!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	estradiol
!ligand_id	CHEBI:23965
!cell_type	MCF-7 cells
!organism	human
!end_metadata
KCNK5	0.125597
FOS	0.119123
LINC00341	0.116414
RASGRP1	0.115454
HOXC6	0.114434
MN1	0.111389
TMPRSS3	0.109691
P2RY2	0.098355
FST	0.095676
SGK1	0.094075
FOXC1	0.093479
TNFRSF11B	-0.092347
PLAC1	0.091874
MYBL1	0.091808
HOXC4	0.087690
ARID5B	-0.087043
EGR3	0.085175
CYP26A1	0.083140
EPB41L3	0.079986
PDZK1	0.078508
TIPARP	0.077871
SIAH2	0.077299
SAG	0.075116
HOXC5	0.074799
SERPINB9	0.074731
KRT13	0.074274
IGFBP4	0.073860
PGR	0.072933
STC2	0.072596
RNF43	-0.072106
CEMIP	0.071182
BIRC3	0.071044
TSKU	0.069406
C8orf4	-0.068139
SEMA3G	0.067047
FILIP1L	-0.064561
NPY1R	0.064447
PFKFB3	0.063816
DKK1	-0.063793
KIAA0226L	0.063663
ID3	-0.063579
SLC22A5	0.063285
MAP6D1	0.062682
CBFA2T3	0.062672
WNT4	0.062069
VWF	0.061384
HCAR3	-0.061311
ID1	-0.060571
ABCG2	0.060503
PDP1	-0.059757
PRSS23	0.058425
SYBU	0.056953
GAB2	0.056749
FZD7	0.056684
TGFB2	-0.056033
GCNT1	-0.055902
BCL11B	0.055835
PTPRE	0.055655
ASB13	0.055251
HEG1	0.055228
WNT5B	0.055197
REEP1	0.054923
CCNG2	-0.054870
EGLN3	-0.054717
CA12	0.054588
CXCL12	0.054502
ELOVL2	0.054352
NRIP1	0.054290
PTGES	0.054203
FAM13A	-0.054164
RHOBTB1	0.053065
BCL6	0.052424
MMD	-0.052042
PPP1R3C	-0.051869
CREB5	-0.051859
SLC16A6	0.051564
EFNA1	-0.050643
ARHGAP32	-0.050241
PMAIP1	0.050238
LMO3	-0.049493
PLAT	0.049198
SEC14L2	0.049188
OLFML2A	0.048589
VEGFC	-0.048129
GATA3	-0.048053
GEM	0.048028
RCL1	0.047705
RET	0.047684
NR5A2	0.047416
MAMLD1	0.047093
RARA	0.046983
SMAD7	0.046874
MICB	0.046861
GRAMD3	-0.046625
HSPB8	0.046491
PITX1	0.046323
IL17RB	0.045989
SESN1	-0.045258
OLFML3	0.045148
HOXC10	0.044959
FADS1	0.044379
FAM63A	0.044184
RGCC	-0.044140
ZNF552	0.044081
ABTB2	0.043943
TBX3	-0.043785
TFF1	0.043586
BCOR	-0.043524
GREB1	0.043522
TRIM36	-0.043487
CASP7	0.043391
MYC	0.042948
ARL4A	-0.042898
RAB20	-0.042687
GFOD1	0.042366
CYR61	0.042332
ARMCX6	0.042283
CDO1	-0.041991
TSPAN5	0.041746
OPN3	0.041726
ENC1	-0.041682
C14orf132	0.041638
CLDN1	-0.041459
RND1	-0.041425
HILPDA	-0.041327
JADE1	0.041208
VLDLR	0.041101
HIVEP2	-0.041079
RWDD2A	-0.040990
ARHGEF26	0.040950
FHL2	0.040830
GPR87	-0.040447
GAS1	-0.040375
CCDC88C	0.039996
JARID2	0.039745
LRIG1	0.039529
KAZN	0.039176
MTCL1	-0.039047
BLNK	-0.038789
C10orf2	0.038148
RHOBTB3	0.037998
MSMB	0.037992
TNFAIP8	-0.037966
IFIT2	-0.037624
PLA2G16	0.037460
WWC1	0.037083
NAV2	0.037024
PEX11A	0.036755
MPPED2	0.036657
HIVEP1	-0.036625
TCF7L1	0.036360
FAM110B	-0.036328
KLHL21	0.036254
CSRNP2	-0.036076
RASL11B	-0.036055
SMOX	0.035919
NMRK1	0.035781
MAF	0.035730
PAX9	0.035711
CDC42EP1	0.035585
PIK3IP1	-0.035475
URB2	0.035384
