!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Vitamin E
!smiles	CC1=C(C(=C2CCC(OC2=C1C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)O
!drugbank_id	DB00163
!pubchem_cid	14985
!cell_type	Brains of aged (30-month-old) B6C3F1 animals fed a diet containing alpha-tocopherol
!organism	mouse
!end_metadata
PTGDS	0.236227
USMG5	0.132700
PEBP1	-0.132215
CTXN1	-0.131116
TTR	0.121740
RHEB	-0.119298
EGR1	-0.104369
BASP1	-0.100311
ARC	-0.095125
CYC1	0.090746
COX4I1	0.084740
THY1	-0.084463
GOT1	0.083712
RPRM	-0.080020
CHCHD2	-0.077154
CKB	0.074297
TMEM256	-0.073190
OLFM1	-0.071978
IGSF8	-0.071890
ARGLU1	-0.071735
RPLP2	-0.069040
STMN1	-0.066327
SEPP1	0.064377
NAP1L5	0.064339
PSAP	-0.063951
RABAC1	0.063729
RHOB	0.062925
RPS23	0.061925
LAPTM4A	0.061678
BEX1	-0.060632
NR4A1	-0.059488
CHCHD10	-0.058724
CHST1	-0.057233
TMA7	-0.056963
CHGB	-0.055593
SLC17A7	-0.055436
CAPNS1	-0.055413
RESP18	0.054474
PMCH	-0.053507
TSPAN3	-0.053077
PLEKHB1	0.052829
PISD	-0.052371
CA2	0.051876
TTC9B	-0.051727
SNCB	-0.051483
RPL6	0.051286
MDH1	-0.051253
SPARCL1	0.051241
ATP6AP2	-0.050965
YPEL3	-0.050459
GPX4	0.050328
SYN1	-0.050267
RPS14	0.050074
DMXL2	0.050029
PABPN1	-0.048981
NDUFA8	0.048800
SARAF	-0.048603
SGK1	0.047885
ACAT2	-0.047520
SNX17	-0.047503
HSPA8	-0.047107
MAP1LC3A	-0.046561
STMN4	-0.046479
TPRG1L	0.046388
MAPK10	0.046060
NDUFA2	-0.045839
RPL19	-0.045531
LY6H	-0.045157
MORF4L2	-0.044970
NRSN1	0.044832
NDUFA1	-0.044718
MTCH1	-0.044640
PKM	0.044299
EMC10	0.044032
RPL12	0.043853
EFHD2	-0.043842
RPL4	-0.043579
SLC25A22	-0.043172
JPH4	-0.043137
WBP5	-0.042597
EEF1A2	-0.042454
MPND	-0.042451
NDUFC1	-0.042432
COX5A	-0.042098
OXT	0.042067
NGFRAP1	-0.041967
BAI1	-0.041896
TUBA1B	-0.041895
DBI	-0.041868
SH3BGRL3	-0.041489
NDUFV3	-0.041336
DDN	-0.041069
PRDX5	-0.040929
RPL14	-0.040857
PGAM1	0.040849
CADPS	0.040540
CSRP1	0.040490
ARPC3	-0.040251
ITIH3	0.040074
CAMK2N1	0.039758
KIFC2	-0.039621
S100B	-0.039582
RPS15A	0.039559
PPP2R1A	-0.039315
LDHB	-0.039263
ARHGAP33	-0.039222
GLUD1	0.039200
APOD	0.039068
NME1	-0.039043
RPS29	0.038951
VDAC1	0.038942
ALDOC	0.038086
HSPD1	-0.038082
DTX3	-0.037840
OCIAD1	-0.037836
RPL18A	0.037817
PHYHIP	-0.037665
KLC2	-0.037546
GPS1	0.037500
OAZ1	-0.037283
ATP5J	-0.037093
ARHGAP44	-0.036644
TRANK1	-0.036523
PPIA	-0.036076
QRICH1	0.035996
SDHC	-0.035972
GPR162	-0.035867
HPCA	-0.035808
RPS11	-0.035697
VSTM2L	-0.035639
SNF8	-0.035374
CAMK2N2	-0.035229
HINT1	-0.035185
HMOX2	-0.035181
JUND	-0.034947
RPS28	-0.034921
LRRC45	-0.034890
TUBB4A	-0.034886
DCTN2	-0.034749
NRN1	-0.034738
PSMA4	-0.034737
MAPRE3	-0.034377
CDK5R2	-0.034330
ZBTB18	0.034325
BHLHE22	-0.034203
SLC22A17	-0.034196
ATP1A2	0.034133
GHITM	0.034010
SCG2	0.033995
VDAC3	-0.033836
ITM2C	0.033782
EEF1B2	-0.033679
NEDD8	-0.033675
