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SOFT file
| Title / Description |
Host Age is a Systemic Regulator of Gene Expression Impacting Cancer Progression |
| Accession |
GSE66414
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| Summary |
Given that aging is the major determinant of cancer incidence, and that cancer incidence is dictated in large part by processes modulating progression of existing subclinical cancers, we demonstrate that aging may be an organizing axis for identifying cancer progression-modulating processes. This would permit the broad understanding of the aging process to directly inform the question of what changes in aggregate host signaling favor cancer progression. Exploring this idea, a syngeneic murine Lewis lung cancer model in adolescent (68 days), young adult (143 days), middle-aged (551 days), and old (736 days) C57BL/6 mice was used to identify the signaling and functional processes varying significantly with host age. As anticipated, many of these specific endpoints proved to be major determinants of cancer progression. Older hosts demonstrated decreased angiogenesis, decreased metabolism and dysregulated apoptosis, all identified as hallmarks of cancer progression. Transforming growth factor 1, downregulated in older hosts, was also identified as a central player in these systemic processes. It is concluded that the strong host-age dependence here observed for tumor advancement facilitates the identification of an overarching tumor control dynamic exerted by the host. Revealed is insight into a mechanistic basis for the role of aging on modulation of tumor progression that may be therapeutically exploitable. |
| Organism |
Mus musculus |
| Platform |
GPL6887 |
| Normalized |
False |
| Parsed SOFT file |
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Metadata
| Differential expression method |
Characteristic Direction
|
| Cutoff |
500 |
| Organism |
Mus musculus |
| Old |
736 |
| Young |
143 |
| Cell_type |
tumor |
| Age_unit |
day |
| Organism |
mouse |
External Links and Downloads
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Gene lists
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Enrichr
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L1000CDS2
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PAEA
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Crowdsourcing |
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