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SOFT file
| Title / Description |
Expression data from hearts of wild-type C57BL/6 mice infected with T. cruzi and controls (uninfected) |
| Accession |
GSE41089
|
| Summary |
An efficient innate immune recognition of the intracellular parasite T. cruzi is crucial for host protection against development of Chagas disease, which often leads to multiple organ damage, particularly the heart leading to cardiomyopathy. Mechanisms modulated by MyD88 have been shown to be necessary for resistance against T, cruzi infection. Recently, Nod-like receptors have been shown to play an important role as innate immune sensors, particularly as they relate to inflammasome function, caspase activation, and inflammatory cytokine production. In this study, we aimed to investigate the participation of innate immune responses in general, and inflammasomes in particular, in heart inflammation and cardiac damage upon infection with the T. cruzi parasite. We used microarrays to gain insight into gene expression in the cardiac tissue of mice infected with the causative agent of Trypanosoma cruzi, and identified distinct classes of up-regulated genes during this process, including important genes involved in inflammasome activation and innate immune responses in general. |
| Organism |
Mus musculus |
| Platform |
GPL8321 |
| Normalized |
False |
| Parsed SOFT file |
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Metadata
| Differential expression method |
Characteristic Direction
|
| Cutoff |
500 |
| Microbe_id |
62515 |
| Microbe_name |
Trypanosoma cruzi |
| Cell_type |
Heart |
| Organism |
mouse |
Visualizations
| Principal Component Analysis |
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| Hierarchical clustering |
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External Links and Downloads
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Gene lists
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Enrichr
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L1000CDS2
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PAEA
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Crowdsourcing |
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