!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	Pioglitazone
!smiles	CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
!drugbank_id	DB01132
!pubchem_cid	4829
!cell_type	3 months
!organism	rat
!end_metadata
COX2	-0.231508
HSPA8	-0.172461
YWHAE	0.155323
MRFAP1	0.150054
UCHL1	0.147134
DPYSL2	0.134698
PTN	-0.132650
HNRNPAB	0.122824
NDRG4	-0.122489
NDUFB11	0.089609
RPL37	0.087474
PTGDS	0.083029
PTPLAD1	0.077999
LRRC58	0.075297
FABP7	-0.068295
RPL17	-0.068210
NDUFB4	-0.068009
ND2	-0.067407
GPRASP1	-0.067155
TUBB2B	-0.063838
TPI1	-0.063270
ABI2	0.061675
RPS29	-0.061100
ITPR1	0.060958
NEFH	0.059897
TUBB2A	-0.058964
BSG	-0.058269
TSPAN3	0.057496
CDH22	-0.056808
SYP	0.055974
RPS13	0.055454
SERBP1	0.054286
HTRA1	0.054079
ATP6V1B2	0.053642
IRGQ	-0.053055
RPL6	-0.052914
PLP1	-0.051957
NDN	-0.049723
KLHL9	-0.049449
HIVEP2	-0.049418
CCT4	-0.049095
RPS8	-0.049004
CRYM	-0.048878
CYTB	-0.048537
ATP5G3	-0.048163
VTA1	0.048064
SNAP25	-0.047504
ZNF330	0.047116
SUB1	-0.046747
GOT1	0.046679
BCAS1	0.046561
SKIL	0.046100
RCN2	-0.046040
SCN3B	0.045818
GSTA5	0.045626
HSPA12A	-0.045287
BHLHE22	-0.045126
RHOB	0.045032
CPNE7	-0.044717
COPS6	0.044457
PLAGL1	-0.044025
RPS3	0.043986
SLC24A2	0.043854
PLCL1	-0.043605
CPNE6	-0.042990
CHST1	0.042911
GABRB1	0.042908
TRIO	-0.042791
COX1	0.042755
TMCC2	0.042469
NCDN	0.042171
COPS8	0.041835
TAX1BP1	0.041745
NDUFV2	-0.041643
RPL12	-0.041533
RPL27A	-0.041308
HMGCS1	-0.040948
GABRA1	0.040697
NDUFA1	0.040681
ITPKA	0.040643
USMG5	0.040479
YWHAH	0.040446
RCHY1	0.040107
PLS3	0.040074
C3	0.039760
NEFL	0.039745
BAG5	0.039695
TRIM2	0.039676
MICU3	0.039572
PGBD5	0.039565
SCG2	-0.039437
TSPYL4	0.039425
RPL18	0.039388
PTBP2	-0.039209
NDUFC2	-0.039060
GABRA2	-0.039001
HNRNPK	0.038772
STK32C	0.038595
SDCBP	-0.038283
NNAT	-0.037941
UBE2O	-0.037672
CASC4	-0.037493
SCCPDH	-0.037457
HPCA	-0.037384
CCDC47	0.037258
ATP6V0D1	0.037240
RPL26	-0.037193
CACNA2D3	-0.037080
ENO2	0.037078
SCN1B	0.036692
ATRNL1	0.036577
MYEOV2	-0.036536
RPL23	0.036499
NDRG2	-0.036478
CELF4	-0.036206
CTBP1	0.036132
CLSTN1	0.036093
CNIH2	0.035956
COX4I1	0.035922
VMP1	0.035907
WIPF3	0.035714
PHGDH	-0.035652
EEF2	-0.035620
PLCXD3	-0.034977
SPARCL1	-0.034941
TXN	0.034904
NCKAP1	-0.034801
GNL3L	0.034608
OCIAD1	-0.034539
SARNP	0.034497
GDI1	0.034402
APOD	0.034299
TTR	-0.034120
PKM	0.033969
PTPN11	0.033872
HSPE1	-0.033837
BCAT1	0.033804
ATP2B1	0.033801
MAP2	-0.033753
MPRIP	-0.033586
AMD1	0.033554
CEND1	0.033535
GABRG2	0.033393
RNASEK	0.033327
USP14	-0.033155
LCMT1	-0.033072
NME2	0.033066
GSTM3	-0.032912
LMO4	-0.032846
STMN1	0.032549
SYNJ1	0.032353
TMEM50B	-0.032352
SUMO2	-0.032135
SLC12A5	0.032069
UQCRB	0.031953
MRPL3	0.031852
MRPS33	-0.031848
SEPP1	0.031828
