!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	estradiol
!ligand_id	CHEBI:23965
!cell_type	MCF-7 cells
!organism	human
!end_metadata
PTGS2	0.128617
MMP13	0.106450
BIRC3	0.091264
COL21A1	0.090738
FGG	0.086708
CCL2	0.080919
PLAC1	0.079917
LMO3	-0.079341
FGB	0.078872
CXCL10	0.078073
GNE	-0.077984
NPY1R	0.077519
CXCL12	0.076983
PRSS23	0.075566
BLNK	-0.068479
CXCL8	0.066646
EGR3	0.065565
CXCL11	0.064274
SGK1	0.064046
PLAT	0.063953
TFF2	0.062919
CXCL1	0.062203
IL17RB	0.062157
ISG20	0.060164
MYBL1	0.060058
KIAA0226L	0.059881
CCL20	0.059591
TMPRSS11E	0.058875
VTCN1	-0.057019
FOS	0.056547
AOX1	0.056452
CXCL3	0.055737
RAB31	0.055644
WISP2	0.055021
PGR	0.055013
DOCK4	0.053743
EPB41L3	0.053679
AREG	0.053409
OPN3	0.052875
STON1	-0.052530
CALML5	-0.051780
HOPX	-0.050665
S100A7	0.050311
TM4SF1	-0.049841
TSPAN8	-0.049819
CXCL2	0.049811
GRB14	-0.049446
RPRM	-0.048993
UGT2B15	0.047271
CSGALNACT1	0.047171
HCRP1	-0.047126
LAMB3	0.046697
TFPI2	0.046373
SLC19A2	0.046192
RAB26	-0.045882
ATP6V0A4	-0.045706
KCNV1	0.045482
IGFBP4	0.045431
PDZK1	0.045361
TMPRSS4	-0.044652
UGT2B28	0.044393
FN1	0.044320
TTR	0.044093
ADAM2	-0.043928
PPFIA2	-0.043879
ODAM	-0.042909
TSPAN12	-0.042739
LINC00341	0.042433
TLR2	0.042238
ACKR3	-0.042136
BIK	-0.041997
CLC	-0.041895
SEC14L5	-0.041754
FJX1	0.041575
RNF43	-0.041551
HCAR3	-0.041279
AKR1D1	0.041077
PMAIP1	0.041035
KIF18A	0.040892
GREB1	0.040799
CAV1	0.039993
APOD	-0.039866
LIF	0.039808
ENPP2	0.039475
KLRC3	0.039258
CA12	0.039022
HEY1	-0.038647
OLFML2A	0.038488
CD83	0.038330
ZNF750	-0.038166
TMEM158	0.038144
TCN1	0.038057
KRT81	-0.037929
PCOLCE2	0.037909
FAM134B	-0.037797
PSTPIP2	0.037732
SLC17A5	-0.037631
BAMBI	-0.037600
ZNF211	-0.037550
TENC1	-0.037385
ENC1	-0.037035
ELOVL2	0.036937
MMP10	0.036921
SERPINA5	0.036737
FBLN5	0.036613
DHRS3	-0.036519
DEPTOR	0.036306
TGFB3	-0.036284
FAM129A	-0.036147
MGP	0.036014
NRIP1	0.035984
SGCG	-0.035848
HOXC4	0.035717
SYT17	-0.035521
CCNG2	-0.035284
PPOX	-0.035251
NELL2	-0.035196
IRF6	-0.035176
SEMA3E	-0.034770
MMP1	0.034742
MYC	0.034701
HOXC5	0.034497
MBOAT2	-0.034447
FRK	0.034213
EFEMP1	-0.034130
EXOC5	0.034128
ABCC5	-0.033813
PLD3	-0.033804
DIO1	0.033757
VEGFC	-0.033642
ASB9	-0.033628
LYPD3	-0.033607
RIN2	-0.033605
ELF5	-0.033532
CTNND2	-0.033442
HOXC6	0.033343
CHML	0.033134
CADPS2	0.033082
PCP4	0.033039
ATP7B	-0.033037
TIPARP	0.033028
RHOBTB3	0.032980
SERPINE2	0.032980
UBE2L6	-0.032831
CTSF	-0.032724
KRT6B	0.032717
FAM13A	-0.032716
BCAS1	-0.032709
APBB3	-0.032701
ARL14	0.032629
RUNDC3B	-0.032555
TBX3	-0.032272
ABCG2	0.032256
ARHGAP11A	0.032087
ALDH4A1	-0.031927
PMEL	-0.031837
CERS4	-0.031788
SGPP1	0.031771
FBP1	-0.031624
IL1R1	-0.031605
ANKRD1	0.031574
CALCR	0.031463
