!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	orotic acid
!smiles	C1=C(NC(=O)NC1=O)C(=O)O
!pubchem_cid	967
!cell_type	Livers ( from inbred Kyotos - fed a diet with 1% orotic acid) - 14 Day
!organism	rat
!end_metadata
APOA1	-0.254604
RPS29	-0.223859
PABPC4	-0.197910
KNG1	-0.178128
FABP1	-0.149695
GC	-0.147097
ND5	0.144468
MPC1	-0.139964
CLU	-0.134202
UPB1	0.132370
COX3	-0.128174
UBC	-0.126632
HSP90B1	0.126318
MGST1	-0.125442
COMT	-0.117033
APOH	-0.114437
ADH1C	-0.109408
PCK1	-0.108755
PON1	-0.108152
ATP6	-0.107489
APOE	-0.105393
PPIA	-0.104465
INSIG1	-0.102701
PCBD1	-0.102208
ITIH3	-0.102011
F2	-0.100360
AMBP	-0.096022
SULT2A1	-0.092539
GSTM5	-0.091619
CYP1A2	-0.091387
AGT	-0.089535
HPD	-0.089448
GSTM1	-0.088854
COX1	-0.088007
RPS12	-0.087943
AFM	-0.087420
TTR	-0.086918
APOM	-0.086596
RPS21	-0.086086
LIPC	0.084978
GAMT	-0.083941
ACAA2	-0.082254
TECR	-0.081676
HMGCS1	-0.081566
TPT1	-0.078990
ABCD3	0.078380
GPX1	-0.078231
RPS16	-0.075989
SERPINA6	-0.073926
SOD1	-0.072975
MGST3	-0.072677
COX4I1	-0.072565
HSD11B1	-0.071897
LDHA	-0.070599
FTL	-0.069352
PIGR	-0.068782
COX2	-0.068729
RPS13	-0.067612
HPX	-0.067359
PEMT	-0.066942
CFB	-0.062887
ZFP36L1	-0.060491
METTL7B	0.058801
ALDH2	-0.057718
ACTB	-0.057456
RPL18A	-0.057374
GPX4	-0.056482
FAU	-0.056185
RNASE4	0.054825
SEPP1	-0.054695
SLC27A2	0.054059
GLUL	-0.053366
IGFBP1	-0.052320
CA3	-0.052267
B2M	-0.052212
FGG	-0.052191
SULT1E1	-0.051857
ARG1	-0.051052
C9	-0.050450
F10	-0.050310
RPL22	-0.049141
SPP2	-0.049085
SDC4	-0.047939
PCYT2	-0.047382
RBP4	-0.046395
ALDH6A1	0.046339
GSTA5	-0.046135
RPL27	-0.046096
RPS14	-0.046031
CTSS	-0.045859
EPHX1	-0.045836
TAT	-0.045830
GHR	-0.045536
VTN	-0.045203
RPS25	-0.044196
IFITM3	-0.043991
APCS	-0.043934
BSG	-0.043607
ND1	-0.043019
SORD	-0.042653
APOC4	-0.041627
PDIA4	0.040985
KHK	-0.040205
ASS1	-0.039942
FTH1	-0.039298
AHCY	-0.039081
TMBIM6	0.039045
RPL28	-0.038709
APOA2	-0.038358
FBP1	-0.038130
PDIA6	0.038094
ATP5H	-0.037931
OAZ1	-0.037811
SULT1B1	-0.037769
HRSP12	-0.037336
MSMO1	-0.037152
RPL12	-0.036723
DBI	-0.035951
SERPING1	-0.035506
NDUFB9	-0.035212
GSTO1	-0.035041
RPL27A	-0.034730
HSPA5	0.034516
CPS1	-0.034124
GJB1	-0.033976
COX8A	-0.033269
GLUD1	-0.033251
PLG	-0.033224
CSAD	-0.032966
PSAP	-0.032932
POMP	-0.032919
NDUFB2	-0.032384
ALB	-0.032211
NDRG2	0.032056
ERRFI1	-0.031892
DDT	-0.031635
MIF	-0.031577
UGDH	0.031461
COPZ1	-0.031221
NDUFA4	-0.031216
SREBF1	0.031020
ALAD	-0.030843
TMED10	0.030700
MBL2	-0.030594
CD63	-0.030569
SEC61B	0.030401
RBP1	-0.030274
GPT	0.030262
FMO1	-0.030045
HMGCS2	-0.029957
TUBA1B	-0.029862
TMED2	0.029790
TST	-0.029330
GRN	-0.029319
RPL18	-0.029051
CRP	0.028955
SLC22A1	-0.028932
CLEC4F	-0.028930
PDIA3	0.028869
PAH	-0.028840
