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| Title / Description | Molecular profile of ketamine in comparison to memantine and phencyclidyne and other psychotropic drugs [mouse striatum] |
| Accession | GSE73799 |
| Summary | Ketamine has been found to elicit a rapid antidepressant effects in treatment-refractory affective disorders. To indicate the underlying mechanism of action we have performed whole-genome microarray profiling. Moreover, the effects of ketamine were compared to other NMDA receptor antagonists phencyclidine and memantine. Type: Drug response, Time-course, Gene expression profiling with Illumina Microarrays Keywords: Ketamine, NMDA antagonist, Phencyclidyne, Memantine, Time-course, Gene Expression, Acute treatment |
| Organism | Mus musculus |
| Platform | GPL6887 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Cell_type | Striatum |
| Drug_id | DB01221 |
| Drug_name | Ketamine - 8hr |
| Organism | Mouse |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | Crowdsourcing | |
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