STK32B	0.022834
ATP1B1	-0.022828
SPTSSA	-0.022755
CALB2	-0.022701
SWI5	0.022642
CPNE4	-0.022617
IMPA1	0.022553
FFAR3	0.022518
DNAJB4	0.022442
PSMD14	-0.022395
TEK	-0.022395
C17orf96	-0.022350
RASSF3	-0.022157
CHST8	-0.022129
NDUFB9	-0.022120
OTX1	-0.022081
DCTN1	-0.021970
CGA	-0.021841
PLTP	-0.021630
SEPT9	-0.021607
SLC3A2	0.021521
SLC2A1	-0.021507
MAF	-0.021370
TMEM108	-0.021326
RPRM	-0.021292
OLFM1	-0.021015
LRRC4C	0.021000
HS3ST2	-0.020994
DKK3	-0.020969
RNF115	0.020864
TXNRD1	0.020813
SATB1	-0.020735
OVOL2	-0.020702
FREM3	0.020676
GNB2L1	0.020595
PTGDS	0.020271
PAN3	0.020186
PMPCB	0.020071
FIBCD1	0.019954
TPPP	-0.019654
ERP44	0.019653
OTOP2	-0.019611
NFIX	-0.019588
ENPP2	-0.019585
CHRM3	-0.019555
SP7	-0.019549
PDLIM1	-0.019539
TNFRSF25	0.019522
LBP	-0.019506
ESYT3	0.019425
ACTA2	-0.019383
SYTL4	0.019288
CD93	-0.019229
IGSF21	-0.018939
HAPLN4	-0.018894
JDP2	-0.018889
CTSS	0.018853
CBLN1	-0.018765
LGALS3BP	0.018745
ARF4	0.018733
TMEM125	-0.018725
NCALD	-0.018554
TRHDE	-0.018551
ANO2	0.018522
IGFBP6	-0.018351
KLF2	-0.018341
PAICS	0.018313
REC8	0.018297
PRR7	0.018289
MRPL39	0.018289
COX7B	0.018095
KRT14	-0.018061
FDX1L	0.017919
APCDD1	-0.017840
NDUFC2	0.017797
LINGO1	-0.017761
GATM	0.017701
LHFP	-0.017682
HOMER2	-0.017678
NLGN1	0.017632
RGS14	0.017607
DKKL1	-0.017525
PRPF38B	0.017515
TMEM204	-0.017510
RXFP3	0.017454
HEPACAM	-0.017396
ISG15	0.017377
LZTS3	0.017346
GPR6	0.017308
IDO1	0.017294
PAM	0.017274
TBC1D8	0.017251
RWDD2B	0.017195
ISLR2	-0.017116
PLEKHA2	-0.017096
CLTA	0.017088
HSPB3	-0.017063
CCKBR	-0.017056
PRSS35	-0.016954
ZFAND1	0.016913
ZNF687	0.016792
SEL1L3	-0.016765
KLHL40	-0.016741
FAIM3	-0.016732
FMN1	-0.016663
GJA4	-0.016627
SLC18A3	0.016572
CXCL12	-0.016557
ADAMTS19	-0.016548
ARHGAP15	-0.016543
GABRA1	0.016533
EMX1	-0.016528
DUSP1	0.016517
CYFIP2	-0.016504
NUDCD2	-0.016500
YWHAZ	0.016389
ATP5A1	-0.016387
PVALB	-0.016369
LRG1	-0.016329
LY6E	-0.016283
KCNAB3	-0.016247
IGF2	-0.016194
ATRNL1	-0.016153
IL22RA1	0.016133
MS4A15	-0.016092
ST8SIA5	-0.016078
TUBA1A	-0.016029
DIO2	0.016014
MYRIP	-0.015993
RAMP2	-0.015949
CHMP5	-0.015933
CALML4	-0.015891
TRIM37	-0.015871
TUBA8	-0.015839
LPAR1	-0.015783
COL24A1	-0.015729
RASL10A	-0.015696
HPD	0.015695
ACTB	0.015622
GNA12	-0.015608
CLIC6	0.015605
RGMA	-0.015589
ARHGAP5	0.015586
SARNP	0.015580
PAMR1	-0.015548
KCNA5	0.015543
PRSS12	-0.015509
SERPINI1	-0.015507
PAK1	-0.015507
LCT	-0.015503
ENG	-0.015491
CRH	0.015480
ASB11	0.015459
INMT	0.015457
MKX	-0.015416
RFNG	-0.015416
PLIN2	0.015381
GFAP	-0.015373
GPR149	0.015355
ACTR6	0.015352
CYCS	0.015348
ENC1	-0.015314
UBE2Z	0.015313
CCL5	0.015311
FZD2	0.015304
PER2	0.015253
OTX2	0.015238
TBL3	0.015237
NOSTRIN	-0.015231
CPSF3	0.015224
ALOX12B	-0.015213
DDX3X	0.015170
CADPS2	-0.015162
PLS3	-0.015156
SNX7	-0.015129
HSP90AA1	0.015127
GLTSCR2	-0.015124
