!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Dactinomycin
!smiles	O=C1N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)CC(=O)N([C@H](C(=O)O[C@@H]([C@@H]1NC(=O)c1c2nc3c(ccc(c3oc2c(c(=O)c1N)C)C)C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C(=O)[C@H]2N(C(=O)[C@H](NC1=O)C(C)C)CCC2)C)C)C(C)C)C
!drugbank_id	DB00970
!cell_type	tristerapolin-deficient
!organism	mouse
!end_metadata
DUSP5	-0.155977
DUSP1	-0.154367
DUSP2	-0.151809
DUSP6	-0.141834
MYC	-0.141396
CYR61	-0.127313
IER2	-0.126485
CSRNP1	-0.119785
EGR1	-0.114340
NFKBIA	-0.113304
BHLHE40	-0.107702
SOCS3	-0.103530
JUN	-0.101971
CHAC1	-0.099901
NFIL3	-0.099555
SMAD7	-0.095886
GADD45G	-0.094841
IER5	-0.094305
SNAI1	-0.093820
JUNB	-0.093643
SERTAD1	-0.093276
KLF10	-0.093189
ID3	-0.089720
FOS	-0.089604
ZFP36	-0.088396
ID1	-0.086852
BTG2	-0.086710
NR4A1	-0.086433
PLEKHF1	-0.082688
CLK1	-0.082376
FOXC2	-0.078489
PHF13	-0.078382
CCNL1	-0.077689
FILIP1L	-0.074412
C8orf4	-0.072559
FOSL2	-0.069131
TIPARP	-0.063710
CEBPB	-0.062501
TRIB1	-0.061443
PTGER4	-0.060910
EGR2	-0.060012
KLF2	-0.058514
CITED2	-0.058297
KCTD11	-0.057434
ANKRD1	-0.057147
FOSB	-0.056471
IRS1	-0.056370
CDC42EP3	-0.055665
NFKBIZ	-0.055457
RHOB	-0.053595
ZNF655	-0.053216
ADAMTS1	-0.051814
AJUBA	-0.051034
RND3	-0.050374
TNFAIP3	-0.050373
ZNF281	-0.049332
ERRFI1	-0.048774
TGIF1	-0.048539
DUSP10	-0.048266
ARRDC3	-0.048132
CTGF	-0.047235
GADD45B	-0.046466
IER5L	-0.046330
SGK1	-0.045712
PPP1R15A	-0.045021
ATF3	-0.044806
FOXG1	-0.044554
DACT1	-0.044250
KIAA1551	-0.044242
FZD2	-0.044082
RNF19A	-0.044046
ZSCAN25	-0.043910
FRAT2	-0.043298
FOSL1	-0.042626
GDNF	-0.042582
BMP4	-0.042325
ZNF623	-0.041591
KLF7	-0.041099
OSER1	-0.040977
FOXC1	-0.040876
PHF23	-0.040758
BCAR1	-0.040534
KLF6	-0.040437
PHLDA1	-0.040334
GAS1	-0.039526
ARID5A	-0.038837
ZNF267	-0.038587
PER1	-0.037680
IRS2	-0.037501
USPL1	-0.037189
MED26	-0.037130
TOPORS	-0.036987
DYRK3	-0.036965
FBXO30	-0.036868
PPP1R15B	-0.036194
BRD2	-0.036142
SNAI2	-0.035784
IFRD1	-0.035495
SKIL	-0.035086
ZNF25	-0.035059
SIAH2	-0.034407
DDIT4	-0.034376
ZBTB1	-0.034167
VEGFA	-0.034058
MCL1	-0.034034
CSRNP2	-0.034008
ZNF761	-0.033765
F3	-0.033731
PAPOLG	-0.033564
CNKSR3	-0.033484
SLC3A2	-0.033275
RCAN1	-0.033000
NUAK2	-0.032794
CTTNBP2NL	-0.032772
TMEM11	-0.032328
TGIF2	-0.032231
MRGPRF	-0.032129
IRF2BP2	-0.031967
FBXO34	-0.031740
KBTBD2	-0.031475
CBX4	-0.031464
NEDD9	-0.031445
FEM1C	-0.031430
CLP1	-0.031402
PLK2	-0.030753
ZNF622	-0.030541
ADAMTS5	-0.030512
ZNF574	-0.030437
CDC42EP1	-0.030357
NAB2	-0.030181
CSTF2T	-0.029956
AMOTL2	-0.029754
PIM3	-0.029746
C14orf169	-0.029593
KLF9	-0.029591
IFFO2	-0.029524
CLK4	-0.029429
VPS37B	-0.029261
MSL2	-0.029194
NR4A2	-0.029052
ZBTB11	-0.029038
PCF11	-0.029021
CDC42EP2	-0.029020
EPC2	-0.029018
NUP62	-0.028663
GTF2B	-0.028637
SLCO4A1	-0.028575
SNX18	-0.028522
ENC1	-0.027980
CBLL1	-0.027818