F9	0.028751
NDUFB4	-0.028708
DAO	-0.028294
HDLBP	0.028222
ITIH4	-0.028206
NDUFC1	-0.027502
HSD17B13	-0.027458
GNMT	0.027424
EEF2	0.027207
PAICS	-0.027126
PXMP2	-0.026829
SEC61A1	0.026774
SIGMAR1	-0.026654
ECI1	0.026447
SERPINA3	-0.026445
TPI1	-0.026405
NDUFB8	-0.026309
RPL13A	-0.026275
UGT2B17	-0.026047
ATP5G1	0.026026
HP	-0.025908
AKR1D1	-0.025617
CTDSP1	-0.025599
CST3	-0.025534
GABARAP	0.025365
RPLP0	-0.024956
ATP5G2	-0.024673
ST6GAL1	-0.024657
HSD17B6	0.024635
ALAS1	0.024319
HAAO	-0.024162
RPS24	0.023814
MDH2	-0.023653
RPS10	-0.023575
RPL15	-0.023511
HSPD1	-0.023462
COX6A1	-0.023352
RPLP2	-0.023306
RPSA	-0.023106
AKR1A1	-0.023015
EEF1A1	0.022933
CYP2E1	-0.022881
FGB	-0.022875
SLC22A18	0.022836
SLC3A2	0.022830
RPS26	-0.022804
CDO1	-0.022732
AVPR1A	-0.022708
GSTK1	-0.022557
HAL	0.022551
PPP2R5A	-0.022530
ACLY	-0.022509
ASL	0.022471
P4HB	0.022315
RPL8	-0.022255
CAT	-0.022223
KLKB1	0.022111
CTSV	0.022107
LCAT	-0.021888
APOA4	-0.021837
PHB2	-0.021714
PROC	-0.021696
UGT1A1	0.021647
UGT2B28	-0.021642
ATP6V0C	-0.021589
NDUFA3	-0.021489
SDS	0.021291
PSMB5	-0.021286
PPDPF	-0.021239
THRSP	-0.021223
PDYN	-0.021066
ACSL5	-0.021055
LAMP2	-0.020771
G6PC	-0.020616
PGRMC1	-0.020610
RPL31	-0.020606
SLC37A4	-0.020425
C1QB	-0.020413
RPL23	-0.020381
HSD3B7	-0.020240
PEBP1	-0.020181
CYP27A1	-0.020052
RPN2	0.020024
ENPP3	-0.019700
ND2	-0.019699
TDO2	0.019649
CYP51A1	-0.019317
GLS2	0.019235
PFN1	-0.019198
PSME1	-0.019181
SERPINA10	-0.019104
RPL30	-0.018975
RPS8	-0.018745
HPN	-0.018731
SLC22A7	-0.018646
HIBADH	-0.018627
RPL7A	0.018572
RPS23	-0.018531
SDHA	0.018482
SLC10A1	0.018476
PLIN2	-0.018345
LGALS9B	0.018215
COPS7A	0.018167
HSP90AB1	-0.018125
PPIF	-0.018067
ALDOB	-0.017912
RPL39	-0.017640
ND4	-0.017577
COX7B	-0.017573
PRKCDBP	0.017514
OPLAH	-0.017389
NDUFV3	-0.017369
CTSH	-0.017359
G0S2	0.017351
ECH1	0.017119
SERP1	0.017019
ASGR1	-0.016914
FABP6	-0.016910
DDX3X	0.016876
MORF4L2	0.016785
OAT	-0.016654
MGST2	-0.016612
CALR	0.016482
RPL11	0.016386
AQP9	-0.016308
SLC6A13	-0.016307
GOT1	0.016283
RPL24	-0.016273
FCGRT	-0.016232
GNB2L1	-0.016210
HSP90AA1	-0.016190
SLC25A5	-0.016142
HAGH	-0.016102
RPL26	-0.015996
CSNK2B	-0.015863
RPS3	-0.015696
YBX1	-0.015663
HSD17B10	-0.015660
HSPE1	-0.015642
SQLE	-0.015588
AK3	-0.015546
TCN2	-0.015546
ACOX2	0.015423
RPS15	-0.015313
ACTG1	-0.015092
GDI2	0.014982
ZFAND6	0.014840
SLC41A2	-0.014807
BAAT	-0.014797
RPL37	-0.014614
COL3A1	-0.014518
DHCR7	-0.014512
GDI1	0.014512
RPS9	-0.014500
SLCO2A1	-0.014475
ATP5C1	0.014372
FABP5	-0.014306
RPL19	-0.014125
LAMP1	-0.014036
ACADM	-0.014026
ETNK2	-0.014021
RPS27L	-0.013936
RPS7	-0.013640
PSMB2	-0.013623
TXN2	-0.013584
ADH5	-0.013507
PPIB	0.013431
DECR1	-0.013333
CYC1	-0.013297
