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| Title / Description | Mechanisms of pparγ activation by non-steroidal anti-inflammatory drugs and GQ16. |
| Accession | GSE64075 |
| Summary | This study was undertaken to assess the similarities (or differences) between the well-established PPARγ agonist Rosiglitazone and Non-steroidal anti-inflammatory drugs (NSAIDs) diclofenac, indomethacin and ibuprofen, as well as the partial agonist GQ16 at the transcriptome level. Assessment of NSAID and GQ16 activities in PPARγ-dependent 3T3-L1 cells reveals that NSAIDs and GQ16 display similar effects toward PPARγ-dependent target genes in a manner similar to that of Rosiglitazone. |
| Organism | Mus musculus |
| Platform | GPL6887 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Organism | Mus musculus |
| Cell | 3T3L1 preadipocyte |
| Perturbation | ibuprofen |
| Concentration | 75 uM |
| Time | 24 hrs |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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