!direction	1
!num_genes	297
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Methotrexate
!smiles	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
!drugbank_id	DB00563
!pubchem_cid	126941
!cell_type	HT29 colon adenocarcinoma cell line
!organism	human
!end_metadata
TM4SF4	0.156708
IFI27	0.138292
ALDH1A1	0.137439
HLA-C	0.114002
B2M	0.113323
HLA-B	0.102189
VBP1	0.092160
HLA-A	0.090784
TSPAN8	0.090059
SSR4	0.089542
MMP7	0.086327
CD24	0.077845
IFITM2	0.070942
BCAP31	0.070407
RPL30	0.066667
IFITM3	0.065927
IRAK1	0.061510
EIF3H	0.059733
RRM2	0.059484
DKC1	0.058120
PABPC3	0.056392
MRPL13	0.055806
DNAJA1	0.055602
LYZ	0.054505
YWHAZ	0.053527
RPL8	0.053525
NOP10	0.049650
KRT8	0.048785
KLK6	0.048755
UBE2C	0.046812
PTMA	0.046287
KRT18	0.046057
RPN2	0.045916
ZWINT	0.045698
HLA-G	0.045628
HMGN1	0.045493
COX2	0.045447
EIF6	0.044499
ISG15	0.044306
RPS6	0.044120
UBE2S	0.043258
LGALS4	0.042967
EIF3E	0.042945
CDH1	0.041065
CRABP2	0.040928
MT1E	0.040909
GTF3C6	0.040458
PSME2	0.039346
RAN	0.038947
FAM96A	0.037942
ACTN4	0.037668
HSPE1	0.037613
PTGES3	0.037207
RPL4	0.036996
PROM1	0.036825
SEPW1	0.036677
SNHG6	0.036462
BST2	0.036148
LAPTM4B	0.036101
KRT20	0.036011
LCN2	0.035865
LAP3	0.035835
CTSH	0.034992
HSPH1	0.034883
MAPRE1	0.034775
LGALS3BP	0.034301
HSPA8	0.034038
GINS1	0.034008
NMI	0.033738
RPF2	0.033663
HMGN2	0.033331
FAM60A	0.033262
YBX1	0.033016
FABP5	0.032855
MAL2	0.032813
CD164	0.032594
PTPLAD1	0.032505
TXNIP	0.032464
HEBP2	0.032445
PLSCR1	0.032269
KIAA0101	0.031357
MRPS21	0.030926
PLS1	0.030397
TOMM5	0.029927
TATDN1	0.029891
EIF3J	0.029684
DYNLL1	0.029611
VAMP7	0.029608
RPL10	0.029601
PPIB	0.029505
NGRN	0.029205
HDAC1	0.028774
COX5A	0.028752
LDHB	0.028238
ANXA4	0.028132
ANXA13	0.028067
LY6E	0.028027
ALYREF	0.028017
S100A6	0.027659
CSE1L	0.027630
HSP90AB1	0.027509
FMR1	0.027269
SUMO2	0.027264
IPO7	0.027203
NDUFB9	0.027182
STIP1	0.027052
PSMA4	0.027000
PTS	0.026876
RAD21	0.026844
AURKA	0.026760
PRR13	0.026682
HMGN3	0.026292
CCT3	0.025980
CYC1	0.025885
PABPC1	0.025659
NUSAP1	0.025596
VIMP	0.025584
NOP58	0.025562
ENOPH1	0.024975
PRC1	0.024830
ANP32B	0.024818
PTDSS1	0.024734
ATP6AP1	0.024595
MRPL17	0.024470
BRCC3	0.024464
FAM84B	0.024424
UBB	0.024387
ATAD2	0.024367
MT1HL1	0.024353
ASUN	0.024268
CDK1	0.024235
NELFCD	0.024188
MRPL15	0.024024
UHRF1	0.023932
RPS20	0.023522
GNL3	0.023513
COX6C	0.023355
LAMP1	0.023143
MEST	0.023129
IMPA1	0.023023
MAPK6	0.023018
