!direction	1
!num_genes	351
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	NA
!organism	human
!end_metadata
ARHGAP36	0.099215
PKIB	0.067373
PCP4	0.058428
PLAC1	0.057543
EXO1	0.055520
IL17RB	0.054792
SGK3	0.054353
DTL	0.054034
EGR3	0.052646
MND1	0.051937
CENPK	0.051814
CDC45	0.050772
CENPU	0.050480
PBK	0.050361
SPC25	0.050113
MCM10	0.049822
CDC6	0.048775
SHCBP1	0.048252
RAD51AP1	0.047975
RERG	0.046880
KIF15	0.046779
BRCA2	0.045921
FANCI	0.045748
CCNE2	0.045581
TK1	0.045424
UHRF1	0.044998
E2F8	0.044742
RRM2	0.044620
HS3ST3A1	0.044427
PGR	0.044361
POLE2	0.044166
MASTL	0.043960
AGR3	0.043580
ZNF367	0.043553
SPC24	0.043413
ATAD2	0.043264
CXCL12	0.042999
PRIM1	0.042813
LINC01016	0.042677
SFXN2	0.042546
RLN2	0.042273
DDIAS	0.041768
CDCA5	0.041669
MYBL2	0.041604
WDHD1	0.041129
FABP5	0.041037
NCAPG	0.041006
NUF2	0.040811
ASF1B	0.040650
BRCA1	0.040411
CEP55	0.040189
CENPH	0.040181
COL21A1	0.040144
CENPM	0.039818
CDC7	0.039734
MAD2L1	0.039652
MELK	0.039593
GMNN	0.039445
ORC1	0.039422
CDT1	0.039228
ANLN	0.039213
TCF19	0.039181
RBM24	0.039020
BLM	0.038776
NDC80	0.038713
KIF11	0.038624
GINS1	0.038193
OIP5	0.038143
GLA	0.038107
FOXM1	0.037853
NCAPH	0.037818
RAB31	0.037773
HEY2	0.037666
TTK	0.037620
KLK11	0.037514
UGT2B15	0.037429
TYMS	0.037023
FEN1	0.037007
DUT	0.036977
TRIP13	0.036974
RAD54L	0.036969
DHFR	0.036889
CDC25A	0.036868
FHL1	0.036852
BUB1B	0.036637
MCM2	0.036602
MCM5	0.036283
UBE2T	0.036253
CDCA7	0.036159
NEIL3	0.036096
HELLS	0.036026
NCAPG2	0.036026
RFC4	0.036024
DONSON	0.035946
SKA3	0.035764
CDKN3	0.035711
KIAA0101	0.035668
TIPIN	0.035538
CHAC2	0.035186
RNASEH2A	0.035063
ERCC6L	0.035048
KNTC1	0.034946
HSPA2	0.034783
FBXO5	0.034645
RRM1	0.034456
CDK1	0.034453
PCNA	0.034402
CCNA2	0.034380
BRIP1	0.034356
PLK4	0.034273
RFC2	0.033980
LMBR1	0.033932
CDCA3	0.033844
SPIN4	0.033788
DNA2	0.033781
MCM3	0.033730
GINS3	0.033691
GGH	0.033532
MKI67	0.033504
RET	0.033448
KIF18B	0.033421
MYBL1	0.033399
CENPQ	0.033363
IGSF1	0.033253
CHEK1	0.033183
TMEM194A	0.033031
SMC2	0.032986
LMNB1	0.032901
C1orf226	0.032697
POLQ	0.032670
FOS	0.032594
KIF23	0.032390
AURKB	0.032374
STIL	0.032276
FIGNL1	0.032026
CENPW	0.031868
TOP2A	0.031868
KIF4A	0.031770
CDCA2	0.031636
UNG	0.031517
LIG1	0.031442
DEPDC1	0.031437
TMPO-AS1	0.031385
ESPL1	0.031385
SGK1	0.031251
NUSAP1	0.031239
BRI3BP	0.031181
ITGB3BP	0.031156
E2F7	0.031148
ABHD2	0.030999
CKS1B	0.030960
DSCC1	0.030909
CDCA8	0.030837
SYTL4	0.030782
ZWINT	0.030744
NPY1R	0.030613
POLA1	0.030574
C4orf46	0.030351
HIST1H4C	0.030178
SPAG5	0.030041
TACC3	0.030000
PRC1	0.029990
SGOL2	0.029908
RGS22	0.029769
DEPDC1B	0.029692
SKA1	0.029635
CHEK2	0.029453
UBE2C	0.029448
VRK1	0.029444
CHRNA5	0.029328
DBF4	0.029129
ZWILCH	0.029106
DSN1	0.029094
CENPN	0.028982
