!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	MLN4924
!smiles	C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
!pubchem_cid	73014187
!cell_type	A375 melanoma cell line - 2 Hours
!organism	human
!end_metadata
UBC	-0.386869
HMOX1	0.226365
CTGF	0.159717
TXNRD1	0.157861
UBB	-0.147873
PRDX1	0.128542
COX1	-0.126515
FTL	0.123535
DUSP6	0.119798
IER3	-0.115947
SGK1	0.098623
FTH1P5	0.095608
PCNA	0.093998
MIR21	0.093609
S100A11	-0.092776
SRXN1	0.091140
ERRFI1	0.085980
SLC26A2	-0.085453
GCLM	0.084935
NQO1	0.080938
SLC7A11	0.080735
PMAIP1	0.080490
LGALS1	-0.078770
COX2	-0.075136
CEBPB	0.072498
HSPA8	0.071972
SLC20A1	-0.070331
DPM1	0.068772
SERPINA3	-0.066033
ORC6	0.065952
SPRY2	-0.063729
ND2	-0.063659
HSP90AB1	0.061749
RPS29	-0.060975
GARS	0.060435
EEF2	-0.060199
MT2A	-0.060055
FTH1	0.058985
DKK1	-0.057956
HSPA1A	0.055139
HLA-DRB1	0.054216
PSMA1	0.052966
OVOS2	0.052059
DUSP4	0.051782
PSAT1	0.051498
UBE2C	0.051383
FBXO30	0.051354
ID1	-0.051244
FAM96B	-0.051028
RPLP0	0.050903
PTGES3	0.050506
TRIM16	0.050456
RPS26	-0.049002
ID3	-0.048452
DANCR	-0.048234
TIPARP	-0.048063
HOXB2	0.047993
CFL1	-0.047956
PPP1CC	0.047769
DEK	0.047742
ATOX1	0.047671
NOP58	0.047652
TPT1	-0.047356
RRM2	0.046828
USMG5	-0.046550
PKD1P1	-0.046057
ATF4	0.044814
CAV1	0.044778
KPNA2	0.044722
SLBP	0.044557
UBE2E3	0.044548
DDIT4	0.044342
UHRF1	0.044026
IGF2BP3	0.043963
MRPS24	-0.043872
SNRPB2	0.043221
HINT1	0.041932
IER2	-0.041890
HMGN2	0.041827
KARS	-0.041821
RPL41	0.041787
FEN1	0.041521
MAT2A	0.041188
NAA50	0.041023
SUMO2	0.040910
LAMTOR5	-0.040605
TRIM28	-0.040559
PRNP	0.039827
KRT18	-0.039612
GGH	0.038807
ACTN4	-0.038723
MDH2	0.038634
PPIB	-0.038498
RPS2	0.038392
LDHA	0.038315
NEAT1	-0.037725
AMIGO2	0.037584
H2AFZ	-0.037485
PSMB3	-0.037373
PPA1	0.037182
RAB1B	-0.036815
CHCHD2	-0.036704
SNX5	0.036535
SH3BGRL3	-0.036331
BAG3	0.036165
CXCL1	0.036038
SDCBP	0.035390
TMEM258	-0.035376
CXCL8	0.034828
RPL36	0.034757
MAGEA3	0.034731
MT1HL1	0.034667
SLC25A3	0.034385
DYNLT3	-0.033911
H1F0	-0.033683
STK17A	0.033647
NARS	0.033583
SNHG5	-0.033547
USP1	0.033417
CPOX	0.033392
MLLT11	0.033377
WDR82	0.033043
ERH	0.032976
RPL30	0.032970
SLC25A6	-0.032965
RPS17	0.032892
RPL7L1	-0.032805
CD63	-0.032651
MAGEA12	0.032359
RARS	-0.032342
CDK1	0.032184
DDB1	-0.031891
HHEX	0.031865
RPL8	0.031843
MAPK6	0.031811
RCC2	-0.031555
UHRF2	0.031419
ENOPH1	0.031331
HYOU1	-0.031209
INHBA	-0.030924
MAGOH	0.030860
PTDSS1	-0.030645
RPL3	0.030599
SOX10	-0.030585
RPS13	0.030479
NSUN2	0.030419
NOP10	0.030193
PSMA6	0.030145
SLC38A2	0.030110
PKM	-0.030076
ZNF367	0.030007
HSPA5	0.029918
PABPC3	0.029890
RPS25	0.029885
NPTN	0.029772
S100A10	0.029583
MRPS30	0.029419
C12orf75	0.029340
IRS2	-0.029313