FOS	-0.033443
RRAGA	0.033421
TUBA4A	-0.033358
OXR1	0.033349
CCK	-0.033177
RAB3A	-0.033150
BHLHE40	-0.032991
DENND5A	0.032989
TMEM132A	-0.032661
GRINA	-0.032580
DNAJB9	0.032552
SWI5	-0.032456
RAPGEF2	0.032435
TUBA1A	0.032424
RPS5	-0.032389
CNIH2	-0.032178
SOD1	-0.032167
CNP	0.032080
PTN	0.032046
HAP1	-0.031983
RPS26	-0.031758
LAMP1	0.031756
ZIC1	0.031714
SLC25A4	-0.031663
RBP4	-0.031658
RPL35	-0.031609
OLIG1	0.031560
CFL1	0.031426
RAP1GAP	0.031417
PENK	-0.031197
EIF4A2	-0.031181
SHISA4	-0.030948
HNRNPUL1	0.030916
TUBB2B	-0.030834
ACOT7	-0.030827
GOLGA2	-0.030717
FAM107A	0.030700
MCFD2	0.030625
SLC4A10	0.030617
ANAPC13	-0.030544
FBXL16	0.030423
SKP1	0.030414
APOE	0.030414
HPCAL4	0.030359
CALY	-0.029909
TBR1	-0.029815
JUNB	-0.029768
C6orf62	0.029687
ATP5B	-0.029622
ACO2	0.029598
ICAM5	-0.029461
VEGFB	-0.029357
ACTG1	-0.029297
GFAP	-0.028983
HSPH1	-0.028972
TCP1	0.028921
DAPK1	0.028822
SMIM13	0.028787
ALDOA	-0.028707
GJA1	0.028644
DUSP1	-0.028635
MED18	0.028494
MID1IP1	0.028452
RPS8	-0.028434
KLHL7	0.028433
DUSP6	-0.028409
FLOT1	-0.028396
CAMKK1	0.028304
GDE1	-0.028059
EMC2	-0.027901
FTH1	0.027855
CADM3	-0.027842
CAMK2B	-0.027829
ENC1	-0.027773
STRN4	-0.027762
GABRA1	0.027685
RAB7A	0.027681
PPP1R1B	-0.027637
NDRG4	-0.027612
ENSA	-0.027584
CYP46A1	-0.027495
EPC2	0.027450
PACSIN1	-0.027368
NDUFV1	0.027284
NGEF	-0.027275
L1CAM	-0.027179
NEFL	0.027089
RNF7	-0.027071
CELF3	-0.027068
CTNNB1	0.027043
TMEM50A	-0.027013
KLC1	-0.026996
CPNE5	-0.026943
LUC7L3	-0.026922
NDUFS2	0.026880
PFKL	-0.026874
CYGB	-0.026870
AKAP11	0.026866
TSG101	0.026829
SNCA	-0.026813
RPL11	0.026724
LIMD2	-0.026723
SERINC1	0.026708
CLDN11	0.026700
BAI2	-0.026666
SPARC	0.026621
PAICS	-0.026466
AATK	-0.026408
EID1	-0.026330
DNM1	-0.026295
AAMP	-0.026270
PYGB	0.026191
C12orf43	-0.026166
PLD3	0.026118
RPP21	-0.026105
DYNLT3	-0.026001
AP2A1	-0.025986
NAB2	-0.025804
PDP1	0.025802
BZRAP1	-0.025571
COX14	-0.025565
MFGE8	0.025540
ITPKA	0.025474
ATP5H	0.025454
PSMB4	0.025389
AMFR	0.025360
UBL3	0.025297
THEM6	-0.025282
ID4	0.025182
NRXN2	-0.025134
LMO4	-0.025128
EEF1A1	0.025056
HN1	-0.024903
UQCR11	-0.024805
RGS7BP	0.024803
SEPT3	-0.024739
MRPS36	-0.024732
TP53I11	-0.024726
PRKACA	-0.024655
PIGP	0.024643
MRPL20	-0.024639
FAM81A	-0.024619
ARL2	-0.024611
RPL18	0.024486
ACTL6B	-0.024483
LANCL1	-0.024435
CLTA	-0.024429
PSMA5	-0.024416
CORO2B	-0.024410
TMEM176B	0.024326
NPY	-0.024306
PPA1	0.024299
HNRNPU	0.024292
MARC2	-0.024284
GDA	-0.024279
RNF44	0.024266
MAL	0.024235
ABR	0.024233
FXYD7	-0.024205
HSPA5	0.023962
MAP2K1	-0.023949
IDH3B	-0.023945
EGLN2	-0.023942
PRICKLE2	-0.023929
RPS27A	-0.023891
STMN2	-0.023871
PPP1CA	0.023785
RPS24	-0.023753
APLP2	0.023653
GRN	-0.023642
FAM219A	-0.023585
P4HTM	-0.023538
ITM2A	0.023537
RPS19	-0.023467
RGS14	-0.023452
