!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!gene	SIRT1
!cell	Liver
!perturbation	Knockout (Homozygous)
!disease	Caloric Restriction
!end_metadata
PBLD	0.200028
SLC38A5	-0.096413
CIART	0.094342
TPMT	0.093844
DBP	0.086620
CSRNP1	0.085192
SLC15A2	-0.081629
DHCR24	-0.075307
MGST1	-0.071683
BCL6	0.071481
DIO1	-0.068556
LARS2	0.068229
ZNF91	0.067438
POU6F1	0.067289
CISH	-0.066378
ADRA2A	-0.066250
APOH	0.066192
LRFN3	-0.065946
SQLE	-0.065915
CXCL2	0.064006
CYP8B1	-0.063997
TMEM25	-0.062489
FDPS	-0.062349
CYP17A1	-0.061803
SLC45A3	-0.061458
ENPP5	0.061314
FHIT	0.059588
ENPP2	-0.058632
CLDN1	-0.056495
CSAD	-0.055580
CDH1	-0.055192
G6PC	-0.054261
GDPD3	-0.053643
NFIL3	-0.052873
NFE2	-0.052524
HJURP	0.052113
GALE	-0.051542
FBXL3	0.050821
NT5C3A	0.050126
SRP9	-0.049813
PDK4	-0.049656
AQP4	-0.049065
CTSE	-0.048926
OVOS2	-0.048774
PPP1R3C	-0.048737
PPAT	0.047895
CCND1	0.047685
PER3	0.047506
SUPV3L1	0.046983
RASSF3	0.046835
SC5D	-0.046734
CDC42EP5	-0.046685
NMRAL1	-0.045736
EIF4EBP3	-0.045274
ENPP6	-0.044342
TWISTNB	0.044323
CHRNA4	-0.044313
C19orf80	0.043913
RCAN1	0.043852
FST	-0.043644
LSS	-0.043336
HACE1	0.043131
CD276	-0.042861
EFNA1	-0.042660
WNT2	0.042625
DUSP1	0.042540
PDZK1IP1	-0.042222
LRIT1	0.041772
BSDC1	0.041706
TIMMDC1	-0.041621
ZFP36	0.041291
ZBTB22	0.041089
PREP	0.040821
GSTA5	0.040780
ALDOC	-0.040577
USP2	0.040574
ATP5G2	-0.040371
PYCR2	-0.040225
CORIN	-0.039950
SLPI	-0.039025
FMN2	-0.038998
PPTC7	0.038842
GDPD1	-0.038750
APOBEC1	-0.038580
C17orf62	-0.038405
AVPR1A	-0.038347
LCN2	0.038261
MVD	-0.038158
PDRG1	-0.038118
TMIE	-0.038038
ACTG2	0.037906
IL17RB	-0.037740
PIM3	0.037631
RSAD1	-0.037620
SOCS2	-0.037591
MTUS2	0.037500
IGSF11	-0.037393
KRT23	-0.036876
PLIN2	-0.036830
SLC13A2	-0.036526
NCEH1	-0.036318
PEG3	-0.036282
KLHL21	0.035861
GSTM1	0.035847
NSDHL	-0.035601
INSC	-0.035583
SLC39A4	0.035376
TPO	0.035262
CYP51A1	-0.034913
HLA-E	0.034906
GRM8	0.034855
OSGIN1	-0.034845
PTK6	-0.034733
TMC5	-0.034538
CES3	-0.034508
ST5	-0.034214
NXPE2	-0.033833
IRS2	-0.033782
ERO1LB	-0.033580
TLR6	-0.033538
RDH11	-0.033464
ARL5A	0.033360
PGLYRP1	0.033245
JAZF1	-0.033147
LGALSL	-0.033030
QPCT	-0.033023
TFF3	-0.033023
FFAR4	-0.032691
RBBP9	0.032659
DHCR7	-0.032620
INHBB	0.032520
WDR46	0.032508
TNFAIP2	-0.032469
HMGCS1	-0.032106
MRPS27	-0.032106
CAMK2B	0.032054
UPP2	0.032031
C5	-0.031819
SLC25A30	-0.031812
FABP5	-0.031808
CD207	-0.031590
FN3KRP	0.031576
PLIN4	0.031549
IGFBP1	-0.031320
DYNLL1	-0.031203
RPS2	0.031037
KLF13	0.031007
ABCC3	0.030992
ID1	0.030726
SLC25A42	-0.030456
SEL1L3	-0.030311
ACSS2	-0.030210
JUNB	0.030004
ARNTL	-0.029924
PCDH20	-0.029916
ANXA4	-0.029849
HSD17B6	0.029775
ZFPM1	0.029642
GYS2	0.029620
NREP	-0.029438
PCDH17	-0.029399
NUDT18	-0.029329