PPIF	0.028979
FANCG	0.028902
GEN1	0.028873
KIF14	0.028861
RFC5	0.028775
FKBP5	0.028733
CDCA4	0.028718
SLC29A1	0.028710
RMI1	0.028593
RACGAP1	0.028485
HAUS1	0.028474
KIF2C	0.028435
MICB	0.028426
MCM4	0.028417
DLGAP5	0.028119
MCM7	0.028113
RAD51	0.028041
CENPL	0.027972
SYCE2	0.027776
RAD54B	0.027755
EZH2	0.027553
IMPA2	0.027490
ORC6	0.027447
BIRC5	0.027221
HSPA4L	0.027103
ACAT2	0.027077
TPX2	0.027005
PHF19	0.026978
RFC3	0.026963
APITD1	0.026918
C5orf34	0.026787
DEPTOR	0.026724
CDH26	0.026707
NCAPD2	0.026408
MGP	0.026351
TMSB15A	0.026282
CTPS1	0.026278
TICRR	0.026239
NRM	0.026117
GREB1	0.026070
FAM111B	0.026065
GPR65	0.026017
MTHFD1	0.025914
EMC3-AS1	0.025892
CHAF1B	0.025799
MTFP1	0.025796
CENPI	0.025602
FAM216A	0.025430
TMEM164	0.025330
TMPRSS3	0.025154
LONRF2	0.025074
RMI2	0.025030
CTNNAL1	0.024939
POLD1	0.024799
CDCA7L	0.024791
DCK	0.024773
C1orf112	0.024758
ACYP1	0.024701
HADH	0.024614
POC1B	0.024607
SERPINA3	0.024584
ISG20	0.024542
BARD1	0.024507
WDR76	0.024434
DOK7	0.024355
CKLF	0.024302
BMP5	0.024288
FAM83D	0.024233
CMC4	0.024202
CDKN2C	0.024192
NEK2	0.024185
PSMC3IP	0.024156
ASPM	0.024146
C8orf46	0.024006
RHNO1	0.023999
WISP2	0.023838
CELSR2	0.023801
DHTKD1	0.023798
LINC00052	0.023756
NUP155	0.023718
C9orf40	0.023632
AREG	0.023613
KIAA1324	0.023483
NUDT1	0.023472
GAS2L3	0.023452
SYBU	0.023425
SNRNP25	0.023422
TEX30	0.023371
EP300-AS1	0.023282
MCM6	0.023280
SLC47A1	0.023263
SLC26A2	0.023234
ANP32E	0.023170
HAUS8	0.023151
C5	0.023142
SLC36A4	0.023077
PRIMA1	0.023069
TMPO	0.022996
SPDL1	0.022981
RBBP8	0.022981
CYP26B1	0.022883
TUBG1	0.022879
AK4	0.022762
GSG2	0.022686
KIF20A	0.022679
FAM64A	0.022669
HJURP	0.022510
POLE	0.022499
USP1	0.022492
MTFR2	0.022419
SKP2	0.022416
POLA2	0.022354
ACOT7	0.022330
EME1	0.022266
CDC20	0.022260
SLC27A2	0.022162
DSCAM	0.022063
SUV39H2	0.021966
DLEU1	0.021948
IRX3	0.021863
CKAP2L	0.021860
RPA3	0.021729
DERA	0.021707
GPR19	0.021647
GALNT4	0.021621
CHTF18	0.021578
RECQL4	0.021516
POLD2	0.021497
XRCC3	0.021479
NDC1	0.021452
CASC5	0.021448
FANCL	0.021432
ATRIP	0.021426
SLC22A4	0.021375
CMSS1	0.021257
PKMYT1	0.021236
TMEM38B	0.021203
JAK2	0.021134
PLAT	0.021086
SGOL1	0.021085
TIFA	0.021076
DCLRE1B	0.021006
HMMR	0.020989
PDZK1	0.020910
FAM57A	0.020836
NCAPD3	0.020699
SOX3	0.020546
UBR7	0.020519
CCDC167	0.020500
SUV39H1	0.020489
ARHGAP11A	0.020481
FANCA	0.020463
RAPGEFL1	0.020445
PTTG1	0.020438
DNAJC9	0.020403
GGCT	0.020376
ELOVL2	0.020352
TIMELESS	0.020320
DIO1	0.020297
CBX5	0.020260
CTR9	0.020238
PRTFDC1	0.020222
CCDC34	0.020209
MIS18A	0.020174
MCEE	0.020142
PAQR4	0.019985
DNMT1	0.019956
TAF5	0.019908
H2AFJ	0.019899
PARPBP	0.019885
LOC81691	0.019842
SERPINA5	0.019711
MSH2	0.019695
TIPARP	0.019652
KCNK5	0.019639
TTI1	0.019613
TOPBP1	0.019575