GLUL	0.031726
S100A13	-0.031721
PLK2	0.031493
SNX25	-0.031340
NELL2	0.031223
CHGB	0.031060
RPS25	0.031043
GOT2	0.030969
AP2M1	-0.030872
TMEM50A	0.030849
NDUFB2	0.030849
TFG	0.030669
MMD	-0.030579
CAMK2B	0.030527
PPP1R13B	-0.030458
LYRM1	-0.030403
NAPA	0.029889
ALDOC	0.029743
FBXL5	0.029735
GPR56	-0.029623
KANSL2	0.029539
PPP2CB	-0.029347
ISCA1	0.029313
S1PR1	-0.029269
HSD17B12	-0.029167
COL4A3BP	0.029145
PARK7	0.029111
ITIH3	0.029094
RPL9	-0.029064
MRPL55	0.029023
RAN	-0.029016
COX7B	0.028958
OSTM1	0.028937
RTN1	0.028922
GSTO1	0.028878
LIX1	-0.028743
ELMOD1	0.028740
TMX4	0.028689
NAPB	0.028574
DDOST	-0.028415
RNF180	-0.028397
RPS15A	0.028360
DDX5	-0.028334
QDPR	-0.028193
GAA	0.028156
TCF4	0.028138
RPS28	0.027995
PSMB1	0.027988
GPR37L1	-0.027974
CAMK2A	0.027921
KLHL5	-0.027909
COMMD3	0.027857
LMBRD1	0.027709
PCP4	0.027612
MED9	-0.027228
DYNC1I1	0.027170
SRP14	0.027153
ANKS1B	0.027109
ATP5A1	0.027090
HRAS	0.027030
ARL6IP5	-0.027023
NDUFB3	0.026990
TRAK1	0.026925
HSPA4	0.026911
SLC38A2	0.026787
PPP3CA	0.026724
BTG1	0.026594
NEUROD6	-0.026547
ZCCHC12	-0.026531
PRPF19	-0.026523
SNN	0.026471
APOE	-0.026457
CD74	0.026457
SRP19	-0.026394
PPFIA3	-0.026361
WASF1	0.026353
TMA7	-0.026334
PICALM	0.026323
WFS1	0.026295
RPS23	0.026244
MAEA	0.026238
ATP5O	0.026153
SCG5	0.026053
WSCD1	0.026046
TTC3	0.026025
PGRMC1	-0.026000
CALY	0.025978
SUCLG2	0.025971
RPS10	0.025888
NDUFA2	0.025793
RAB3A	0.025733
ATP5B	0.025690
SEPW1	-0.025653
RPS20	0.025608
DYNLL1	0.025493
CHMP2A	0.025448
TMEM9B	0.025433
SGK1	-0.025420
ERH	-0.025382
VPS29	0.025366
RAB2A	-0.025244
SLC25A4	0.025182
CDC40	0.025176
LAPTM4B	-0.025127
AP2A2	0.025104
UGP2	-0.025073
EIF3E	0.024945
STIP1	-0.024926
SULT4A1	0.024923
OGT	-0.024888
FLOT1	-0.024841
ITM2B	0.024818
THTPA	-0.024798
RPS21	-0.024733
RPS19	-0.024705
ARHGAP39	0.024695
NSA2	0.024649
TMEM47	-0.024626
FAM134A	0.024617
SEC62	0.024610
IQSEC3	-0.024610
NDUFB6	0.024569
CKB	0.024511
PCNX	0.024432
SRSF1	-0.024419
BCAP29	-0.024339
RPS7	0.024337
RPL5	-0.024331
BECN1	0.024299
PDIA3	-0.024296
COX8A	0.024293
MEX3B	0.024272
RPL13A	0.024259
PIP5K1C	-0.024214
APOPT1	-0.024193
PRDX2	0.024120
SUGT1	0.024115
FAHD1	0.024103
USP54	0.024089
B4GALT6	0.024077
DUSP3	0.024077
PAQR8	0.024044
ZDHHC20	-0.024039
PELI1	0.023892
RPLP0	0.023892
DNAJC27	0.023868
POLR2G	0.023855
EIF3I	-0.023840
WNT4	0.023765
CAB39	0.023754
RYR2	0.023691
ACTR2	0.023681
BIN1	0.023658
CACNA2D1	0.023658
MORC3	-0.023632
MOCS2	-0.023631
EIF4G3	0.023518
RNF44	-0.023448
STX1B	0.023413
TUBA4A	0.023388
ALDOA	0.023375
DYNC1H1	0.023312
RASGEF1A	-0.023290
MFGE8	-0.023284
GRINA	0.023264
MAP1A	0.023241
G3BP2	-0.023201
LRRN2	0.023193
GGH	-0.023138
LXN	-0.023137
ANXA11	0.023120
TVP23A	0.023072