CDC25B	-0.029209
LBR	0.029022
PARK7	-0.028760
PFN1	-0.028730
KIF11	0.028523
SRP14	0.028318
AKR1B1	0.028285
COX7C	0.028246
IFITM3	-0.028189
EIF3H	-0.028109
NCL	0.027965
SRSF9	-0.027965
WNT5A	0.027964
ALYREF	0.027943
ADRM1	-0.027686
RPL6	-0.027439
HIST1H4C	-0.027162
GABARAP	-0.027130
ADM	0.027060
NUF2	0.027042
POPDC3	0.027032
TXN	0.026978
SMNDC1	0.026792
ZNF217	0.026766
SMURF2	0.026742
HLA-DRA	0.026735
MTHFD2	0.026360
FKBP1A	-0.026256
TMX2	-0.026256
TOMM20	0.026251
EIF1	0.026064
PRIM1	0.026027
GADD45A	0.025901
HMGN3	-0.025877
SSR4	-0.025792
ATP5E	-0.025723
CCNB1	0.025644
SNRPE	-0.025617
MAGEA6	0.025515
NACAP1	0.025285
DUT	0.025209
MANF	-0.025040
PSMB4	-0.025027
GDI2	0.024908
RND3	0.024762
HERPUD1	0.024728
GRPEL1	0.024504
RAP1B	-0.024473
COX7A2	-0.024446
RAN	0.024387
TBK1	0.024347
ATP6V0B	-0.024307
USP53	0.024297
DYNLL1	-0.024111
CDC37	-0.024054
KRTAP2-3	0.024039
COX3	-0.023947
TM4SF1	0.023932
PLIN2	0.023747
AAMP	-0.023662
HOXC6	-0.023643
SIGMAR1	-0.023559
CYR61	0.023491
RPS14P3	-0.023444
DTL	0.023433
NNMT	0.023409
RPS11	-0.023269
BZW2	-0.023146
BRIX1	0.023134
EI24	0.023096
RGS2	0.023058
RRS1	0.023022
IGFBP4	-0.023015
HSP90AA1	0.023010
OST4	-0.022937
STX17-AS1	0.022925
ATP6V1A	0.022905
NPC2	0.022862
MANSC1	0.022854
C6orf62	0.022852
RPL35A	0.022637
GPI	-0.022593
ATP5I	0.022567
PTTG1	0.022520
MSN	0.022511
DDX47	0.022511
GRPEL2	0.022480
PGK1	0.022464
LINC01419	-0.022448
EZH2	0.022445
BNIP3	0.022318
PDK1	0.022116
BIRC2	0.022109
EMP3	-0.022095
SHFM1	-0.021916
POLE3	0.021765
LOXL4	-0.021692
MRPS21	0.021686
PTTG1IP	0.021639
HNRNPK	-0.021636
CLK2	0.021556
MAD2L1	0.021507
TRMT11	0.021450
LINC00622	0.021446
PTP4A2	0.021407
POLR2G	-0.021314
MALAT1	-0.021309
RPL23A	0.021286
AK4	0.021246
UQCRH	-0.021201
CCNE2	0.021149
RPL36A	-0.021121
DNAJB4	0.021119
PTS	0.021100
RRM1	0.021014
PRKAR1A	-0.020980
PRDX4	-0.020954
RPF2	-0.020837
TMSB10	-0.020803
NONO	0.020741
CCT4	0.020716
TMBIM6	-0.020627
MICU2	0.020601
NAP1L1	0.020552
FXYD5	-0.020527
RPS12	0.020526
NHP2	-0.020475
SLC25A5	0.020462
SNHG1	0.020414
PBK	0.020408
ZCCHC8	0.020362
CMSS1	-0.020329
EEF1B2	-0.020316
NUTF2	0.020237
LAMTOR4	-0.020233
UBA52	0.020211
TFPI2	0.020123
MAP7D1	-0.020077
NOB1	-0.020000
LRRC47	0.019929
SNRPD1	0.019914
MLF2	-0.019907
MIF	0.019871
YWHAQ	-0.019845
POLR2F	-0.019723
MRPL51	0.019717
STRAP	-0.019687
MRPL15	0.019679
NDUFA1	0.019672
LGALS3BP	-0.019633
RPS18	0.019576
EIF3M	0.019535
LINC00326	0.019532
ELK3	0.019529
ASF1A	0.019504
NOP56	0.019441
CDC6	0.019381
KIFAP3	-0.019354
RPL22	-0.019318
COMMD8	0.019316
RPL24	-0.019301
NSA2	0.019300
EIF2B1	0.019252
RABGGTB	-0.019195
MTCH2	0.019174
ATP5G1	0.019146
MYC	0.019081
EFTUD2	0.019075
NEIL3	0.019071
PSMD3	-0.019055
TPI1	-0.019047
