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| Title / Description | Estradiol effect on ERK1/ERK2-deficient MCF-7 breast adenocarcinoma cells: time course |
| Accession | GSE24592 |
| Summary | Analysis of MCF7 cells depleted of ERK1 or ERK2 and treated with estradiol for up to 24hrs. ERK1 and ERK2 are downstream effectors in the MAP kinase pathway; estrogen receptor α (ERα) and MAPKs play key roles in hormone-dependent cancers. Results provide insight into ERα and MAPK interactions. |
| Organism | Homo sapiens |
| Platform | GPL571 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Drug_name | Estradiol |
| Smiles | CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O |
| Drugbank_id | DB00783 |
| Pubchem_cid | 5757 |
| Cell_type | MCF7 cells depleted of ERK2 - 4 Hours after treatment |
| Organism | human |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | Crowdsourcing | |
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