SNX24	0.035306
DDX10	0.035125
NCF2	0.035014
TRIB1	-0.034953
DAB2	0.034765
CXCR4	-0.034716
EN2	0.034626
FAIM3	0.034412
RPRM	-0.034390
FJX1	0.034358
ITGB6	-0.034289
RPS6KA2	0.034122
SEMA4C	-0.033990
EFNA4	-0.033879
SH3TC1	0.033690
KLF4	0.033609
CAV1	0.033511
IRX5	-0.033467
ADRB1	0.033357
SLK	0.033265
KITLG	-0.033144
AMIGO2	-0.033136
SLC17A5	-0.032841
SWAP70	-0.032813
ADCY9	0.032749
INHBB	0.032635
HHEX	-0.032609
ANKRD2	0.032577
CCND1	0.032365
ID2	-0.032328
FCGR2B	0.032309
GADD45G	0.032299
GNAI1	-0.032164
SLC7A5	0.032069
CYP1B1	0.032037
RAB31	0.031959
DDIT4	-0.031946
TLN2	0.031901
SLC25A24	0.031798
PODXL	0.031745
PLEKHF2	-0.031730
ARMCX3	0.031718
HK2	0.031671
CTGF	-0.031617
KLF5	-0.031501
SOX3	0.031498
ARHGAP12	-0.031426
SLC26A2	0.031422
E2F6	0.031391
CHST8	0.031306
RND3	-0.031287
NEDD9	-0.031041
DAPK2	0.030865
MREG	0.030864
ANXA1	-0.030827
DHRS3	0.030801
EDN2	0.030787
SOS1	0.030766
ELF1	0.030762
C3orf52	-0.030600
MAP3K1	0.030508
ZBTB10	-0.030313
STK38L	-0.030283
TGIF2	0.030190
DNMBP	0.030120
DUSP10	-0.030103
SOX4	-0.029920
GADD45B	0.029726
FAM189A2	0.029570
UPF1	0.029481
CHSY1	0.029372
SLC19A2	0.029332
AEN	0.029285
MYLK	0.029231
PALMD	-0.029043
GADD45A	-0.028984
OSTF1	0.028914
GATA6	0.028857
DSE	-0.028822
MED13L	0.028778
DLX2	-0.028684
TBKBP1	0.028631
ZNF107	0.028525
SLC22A4	0.028368
PIM1	0.028126
PPRC1	0.028107
SPSB1	0.027999
DIXDC1	-0.027918
ARHGEF10L	0.027907
C3	0.027536
SERTAD3	-0.027411
FAM102A	0.027234
BTG2	-0.027196
FAS	-0.027190
TPD52L1	0.027151
CRKL	0.027058
RIC8B	-0.027012
RAB9A	-0.026877
DHRS2	0.026862
PARD6B	0.026814
AMMECR1	0.026752
MYB	0.026736
DEPTOR	0.026709
BHLHE41	0.026668
CDKN1B	-0.026662
CCNE2	-0.026624
SH3BP4	-0.026604
TLR5	0.026534
FKBP4	0.026526
MAFF	0.026363
NT5DC3	0.026346
VAV3	-0.026270
MEIS1	0.026257
PDLIM3	0.026231
TM4SF1	-0.026179
FGD6	0.026106
SAMD4A	-0.026067
LPIN2	-0.026060
SLC9A3R1	0.026007
PIK3R3	-0.025984
UNC119	0.025972
FAM216A	0.025787
ZNHIT6	0.025715
SPRY1	-0.025688
CRISPLD2	0.025604
ENPP2	0.025547
HOXC11	0.025439
AKAP1	0.025321
CLCF1	-0.025280
MMRN2	0.025271
TAZ	0.025260
C4orf19	0.025257
TFF2	0.025147
ACTG2	-0.025124
CCDC86	0.025091
DHCR7	0.025049
FZD2	-0.025027
USP36	0.025014
KDM6A	-0.025011
TBX2	0.024966
TRIB2	-0.024914
MYO1E	-0.024847
SBNO2	0.024775
RASL10A	0.024737
MAX	0.024726
IFIT3	-0.024702
CISH	0.024690
ANXA9	0.024671
RNF39	-0.024651
KDM4B	0.024524
WEE1	-0.024494
PLK2	-0.024488
TUBA3D	0.024478
C1orf109	0.024473
HLA-DRB1	0.024437
ACE2	-0.024432
ZNF184	-0.024380
IRS2	0.024379
HEY1	-0.024368
JAK2	0.024347
TWF2	0.024274
BIK	-0.024205
FBN2	-0.024163
ST3GAL5	0.023970
NKX2-2	-0.023940
KCNN2	-0.023810
C9orf91	0.023796
SHB	0.023766
WFS1	0.023765
PPP1R12A	-0.023738
