!direction	1
!num_genes	354
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	NA
!organism	human
!end_metadata
EGR3	0.086859
RASGRP1	0.070170
IL20	0.069860
KCNK6	0.064100
GEM	0.051956
PMAIP1	0.051690
SGK1	0.050172
SMTNL2	0.049629
PKDCC	0.049186
FOXN1	0.046268
FOXC1	0.046218
P2RY2	0.043659
LONRF2	0.043523
LOC400768	0.042410
SGK223	0.041754
FOS	0.041447
HIST1H4C	0.041103
CXXC5	0.040600
NMRK1	0.040261
VASN	0.040006
USP31	0.039776
SYBU	0.039628
TIPARP	0.039163
SLX4IP	0.039048
RHOBTB1	0.037792
VMP1	0.037759
RAPGEFL1	0.037254
RPS11	0.037132
NRIP1	0.037079
MIR21	0.035686
AKAP1	0.035668
ARMCX6	0.035465
ELF1	0.035370
C14orf182	0.035297
CCND1	0.035276
FZD7	0.034857
HSPB8	0.034274
KBTBD6	0.034012
PGR	0.033918
SIGLEC15	0.032996
DLG5	0.032352
TGIF2	0.032329
FAM110D	0.031595
LINC00341	0.031092
C8orf46	0.031081
FHL2	0.031074
TMED8	0.031050
MIF-AS1	0.031027
PREX1	0.030894
RBM24	0.030429
IGFBP4	0.030385
ZNF703	0.030364
RALGDS	0.030360
SCNN1G	0.030177
CCNT1	0.029615
SLC16A6	0.029569
MXD1	0.029441
GARS	0.028998
SLC25A36	0.028971
TSPYL5	0.028931
RCL1	0.028644
TSKU	0.028616
GCOM1	0.028528
LTB4R2	0.028049
ARHGEF26	0.028014
DOK7	0.028013
SSC4D	0.027874
KCNK5	0.027871
PGLYRP2	0.027861
RPL37A	0.027772
UHMK1	0.027743
SLC22A5	0.027455
PIK3R1	0.027454
ND6	0.027123
RUSC2	0.026922
ZSWIM6	0.026675
CA2	0.026260
PRKCD	0.026174
CTGF	0.026107
RAB31	0.026069
MYC	0.025967
LHB	0.025707
PPTC7	0.025522
ONECUT2	0.025518
LOC100289333	0.025354
BLVRB	0.025300
USP35	0.025254
DNAJB8	0.025169
PTGES	0.025107
AEN	0.025014
ESF1	0.024874
UBE2T	0.024732
ABTB2	0.024723
TPBG	0.024720
GALNT4	0.024694
MBOAT1	0.024619
TOP1	0.024555
TRIM59	0.024390
ZFP91	0.024336
NOP56	0.024306
CEBPB	0.024268
SLC7A5P2	0.024254
SIAH2	0.023958
TMEM238	0.023883
MGC10814	0.023798
ASB13	0.023775
KIT	0.023682
CTR9	0.023593
MEIS3P1	0.023532
KCTD6	0.023519
HIST1H4B	0.023518
GTF2H3	0.023286
EGR1	0.023141
ARMC1	0.023132
EIF5B	0.023096
C1orf226	0.023041
WSB1	0.022932
THOC5	0.022765
SSB	0.022709
C19orf33	0.022692
FABP2	0.022627
GAB2	0.022609
TMEM151A	0.022509
TMEM181	0.022449
DDHD1	0.022332
SRGAP1	0.022296
TIFA	0.022224
PDZK1	0.022209
RPL38	0.022168
NINL	0.021990
POLR1C	0.021988
SMOX	0.021972
ATRX	0.021930
TDG	0.021914
CBFA2T3	0.021871
SCYL1	0.021859
SHB	0.021847
KLF4	0.021834
KIAA1033	0.021784
C6orf132	0.021757
KAZN	0.021743
RAB11FIP1	0.021673
PSTPIP2	0.021615
DUSP15	0.021567
NOB1	0.021534
SLC26A2	0.021516
FAM63A	0.021502
RP9	0.021483
C5orf30	0.021349
PSMA7	0.021220
S100A8	0.021211
CCAR1	0.021193
ANKRD36B	0.021147
SPIN1	0.021074
RPL7AP9	0.021060
MREG	0.021059
TULP4	0.021038
CISD1	0.021035
SGK3	0.021008
CXCL12	0.020995
PSMA4	0.020929
CYP11B2	0.020907
HAUS1	0.020900
KIF3A	0.020871
KLF10	0.020869
FNIP2	0.020848
FAM60A	0.020760
GUCD1	0.020702
SNAPC1	0.020645
HLA-DRB1	0.020583
NKAIN1	0.020563
IL34	0.020557
PLOD2	0.020538