GLDN	-0.029308
INHBA	-0.029292
TLCD2	-0.029287
EGFR	-0.029180
TFB1M	0.029027
PMVK	-0.028976
CFB	0.028923
HSPB1	-0.028904
GMDS	-0.028791
CSRP3	-0.028756
TTC27	-0.028653
PLTP	-0.028605
CCRN4L	0.028583
GPC3	-0.028566
MRPL10	0.028556
S100A8	0.028400
GNA14	-0.028381
MTSS1	0.028313
HTR1D	-0.028232
FADS2	-0.028191
ASNS	-0.028171
HOOK2	0.028117
ST3GAL6	-0.028076
SPSB4	0.028060
DISP1	-0.028025
TEAD2	0.027789
PRTN3	-0.027655
BMP4	-0.027628
PARP16	0.027526
SLC5A6	0.027522
ENC1	-0.027466
CCDC28A	-0.027349
HIST1H2AJ	0.027343
B3GALT6	0.027282
MSMO1	-0.027250
CCBL1	-0.027248
HSD17B7	-0.027228
CUX2	0.027156
ZNF608	-0.027087
C8B	-0.027047
KCNJ8	-0.026917
BBS4	-0.026881
BMPER	-0.026880
LNX1	0.026860
CDKN1A	-0.026653
SGSM1	-0.026574
SLC25A3	0.026545
CBWD1	0.026520
BDH2	-0.026493
SLC38A2	0.026488
TGFBR2	-0.026472
HSPA2	0.026387
ELOVL6	-0.026363
FKBP11	-0.026340
ADH4	0.026334
FGF21	-0.026110
C8A	-0.026035
SDS	0.026002
WNT5A	-0.025984
NNMT	0.025822
STT3B	0.025708
MORC3	0.025686
CRYM	-0.025610
NT5E	-0.025578
SRR	0.025572
ADCK4	0.025547
MRAP	-0.025492
KAT7	0.025437
SPON2	-0.025327
TFF2	0.025319
FMO3	0.025201
SPATA2L	0.025121
INSIG2	-0.025049
RASL11B	-0.025029
ALAS1	0.025017
LRRC3	-0.025013
GBP3	-0.024867
CYP2F1	-0.024827
PREX1	0.024806
SLC6A6	0.024635
HLA-DRA	-0.024630
LRRC28	0.024626
COL27A1	-0.024574
TMEM45B	-0.024573
FXYD6	0.024573
RASIP1	0.024557
UNC13B	-0.024482
GIMAP8	-0.024451
CPEB2	-0.024369
SLC30A10	-0.024334
PER1	0.024282
CD300LG	-0.024253
TSC22D3	0.024039
SPATA24	-0.023826
ACTA2	0.023709
FOXO1	0.023651
C17orf78	-0.023646
EPPK1	0.023643
CCDC3	0.023641
SDR9C7	-0.023616
RETSAT	-0.023560
ACER2	0.023534
ATG101	-0.023443
C5orf45	-0.023424
PPFIBP2	-0.023335
GPAM	-0.023319
B3GALNT1	-0.023216
AARS	0.023212
SETD4	0.023211
PAQR9	-0.023192
TCF21	-0.023191
FAM117A	0.023143
TNNC1	-0.023141
BCMO1	-0.023139
TJP3	-0.023108
CCDC126	0.023081
GAS6	0.023065
ADCK5	-0.023001
PPARGC1B	0.022947
HIST1H4I	0.022937
CENPL	0.022904
SRSF3	-0.022898
RERG	-0.022835
USP50	0.022824
NHLRC2	0.022811
SGK2	-0.022749
HOXB7	-0.022693
NET1	-0.022676
CD74	-0.022670
TUFT1	-0.022605
IGF2	0.022595
RAD51C	-0.022545
MIPEP	-0.022540
PLEKHB1	0.022540
RBP1	-0.022443
APOC2	0.022439
DCUN1D4	0.022414
HDC	0.022373
AKR1C3	-0.022307
MFSD2A	0.022294
ARHGAP26	-0.022193
TBX3	-0.022133
APOA4	-0.022123
MTL5	-0.022094
ACKR2	-0.022087
C15orf27	0.022086
EPM2AIP1	0.022068
NUDT7	0.022047
SMARCB1	-0.022045
PPP2R5E	0.022028
ARHGAP44	-0.021982
RGS16	0.021962
GPX7	-0.021914
LPAR6	-0.021852
HLA-DMA	-0.021708
SERPINB1	-0.021697
RPP14	-0.021666
LTBR	0.021629
SLC25A25	-0.021625
SLC17A9	-0.021610
URAD	-0.021563
POP4	0.021559
KIAA0753	-0.021558
LRAT	-0.021529
SGMS1	0.021507
TRIM2	-0.021456
SCRN2	0.021448
HSD17B11	-0.021447
AP3M1	0.021431