TPX2	0.022992
MT2A	0.022963
PSMA7	0.022943
GTF3A	0.022807
YWHAB	0.022770
LYPLA1	0.022669
RRM1	0.022586
SNRPA1	0.022559
IFITM1	0.022517
COPS5	0.022377
NSA2	0.022329
HPRT1	0.022326
KNSTRN	0.022291
OIP5	0.022253
TRMT5	0.021891
GPX1	0.021855
IER3	0.021811
MRPS35	0.021680
ADRM1	0.021659
CTPS1	0.021639
AQP3	0.021538
ANLN	0.021501
CTNNAL1	0.021461
MORF4L1	0.021431
HLA-F	0.021415
PSMB8	0.021233
EIF2S2	0.021109
SLC25A32	0.021082
RFK	0.020844
BUB1B	0.020793
C1QBP	0.020694
UBE2T	0.020682
FBL	0.020615
PPIF	0.020463
DDX39A	0.020443
SRP14	0.020391
SLIRP	0.020386
MTHFD1	0.020256
FAM122B	0.020219
AHSA1	0.020140
LYSMD2	0.020075
PAICS	0.020057
FUNDC2	0.019995
CXorf40A	0.019958
CCT2	0.019950
GDI2	0.019949
ANP32A	0.019873
IFI6	0.019819
ESRP1	0.019751
IDH3G	0.019749
SERPINA1	0.019631
NCAPG2	0.019631
FANCI	0.019578
SORD	0.019564
MRPL27	0.019506
PNRC2	0.019420
KLK11	0.019370
CXorf40B	0.019296
CENPW	0.019227
GCNT3	0.019179
CKS1B	0.019031
NDUFAB1	0.018836
KIF5B	0.018773
GMDS	0.018758
UCHL3	0.018742
ZNF706	0.018733
PITPNB	0.018651
TCEB1	0.018588
DYNLRB1	0.018565
IARS	0.018437
RPL9	0.018375
TMEM54	0.018374
CETN2	0.018240
CYFIP1	0.018148
TUBA4A	0.018131
SIGMAR1	0.018048
RAB11A	0.018025
EEF1A1	0.018012
ETFA	0.017993
ZWILCH	0.017989
EEF1D	0.017988
POLR2K	0.017951
EREG	0.017934
PTPRK	0.017913
TUBA1C	0.017758
KARS	0.017748
NAE1	0.017740
H2AFZ	0.017736
LACTB2	0.017724
SLC1A1	0.017723
PSMA1	0.017720
NDUFB2	0.017627
PRSS2	0.017568
OAZ1	0.017507
CBFB	0.017499
EMC4	0.017479
MRPL42	0.017384
NPTN	0.017328
IFNGR1	0.017325
SNX3	0.017305
PSME1	0.017191
TAF1D	0.017155
ATIC	0.017143
TUBA1B	0.017114
DSCC1	0.016947
RPS27L	0.016942
RUVBL2	0.016941
EZH2	0.016902
ATP6V0B	0.016899
CDKN2A	0.016834
REPIN1	0.016819
CYSTM1	0.016805
PRPS1	0.016764
BANF1	0.016733
CHORDC1	0.016612
ARPC1B	0.016611
RPL24	0.016609
MRPL16	0.016507
RNF139	0.016489
C12orf75	0.016403
DCTPP1	0.016383
ARHGAP18	0.016325
H3F3B	0.016256
RPS12	0.016230
LBR	0.016188
CIRH1A	0.016176
VMA21	0.016168
PFDN2	0.016162
PTTG1IP	0.016135
FAM91A1	0.016107
CHCHD3	0.016095
TPD52L2	0.016057
TSG101	0.015992
PLP2	0.015918
SRSF2	0.015887
SOD1	0.015854
CFL1	0.015844
HEXB	0.015833
ENC1	0.015816
CKS2	0.015802
MELK	0.015798
CDCA7	0.015768
HMGB3	0.015739
PIGP	0.015737
MCM7	0.015692
TRMT11	0.015586
HSP90AA1	0.015490
SEC11A	0.015480
NMB	0.015465
SERPINB1	0.015400
CEACAM6	0.015379
GGCT	0.015343
MUC13	0.015341
RBMX	0.015246
ERMP1	0.015190
CCT6A	0.015131