HNRNPU	0.015096
DIO3	0.015092
MRGPRG	0.015086
IGFBP2	-0.015076
DEF6	0.015068
DUSP14	0.015060
TRH	-0.015057
USP10	0.015046
RAD21	0.015032
PRLR	0.015011
TANC1	-0.015006
MPPED1	-0.014995
IGFN1	-0.014969
OCM	0.014950
PECR	0.014945
LGR5	-0.014897
ISCA2	0.014868
DDB1	-0.014854
GCA	-0.014839
TRPC7	0.014829
ARL4D	0.014818
LRP1	0.014731
SORBS3	-0.014729
SNCG	0.014665
RARB	0.014664
NECAB1	0.014661
SH3D19	0.014642
C10orf54	-0.014614
STARD8	-0.014574
BCAS2	-0.014551
TRAF7	0.014545
PIDD	-0.014544
FHIT	-0.014544
PRICKLE1	-0.014535
PCNA	0.014532
UTP15	0.014528
SLAIN1	-0.014524
RAB39B	0.014517
ADCY4	-0.014496
TBX1	-0.014464
PENK	0.014442
DAPK2	-0.014410
TSPAN13	0.014392
SLC37A4	0.014355
RGS5	-0.014345
SYT17	0.014281
NXPH4	-0.014281
SEC11C	-0.014281
S100A9	-0.014271
PGLYRP1	-0.014254
PLSCR3	-0.014244
STEAP1	0.014237
FRZB	-0.014236
SYT13	-0.014218
ITM2A	-0.014206
LANCL3	0.014193
RESP18	0.014190
DRD1	0.014160
IER5L	0.014140
SLIT1	-0.014125
DND1	0.014118
MYLK	-0.014101
SLC26A4	-0.014089
COL5A1	-0.014069
IRS2	0.014068
SLC24A1	0.014065
OTOF	0.014061
SCX	0.014053
KCNMB4	-0.014046
TBX21	-0.014042
UBE2QL1	-0.014027
PIM2	0.013970
SPP1	0.013935
ARHGEF19	-0.013916
NDUFAF5	0.013897
TBC1D21	0.013879
OSBPL5	-0.013872
GRP	0.013868
HKDC1	-0.013862
KTI12	0.013855
HEXB	0.013822
EHHADH	-0.013763
SLC25A25	0.013758
TRHR	0.013752
MAL	-0.013744
ICAM2	-0.013708
DLGAP1	-0.013704
LTBP4	-0.013677
KCNC4	-0.013642
OPTC	-0.013632
RELL1	-0.013630
ACTR8	0.013620
KCNN4	-0.013615
RER1	0.013603
GARNL3	-0.013559
TOP2B	0.013559
NONO	0.013515
HIST1H2AB	0.013511
RGS9	0.013492
SLC10A4	0.013490
VASN	-0.013474
ANKRD46	-0.013455
JMJD1C	0.013447
LHX8	0.013440
C2	0.013425
FXYD5	-0.013358
MAGEE2	0.013339
FHAD1	-0.013303
TPBG	-0.013279
TIE1	-0.013279
HAP1	0.013241
TBPL1	0.013229
PGAM1	0.013220
AGPAT3	-0.013219
HLA-DQB1	-0.013216
SLC22A3	0.013210
R3HDM4	-0.013202
PER1	0.013174
CAV1	-0.013172
CIART	0.013153
SLC39A10	-0.013132
EIF5A2	0.013130
DYNLT3	-0.013119
SRP72	0.013112
ALCAM	0.013092
MOBP	-0.013054
CCDC109B	-0.013053
NRARP	0.013026
PSMA6	0.013021
GPR21	-0.013004
RMI1	0.013003
CD74	-0.012984
FAM196B	0.012978
DPF2	0.012946
IGFBP5	-0.012936
THRA	0.012922
SMU1	0.012896
SEMA4C	-0.012888
CLEC3B	0.012884
NDRG1	-0.012879
ST6GALNAC2	-0.012875
HNRNPA2B1	0.012863
CDC42SE2	0.012825
RSPO3	-0.012816
AMD1	0.012807
PDAP1	0.012806
NAP1L3	-0.012785
PECAM1	-0.012771
HOXA6	0.012762
ACY3	-0.012749
MYO1F	-0.012741
VIP	-0.012722
NGFR	0.012716
ATP2A3	-0.012699
TPRN	-0.012693
WNT10A	-0.012691
TSPAN17	-0.012654
FLVCR2	-0.012645
PAIP2	-0.012639
LTV1	-0.012637
PICALM	-0.012632
MEX3D	-0.012631
KLHL2	0.012628
SH3GLB1	0.012621
PSCA	0.012579
HDAC7	-0.012562
DCT	-0.012551
WFDC1	-0.012545
MRPL13	0.012537
LEPREL4	-0.012520
TF	-0.012512
FOSB	0.012512
ATP13A5	-0.012500
UCP1	0.012491
CAMSAP3	0.012478
EVPL	0.012459
PCNP	0.012437
OPALIN	-0.012426