EID1	0.023006
ROGDI	0.022865
SOD1	-0.022844
AQP4	-0.022811
SEPT7	0.022797
BLOC1S1	0.022702
SV2B	-0.022681
PRRC2A	0.022663
BSN	0.022480
ARL8B	-0.022453
CDK17	0.022440
ARPC3	0.022425
PSMA2	0.022330
SLC7A11	-0.022329
TOMM20	0.022237
XPNPEP1	-0.022219
DMTN	-0.022205
MAGED1	0.022167
GCC2	0.022129
CCND2	-0.022085
MAP2K1	0.022080
BCAP31	-0.022059
PHACTR1	-0.022049
PCBD2	-0.022043
TECR	-0.022015
RANBP3	-0.021946
HIF1A	0.021886
CHMP5	-0.021817
PRNP	-0.021790
CCNG2	0.021788
ATP2B3	0.021776
NRN1	0.021727
BLOC1S2	-0.021718
EFNB3	-0.021605
CRMP1	0.021500
TMEM14A	0.021479
PDE2A	-0.021446
GFAP	-0.021390
EDNRB	-0.021354
PPP3R1	0.021338
TRAPPC6B	0.021313
PRKAR1B	-0.021290
MRPL32	0.021222
AUH	0.021168
GNAO1	0.021140
ENPP2	-0.021137
SAE1	-0.021109
UPF2	0.021097
SLC25A12	0.021075
CITED2	-0.021055
ACTN4	0.021032
RPL18A	0.021031
AARSD1	-0.021027
RPL35	-0.020980
TRIL	-0.020935
VCP	0.020897
ABRACL	0.020880
ATP6V1A	0.020849
PAPD5	-0.020820
GATM	-0.020796
STUB1	0.020766
ARPC2	0.020738
WSB1	0.020663
ATP1A1	0.020662
UQCR10	0.020645
PLEKHG5	0.020627
C11orf73	0.020574
TUBB4A	0.020555
FKBP8	-0.020539
CX3CL1	0.020533
MAOB	-0.020524
DDX6	-0.020512
SPNS1	-0.020506
TBCB	-0.020495
SH3BP5	0.020474
HNRNPL	-0.020461
PCSK1N	0.020460
SPHKAP	0.020460
HYPK	-0.020418
SHFM1	-0.020379
CPEB4	0.020338
GLRX5	-0.020261
SUMO3	0.020223
CSRP1	0.020214
PPP6R3	-0.020183
GNB1	-0.020153
COX7A2	0.020126
FUNDC1	-0.020095
RABAC1	0.020069
MFSD6	0.020056
UCHL3	-0.020041
OAT	-0.019998
ACSL4	-0.019977
ZMYND8	0.019971
LATS2	-0.019940
NDUFS7	0.019935
CDK5	0.019927
VGF	0.019914
PSMB2	0.019911
RASGRP1	0.019909
GAPDH	0.019894
PIAS1	-0.019867
CHGA	0.019863
WNT1	0.019798
SARM1	-0.019767
MTG2	-0.019721
PTP4A3	0.019586
TSC22D3	-0.019581
GRIA2	0.019514
APBB1	0.019460
VDAC1	0.019397
NTRK2	0.019396
RTCB	0.019387
TMEM30A	-0.019359
PDCD10	-0.019273
LARP4B	0.019273
ALKBH6	-0.019225
PRICKLE2	0.019213
NDUFA6	-0.019204
SMAP1	0.019203
EMB	0.019192
GPC4	0.019188
TST	-0.019172
LDHB	0.019152
JAZF1	-0.019126
PCBP1	-0.019123
SPRY2	0.019098
ASPHD2	-0.019089
LDHA	0.019078
SLC30A3	0.019053
GRN	0.019028
RPH3AL	-0.019017
ID3	0.018992
GAS7	-0.018991
VPS28	0.018981
ZWINT	-0.018927
RPL21	-0.018919
DLGAP1	0.018911
EIF5	0.018888
TRNAU1AP	-0.018874
CD200	-0.018850
LSAMP	-0.018847
STRN3	0.018821
PSMB7	0.018817
GJA1	-0.018807
WDR37	0.018771
HSP90B1	-0.018765
SNRPA1	0.018645
XBP1	-0.018580
SLC25A5	-0.018550
DCAF12	0.018539
NPC2	0.018517
ACSL3	0.018514
TNFAIP1	0.018487
ACO2	-0.018448
MIEN1	0.018439
AKR1A1	-0.018421
DBI	-0.018418
KLHL7	-0.018383
ATP5J2	0.018315
LARP1	-0.018313
COMMD10	-0.018294
IDH3A	-0.018293
UBAC1	-0.018277
R3HDM1	0.018240
KDM2B	-0.018201
SEPT4	0.018194
CNRIP1	-0.018183
TPT1	0.018171
ARPC1A	0.018132