SLC16A10	0.021367
SYS1	-0.021353
PSAT1	-0.021346
ETNK2	0.021326
AS3MT	-0.021325
GNA12	0.021277
YRDC	0.021276
JOSD2	-0.021253
NEU1	0.021225
SLC38A4	0.021118
ST6GAL1	0.021078
SLC7A7	-0.021074
IL13RA1	0.021039
GNAT1	0.020981
SERPINA12	-0.020980
BRI3	0.020924
STARD13	-0.020911
COG8	0.020858
ZHX2	0.020834
ATP1B1	0.020816
IGFBP2	-0.020810
SLC44A3	-0.020803
CXorf57	-0.020782
SRSF4	0.020771
ARHGAP29	-0.020749
NR1D1	0.020740
CRYGN	-0.020695
ADRB2	-0.020692
DDO	-0.020687
CCDC68	-0.020667
ACOX2	-0.020634
RGS5	-0.020596
ACTN1	0.020555
HIST1H2AH	0.020554
LDHD	0.020522
CRYL1	0.020497
MEGF9	0.020470
SLC23A3	-0.020458
RASSF4	-0.020455
LBP	0.020438
IGFALS	0.020436
N4BP2L1	0.020401
NOL12	-0.020380
PICALM	0.020370
CRELD2	-0.020365
EGR1	0.020356
SLC4A1	-0.020330
ARV1	0.020288
CYP4A11	-0.020285
PCK1	0.020259
SLC51B	-0.020249
NEK3	-0.020246
FGFRL1	0.020192
TMEM176A	-0.020190
KLC4	-0.020187
PHLDA1	-0.020181
PAQR7	-0.020152
FEZ1	-0.020106
PLA2G12B	-0.020065
UGP2	0.020057
ACSL1	-0.019988
SCARA3	0.019980
AGXT	0.019967
BET1	-0.019948
CSNK1G3	0.019940
KIAA1456	-0.019924
LGR5	0.019920
NOSIP	0.019899
SEMA3F	0.019898
PLK3	0.019887
CDCA7	-0.019855
NOX4	0.019817
SATB1	-0.019798
FITM2	-0.019793
SCARA5	-0.019793
FPGS	-0.019764
RBM43	-0.019714
ORAI1	0.019689
OCIAD2	-0.019669
GP9	-0.019663
C10orf10	-0.019624
IFI35	-0.019611
POLD2	-0.019602
HSD17B12	-0.019589
CHST2	-0.019540
KANK1	-0.019540
C3orf67	-0.019511
PNPLA5	-0.019485
ZMAT2	0.019483
NCAM2	-0.019478
SAE1	0.019475
SYT1	0.019459
TMEM97	-0.019454
F11	-0.019446
SLC1A2	0.019437
MMRN2	0.019429
USP38	0.019419
PDE6H	0.019401
LCN12	-0.019310
REPIN1	-0.019260
ZNF395	0.019201
EIF1AX	-0.019177
CD83	-0.019164
TBL1X	0.019150
CHI3L1	0.019132
NHSL1	-0.019072
SUPT3H	-0.019047
DAPK1	-0.019045
KALRN	0.019040
REEP4	-0.019034
REEP3	0.019024
CWC22	0.019024
FBXO36	-0.019016
PSMC3IP	-0.018958
ARRDC4	0.018958
FAM180A	-0.018889
COQ10B	0.018889
LACC1	-0.018888
UGT3A1	0.018874
JADE1	0.018836
ELL3	0.018796
ALG2	0.018761
TSPAN8	0.018735
ESAM	0.018695
FZD7	-0.018688
ZNF131	0.018673
ASB2	-0.018650
NEK4	-0.018602
INTS6	0.018592
FGFR1OP2	-0.018575
PDE6C	0.018566
CCNO	0.018560
PCSK4	0.018544
RHOBTB3	-0.018525
FOS	0.018501
NEU2	-0.018484
SGK1	-0.018480
GFOD2	-0.018445
HIST1H4L	0.018408
ANXA5	-0.018390
TBCEL	0.018389
C6orf106	0.018383
CR1L	-0.018373
ADSSL1	0.018367
PPARGC1A	0.018366
POLD4	-0.018347
TMEM106B	0.018340
ACOT11	-0.018328
GAL3ST1	0.018312
SLC25A17	-0.018291
RFX2	0.018273
CD9	-0.018249
PKP3	0.018159
SLC25A10	0.018125
SLC7A5	-0.018111
PDGFRA	-0.018067
FLYWCH2	-0.018061
MAPKAPK2	0.018057
CITED2	-0.018042
ONECUT2	-0.018035
DDX3X	0.018007
SRXN1	-0.017969
GABRB3	0.017966
PSTPIP2	-0.017890
DUS1L	0.017888
POGLUT1	-0.017885
IRAK2	-0.017867
CELSR1	-0.017835
SLC26A1	0.017822