!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	NICKEL
!smiles	[Ni]
!pubchem_cid	935
!cell_type	Skins biopsies from nickel-allergic patients whose skins were exposed to nickel - 48 hours
!organism	human
!end_metadata
IGLV1-36	0.121018
IGJ	0.094172
SELE	0.085530
IGKV1OR2-108	0.080652
CXCL9	0.077194
IGLL3P	0.076502
IGLJ3	0.072041
CXCL10	0.062485
CIART	-0.060299
SCD	0.059256
PNMAL1	-0.058709
IGKC	0.057948
CH25H	0.057565
ZBTB16	-0.055852
SPRR2G	-0.055150
GZMB	0.051058
PLA2G2A	0.049931
CD27	0.049716
IGHM	0.048123
CCL2	0.046391
IGLV3-19	0.045325
MZB1	0.045208
SPRR2B	-0.045123
LOC344887	0.043563
MMP12	0.043010
POU2AF1	0.042983
CD2	0.042170
WFDC12	-0.041024
HLA-DQA1	0.039883
TNFRSF17	0.039726
UPK1A	0.039629
IRF1	0.039562
SELL	0.038369
TRBC1	0.037870
CD79A	0.037718
ZNF750	-0.037391
GPR171	0.036875
PLIN4	0.036520
SPRR1A	-0.036453
PLAC8	0.036414
PLIN1	0.035903
LRIG3	-0.035741
HLA-DRB4	-0.034676
ELOVL4	-0.034269
IL36G	-0.034099
LEP	0.034049
VMP1	0.033936
TIMP4	0.033741
NR1D2	-0.033435
IL2RG	0.033328
FMO1	-0.033146
ELOVL3	-0.033117
FKBP5	-0.032974
PLA2G7	-0.032943
CDSN	-0.032656
G0S2	0.032615
APPL2	-0.032407
CCR2	0.032392
IGKV4-1	0.032328
SPRR4	-0.032013
MLIP	0.031362
LCK	0.031329
PER1	-0.031234
HLA-DQB1	0.031110
CLCA4	-0.030939
CCL5	0.030927
RHOH	0.030898
NIPSNAP3A	-0.030445
GPAM	0.030418
CORO1A	0.030348
RNASE7	-0.030330
RNF128	-0.030241
LCE3D	-0.030003
SLC46A2	-0.029968
SCO2	0.029957
LOC729218	-0.029902
KRT31	-0.029792
HSD3B1	-0.029044
ISG20	0.028770
COL6A6	0.028725
BMS1P20	0.028652
CD3D	0.028647
SASH3	0.028526
ENO2	0.028501
CXCL11	0.028302
FAM46C	0.028286
NELL2	0.028212
PLEKHO1	0.028065
BEX2	-0.027985
PDZK1	-0.027860
APLNR	0.027774
ND6	-0.027485
TBC1D10C	0.027425
RAC2	0.027228
NRROS	0.027219
PM20D1	-0.027073
TMPRSS11E	-0.027056
CCL17	0.027032
PRKCQ	0.026788
GFPT2	0.026736
UAP1	0.026716
CCL19	0.026672
KRTAP1-5	-0.026629
CCR5	0.026582
IL7R	0.026562
CD69	0.026526
TNFAIP6	0.026436
KLK6	-0.026426
NLRC3	0.026397
FAM46B	-0.026386
ITK	0.026263
GPT2	-0.026227
TRABD2A	0.026015
MUC15	-0.025983
ABCA12	-0.025952
BTN3A2	0.025943
PSAPL1	-0.025901
BEX4	-0.025870
CRISPLD1	-0.025855
PPP1R13L	-0.025662
FPR3	0.025659
PPP1R18	0.025628
FAM174A	-0.025619
PPP1R10	0.025523
TRAC	0.025465
IL32	0.025430
SLAMF7	0.025357
ZAP70	0.025290
MANSC1	-0.025287
CRNKL1	0.025271
RUNX1-IT1	0.025238
CCR1	0.025167
PHF23	0.025059
CLEC2B	-0.025049
SRD5A1	-0.025045
IGFBP6	0.024883
MOGAT1	-0.024812
SCGB2A2	-0.024741
LIF	0.024667
BATF	0.024648
RERGL	-0.024635
P2RY14	-0.024611
IGKV3-20	0.024559
LOC100506606	-0.024341
KRT34	-0.024201
IGL	0.024183
HSD17B2	0.024174
KRT16	0.024062
LRP4	-0.024049
NUSAP1	-0.024034
AZGP1	-0.024015
FLG	-0.023990
MSMO1	-0.023975
TCIRG1	0.023791
PRSS8	-0.023693
FOS	0.023612
GZMK	0.023606
ABHD5	-0.023537
CTSV	-0.023522