GEM	-0.027617
SMAD6	-0.027454
ZNF189	-0.027402
HAS2	-0.027240
STK40	-0.027204
KLF4	-0.027180
RAB33B	-0.026919
PCDH18	-0.026909
REL	-0.026572
SOX9	-0.026547
ZNF212	-0.026120
MAD2L1BP	-0.026052
ZNF513	-0.025791
MIER3	-0.025786
NSRP1	-0.025547
YTHDF2	-0.025509
PNRC1	-0.025477
MIDN	-0.025441
KDM6B	-0.025422
BDNF	-0.025397
TSC22D2	-0.025322
SGK223	-0.025049
CDT1	-0.024950
IRF1	-0.024877
KDM3A	-0.024856
RAB9A	-0.024834
RND1	-0.024803
DNAJB1	-0.024728
EGR3	-0.024719
ZFPM2	-0.024607
LMO4	-0.024552
SF3B3	-0.024513
TRMT10C	-0.024440
DNAJB4	-0.024321
BACH1	-0.024028
RABGGTB	-0.023815
CDCA4	-0.023738
ATOH8	-0.023714
ZNF830	-0.023578
C17orf99	0.023519
BCL3	-0.023507
SLC38A2	-0.023489
ZBTB6	-0.023395
DUSP16	-0.023355
TRIM13	-0.023335
EP300	-0.023249
WEE1	-0.023203
KMT2E	-0.023048
SPRY2	-0.023022
KCTD15	-0.022899
IGF2BP1	-0.022842
UBC	-0.022685
ZNF32	-0.022651
NOC2L	-0.022598
CTU1	-0.022534
ZNF280B	-0.022508
SNIP1	-0.022485
PRDM2	-0.022484
FHL2	-0.022480
GNL3	-0.022454
MED7	-0.022451
SHB	-0.022332
TBCC	-0.022237
MAT2B	-0.022217
ING2	-0.022206
IRAK2	-0.022190
ARID1A	-0.022189
MOGS	-0.022052
RPL12	-0.022046
ZNF566	-0.022027
RBBP6	-0.021773
KMT2B	-0.021732
RNF34	-0.021675
FOXQ1	-0.021549
VPS37C	-0.021486
ZNF496	-0.021472
DCUN1D3	-0.021449
ZNF250	-0.021443
CLDN12	-0.021413
ADM	-0.021384
UTP3	-0.021359
ID2	-0.021293
ELMSAN1	-0.021257
PPAN	-0.021227
PDGFRB	-0.021193
RNF111	-0.021083
STIL	-0.021005
NUFIP2	-0.020973
TBX18	-0.020939
IFIT1B	-0.020931
ID4	-0.020908
ZNF521	-0.020839
STARD13	-0.020832
NFKBIE	-0.020750
ZBTB39	-0.020740
IER3	-0.020733
MGAT1	-0.020619
ADNP2	-0.020606
ZFP62	-0.020593
MNT	-0.020530
SMG8	-0.020514
PLEKHO2	-0.020507
RAPGEF2	-0.020478
SHROOM4	-0.020445
IRF2BPL	-0.020418
C11orf68	-0.020416
GAB1	-0.020385
HIVEP1	-0.020251
ZNF131	-0.020205
FAM110C	-0.020181
CRY2	-0.020177
ZFYVE26	-0.020171
ZC2HC1A	-0.020155
MSH6	-0.020054
DLC1	-0.019985
CXCL10	-0.019776
JARID2	-0.019776
IQCB1	-0.019729
H1F0	-0.019709
ZNF644	-0.019705
FAM222B	-0.019669
LRIG2	-0.019612
ARID5B	-0.019600
YTHDC1	-0.019575
ZNF778	-0.019567
BRPF1	-0.019537
TRPS1	-0.019485
USP42	-0.019459
ABT1	-0.019407
PABPC1	-0.019352
CCDC71L	-0.019341
NRBF2	-0.019312
NGLY1	-0.019276
RAD17	-0.019247
CTXN1	0.019234
TMEM86A	-0.019227
SMCR8	-0.019190
C11orf95	-0.019176
WSB1	-0.019175
C6orf120	-0.019165
BTG1	-0.018972
ZNF175	-0.018922
HAUS3	-0.018881
CDKN3	0.018848
EHMT1	-0.018787
DDIT3	-0.018745
FAM192A	-0.018686
PPRC1	-0.018667
KTI12	-0.018652
TRIM59	-0.018577
XBP1	-0.018543
ZBTB22	-0.018417
ZNF260	-0.018398
TOB1	-0.018357
SDE2	-0.018307
EIF4A2	-0.018300
CCNG2	-0.018231
C16orf72	-0.018224
MAGI3	-0.018146
RHOU	-0.018091
RASL11B	-0.018070
MSL1	-0.018057
TLR2	-0.018039
MYL6	-0.017998
C16orf87	-0.017975
TDP2	-0.017961
SPRY1	-0.017943
LSM5	0.017930
TIGD2	-0.017926
TAF1D	-0.017846
EFNA1	-0.017741
GNB2L1	-0.017705
LARGE	-0.017705
ATF4	-0.017687
SQLE	-0.017656
