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| Title / Description | Gene expression data from iPSC-derived neural cells, comparison between APP wild and E693delta mutation |
| Accession | GSE43326 |
| Summary | Oligomeric forms of amyloid-beta peptide (Abeta) are presumed to play a pivotal role in the pathogenesis of Alzheimer’s disease (AD). However, it is still unclear how Abeta oligomers contribute to AD pathogenesis in patient neural cells. We generated induced pluripotent stem cells (iPSCs) from a familial AD patient and differentiated them into neural cells. Abeta oligomers were accumulated in neural cells of AD bearing amyloid precursor protein (APP)-E693delta mutation. To uncover Abeta oligomers in AD(APP-E693delta) neural cells, we analyzed gene expression profiles of control and the AD neural cells |
| Organism | Homo sapiens |
| Platform | GPL6244 |
| Normalized | True |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 1000 |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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