LOC100288152	0.023513
PALD1	0.023457
SEPP1	-0.023409
SOAT1	-0.023369
HMGCS1	-0.023344
PNPLA3	-0.023311
KRTAP8-1	-0.023253
LOC100506718	-0.023238
KRT75	-0.023232
THY1	0.023224
TMEM254	-0.023224
THSD7A	-0.023217
SAMD9L	0.023085
TAF5LP1	0.023082
P2RY8	0.023054
KRT35	0.023044
ELMOD1	-0.023041
GZMA	0.023012
ZNF232	0.022937
SDF2L1	0.022908
ACKR4	-0.022884
CHMP4C	-0.022834
IL10RA	0.022787
RAPGEF4	-0.022760
PCAT6	-0.022732
HLA-DQB2	0.022713
PRR9	-0.022579
SGPP2	-0.022552
KRTAP19-1	-0.022547
HLF	-0.022546
REL	-0.022529
IRF9	0.022499
DHCR7	-0.022445
IGLV6-57	0.022400
ALOX15B	-0.022359
CD3E	0.022341
KRT33A	-0.022331
FLT3LG	0.022325
PNLIPRP3	-0.022317
PPP1R1A	0.022288
LINC00685	0.022282
KRT23	-0.022267
AWAT1	-0.022248
TMEM91	-0.022151
LPL	0.022129
SIT1	0.022124
ARHGAP9	0.022084
FKBP11	0.022073
ZNF256	-0.022050
PSORS1C1	-0.022022
CTBS	-0.022008
TMEM255A	-0.021993
APOBEC3B	-0.021920
SPAG1	-0.021899
LOC100287497	-0.021894
GRAMD1C	-0.021890
HAS3	0.021880
AMPD1	0.021844
ICAM3	0.021836
CCL21	0.021835
PYDC1	-0.021825
PCDH18	0.021804
KLHDC7B	0.021791
IRX3	-0.021788
MIR155HG	0.021783
SEL1L3	0.021770
ZNF662	-0.021743
IDO1	0.021663
CYFIP2	0.021635
CRCT1	-0.021616
SNHG5	0.021612
LYPLA1	-0.021593
MAP4K3	-0.021555
ACSL1	-0.021526
KRT80	-0.021512
ZBED8	0.021491
EZH2	-0.021438
SPAG4	0.021428
TRIB2	0.021421
GPR115	-0.021394
PGRMC2	-0.021350
LYRM5	-0.021343
SCAPER	-0.021316
MIR21	0.021313
RGS19	0.021296
FXYD5	0.021259
BIN2	0.021256
FLG2	-0.021256
PLAU	0.021233
TRIM21	0.021213
PSMB9	0.021168
LIPG	0.021158
AKR1B10	0.021125
BDKRB2	0.021117
GLIS2	0.021088
DENND2D	0.021059
FCGR2B	0.021037
TYRP1	-0.021009
FLRT2	0.020987
PDK4	-0.020981
ASPRV1	-0.020975
CPA4	-0.020965
IL18	-0.020960
ZSCAN31	0.020948
RAD51AP1	-0.020943
TMEM133	-0.020939
EVL	0.020936
PIGW	-0.020934
NAF1	-0.020932
KRTAP9-8	-0.020909
MAP4K1	0.020839
TGIF2	0.020830
FBXO6	0.020742
ODC1	0.020739
CARD18	-0.020733
GADD45A	-0.020628
CD38	0.020605
IRF7	0.020591
IL4I1	0.020582
HMHA1	0.020534
MYADM	0.020528
ZG16B	-0.020522
PLEKHO2	0.020520
PRR5	0.020506
IGLV2-23	0.020495
SLAMF6	0.020429
YOD1	-0.020416
STARD3NL	0.020377
GNRH1	-0.020362
LURAP1L	0.020354
MYO1F	0.020350
NANOG	-0.020338
PPAP2C	-0.020322
SLU7	-0.020287
DKFZP586B0319	-0.020278
TSNAX	-0.020271
ITPRIP	-0.020262
CST7	0.020258
ACSM3	-0.020239
MATN4	-0.020172
RASA4	-0.020172
USP53	-0.020153
MMP1	0.020132
POP1	0.020126
SLC25A43	-0.020116
HCLS1	0.020072
CSN1S1	0.020070
LYL1	0.020050
PEX7	-0.020046
SPRR3	-0.020045
BPIFC	-0.020034
KRTAP2-2	-0.020029
LOC100131043	0.019977
FAR2	-0.019967
PANK1	-0.019958
EVPLL	0.019958
HAO2	-0.019956
ADTRP	-0.019946
MME	0.019935
SEC14L4	-0.019888
PTPRZ1	-0.019886
SLC31A2	-0.019877
MPEG1	0.019870
HHATL	0.019860
CD37	0.019803
CDHR1	-0.019797
FOSL1	0.019779
TTC32	-0.019776
SLAMF1	0.019736
RARRES3	0.019734
PI3	-0.019727
