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| Title / Description | The transcriptome of TRPV1-positive sensory neurons revealed by subgroup-elimination transcriptomics |
| Accession | GSE59727 |
| Summary | We developed an approach to rapidly eliminate the subgroup of sensory neurons expressing the heat-gated cation channel TRPV1 from dissociated rat sensory ganglia using agonist treatment followed by density centrifugation. To identify transcripts predomintly expressed in TRPV1-positive neurons, we compared the transcriptome of all cells within sensory ganglia versus all cells without TRPV1 expressing neurons using RNA-Seq. |
| Organism | Rattus norvegicus |
| Platform | GPL6101 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Drug_name | Capsaicin |
| Smiles | CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC |
| Pubchem_cid | 1548943 |
| Cell_type | DRG neurons - 10 µM for 30 min |
| Organism | rat |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | Crowdsourcing | |
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