MXI1	0.020512
FKBP2	0.020511
KMT2C	0.020500
MICB	0.020493
CHSY1	0.020487
SNORA28	0.020308
PRICKLE2	0.020306
KAT6B	0.020295
DDX17	0.020246
LGI2	0.020241
SLK	0.020221
KIF21A	0.020217
SLC38A3	0.020170
RAB37	0.020166
TST	0.020156
GSG1L	0.020119
GPR144	0.020106
LINGO1	0.020094
ZSCAN29	0.020072
NPTX1	0.020067
ADRA2A	0.020040
CAV1	0.019982
CCDC59	0.019979
LYAR	0.019946
FLJ38668	0.019916
DHX36	0.019835
AVP	0.019811
IGHE	0.019794
LOC157860	0.019764
SUV39H2	0.019724
PHLDA1	0.019710
HIST1H3G	0.019708
RBBP8	0.019673
METRNL	0.019638
KIAA1614	0.019636
TMEM159	0.019630
NPFFR1	0.019628
C18orf21	0.019618
NOTCH2NL	0.019611
ARRDC1-AS1	0.019599
LOC728061	0.019557
LOC93622	0.019542
C10orf2	0.019528
CNIH2	0.019516
DNAJC1	0.019491
NPEPPS	0.019438
E2F6	0.019426
FOXO4	0.019408
NEBL-AS1	0.019342
EFNB2	0.019333
FMOD	0.019299
FABP5	0.019271
ZNF562	0.019235
JAK2	0.019221
TWF2	0.019218
TBL1Y	0.019208
TOE1	0.019155
WDR43	0.019151
GLA	0.019141
NXNL2	0.019126
LOC652993	0.019114
MEFV	0.019108
MALAT1	0.019096
SLC30A1	0.019095
NXT1	0.019061
SNHG8	0.019059
ANKRD2	0.019035
FOXO3	0.019034
PPRC1	0.018991
RIPK3	0.018987
AREG	0.018854
SAA3P	0.018847
APOBEC3C	0.018818
LCN1	0.018811
FGF18	0.018791
ULK1	0.018772
MGMT	0.018756
OSGIN1	0.018728
PRKCE	0.018680
MRPS21	0.018676
DIRAS2	0.018655
LGALS2	0.018654
HIST1H2APS5	0.018650
CHURC1	0.018649
BOLA1	0.018645
SLC14A1	0.018619
UGCG	0.018579
IFT46	0.018562
GRHL2	0.018561
PPIF	0.018557
CCL2	0.018540
NAT8B	0.018519
EPRS	0.018516
EIF3G	0.018494
SLC10A3	0.018482
RPRML	0.018482
UBL5	0.018438
TSPAN5	0.018436
MIR101-1	0.018420
HIST1H2BI	0.018380
VEGFA	0.018364
MPST	0.018361
MRPL17	0.018341
S100A9	0.018334
TXN	0.018322
HIST1H2BE	0.018315
SULT2B1	0.018308
ARHGEF3	0.018291
NET1	0.018253
UBN1	0.018248
ARF6	0.018239
WFS1	0.018153
FOXA3	0.018143
MGC16275	0.018113
C1QTNF6	0.018107
ARID5A	0.018071
SGOL2	0.018028
FAM86C1	0.018004
CITED2	0.017989
CCT7	0.017973
JARID2	0.017966
AURKB	0.017950
PUS3	0.017947
SLC9A3R1	0.017945
HS3ST3A1	0.017918
RBX1	0.017886
NIP7	0.017855
TOP2A	0.017836
BTNL2	0.017828
EFNB1	0.017813
FLJ36840	0.017784
PARD6B	0.017759
RFPL1S	0.017742
ERN1	0.017690
OTUD6B	0.017687
SCNM1	0.017660
NBPF1	0.017589
SFXN2	0.017586
DIO3	0.017554
SCNN1B	0.017539
PPAP2B	0.017538
FAM86A	0.017532
H2BFS	0.017447
PRPS2	0.017407
ZNF205	0.017405
CCDC51	0.017397
RPL22L1	0.017388
FUOM	0.017388
ZFP30	0.017379
SCRN1	0.017359
SOX4	0.017357
PMEL	0.017338
TPR	0.017331
DAPK2	0.017322
TRAK2	0.017252
FEM1A	0.017252
PSMB4	0.017239
TRBC2	0.017218
RPS26	0.017206
ARPC2	0.017201
TEAD1	0.017177
PITX1	0.017175
GDAP2	0.017166
ECE1	0.017157
NFAT5	0.017141
MBD4	0.017097
NUBP2	0.017090
MPLKIP	0.017082
LRRK1	0.017077
RBM27	0.017072
TAZ	0.017066
RELT	0.017043
SNRPG	0.017008
MGA	0.016959
AGO3	0.016947
SRSF7	0.016945
RAB17	0.016923
SNX24	0.016919
POLR2H	0.016907
COMP	0.016904
PPAN	0.016896