SLPI	-0.019725
PIM2	0.019716
CNFN	-0.019716
TRIM27	0.019670
AGPAT9	0.019648
MX1	0.019645
DHRS1	-0.019607
C5orf46	-0.019589
MN1	0.019587
ENDOU	-0.019573
KIAA0125	0.019539
NFKBIE	0.019538
LENG8	0.019537
LNX1	-0.019522
ELOVL7	-0.019510
RPL7AP9	-0.019509
ZSCAN26	0.019500
SLC19A2	-0.019499
SH2B3	0.019482
PLP1	-0.019474
IL9	0.019409
ZNF304	-0.019403
HOOK1	-0.019366
SLC18B1	-0.019362
LOC653602	-0.019357
TPSB2	0.019353
SHISA2	-0.019342
RBP4	0.019342
EP300-AS1	-0.019340
MAP1S	0.019339
ZNF691	0.019335
UBE2S	0.019332
ACER1	-0.019315
UPP1	0.019308
HIBCH	-0.019281
KCTD9	-0.019268
MORC3	-0.019258
GPSM3	0.019252
CD97	0.019212
DEFB4A	-0.019210
MRVI1	-0.019167
ZBED5-AS1	-0.019143
SPATC1L	0.019140
ATRIP	0.019108
NCF4	0.019100
ARHGEF34P	-0.019083
LOC158402	0.019082
WARS	0.019068
ARHGAP15	0.019068
GABRP	-0.019062
DAPL1	-0.019012
VAV3	-0.019004
CCR4	0.018947
WDR11	-0.018933
GYG2	0.018913
EHHADH	-0.018898
RSPH10B2	-0.018888
DCLRE1A	0.018886
LAPTM5	0.018884
EGR3	-0.018881
ACSBG1	-0.018872
FIBIN	-0.018860
ZNF580	0.018843
INHBC	-0.018812
F2R	-0.018784
CYTIP	0.018762
EGFL6	-0.018730
MMP13	0.018707
LOC100132884	-0.018704
TRIM35	-0.018693
CERS4	-0.018643
CCL8	0.018636
SLURP1	-0.018629
HAPLN3	0.018626
PTPN7	0.018622
ZNF43	-0.018610
FAM83E	0.018605
LOC100130429	-0.018602
PTPRCAP	0.018576
SELM	0.018574
SLFN11	0.018574
LOC284023	-0.018571
FHOD1	0.018558
TRANK1	0.018530
FAM213A	-0.018529
DHRS9	-0.018521
CD33	0.018520
LYPD5	-0.018511
CLDN8	-0.018495
DCT	-0.018483
PPP1R14A	0.018474
CALB2	0.018472
LPCAT1	0.018472
PSCA	0.018471
DLX3	-0.018459
PSTPIP1	0.018454
SPCS2	-0.018452
C2orf44	0.018439
GK5	-0.018432
SLC44A3	-0.018424
CA2	0.018377
SLAMF8	0.018353
SCUBE2	-0.018342
TM7SF2	-0.018324
SOWAHC	-0.018323
DKK2	-0.018322
ZNF432	-0.018309
BCAR3	-0.018297
SEC14L1P1	-0.018262
IRF2	0.018249
CELP	0.018229
RNF19B	0.018226
DERL3	0.018222
GNLY	0.018213
C19orf80	0.018205
TPRA1	0.018202
RBM4	-0.018196
CHI3L2	-0.018190
ZNF593	0.018185
IGKV1-5	0.018174
CLDN1	-0.018143
LOC153684	0.018135
ACAT2	-0.018130
ADRB2	-0.018127
IL27RA	0.018116
CAV3	0.018086
BFAR	0.018079
ZNF488	0.018038
SLC2A3	0.018033
CRISP3	-0.018028
ACP6	-0.018012
LTB	0.018009
KRTAP4-1	-0.017994
SNHG17	0.017986
GUSBP11	0.017974
ATP13A2	0.017966
PTPN6	0.017964
TBL3	0.017944
IGLV1-44	0.017942
C15orf48	-0.017902
ERRFI1	-0.017892
TMEM45B	-0.017889
POU2F3	-0.017884
TTC37	-0.017880
OVOS2	-0.017878
CCDC113	-0.017875
PAGE5	0.017871
BATF3	0.017826
ABHD17A	0.017826
UBA2	-0.017824
KLRB1	0.017822
WDR43	-0.017815
THAP8	0.017806
ZNF503-AS1	-0.017804
MAL2	-0.017792
IGFL2	-0.017789
GTF2H2B	-0.017777
ADIRF-AS1	-0.017761
IL19	0.017751
RTN4RL1	-0.017739
PRKRA	-0.017722
PDZD2	-0.017722
REV3L	-0.017718
UCP2	0.017706
PER2	-0.017700
PIK3R1	-0.017679
NPDC1	0.017676
ZNF57	-0.017664
ICAM2	0.017663
DEGS1	-0.017648