!direction	1
!num_genes	324
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Tretinoin
!smiles	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
!drugbank_id	DB00755
!pubchem_cid	444795
!cell_type	ME180 squamous cell carcinoma cell line - 1 hour 10μM
!organism	human
!end_metadata
CCL20	0.157689
FOSB	0.150554
EGR2	0.142821
CTGF	0.120884
DUSP1	0.118971
FOSL1	0.102965
DUSP5	0.097970
HBEGF	0.097677
CYP26B1	0.093174
F3	0.091871
IL1B	0.086219
EDN1	0.082616
CXCL8	0.080224
CYR61	0.079219
PTGS2	0.076292
RASD1	0.074946
BHLHE40	0.070949
CSRNP1	0.069983
SIK1	0.069159
EPHA2	0.068060
GADD45B	0.067719
IFFO1	0.066247
EDN2	0.066020
PTGER4	0.065578
TRIB1	0.065076
DUSP6	0.064556
ERRFI1	0.064256
ZFP36	0.062295
ELF3	0.059911
NR4A2	0.059654
CITED2	0.058706
IL36G	0.057937
LIPG	0.057238
RND3	0.056738
MAP3K8	0.056034
IER3	0.055746
IGFL1	0.054240
FOS	0.054065
TIPARP	0.051359
SLC20A1	0.049961
IL1A	0.049919
TNFAIP3	0.049747
NCOA7	0.049540
CD55	0.048983
MIR614	0.048778
ZC3H12A	0.048130
BCL3	0.047823
NR4A1	0.047208
EGR1	0.047084
JUN	0.046900
DEFB103A	0.046399
MAFF	0.046361
LCE3D	0.046316
GPRC5A	0.046006
THBS1	0.045640
ITPRIP	0.045014
ANKRD37	0.044175
KPRP	0.044138
JUNB	0.043363
CRCT1	0.043235
KLF6	0.043224
GADD45A	0.042784
ITPKC	0.042502
CPA4	0.041936
PPP1R15A	0.041124
FAM84B	0.040112
SPINK6	0.040019
KRT75	0.039786
TRIM31	0.039637
IFFO2	0.039573
FERMT2	0.039453
GLIPR1	0.039088
ARL14	0.038950
SOWAHC	0.038875
TXNRD1	0.038264
STC2	0.038156
RNF39	0.038124
MIR21	0.037988
SOX7	0.037609
LIF	0.036853
LDLR	0.036328
TMEM40	0.036202
PSG9	0.035781
PLAUR	0.035717
ADAMTS1	0.035713
SLC20A2	0.035622
CYP26A1	0.035514
OVOL1	0.035120
DUSP16	0.035075
SPINK13	0.034929
TAGLN	0.034785
TP53INP2	0.034702
PIM1	0.034562
KRT34	0.034419
KRTAP21-2	0.034309
IER2	0.034232
GCNT3	0.034120
ATF3	0.034006
EGR3	0.033554
MAP3K9	0.033257
PHLDA1	0.032659
ADRB2	0.032586
IRS2	0.032015
ENC1	0.032000
TIMP3	0.031943
PTPRH	0.031640
RELB	0.031210
TRAF4	0.031185
SAMD4A	0.031103
BTG2	0.030865
SERPINB2	0.030811
PI3	0.030729
KRT80	0.030645
CASP9	0.030473
MYC	0.030334
FST	0.030037
TSPAN1	0.030001
ZFP36L1	0.029825
ETS2	0.029569
C1orf116	0.029384
MIDN	0.029031
OSBP2	0.028912
TNFRSF12A	0.028843
CBX4	0.028801
ENTPD7	0.028606
C3orf52	0.028602
RCAN1	0.028430
SDC4	0.028088
MFAP5	0.027980
PTHLH	0.027889
AVPI1	0.027711
DUSP8	0.027609
FBN2	0.027488
MCL1	0.027429
TMEM2	0.027215
TSC22D2	0.027155
ELOVL1	0.026900
SPOCD1	0.026854
FAM110C	0.026541
DCUN1D3	0.026405
HAS3	0.026380
SCHIP1	0.026248
TUFT1	0.026210
SERTAD4-AS1	0.025786
MAP3K14	0.025778
DUSP2	0.025726
TOB1	0.025678
KRT6C	0.025265
RAB30	0.025253
NTF3	0.025188
DENND3	0.025112
SGMS2	0.025054
MYLK	0.025045
