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| Title / Description | Effect in MV4;11 cells of 3hr cortistatin A treatment on gene expression |
| Accession | GSE65019 |
| Summary | We characterized the marine natural product cortistatin A (CA) as an inhibitor of CDK8 to determine whether pharmacologic inhibition of CDK8 regulates super-enhancer function and inhibits AML proliferation. In this series, we examine the transcriptional effect on MV4;11 cells of 3hrs exposure to CA to identify immediate effects. |
| Organism | Homo sapiens |
| Platform | GPL570 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Cell_type | MV4;11 cells |
| Drug_id | CID 11561907 |
| Drug_name | Cortistatin A |
| Organism | Human |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | Crowdsourcing | |
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