CPSF7	-0.019027
SF3B6	0.018983
UFD1L	0.018968
PEBP1	-0.018912
EIF4A3	0.018900
RPL18	0.018893
TMA7	0.018866
TNPO1	0.018826
CEP55	0.018758
PRR11	0.018752
MYL12B	0.018731
ZFAS1	-0.018725
TRIB2	0.018681
RPA2	0.018658
KCNN4	-0.018597
SLC5A3	-0.018596
PET117	0.018525
MSRB1	-0.018525
ISCU	-0.018484
ATP5O	-0.018442
TRIB3	0.018407
PSMC6	0.018303
PPIF	0.018291
LOC344887	0.018270
PRPF8	-0.018253
GLRX2	0.018189
TRMT6	0.018142
BUB3	0.018041
CHAC1	0.018024
GHITM	0.017982
ANXA1	0.017968
P4HB	-0.017899
TLR4	0.017847
IER5	0.017826
PHB2	-0.017803
CMTM7	-0.017797
COL4A2	-0.017789
FOXD1	0.017779
MRFAP1	0.017761
FAM216A	0.017720
NDUFB11	-0.017675
ANP32B	-0.017640
SCOC	0.017632
TNC	-0.017600
PNO1	0.017593
NDUFC2	0.017559
CS	-0.017525
ETF1	0.017506
SLC34A3	-0.017471
C12orf57	-0.017461
RTN4	0.017447
CCND1	0.017401
DCAF13	0.017334
TALDO1	0.017321
GABARAPL2	-0.017318
ADI1	-0.017222
EPB41L4A-AS1	0.017206
ATP1A1	-0.017112
SLC7A5	-0.017108
STARD7	0.017103
SACS	0.017074
PMPCA	-0.017027
ARL6IP1	0.017010
GLA	0.016981
NUDT15	0.016957
PSMD10	0.016920
NAF1	0.016851
BTF3	-0.016844
PSMA7	0.016819
RAB5C	-0.016816
SNHG7	-0.016799
RPS23	0.016768
GAR1	-0.016685
UFSP2	-0.016667
LINC00657	-0.016637
HSPD1	0.016587
EIF6	0.016550
EMC4	-0.016539
PSMA2	0.016531
C14orf2	-0.016519
DNTTIP2	0.016493
PSMB6	0.016414
TMEM126A	0.016411
GMNN	0.016375
IL13RA2	-0.016354
ATP6V0C	-0.016348
ND6	-0.016301
MORF4L1	-0.016299
SYPL1	0.016273
CDK2AP1	-0.016249
DDX21	-0.016215
FAM83D	0.016160
DBF4	0.016157
KIF14	0.016152
UBE2N	0.016124
DDB2	-0.016113
PTPLAD1	0.016101
SNHG19	-0.016096
TTC19	-0.015991
TSC22D1	0.015972
GAPDH	0.015893
HDGF	-0.015886
MYOF	-0.015852
NET1	0.015848
TPX2	0.015831
C1orf131	-0.015821
DUSP10	-0.015820
RPL29	-0.015806
ZFAND5	0.015750
DPYSL2	0.015747
RAD21	0.015711
LAMP1	-0.015703
DAP3	0.015689
CTPS1	0.015684
TUBA1A	-0.015624
C16orf72	0.015613
HGS	-0.015590
GNL3	-0.015571
COX8A	0.015549
HAX1	-0.015546
SMIM15	0.015530
ZWINT	0.015492
TNFRSF21	0.015421
NCAPD3	0.015400
UQCRFS1	0.015375
OPHN1	-0.015365
ANLN	0.015362
DLEU1	0.015283
RPS3A	-0.015241
TUSC1	0.015229
DSTN	0.015202
SLC3A2	0.015121
NDUFA13	-0.015110
ATP1B1	-0.015105
UBE2E1	-0.015089
SPCS1	-0.015075
BCAR3	0.015068
SERBP1	0.015065
RCN1	-0.015064
TFRC	0.015055
ARPC2	0.015054
ATXN10	-0.015052
TBCB	-0.015049
ASNS	0.015030
SNRPG	0.015022
MCM6	0.015015
CFAP36	-0.015008
GNAS	-0.015000
CNIH1	0.014982
COX7A2L	0.014971
EIF4A2	-0.014942
TOP2A	0.014831
SNX17	-0.014820
PTRF	-0.014811
C11orf58	0.014793
MYBL2	-0.014790
CYC1	0.014783
ITM2B	0.014775
DROSHA	0.014768
PAICS	0.014748
SRPR	-0.014741
TUBB4B	-0.014736
DDX46	0.014721
BSG	-0.014687
FST	-0.014673
MTHFD1	0.014663
HMMR	0.014655
VDAC1	0.014643
PLK2	0.014621
HEY1	0.014595