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| Title / Description | The downstream molecules of Notch signaling in vascular endothelial cell senescence |
| Accession | GSE40403 |
| Summary | To further investigate the mechanism how the decline in Notch signaling induces premature senescence in endothelial cells, we performed microarray analysis and identified Id1 nd DUSP1 as the downstream molecules of Notch pathway. In quantitative PCR and western blot analyses, the expression level of Id1 and DUSP1 increased in Notch1 over-expressing endothelial cells and decreased in knockdown similar to the result of microarray. |
| Organism | Homo sapiens |
| Platform | GPL6480 |
| Normalized | True |
| Parsed SOFT file |
| Differential expression method | foo |
| Correction method | BH |
| Cell | HUVEC |
| Perturbation | Notch1 shRNA |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | |
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