MARCH7	-0.017647
CCL13	-0.017604
TMEM165	-0.017574
LURAP1L	-0.017565
L3MBTL3	-0.017549
PLCXD2	-0.017506
SNX33	-0.017492
UBE2C	0.017448
EPC1	-0.017437
GYPC	-0.017431
FIZ1	-0.017413
ITPRIP	-0.017406
MPP5	-0.017364
SESN2	-0.017355
FGF7	-0.017320
ZBTB10	-0.017318
NCKAP5	-0.017306
RILPL2	-0.017260
FLCN	-0.017260
HEXIM1	-0.017222
HPS4	-0.017210
MFAP3	-0.017115
S1PR2	-0.017074
PHRF1	-0.017073
SERTAD3	-0.017044
ZBTB2	-0.016990
ZFAND5	-0.016987
SERPINE1	-0.016960
PDCD4	-0.016952
KIAA0247	-0.016951
HIC2	-0.016934
HPS6	-0.016933
DUSP8	-0.016912
BBC3	-0.016909
ZNHIT1	0.016897
TP53INP1	-0.016892
KPNA2	-0.016853
CLTC	-0.016839
SOWAHC	-0.016829
TJP1	-0.016825
ZSCAN21	-0.016763
RAB1B	0.016700
ASXL1	-0.016699
ZNF7	-0.016681
NR1D1	-0.016634
CHKA	-0.016626
ZNF292	-0.016609
ZMAT1	-0.016601
CDK5R1	-0.016574
FBXO5	-0.016571
RAB23	-0.016535
CASP8AP2	-0.016506
HERPUD1	-0.016450
NPAT	-0.016439
CCNT1	-0.016410
TENC1	-0.016398
C1orf52	-0.016373
NUP50	-0.016230
IFIT2	-0.016218
SETD2	-0.016194
RIN2	-0.016175
CD14	-0.016161
ATF7IP	-0.016140
SPRTN	-0.016133
DTWD1	-0.016113
GLI3	-0.016078
B3GNT9	-0.016048
HMOX1	-0.016021
BIRC2	-0.016016
LPAR4	-0.016013
PLK1	-0.015989
GATA2	-0.015969
FNDC8	0.015966
AXIN1	-0.015949
CLK2	-0.015918
MUM1L1	-0.015888
LFNG	-0.015887
KAT8	-0.015850
TNFRSF11B	0.015844
NUAK1	-0.015784
ZNF639	-0.015784
SAT1	0.015732
ZFX	-0.015716
METTL14	-0.015688
TMEM170A	0.015618
PLEKHG2	-0.015615
STARD3NL	0.015594
SRSF4	-0.015581
TCF7L1	-0.015566
PHF20	-0.015554
C17orf103	-0.015544
RAB30	-0.015542
DBR1	-0.015540
ZXDC	-0.015537
SAP30	-0.015536
C15orf39	-0.015511
ZNF91	-0.015485
SLC33A1	-0.015484
SLC30A6	-0.015480
CHST12	-0.015453
BCL2L11	-0.015415
CASC3	-0.015401
VEZF1	-0.015400
TMC4	0.015376
RBM45	0.015368
LCN2	0.015359
TMEM55B	-0.015358
FKBP8	0.015349
ZNF777	-0.015334
TRIM47	-0.015333
TMEM120A	0.015329
RGS3	-0.015282
ITPKC	-0.015250
HIC1	-0.015243
MPHOSPH8	-0.015206
RGMA	-0.015184
LYSMD3	-0.015166
KIAA0232	-0.015147
P2RY1	-0.015143
TEX10	-0.015124
PFKFB4	0.015122
OSR1	-0.015110
S1PR3	-0.015102
ALKBH4	-0.015098
ZNF322	-0.015093
ZBTB7A	-0.015089
ABL2	-0.015063
NDNL2	-0.015046
AES	0.015023
USP36	-0.015017
INTS12	-0.015017
ETV3	-0.014981
DCXR	0.014972
RBM15	-0.014971
CD34	0.014925
GOLGA5	-0.014898
NGEF	0.014888
ZSCAN26	-0.014882
SWAP70	-0.014877
ZUFSP	-0.014874
FLNB	-0.014871
ATG101	-0.014855
FAM126B	-0.014841
KMT2A	-0.014841
LPIN1	-0.014792
TBX3	-0.014779
NR4A3	-0.014773
NR2F1	-0.014764
GON4L	-0.014755
ARGLU1	-0.014749
SPATA2	-0.014734
LCOR	-0.014731
TIFA	-0.014724
EDC4	-0.014713
SYVN1	-0.014708
FOXJ3	-0.014693
PIK3R4	-0.014682
CDC42EP4	-0.014681
AREG	0.014679
LPHN2	-0.014630
RUNDC1	-0.014600
CDK5RAP1	-0.014587
ZNF384	-0.014583
GRINA	0.014580
TOB2	-0.014576
GLTSCR1	-0.014575
PPP1R18	-0.014534
THAP11	-0.014522
FBXL8	-0.014503
ANKRD28	-0.014471
UROD	0.014469
ZCCHC7	-0.014466
EIF6	0.014464
FBXO33	-0.014455
ITGB1BP1	0.014438