MAGT1	0.013264
PTP4A1	-0.013248
EIF2S1	0.013218
UBQLN1	0.013081
NDUFB10	-0.013052
ATP1A1	0.012986
ACADS	-0.012897
UBR5	0.012862
MPST	-0.012845
RPL17	0.012843
PSMD11	0.012819
GOT2	-0.012817
EGR1	-0.012785
NME2	-0.012720
ACADVL	0.012711
NDUFA8	-0.012668
NEDD8	-0.012660
RPS11	-0.012659
FDPS	-0.012649
HSPA9	0.012626
TUBA1C	-0.012483
CPQ	-0.012405
ALDH3A2	0.012224
UBXN1	-0.012219
RPL10A	-0.012197
ORMDL2	0.012166
PEX14	-0.012120
RPL35	0.012097
GNE	-0.012014
AUH	-0.011920
HSPA8	-0.011919
MAOB	-0.011911
TIMM23	0.011892
RAF1	-0.011789
GPD1	0.011757
MAP2K2	-0.011747
ATP5O	0.011735
ACADL	-0.011690
GNAS	-0.011676
KRT18	0.011616
PRKCG	-0.011567
MDH1	-0.011563
TMEM59	0.011512
RPL6	-0.011411
DIO1	-0.011276
ARF1	0.011247
DNAJA1	-0.011226
CEBPB	-0.011138
TMEM47	-0.011129
PGK1	-0.011097
ACAT2	-0.011077
AES	-0.011070
PROS1	-0.011048
RABAC1	-0.011037
PTGR1	-0.010911
RGN	-0.010880
TIMP2	-0.010867
ACY1	-0.010850
HSD17B12	-0.010842
SLC6A6	0.010818
GRB2	-0.010784
CISH	-0.010731
ABCB11	-0.010725
PNRC1	-0.010673
PPP2R1A	-0.010648
SLC35B1	0.010645
MTHFD1	0.010645
LIPA	-0.010606
CLTA	-0.010590
TAF10	-0.010589
COX5A	-0.010569
PAPSS2	0.010544
DUSP1	-0.010519
TTC36	-0.010450
MYL12A	-0.010443
BGN	-0.010442
NPHP1	-0.010386
DARS	0.010348
FKBP11	0.010332
ATP2A2	0.010297
FUCA1	-0.010293
PDK2	-0.010231
ARF6	-0.010156
TUBA1A	-0.010143
FIS1	-0.010139
ABCC6	-0.010053
CYBA	-0.010024
KCNH3	-0.009963
ECHS1	-0.009936
GSTA3	0.009925
PPP1CA	-0.009825
GRHPR	0.009816
EIF4E2	0.009782
PICALM	0.009765
NCKAP1	0.009761
ENO1	-0.009620
CTSD	-0.009587
BTG1	-0.009566
APMAP	-0.009550
ABAT	-0.009500
QDPR	-0.009479
KLF9	-0.009412
ACSL4	0.009342
GNB2	-0.009289
NDUFA6	-0.009269
AZGP1	0.009175
C8B	-0.009141
BDH1	-0.009140
NDUFC2	0.009115
SLC25A30	-0.009110
RPL3	0.009014
RPL9	-0.008962
GCHFR	-0.008939
CDC37	-0.008905
APOB	-0.008842
YWHAE	0.008820
CLTC	0.008812
CELA1	-0.008786
DNAJA3	0.008613
MMP14	-0.008585
CFP	-0.008581
NR1H2	-0.008489
GAPDH	-0.008486
ALDH7A1	-0.008474
SUCLG1	-0.008453
ATP5F1	-0.008450
ATP5D	-0.008449
PSMB9	-0.008447
TSPO	-0.008407
GRINA	-0.008393
ARF4	0.008393
SERPINA7	0.008369
PSMB4	0.008298
HIGD2A	-0.008291
PSMB1	0.008273
EIF4A2	0.008258
SEPHS2	-0.008225
ZFP36	-0.008181
AP2M1	-0.008173
TNFRSF1A	-0.008168
PRKAR1A	0.008166
CLDN3	-0.008154
AMACR	0.008125
CITED2	-0.008099
LEP	-0.008064
JUN	-0.008029
BAD	-0.008021
CCBL1	-0.008013
ABCC2	0.007975
ASGR2	-0.007966
RBPMS	-0.007946
GCKR	-0.007937
SDC2	0.007908
CPT2	0.007894
TSC22D1	-0.007894
RAB14	0.007884
ALAS2	-0.007882
NUDT4	-0.007877
HNRNPAB	-0.007824
KARS	0.007782
MYADM	-0.007733
NAPA	-0.007686
SCAMP2	-0.007659
GNAI2	-0.007646
MFGE8	-0.007638
IGFBP3	-0.007636
SLC4A4	0.007610
SDCBP	0.007595
HMGA1	-0.007594
PSMB3	-0.007592
NDUFB11	0.007591