PARP8	-0.023627
DIO1	0.023627
PSTPIP2	0.023613
TMEM104	0.023606
GMPR	-0.023603
HEY2	0.023587
RNF144A	0.023577
RGS16	0.023571
LRP5L	0.023551
MARK1	-0.023449
FAM134B	0.023427
LOXL1	0.023418
CDK17	-0.023399
OGFOD1	0.023345
COA7	0.023296
SYTL2	-0.023294
DNAJB9	0.023292
ERF	-0.023274
PRUNE	0.023214
LMO4	-0.023169
C12orf5	-0.023137
PPIF	0.023077
OR7E14P	0.023013
GPR126	-0.022960
CHD1	-0.022911
GRHL2	0.022909
METTL21B	0.022895
LYPD1	0.022780
IL24	0.022748
GRB14	-0.022631
CALD1	-0.022627
ZNF750	-0.022622
ACVR1	-0.022613
TFAP2A	-0.022602
CXADR	-0.022585
PAWR	-0.022495
GEMIN4	0.022466
SIX1	-0.022462
CCDC68	0.022449
CEBPD	-0.022431
C21orf91	-0.022356
LIMK2	-0.022330
TRAF5	-0.022162
NXT1	0.022107
TSC22D1	-0.022061
TPBG	0.022048
POP1	0.022020
MKNK2	-0.022011
ZNF217	-0.021951
ZNF324	0.021909
SOX9	-0.021879
SACS	0.021871
MARCH3	0.021861
MCF2L-AS1	0.021858
CITED1	0.021817
TRIB3	-0.021788
AREG	0.021744
PLS1	-0.021672
GNE	-0.021488
LINC00472	-0.021398
NFRKB	-0.021364
PLEKHO1	-0.021306
DUSP5	-0.021235
BATF	0.021202
WWTR1	-0.021195
RAI14	0.021138
ZNF239	0.021066
PLEKHO2	0.020977
ZDHHC7	-0.020965
KLF6	-0.020933
ZCCHC24	-0.020863
DDX58	-0.020800
TOB2	-0.020718
HCRP1	-0.020628
PDGFRL	0.020606
CYP4F11	0.020579
DLEU1	0.020563
CCSER2	-0.020449
MID1IP1	-0.020444
F2RL1	-0.020410
TOE1	0.020404
MED24	0.020372
ATP2B1	-0.020342
PPP1R15A	-0.020318
MOCS3	0.020299
TRIM45	-0.020220
XYLT1	0.020210
CHML	0.020173
MPZL2	-0.020126
SFMBT1	0.020124
KIAA0922	-0.020118
PPAN	0.020110
PIGA	-0.020084
BRWD1	-0.020060
POLR1C	0.020040
RAB30	0.020001
JUNB	-0.019994
CYP27B1	0.019986
COBLL1	-0.019952
ACVR2A	-0.019938
LIMA1	-0.019864
MDN1	0.019852
RAB33B	-0.019708
CCL2	0.019638
PNRC1	-0.019621
ARHGEF18	0.019579
GPC1	0.019570
ABHD2	0.019560
CASP8AP2	-0.019542
ZNF185	0.019484
KDM6B	-0.019346
REL	-0.019285
HERC5	0.019229
KAT6B	0.019222
CXCL8	0.019208
EPHB3	0.019203
ITGB8	-0.019121
NIP7	0.019070
KIAA0040	0.019054
IRF6	-0.019022
GBP1	-0.019009
VEGFA	0.018999
CLDN9	-0.018966
PTGER4	-0.018908
RGL1	-0.018875
TGFBI	-0.018870
IER2	-0.018826
SOCS1	0.018818
TDRD1	0.018815
RAB40C	0.018795
NR4A2	0.018746
AXIN1	0.018728
IFNGR1	-0.018716
JADE3	-0.018709
TMEM140	-0.018675
KCNF1	0.018618
RSRP1	-0.018555
SSFA2	-0.018506
CR2	0.018442
MPP5	-0.018440
FERMT2	-0.018405
ID4	-0.018387
FLVCR2	0.018333
TRIM38	-0.018329
EIF2AK3	-0.018327
CEBPB	0.018311
POLR1B	0.018300
SH2B2	0.018293
HOXC13	0.018275
INTS6	-0.018274
PGBD5	0.018261
FAM69A	-0.018228
PUS1	0.018222
CHAC1	0.018192
WDR74	0.018191
SLC2A1	0.018125
CD3EAP	0.018093
MIR22HG	-0.018089
ENDOD1	0.018043
CHST11	0.018038
ZNF280D	-0.018014
HOMER2	0.018007
RBBP8	0.017996
ZMIZ1	0.017960
ARHGEF2	-0.017930
TGIF1	-0.017916
CLDN4	-0.017895
TUBGCP3	0.017894