DNASE1	-0.031420
LIMA1	-0.031408
NBEA	-0.031373
TPK1	-0.031190
TNFAIP3	0.031155
SELENBP1	-0.031070
KCNN2	-0.031032
GALT	-0.030970
GSTA4	-0.030920
TMEM135	-0.030877
SOD2	0.030837
CEBPD	0.030828
PARP8	-0.030821
NCS1	0.030739
GGT1	-0.030584
SUV39H2	0.030562
FAM216A	0.030449
PVALB	-0.030370
RBKS	-0.030363
ABCG1	-0.030324
F5	0.030272
RELB	0.030219
SATB1	-0.030101
A2M	-0.029937
TMPRSS3	0.029924
FGF13	-0.029886
PPP1R3C	-0.029863
MAN1C1	-0.029828
PAPSS2	0.029787
PHLDA1	0.029707
FOXC1	0.029619
GNA14	0.029511
EXO1	0.029450
IFI44L	-0.029383
ADAMTS1	0.029074
CA5B	-0.028826
TPD52L1	0.028754
AKR1B10	-0.028670
KLF4	0.028597
NFE2L3	0.028560
UBIAD1	0.028455
ORC1	0.028407
GCNT1	-0.028367
ERCC8	0.028366
SMYD3	-0.028341
MAP3K8	0.028319
TMEM194A	0.028316
GLUL	0.028308
SYTL2	-0.028278
ACPP	-0.028228
CLMN	-0.028222
BANK1	0.028217
POP1	0.028159
ING4	-0.028125
SLC4A8	-0.028060
KCNK5	0.027972
PMP22	-0.027942
ATP8A1	-0.027939
RAC3	-0.027893
DNAJB9	0.027792
CXCL5	0.027762
INSIG2	-0.027760
TNFRSF11B	0.027723
CP	0.027698
TAF13	0.027648
SSBP2	-0.027591
CEACAM6	-0.027585
ZNF804A	-0.027584
DEPDC1	0.027536
QPRT	-0.027437
DAB2	-0.027431
HOMER2	0.027426
SLC2A6	0.027414
DENND4A	0.027410
FAM114A1	-0.027405
URB2	0.027379
BAG2	0.027369
SDC2	0.027358
TSPAN5	0.027323
SOX3	0.027315
ROGDI	-0.027276
SLC7A5	0.027250
LEPREL1	0.027234
ERBB4	-0.027228
THBS3	-0.027220
PTGES	0.027187
MAN1A1	0.027093
CBX6	-0.027037
SIK1	0.027022
GSAP	-0.026892
BRCA2	0.026888
MAMLD1	0.026869
FKBP4	0.026816
SNHG3	0.026664
SLC35C1	0.026592
KLHL24	-0.026559
UTP20	0.026516
RPS6KA5	-0.026498
LAMB2	-0.026491
FAM46A	0.026293
PPL	-0.026272
NAIP	-0.026160
BCL2A1	0.025992
PALMD	-0.025990
PIK3IP1	-0.025981
NDC1	0.025976
RASGRP1	0.025930
HIST1H2AG	-0.025891
SLC24A3	-0.025870
SLC12A5	-0.025830
CTSH	-0.025812
IGFBP5	-0.025769
RASA4	-0.025757
PPIF	0.025727
RLN2	0.025645
PUS1	0.025493
MCM10	0.025480
MB	-0.025478
CRISP3	-0.025330
FST	0.025222
RTN2	-0.025198
RAI14	0.025138
SPANXC	-0.025137
CERK	-0.025041
FAM189A2	0.025020
UGDH	0.024991
HIST1H3H	-0.024982
SYCP2	-0.024859
SYBU	0.024852
WDR76	0.024833
LARP6	-0.024794
REEP1	0.024792
SASH1	-0.024774
TNFSF10	-0.024734
LOC100272216	-0.024733
BFSP2	0.024697
MOCOS	0.024670
SLC47A1	0.024604
ZNF185	-0.024589
CLU	-0.024582
PTK6	-0.024527
CHRNA5	0.024496
GBP1	0.024452
CCDC86	0.024442
B3GNT2	0.024296
PTPN13	-0.024232
SERPINA3	0.024125
ICAM1	0.024092
TFF1	0.024072
SEC14L2	0.024071
NAP1L2	0.024067
ANGPTL4	-0.024040
ABLIM3	-0.024034
FLNB	0.024007
MGAT4A	0.023974
GLA	0.023967
SEMA3C	0.023855
PROCR	0.023849
DPH2	0.023787
DDX21	0.023780
EHD3	-0.023764
CCNO	-0.023764
ADRA2C	-0.023755
ECH1	-0.023748
CDCA8	0.023738
SYNC	-0.023734
SERPINI1	-0.023690
FZD4	-0.023626
LTBP2	-0.023582
