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| Title / Description | Age-mediated transcriptomic changes in adult mouse brain ventral tegmental area |
| Accession | GSE45044 |
| Summary | Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. However, ventral tegmental area (VTA), a region adjacent to SNpc, is less affected in PD. Until now, molecular mechanisms behind VTA aging have not been fully investigated using high throughput techniques. Here, aging-associated early changes in transcriptome of VTA were investigated comparing late middle-aged (18 months old) to young (2 months old) mice. |
| Organism | Mus musculus |
| Platform | GPL1261 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Cell | Ventral Tegmental Area |
| Perturbation | Aging |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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