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| Title / Description | Transcriptomic profiling of regulatory effects of quercetin and resveratrol supplementation in high fat diet fed mice |
| Accession | GSE38325 |
| Summary | To systemically evaluate the comprehensive alterations under the supplements of quercetin and/or resveratrol in high fat diet (HFD) fed mice, we have employed whole genome microarray expression profiling as a discovery platform to identify genes that differentially altered by different treatments. Gene expression profiles were significantly altered by long term HFD feeding. However, quercetin, resveratrol and their combination could effectively attenuate this alteration. Especially, combination use of quercetin and resveratrol showed more signifcant benefits on the changes of genes, involved in metabolic disorders, induced by HFD, which revealed a synergistic effect of quercetin and resveratrol supplementation in high fat diet fed mice. |
| Organism | Mus musculus |
| Platform | GPL7202 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Organism | Mus musculus |
| Cell | liver |
| Perturbation | resveratrol |
| Concentration | 4g/kg diet |
| Relevant information | Standard Diet X High fat diet |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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