BYSL	0.023579
NOP56	0.023560
ID1	0.023552
RAB27B	-0.023535
ZNF137P	-0.023486
NIPSNAP1	-0.023460
FHL2	0.023459
PLEKHB1	-0.023455
GLCE	-0.023449
THBD	0.023409
IGFBP3	-0.023407
PDZD2	-0.023395
SRPRB	0.023381
POLQ	0.023355
STC2	0.023324
NOC3L	0.023294
CDC6	0.023290
ERLIN1	0.023271
SLC2A10	-0.023219
HDAC7	-0.023195
AIM1	-0.023173
SUOX	-0.023171
TSEN2	0.023171
TFPI	-0.023122
C10orf2	0.023117
UPK1A	-0.023066
INHBB	-0.023036
RAB29	-0.023029
TUBB6	0.023020
SIDT1	-0.023013
NR3C1	0.022954
SH2D4A	-0.022915
LOC100507424	-0.022911
ATXN1	-0.022906
ZBTB10	-0.022906
PAIP2B	-0.022861
MT1F	-0.022846
CYP2C8	-0.022768
MYO19	0.022727
ACSS3	-0.022727
HIST1H2AC	-0.022723
C2orf27A	-0.022709
CHD3	-0.022687
GALNT6	-0.022654
MAGED2	-0.022644
HCFC1R1	-0.022643
KIAA1107	-0.022641
CTPS1	0.022636
KIAA0020	0.022629
POGLUT1	0.022616
SLIT2	-0.022609
UCP2	-0.022580
CYP4B1	-0.022567
TBC1D8B	-0.022565
CITED2	0.022533
PDSS1	0.022503
SHROOM2	-0.022321
DDX10	0.022316
GAL	0.022315
HIST1H2BD	-0.022285
PAK6	-0.022272
PLK1	0.022258
TSPAN1	-0.022252
PRRG4	0.022232
TRAM2	-0.022210
PARM1	0.022171
PADI2	-0.022167
WDR4	0.022157
ETHE1	-0.022124
GEMIN4	0.022096
LPPR2	-0.022041
PHYH	-0.022031
SLC39A6	0.022024
CUL7	-0.021959
ITM2C	-0.021952
KAT2B	-0.021901
ZNF257	0.021875
CXCR4	-0.021847
NR1D2	-0.021797
GPNMB	-0.021786
FGGY	-0.021778
POLR3G	0.021777
MIA3	-0.021762
SIAH2	0.021749
CSTA	-0.021698
ALDH6A1	-0.021655
WDR12	0.021583
LDOC1	-0.021561
BCAS3	-0.021540
LINC00963	-0.021509
SLC7A11	0.021492
FAM57A	0.021483
LRIG1	0.021438
GABBR1	-0.021435
IRS2	0.021393
FOLH1B	-0.021368
SORL1	-0.021365
RBBP8	0.021347
ANXA3	-0.021281
RNF219	0.021235
CALML4	0.021211
TRAP1	0.021165
UCK2	0.021101
ZC3H12A	0.021087
SGSM2	-0.021085
DKC1	0.021062
AEN	0.021032
SRM	0.021024
DUSP10	-0.020997
MXD4	-0.020958
NOL6	0.020896
ORAI3	-0.020831
TNF	0.020821
ZNF606	-0.020818
SEPP1	-0.020714
HSPB8	0.020677
POMT1	-0.020667
OSMR	0.020655
BBS1	-0.020630
OBSL1	-0.020629
TEAD1	0.020577
SLCO4A1	0.020570
CORO2A	-0.020557
SLC22A18	-0.020544
NMD3	0.020539
CD44	0.020516
MLLT3	-0.020506
ALAD	-0.020499
ABCE1	0.020480
WDR77	0.020471
BRIP1	0.020470
LIN7A	-0.020447
ATP2C2	-0.020407
CRIM1	0.020397
GDPD3	-0.020394
EFHD1	-0.020387
HYOU1	0.020381
ZNF613	-0.020366
NPM3	0.020359
HOXC13	0.020357
TIMM50	0.020313
SLC7A6	0.020278
GNAI1	-0.020262
ID4	0.020251
ARNTL2	0.020235
CARD8	0.020209
SYNJ2BP	-0.020184
SLCO4C1	-0.020173
IFRD2	0.020164
AKR1C2	0.020151
KIF2C	0.020140
IFIT1	-0.020115
B4GALNT1	0.020103
FBXL7	-0.020089
BBS7	0.020084
TGDS	0.020066
PRSS8	-0.020042
FUT8	-0.020042
HIPK2	0.020031
EGLN3	0.020005
KMO	0.019990
ZNF215	0.019981
HILPDA	-0.019979
MDN1	0.019966
ACSL3	-0.019959
OAS1	-0.019942
ZMYM3	-0.019934
PEG10	0.019928
PNP	0.019927