PINK1	-0.023414
ADPRH	-0.023396
CACNB4	0.023321
REEP5	-0.023320
FEZ1	-0.023302
MLF2	-0.023291
YWHAH	-0.023197
ATP5J2	0.023139
FAM173A	-0.023039
PGRMC1	-0.023038
TUBB2A	-0.023029
RPL24	0.023026
KLHDC3	0.023015
MAPK3	-0.023002
WDR6	-0.022998
CSTF2T	0.022972
MAZ	-0.022921
SAP30L	-0.022912
COG7	-0.022904
PRNP	0.022901
MYL12A	-0.022886
DGKZ	-0.022877
SPOCK2	-0.022876
PDXK	0.022874
TMOD1	-0.022869
EPN1	-0.022799
PCBP2	0.022685
SPRYD3	-0.022631
ZMIZ2	-0.022570
TRAPPC8	0.022528
MYRF	-0.022517
NELL2	-0.022488
GUK1	-0.022443
RAN	-0.022370
NDUFA13	-0.022345
YWHAE	-0.022344
CCDC85B	-0.022324
EPHX4	-0.022291
MRPL32	-0.022252
ATP6V1C1	-0.022148
CD81	0.022080
VBP1	0.021993
STX1A	-0.021934
YWHAQ	0.021910
TSPYL4	-0.021896
PPP2CA	0.021837
SLC6A7	-0.021820
DAD1	-0.021809
AKAP8L	-0.021787
TRAPPC6B	0.021705
ELOVL5	0.021660
STMN3	-0.021611
TIMP2	-0.021531
HRH3	-0.021504
PRDX3	0.021478
ANKRD34A	-0.021466
SLC36A4	0.021464
RANBP9	0.021403
CELF5	-0.021334
DNAJB2	-0.021285
CNTD1	-0.021285
EID2	-0.021237
HPCAL1	-0.021157
RPS13	-0.021151
TSPAN7	0.021132
LAMP5	-0.021125
DDT	0.021082
SLC25A18	0.021076
DLG3	-0.021008
SH3GL2	-0.020999
HIVEP2	0.020997
NDUFA7	-0.020955
SEPW1	-0.020950
CDK9	-0.020923
CDIPT	-0.020897
PMPCB	0.020886
GAD1	0.020878
CSDE1	0.020868
SLC6A1	0.020839
EIF3B	0.020818
DNAJC12	0.020774
PCSK1N	-0.020754
GSK3A	-0.020741
STUB1	-0.020725
MAP1A	0.020721
AGRN	-0.020707
CPLX2	-0.020646
TRAPPC2L	0.020641
VGF	0.020607
CEND1	-0.020591
LSM4	-0.020543
PGBD5	-0.020470
ATP6V1G2	-0.020449
FKBP1A	-0.020440
PTOV1	-0.020426
SCN4B	-0.020408
CST3	-0.020395
CLTC	0.020388
PSMC2	-0.020336
MEGF8	-0.020329
VPS72	-0.020328
SLC12A5	-0.020324
DNAJC27	0.020295
FAM127A	0.020286
GRASP	-0.020257
PSMB2	0.020255
ERP29	-0.020251
DNER	-0.020232
FBXO41	-0.020188
ATP1B3	0.020185
ANKH	0.020181
DYNLL2	-0.020167
LINGO1	-0.020135
MPP2	-0.020102
GAPDH	0.020102
DLG4	-0.020083
LGMN	0.020046
NDUFA5	-0.020044
UBC	-0.020042
PDE2A	-0.019964
TESC	-0.019950
OXCT1	-0.019949
ITM2B	0.019925
PRDX1	0.019904
SCN1B	0.019878
CRYM	-0.019754
AP4S1	0.019729
SLC30A4	-0.019636
PDAP1	-0.019624
TMEM147	-0.019623
SNRNP70	-0.019553
ROMO1	-0.019538
SEPT8	-0.019530
CELSR2	-0.019494
C14orf1	-0.019412
HPRT1	0.019352
ATP6V1D	-0.019307
BOD1	-0.019298
SELK	0.019190
KCTD12	0.019151
BSG	0.019135
ALDH6A1	0.019112
GIT1	-0.019083
IFITM3	-0.019060
RAP1GAP2	0.018972
CLIP3	-0.018945
FAM8A1	-0.018884
C17orf89	-0.018819
MIEN1	-0.018755
ATP1B2	-0.018737
REXO2	-0.018727
OSBPL1A	-0.018570
RPS18	-0.018562
EGR3	0.018551
TRNP1	-0.018547
ATP6V1G1	-0.018539
PRKAG1	-0.018507
RBBP7	-0.018502
SCG3	0.018489
PDDC1	0.018484
HNRNPDL	-0.018458
HRAS	-0.018444
ARFGAP1	-0.018430
ASPA	0.018408
CCT5	0.018364
SREBF1	0.018350
PRKCB	0.018246
TMED9	-0.018217
ROGDI	-0.018192
NSUN2	-0.018186
KCNMB4	-0.018182
EPS15	0.018143