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| Title / Description | Estradiol effect on ERK1/ERK2-deficient MCF-7 breast adenocarcinoma cells: time course |
| Accession | GDS4052 |
| Summary | Analysis of MCF7 cells depleted of ERK1 or ERK2 and treated with estradiol for up to 24hrs. ERK1 and ERK2 are downstream effectors in the MAP kinase pathway; estrogen receptor α (ERα) and MAPKs play key roles in hormone-dependent cancers. Results provide insight into ERα and MAPK interactions. |
| Organism | Homo sapiens |
| Platform | GPL571 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Cell | MCF7 |
| Perturbation | treatment response |
| Disease | cancer |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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