IRF1	0.024995
GPR3	0.024980
KRTAP3-1	0.024902
HMOX1	0.024831
CHMP1B	0.024639
PRIM2	0.024575
TBC1D2	0.024444
CYSRT1	0.024369
CLCF1	0.024216
LMCD1	0.024152
PSG5	0.024134
B4GALT1	0.024022
KRT23	0.024018
TICAM1	0.023894
SPRR2G	0.023889
CD59	0.023790
AP2B1	0.023730
KRT16	0.023708
GDF15	0.023667
LOC646626	0.023584
GBP1	0.023512
FAM46A	0.023443
RNA28S5	0.023350
MAT2A	0.023172
MYADM	0.023135
CLASRP	0.023106
PRDM8	0.023030
IRF2BP2	0.023003
TPM1	0.023001
IL1R2	0.022996
KBTBD2	0.022967
GPCPD1	0.022831
RHOBTB2	0.022776
PISD	0.022729
TGFA	0.022714
ULBP1	0.022695
CLDN4	0.022554
EGR4	0.022421
SOX9	0.022356
FHL1	0.022272
IL1F10	0.022265
PSG4	0.022240
HOXD1	0.022191
PLA2G4C	0.022110
GJB4	0.022069
RP9P	0.021963
KLHL29	0.021941
KRTDAP	0.021857
NFKBIA	0.021855
SCNN1G	0.021777
EMP1	0.021736
GABARAPL1	0.021717
USP36	0.021567
SERTAD1	0.021414
KRT6B	0.021315
SPRED2	0.021289
CCL8	0.021252
SLFN5	0.021229
CD70	0.021146
NT5C3A	0.021101
ETV4	0.021091
NT5E	0.021064
LRRC75B	0.020898
RUSC2	0.020864
EPHA4	0.020800
PHLDA2	0.020709
ZYX	0.020668
VMP1	0.020614
SOCS3	0.020485
TTLL1	0.020436
KDM6B	0.020310
DRAM1	0.020259
LDLRAD4-AS1	0.020196
ALDH1A3	0.020152
FEM1B	0.020062
LAMC2	0.020050
ULBP2	0.020030
RHOB	0.020026
UGCG	0.020012
GUCY1A2	0.019978
INPP4B	0.019906
SAV1	0.019848
CCNL1	0.019755
CLK1	0.019706
CLDN23	0.019690
VGLL1	0.019665
JOSD1	0.019594
BAMBI	0.019568
GRAMD3	0.019528
RAET1L	0.019500
CPA2	0.019496
GFOD1	0.019492
GLI3	0.019479
ITGB8	0.019478
CSMD2	0.019292
DOCK5	0.019255
TINAGL1	0.019241
ERO1L	0.019215
MESDC1	0.019185
FSTL1	0.019112
KLK5	0.019085
PLAT	0.018882
SLCO5A1	0.018847
FOSL2	0.018829
SPRR2D	0.018781
C10orf67	0.018765
S1PR3	0.018706
TMEM88	0.018681
NFKB2	0.018632
SULF1	0.018604
C11orf24	0.018590
SRF	0.018527
SDPR	0.018495
TRIM16	0.018409
MPP6	0.018389
SVEP1	0.018381
ANP32AP1	0.018350
DCP1A	0.018169
NOS1AP	0.018092
CLDN1	0.018084
PACRG-AS1	0.018068
BMP2	0.018030
FLNC	0.017983
ANXA3	0.017907
DOK7	0.017852
FUT1	0.017746
F11R	0.017736
RIMKLB	0.017734
SPOCK2	0.017668
MIR25	0.017570
KIAA0040	0.017542
ZSWIM5	0.017538
ETV5	0.017535
UTP18	0.017514
LETM2	0.017488
SSC4D	0.017486
TUBB2A	0.017444
LCE3E	0.017434
DSG1	0.017420
C15orf39	0.017419
IL7R	0.017408
PLK2	0.017398
RHPN2	0.017388
COL16A1	0.017370
KRTAP3-2	0.017358
SLMAP	0.017304
CSRP1	0.017303
BIK	0.017263
PRR7	0.017241
RGCC	0.017202
LIMCH1	0.017184
ZNF217	0.017163
HOOK2	0.017056
MIR1323	0.017011
C12orf5	0.017009
CGA	0.016938
STX11	0.016875
TRIM16L	0.016873
RGL1	0.016873
LHFPL1	0.016847
SLC25A25	0.016835
NRIP1	0.016808
SIAH2	0.016753
TGIF1	0.016703
MNT	0.016647
NABP1	0.016620
SAR1A	0.016613
SDE2	0.016511
F2RL1	0.016426
FOXC1	0.016391
CEMIP	0.016370